BRPI0517752A - processo para a preparação de drospirenona - Google Patents
processo para a preparação de drospirenonaInfo
- Publication number
- BRPI0517752A BRPI0517752A BRPI0517752-9A BRPI0517752A BRPI0517752A BR PI0517752 A BRPI0517752 A BR PI0517752A BR PI0517752 A BRPI0517752 A BR PI0517752A BR PI0517752 A BRPI0517752 A BR PI0517752A
- Authority
- BR
- Brazil
- Prior art keywords
- drospirenone
- preparation
- antimineralocorticoid
- progestogenic
- androstane
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C07J53/008—3 membered carbocyclic rings in position 15/16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Reproductive Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Gynecology & Obstetrics (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pens And Brushes (AREA)
- Macromonomer-Based Addition Polymer (AREA)
Abstract
PROCESSO PARA A PREPARAçãO DE DROSPIRENONA. Um processo é descrito para a preparação de drospirenona, um esterólde sintético com atividade progestogênica, antimineralocorticóidica e antiandrogênica, útil para preparação de composições farmacêuticas com ação contraceptiva; compreendendo a oxidação de 17<224>-(3-hidroxipropil) -6<225>, 7<225>; 15<225>, l6<225>-dimetileno-5<225>-androstano-3<225>, 5, 17<225>-triol.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT002338A ITMI20042338A1 (it) | 2004-12-06 | 2004-12-06 | Processo per la preparazione di drospirenone |
PCT/EP2005/055963 WO2006061309A1 (en) | 2004-12-06 | 2005-11-14 | Process for the preparation of drospirenone |
Publications (4)
Publication Number | Publication Date |
---|---|
BRPI0517752A true BRPI0517752A (pt) | 2008-10-21 |
BRPI0517752B1 BRPI0517752B1 (pt) | 2018-12-26 |
BRPI0517752B8 BRPI0517752B8 (pt) | 2019-02-19 |
BRPI0517752C1 BRPI0517752C1 (pt) | 2021-05-25 |
Family
ID=35840070
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0517752A BRPI0517752C1 (pt) | 2004-12-06 | 2005-11-14 | processo para a preparação de drospirenona |
Country Status (20)
Country | Link |
---|---|
US (3) | US20080207575A1 (pt) |
EP (2) | EP2108652B1 (pt) |
JP (1) | JP5626616B2 (pt) |
CN (1) | CN101065396B (pt) |
AT (1) | ATE491716T1 (pt) |
BR (1) | BRPI0517752C1 (pt) |
CA (1) | CA2589928C (pt) |
CL (1) | CL2007001581A1 (pt) |
CY (1) | CY1111209T1 (pt) |
DE (1) | DE602005025396D1 (pt) |
DK (1) | DK1828222T3 (pt) |
ES (2) | ES2355982T3 (pt) |
IL (1) | IL183645A (pt) |
IT (1) | ITMI20042338A1 (pt) |
MX (1) | MX2007006701A (pt) |
PL (1) | PL1828222T3 (pt) |
PT (1) | PT1828222E (pt) |
SI (1) | SI1828222T1 (pt) |
WO (1) | WO2006061309A1 (pt) |
ZA (1) | ZA200705492B (pt) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7319154B2 (en) | 2005-07-21 | 2008-01-15 | Bayer Schering Pharma Ag | Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes |
KR101410583B1 (ko) * | 2005-07-21 | 2014-06-23 | 바이엘 파마 악티엔게젤샤프트 | 17-(3-히드록시프로필)-3,17-디히드록시안드로스탄의금속-무함유 산화에 의한3-옥소-프레근-4-엔-21,17-카르보락톤의 제조 방법 |
DE502005004948D1 (de) * | 2005-07-21 | 2008-09-18 | Bayer Schering Pharma Ag | Verfahren zur Herstellung von 3-Oxo-pregn-4-en-21,17-carbolactonen durch die metallfreie Oxidation von 17-(3-hydroxypropyl)-3,17-dihydroxyandrostanen |
WO2008137050A2 (en) * | 2007-05-01 | 2008-11-13 | Sicor Inc. | A process for preparing drospirenone and intermediate thereof |
DE102007027635A1 (de) * | 2007-06-12 | 2008-12-18 | Bayer Schering Pharma Aktiengesellschaft | 17ß-Cyano-19-androst-4-en-Derivat, dessen Verwendung und das Derivat enthaltende Arzneimittel |
