MX356791B - Procedimiento para la preparacion de drospirenona. - Google Patents

Procedimiento para la preparacion de drospirenona.

Info

Publication number
MX356791B
MX356791B MX2015014331A MX2015014331A MX356791B MX 356791 B MX356791 B MX 356791B MX 2015014331 A MX2015014331 A MX 2015014331A MX 2015014331 A MX2015014331 A MX 2015014331A MX 356791 B MX356791 B MX 356791B
Authority
MX
Mexico
Prior art keywords
drospirenone
dimethylene
preparation
antimineralocorticoid
carbolactone
Prior art date
Application number
MX2015014331A
Other languages
English (en)
Other versions
MX2015014331A (es
Inventor
Roberto Lenna
Francesco Barbieri
Maria Giovanna Luoni
Monica Noseda
Original Assignee
Ind Chimica Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ind Chimica Srl filed Critical Ind Chimica Srl
Publication of MX2015014331A publication Critical patent/MX2015014331A/es
Publication of MX356791B publication Critical patent/MX356791B/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J53/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002Carbocyclic rings fused
    • C07J53/0043 membered carbocyclic rings
    • C07J53/0083 membered carbocyclic rings in position 15/16
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18Feminine contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Se describe un procedimiento en el cual, empleando como producto de partida 17a- (3-hidroxipropil)-6ß,7ß; 15ß, 16ß-dimetilen-5ß-androstan-3ß,5,17ß-triolo (II) ó 3ß,5-dihidroxi- 6ß,7ß;15ß,16ß-dimetilen-5ß,17a-pregnano-21,17-carbolactona (III), a través de una reacción de un solo paso se obtiene drospirenona, (I), un esteroide sintético con actividad progestogéníca, antimineralocorticoide y antiandrogénica, útil para la preparación de composiciones farmacéuticas de acción anticonceptiva. (ver Fórmulas).
MX2015014331A 2013-04-12 2013-04-12 Procedimiento para la preparacion de drospirenona. MX356791B (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2013/052918 WO2014167386A1 (en) 2013-04-12 2013-04-12 Process for the preparation of drospirenone

Publications (2)

Publication Number Publication Date
MX2015014331A MX2015014331A (es) 2015-12-08
MX356791B true MX356791B (es) 2018-06-12

Family

ID=48539320

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015014331A MX356791B (es) 2013-04-12 2013-04-12 Procedimiento para la preparacion de drospirenona.

Country Status (14)

Country Link
US (1) US9556220B2 (es)
EP (1) EP2984100B1 (es)
JP (1) JP6469078B2 (es)
CN (1) CN105164144B (es)
AR (1) AR095833A1 (es)
BR (1) BR112015025816B1 (es)
CA (1) CA2909087C (es)
DK (1) DK2984100T3 (es)
ES (1) ES2630331T3 (es)
HU (1) HUE032858T2 (es)
MX (1) MX356791B (es)
PL (1) PL2984100T3 (es)
PT (1) PT2984100T (es)
WO (1) WO2014167386A1 (es)

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3042136A1 (de) 1980-11-03 1982-06-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur herstellung von 3 (beta), 7 (beta) -dihydroxy- (delta) (pfeil hoch)5(pfeil hoch) -steroiden
EP0075189B1 (en) 1981-09-21 1985-08-28 Schering Aktiengesellschaft 3-beta,7-beta,15-alpha-trihydroxy-5-androsten-17-one, its 3,15-dipivalate, and its preparation
DE19633685C1 (de) * 1996-08-12 1997-10-09 Schering Ag Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens
JP4645779B2 (ja) * 2000-05-16 2011-03-09 日産化学工業株式会社 キノリンカルボアルデヒドの製造法
ITMI20040367A1 (it) * 2004-03-01 2004-06-01 Ind Chimica Srl Processo per la preparazione di drospirenone
ITMI20042338A1 (it) 2004-12-06 2005-03-06 Ind Chimica Srl Processo per la preparazione di drospirenone
DE502005004948D1 (de) * 2005-07-21 2008-09-18 Bayer Schering Pharma Ag Verfahren zur Herstellung von 3-Oxo-pregn-4-en-21,17-carbolactonen durch die metallfreie Oxidation von 17-(3-hydroxypropyl)-3,17-dihydroxyandrostanen
CN100480256C (zh) * 2006-06-21 2009-04-22 上海迪赛诺医药发展有限公司 合成曲螺酮的方法
WO2008137050A2 (en) * 2007-05-01 2008-11-13 Sicor Inc. A process for preparing drospirenone and intermediate thereof
RS51892B (en) * 2007-07-26 2012-02-29 Newchem S.P.A. DROSPIRENON PREPARATION PROCESS
CN101503455B (zh) 2009-03-11 2011-02-16 药源药物化学(上海)有限公司 一种制备屈螺酮的方法及中间体
ES2432063T3 (es) 2009-06-16 2013-11-29 Crystal Pharma, S.A.U. Procedimiento para la obtención de 17-espirolactonas en esteroides
ES2419663T3 (es) * 2010-08-03 2013-08-21 Newchem S.P.A. Métodos para la preparación de Drospirenona y productos intermedios de la misma

Also Published As

Publication number Publication date
US20160052960A1 (en) 2016-02-25
JP6469078B2 (ja) 2019-02-13
BR112015025816B1 (pt) 2021-02-02
CN105164144A (zh) 2015-12-16
PT2984100T (pt) 2017-07-14
AR095833A1 (es) 2015-11-11
WO2014167386A1 (en) 2014-10-16
HUE032858T2 (en) 2017-11-28
JP2016516095A (ja) 2016-06-02
CA2909087A1 (en) 2014-10-16
PL2984100T3 (pl) 2017-10-31
DK2984100T3 (en) 2017-07-10
BR112015025816A2 (pt) 2017-07-25
ES2630331T3 (es) 2017-08-21
US9556220B2 (en) 2017-01-31
CN105164144B (zh) 2017-03-08
EP2984100B1 (en) 2017-04-05
CA2909087C (en) 2020-01-07
MX2015014331A (es) 2015-12-08
EP2984100A1 (en) 2016-02-17

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