DK1828222T3 - Fremgangsmåde til fremstilling af drospirenon - Google Patents

Fremgangsmåde til fremstilling af drospirenon

Info

Publication number
DK1828222T3
DK1828222T3 DK05819134.7T DK05819134T DK1828222T3 DK 1828222 T3 DK1828222 T3 DK 1828222T3 DK 05819134 T DK05819134 T DK 05819134T DK 1828222 T3 DK1828222 T3 DK 1828222T3
Authority
DK
Denmark
Prior art keywords
drospirenone
preparation
antimineralocorticoid
progestogenic
androstane
Prior art date
Application number
DK05819134.7T
Other languages
English (en)
Inventor
Francesca Costantino
Roberto Lenna
Silvia Piuri
Original Assignee
Ind Chimica Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35840070&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1828222(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ind Chimica Srl filed Critical Ind Chimica Srl
Application granted granted Critical
Publication of DK1828222T3 publication Critical patent/DK1828222T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Pens And Brushes (AREA)
DK05819134.7T 2004-12-06 2005-11-14 Fremgangsmåde til fremstilling af drospirenon DK1828222T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT002338A ITMI20042338A1 (it) 2004-12-06 2004-12-06 Processo per la preparazione di drospirenone
PCT/EP2005/055963 WO2006061309A1 (en) 2004-12-06 2005-11-14 Process for the preparation of drospirenone

Publications (1)

Publication Number Publication Date
DK1828222T3 true DK1828222T3 (da) 2011-02-21

Family

ID=35840070

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05819134.7T DK1828222T3 (da) 2004-12-06 2005-11-14 Fremgangsmåde til fremstilling af drospirenon

Country Status (20)