DE102007030596B3 (de) * | 2007-06-28 | 2009-03-12 | Bayer Schering Pharma Aktiengesellschaft | Verfahren zur Herstellung von 17-(3-Hydroxypropyl)-17-hydroxysteroiden |
RS51892B (en) * | 2007-07-26 | 2012-02-29 | Newchem S.P.A. | DROSPIRENON PREPARATION PROCESS |
US7960368B2 (en) * | 2008-03-05 | 2011-06-14 | Everstra, Inc. | Bismethylene-17A carbolactones and related uses |
US8222237B2 (en) * | 2008-11-25 | 2012-07-17 | Evestra, Inc. | Progestational 3-(6,6-ethylene-17B-hydroxy-3-oxo-17A-pregna-4-ene-17A-yl)propionic acid G-lactones |
US8334375B2 (en) * | 2009-04-10 | 2012-12-18 | Evestra, Inc. | Methods for the preparation of drospirenone |
ES2432063T3 (es) | 2009-06-16 | 2013-11-29 | Crystal Pharma, S.A.U. | Procedimiento para la obtención de 17-espirolactonas en esteroides |
CN101775057B (zh) * | 2010-02-09 | 2014-07-16 | 浙江仙琚制药股份有限公司 | 屈螺酮及其中间体的制备方法 |
CN101830959B (zh) * | 2010-05-27 | 2012-07-18 | 杭州龙山化工有限公司 | 一种曲螺酮的合成方法 |
US11351122B1 (en) | 2010-07-28 | 2022-06-07 | Laboratorios Leon Farma Sa | Synthetic progestogens and pharmaceutical compositions comprising the same |
AR081670A1 (es) | 2010-06-29 | 2012-10-10 | Leon Farma Sa Lab | Composicion farmaceutica que comprende drospirenona y kit anticonceptivo |
US10849857B2 (en) | 2010-07-28 | 2020-12-01 | Laboratorios Leon Farma Sa | Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same |
US9603860B2 (en) | 2010-07-28 | 2017-03-28 | Laboratorios Leon Farma Sa | Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same |
ES2419663T3 (es) | 2010-08-03 | 2013-08-21 | Newchem S.P.A. | Métodos para la preparación de Drospirenona y productos intermedios de la misma |
CN102040650B (zh) * | 2010-10-26 | 2014-03-26 | 西安科技大学 | 串联反应构建甾体-6β,7β-亚甲基结构的方法 |
WO2012107513A1 (en) | 2011-02-10 | 2012-08-16 | Crystal Pharma, S.A.U. | Process for obtaining drospirenone |
ITMI20111383A1 (it) | 2011-07-25 | 2013-01-26 | Ind Chimica Srl | Processo per la preparazione di drospirenone |
CA2856324C (en) | 2011-11-22 | 2019-08-13 | Industriale Chimica S.R.L. | Process for the preparation of drospirenone |
EP2597101A1 (en) | 2011-11-22 | 2013-05-29 | Industriale Chimica S.R.L. | Process for the preparation of drospirenone |
ITMI20120146A1 (it) * | 2012-02-03 | 2013-08-04 | Ind Chimica Srl | Processo per la preparazione di composti policiclici insaturi dotati di attivita' farmacologica |
CN102887934B (zh) * | 2012-09-20 | 2015-05-27 | 杭州福斯特药业有限公司 | 一种屈螺酮的制备方法 |
ITMI20130183A1 (it) * | 2013-02-08 | 2014-08-09 | Ind Chimica Srl | Processo per la preparazione di drospirenone. |
ES2651145T3 (es) | 2013-02-20 | 2018-01-24 | Industriale Chimica S.R.L. | Proceso para la preparación de drospirenona |
HUE032858T2 (en) | 2013-04-12 | 2017-11-28 | Ind Chimica Srl | Method for producing drospirenone |
WO2014174338A1 (en) * | 2013-04-22 | 2014-10-30 | Industriale Chimica S.R.L. | Process for preparing an intermediate useful in the production of drospirenone |
CN104174341B (zh) * | 2013-05-27 | 2017-09-26 | 乌鲁木齐益好天成新型节能材料有限公司 | 一种固相硅凝胶的制备方法 |
MY187233A (en) | 2015-06-23 | 2021-09-13 | Laboratorios Leon Farma Sa | Drospirenone-based contraceptive for a female patient affected with excess weight |
EP3108889A1 (en) | 2015-06-23 | 2016-12-28 | Philippe Perrin | Drospirenone-based contraceptive for a female patient affected with excess weight |
CN105017362A (zh) * | 2015-07-22 | 2015-11-04 | 浙江圃瑞药业有限公司 | 将表雄酮氧化为雄烷二酮的清洁生产方法 |
CN110407905B (zh) * | 2019-08-22 | 2021-09-28 | 武汉九珑人福药业有限责任公司 | 一种屈螺酮及其中间体的制备方法 |
EP4134082A1 (en) | 2021-08-12 | 2023-02-15 | Chemo Research, S.L. | Method for treating endometriosis and providing effective contraception |
CN114437169B (zh) * | 2022-01-25 | 2023-04-07 | 台州仙琚药业有限公司 | 一种屈螺酮关键中间体溴代物的合成方法 |
WO2023152658A1 (en) | 2022-02-10 | 2023-08-17 | Lupin Limited | Slow release drospirenone tablet composition |
WO2023165988A1 (en) | 2022-03-01 | 2023-09-07 | Chemo Research, S.L. | Chewable oral contraceptive |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3042136A1 (de) * | 1980-11-03 | 1982-06-09 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur herstellung von 3 (beta), 7 (beta) -dihydroxy- (delta) (pfeil hoch)5(pfeil hoch) -steroiden |
EP0075189B1 (en) * | 1981-09-21 | 1985-08-28 | Schering Aktiengesellschaft | 3-beta,7-beta,15-alpha-trihydroxy-5-androsten-17-one, its 3,15-dipivalate, and its preparation |
DE3916112A1 (de) * | 1989-05-16 | 1990-11-22 | Schering Ag | Dihydrospirorenon als antiandrogen |
DE69415345T2 (de) * | 1993-12-17 | 1999-05-12 | Upjohn Co | Verfahren zur herstellung von bisnoraldehyden aus bisnoralkohol |
DE19633685C1 (de) | 1996-08-12 | 1997-10-09 | Schering Ag | Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens |
EP1534732B1 (en) * | 2002-08-16 | 2006-09-13 | Pharmacia & Upjohn Company LLC | 5 androsten-3-ol steroid intermediates and processes for their preparation |
WO2004043987A1 (en) * | 2002-11-06 | 2004-05-27 | Pharmacia & Upjohn Company Llc | Processes for preparing 7-carboxy substituted steroids |
ITMI20040367A1 (it) * | 2004-03-01 | 2004-06-01 | Ind Chimica Srl | Processo per la preparazione di drospirenone |
HUP0402466A2 (en) * | 2004-11-30 | 2006-07-28 | Richter Gedeon Vegyeszet | Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main, intermediates of the process |
HUP0402465A2 (en) * | 2004-11-30 | 2006-07-28 | Richter Gedeon Vegyeszet | Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main intermediates of the process |
US7319154B2 (en) * | 2005-07-21 | 2008-01-15 | Bayer Schering Pharma Ag | Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes |
-
2004
- 2004-12-06 IT IT002338A patent/ITMI20042338A1/it unknown
-
2005
- 2005-11-14 EP EP09159293.1A patent/EP2108652B1/en active Active
- 2005-11-14 BR BRPI0517752A patent/BRPI0517752C1/pt active IP Right Grant
- 2005-11-14 MX MX2007006701A patent/MX2007006701A/es active IP Right Grant
- 2005-11-14 PT PT05819134T patent/PT1828222E/pt unknown
- 2005-11-14 CA CA2589928A patent/CA2589928C/en active Active
- 2005-11-14 US US11/792,465 patent/US20080207575A1/en not_active Abandoned
- 2005-11-14 DE DE602005025396T patent/DE602005025396D1/de active Active
- 2005-11-14 PL PL05819134T patent/PL1828222T3/pl unknown
- 2005-11-14 EP EP05819134A patent/EP1828222B9/en not_active Revoked
- 2005-11-14 ES ES05819134T patent/ES2355982T3/es active Active
- 2005-11-14 WO PCT/EP2005/055963 patent/WO2006061309A1/en active Application Filing
- 2005-11-14 DK DK05819134.7T patent/DK1828222T3/da active
- 2005-11-14 ES ES09159293.1T patent/ES2602823T3/es active Active
- 2005-11-14 CN CN2005800407958A patent/CN101065396B/zh active Active
- 2005-11-14 AT AT05819134T patent/ATE491716T1/de active
- 2005-11-14 JP JP2007543825A patent/JP5626616B2/ja active Active
- 2005-11-14 SI SI200531215T patent/SI1828222T1/sl unknown
-
2007
- 2007-06-01 CL CL2007001581A patent/CL2007001581A1/es unknown