Country Link
US (3) US20080207575A1 (da)
EP (2) EP1828222B9 (da)
JP (1) JP5626616B2 (da)
CN (1) CN101065396B (da)
AT (1) ATE491716T1 (da)
BR (1) BRPI0517752C1 (da)
CA (1) CA2589928C (da)
CL (1) CL2007001581A1 (da)
CY (1) CY1111209T1 (da)
DE (1) DE602005025396D1 (da)
DK (1) DK1828222T3 (da)
ES (2) ES2602823T3 (da)
IL (1) IL183645A (da)
IT (1) ITMI20042338A1 (da)
MX (1) MX2007006701A (da)
PL (1) PL1828222T3 (da)
PT (1) PT1828222E (da)
SI (1) SI1828222T1 (da)
WO (1) WO2006061309A1 (da)
ZA (1) ZA200705492B (da)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7319154B2 (en) 2005-07-21 2008-01-15 Bayer Schering Pharma Ag Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes
HUE027858T2 (en) * 2005-07-21 2016-11-28 Bayer Pharma AG Process for the preparation of 3-oxo-pregn-4-ene-21,17-carbolactones by the metal-free oxidation of 17- (3-hydroxypropyl) -3,17-dihydroxyandrostanes \ t
ATE403668T1 (de) * 2005-07-21 2008-08-15 Bayer Schering Pharma Ag Verfahren zur herstellung von 3-oxo-pregn-4-en-21,17-carbolactonen durch die metallfreie oxidation von 17-(3-hydroxypropyl)-3,17- dihydroxyandrostanen
EP2057182A2 (en) * 2007-05-01 2009-05-13 Sicor, Inc. A process for preparing drospirenone and intermediate thereof
DE102007027635A1 (de) * 2007-06-12 2008-12-18 Bayer Schering Pharma Aktiengesellschaft 17ß-Cyano-19-androst-4-en-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel
DE102007030596B3 (de) * 2007-06-28 2009-03-12 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Herstellung von 17-(3-Hydroxypropyl)-17-hydroxysteroiden
PT2019114E (pt) * 2007-07-26 2011-02-07 Newchem S P A Processo para a preparação de drospirenona
EP2265629B1 (en) * 2008-03-05 2015-06-24 Evestra, Inc. Bismethylene-17 carbolactones and related uses
EP2367808A4 (en) * 2008-11-25 2012-05-09 Evestra Inc g-LACTONES OF 3- (6,6-ETHYLENE-17β-HYDROXY-3-OXO-17α-PREGEN-4-EENE-17α-YL) PROGESTATIVE PROPIONIC ACID
US8334375B2 (en) * 2009-04-10 2012-12-18 Evestra, Inc. Methods for the preparation of drospirenone
ES2432063T3 (es) 2009-06-16 2013-11-29 Crystal Pharma, S.A.U. Procedimiento para la obtención de 17-espirolactonas en esteroides
CN101775057B (zh) * 2010-02-09 2014-07-16 浙江仙琚制药股份有限公司 屈螺酮及其中间体的制备方法
CN101830959B (zh) * 2010-05-27 2012-07-18 杭州龙山化工有限公司 一种曲螺酮的合成方法
US10849857B2 (en) 2010-07-28 2020-12-01 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
US11351122B1 (en) 2010-07-28 2022-06-07 Laboratorios Leon Farma Sa Synthetic progestogens and pharmaceutical compositions comprising the same
AR081670A1 (es) 2010-06-29 2012-10-10 Leon Farma Sa Lab Composicion farmaceutica que comprende drospirenona y kit anticonceptivo
US9603860B2 (en) 2010-07-28 2017-03-28 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
EP2415778B1 (en) 2010-08-03 2013-05-15 Newchem S.p.A. Methods for the preparation of Drospirenone and intermediates thereof
CN102040650B (zh) * 2010-10-26 2014-03-26 西安科技大学 串联反应构建甾体-6β,7β-亚甲基结构的方法
WO2012107513A1 (en) 2011-02-10 2012-08-16 Crystal Pharma, S.A.U. Process for obtaining drospirenone
ITMI20111383A1 (it) * 2011-07-25 2013-01-26 Ind Chimica Srl Processo per la preparazione di drospirenone
EP2597101A1 (en) 2011-11-22 2013-05-29 Industriale Chimica S.R.L. Process for the preparation of drospirenone
ITMI20120146A1 (it) * 2012-02-03 2013-08-04 Ind Chimica Srl Processo per la preparazione di composti policiclici insaturi dotati di attivita' farmacologica
US9394334B2 (en) 2011-11-22 2016-07-19 Industriale Chimica S.R.L. Process for the preparation of drospirenone
CN102887934B (zh) * 2012-09-20 2015-05-27 杭州福斯特药业有限公司 一种屈螺酮的制备方法
ITMI20130183A1 (it) * 2013-02-08 2014-08-09 Ind Chimica Srl Processo per la preparazione di drospirenone.
WO2014128525A1 (en) 2013-02-20 2014-08-28 Industriale Chimica S.R.L. Process for the preparation of drospirenone
US9556220B2 (en) 2013-04-12 2017-01-31 Industriale Chimica S.R.L. Process for the preparation of drospirenone
WO2014174338A1 (en) * 2013-04-22 2014-10-30 Industriale Chimica S.R.L. Process for preparing an intermediate useful in the production of drospirenone
CN104174341B (zh) * 2013-05-27 2017-09-26 乌鲁木齐益好天成新型节能材料有限公司 一种固相硅凝胶的制备方法
ES2970532T3 (es) 2015-06-23 2024-05-29 Laboratorios Leon Farma Sa Anticonceptivo basado en drospirenona para una paciente que presenta exceso de peso
EP3108889A1 (en) 2015-06-23 2016-12-28 Philippe Perrin Drospirenone-based contraceptive for a female patient affected with excess weight
CN105017362A (zh) * 2015-07-22 2015-11-04 浙江圃瑞药业有限公司 将表雄酮氧化为雄烷二酮的清洁生产方法
CN110407905B (zh) * 2019-08-22 2021-09-28 武汉九珑人福药业有限责任公司 一种屈螺酮及其中间体的制备方法
EP4134082A1 (en) 2021-08-12 2023-02-15 Chemo Research, S.L. Method for treating endometriosis and providing effective contraception
CN114437169B (zh) * 2022-01-25 2023-04-07 台州仙琚药业有限公司 一种屈螺酮关键中间体溴代物的合成方法
WO2023152658A1 (en) 2022-02-10 2023-08-17 Lupin Limited Slow release drospirenone tablet composition
WO2023165988A1 (en) 2022-03-01 2023-09-07 Chemo Research, S.L. Chewable oral contraceptive

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3042136A1 (de) * 1980-11-03 1982-06-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur herstellung von 3 (beta), 7 (beta) -dihydroxy- (delta) (pfeil hoch)5(pfeil hoch) -steroiden
EP0075189B1 (en) * 1981-09-21 1985-08-28 Schering Aktiengesellschaft 3-beta,7-beta,15-alpha-trihydroxy-5-androsten-17-one, its 3,15-dipivalate, and its preparation
DE3916112A1 (de) * 1989-05-16 1990-11-22 Schering Ag Dihydrospirorenon als antiandrogen
KR100355516B1 (ko) * 1993-12-17 2003-02-11 파마시아 앤드 업존 캄파니 비스노르알콜을비스노르알데히드로전환시키는방법
DE19633685C1 (de) * 1996-08-12 1997-10-09 Schering Ag Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens
ATE339437T1 (de) * 2002-08-16 2006-10-15 Pharmacia & Upjohn Co Llc 5-androsten-3-olsteroidzwischenprodukte und verfahren zu deren herstellung
PL376919A1 (pl) * 2002-11-06 2006-01-09 Pharmacia & Upjohn Company Llc Sposoby wytwarzania 7-karboksy-podstawionych steroidów
ITMI20040367A1 (it) * 2004-03-01 2004-06-01 Ind Chimica Srl Processo per la preparazione di drospirenone
HUP0402465A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main intermediates of the process
HUP0402466A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main, intermediates of the process
US7319154B2 (en) * 2005-07-21 2008-01-15 Bayer Schering Pharma Ag Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes

Also Published As

Publication number Publication date
EP2108652A3 (en) 2011-06-22
ES2602823T3 (es) 2017-02-22
CA2589928A1 (en) 2006-06-15
BRPI0517752B1 (pt) 2018-12-26
BRPI0517752A (pt) 2008-10-21
BRPI0517752C1 (pt) 2021-05-25
PL1828222T3 (pl) 2011-04-29
EP2108652A2 (en) 2009-10-14
WO2006061309A1 (en) 2006-06-15
IL183645A (en) 2012-02-29
CA2589928C (en) 2013-07-02
EP1828222A1 (en) 2007-09-05
ATE491716T1 (de) 2011-01-15
JP2008522962A (ja) 2008-07-03
CY1111209T1 (el) 2015-06-11
EP1828222B1 (en) 2010-12-15
CN101065396B (zh) 2012-05-23
US20100331291A1 (en) 2010-12-30
US8227596B2 (en) 2012-07-24
CL2007001581A1 (es) 2008-01-04
ITMI20042338A1 (it) 2005-03-06
EP1828222B9 (en) 2011-08-31
BRPI0517752B8 (pt) 2019-02-19
US20080207575A1 (en) 2008-08-28
PT1828222E (pt) 2011-01-31
SI1828222T1 (sl) 2011-03-31
JP5626616B2 (ja) 2014-11-19
MX2007006701A (es) 2007-11-09
US20120264723A1 (en) 2012-10-18
EP2108652B1 (en) 2016-08-17
DE602005025396D1 (de) 2011-01-27
ES2355982T3 (es) 2011-04-01
IL183645A0 (en) 2007-09-20
CN101065396A (zh) 2007-10-31
ZA200705492B (en) 2008-08-27

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