- 2007-06-04 IL IL183645A patent/IL183645A/en active IP Right Grant
- 2007-07-05 ZA ZA200705492A patent/ZA200705492B/xx unknown
-
2010
- 2010-08-04 US US12/850,246 patent/US8227596B2/en active Active
-
2011
- 2011-02-16 CY CY20111100198T patent/CY1111209T1/el unknown
-
2012
- 2012-05-30 US US13/483,229 patent/US20120264723A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0517752B8 (pt) | processo para a preparação de drospirenona | |
EP1571153A3 (en) | A process for the preparation of drospirenone | |
TR200002774T2 (tr) | Alzheimer hastalığının tedavisi için steroit sapogenler ve bunların türevleri | |
EP1632237A3 (en) | Compositions comprising drospirenone and a complex between ethinyl-estradiol and a cyclodextrin | |
HUP0104718A3 (en) | Micronized eplerenone compositions, process for their preparation and use thereof for the preparation of pharmaceutical compositions | |
BRPI0512993A (pt) | uso de um antagonista de pr, kit farmaceuticamente últil, e, método de contracepção em uma fêmea em idade de parto | |
ME00298B (me) | Farmaceutski preparat | |
WO2005077968A3 (en) | 17-methylene-or 17 - spiro - cyclopropane 7 - substituted estra - 1, 3, 5 (10) - triene derivatives with anti - estrogenic activity | |
HUP0202500A2 (en) | Use of a pharmaceutical combination of ethinylestradiol and drospirenone for producing pharmaceutical compositions having contraceptive activity | |
BR0308660A (pt) | C-17 espirolactonização e 6,7 oxidação de esteróides | |
BR9814136A (pt) | Conjunto contraceptivo, processos de fabricação do mesmo e de tratamento de sangramento, usos de anti-progestogênio, de progestogênio e de anti-progestogênio, e, de um composto. | |
WO1999045886A3 (en) | New contraceptive kit for monotherapy | |
BR0116127A (pt) | Composto, composição farmacêutica, uso de um composto, e, conjunto para a contracepção masculina | |
PE20020709A1 (es) | Composiciones de complejos de estrogeno-ciclodextrina | |
AR061251A1 (es) | Proceso para la preparacion de drospirenona y una composicion farmaceutrica | |
HUP0301190A3 (en) | 16,17-carbocyclic condensed steroid compounds having selective estrogenic activity, pharmaceutical compositions containing them and their use | |
ITMI20051516A1 (it) | Derivati 17 alfa-sostituti dell'estradiolo ad attivita' cicatrizzante | |
RU2002130065A (ru) | Состав, обладающий контрацептивной активностью | |
MX356791B (es) | Procedimiento para la preparacion de drospirenona. | |
DE29720263U1 (de) | Beintrainer, insbesondere für die Benutzung durch ältere und behinderte Personen | |
EA200500222A1 (ru) | СОДЕРЖАЩАЯ ОБЛАДАЮЩИЙ АНДРОГЕННЫМ ДЕЙСТВИЕМ 11β-ГАЛОГЕНСТЕРОИД И ГЕСТАГЕН КОМПОЗИЦИЯ И МУЖСКОЙ КОНТРАЦЕПТИВ НА ОСНОВЕ ЭТОЙ КОМПОЗИЦИИ | |
PE20020520A1 (es) | Uso de antiprogestinas para la profilaxis y el tratamiento de enfermedades dependientes de hormonas | |
DOP2010000130A (es) | Combinacion de un gestageno y un estrogeno y uno o varios excipientes/portadores farmaceuticamente aceptables para ser aplicada como anticonceptivo para la anticoncepcion oral sin lactosa |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/12/2018, OBSERVADAS AS CONDICOES LEGAIS. |
|
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/12/2018, OBSERVADAS AS CONDICOES LEGAIS. (CO) REFERENTE A RPI 2503 DE 26/12/2018, QUANTO A MONTAGEM DO CONJUNTO. |
|
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/11/2005 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |