DE602005024470D1 - Verfahren zur Herstellung von Drospirenon - Google Patents

Verfahren zur Herstellung von Drospirenon

Info

Publication number
DE602005024470D1
DE602005024470D1 DE602005024470T DE602005024470T DE602005024470D1 DE 602005024470 D1 DE602005024470 D1 DE 602005024470D1 DE 602005024470 T DE602005024470 T DE 602005024470T DE 602005024470 T DE602005024470 T DE 602005024470T DE 602005024470 D1 DE602005024470 D1 DE 602005024470D1
Authority
DE
Germany
Prior art keywords
dimethylene
preparation
carbolactol
pregn
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005024470T
Other languages
English (en)
Inventor
Francesca Costantino
Roberto Lenna
Silvia Piuri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Industriale Chimica SRL
Original Assignee
Industriale Chimica SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Industriale Chimica SRL filed Critical Industriale Chimica SRL
Publication of DE602005024470D1 publication Critical patent/DE602005024470D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE602005024470T 2004-03-01 2005-02-28 Verfahren zur Herstellung von Drospirenon Active DE602005024470D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000367A ITMI20040367A1 (it) 2004-03-01 2004-03-01 Processo per la preparazione di drospirenone

Publications (1)

Publication Number Publication Date
DE602005024470D1 true DE602005024470D1 (de) 2010-12-16

Family

ID=34746713

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005024470T Active DE602005024470D1 (de) 2004-03-01 2005-02-28 Verfahren zur Herstellung von Drospirenon

Country Status (6)

Country Link
US (1) US7585971B2 (de)
EP (2) EP2433951A3 (de)
AT (1) ATE486885T1 (de)
CA (2) CA2761534C (de)
DE (1) DE602005024470D1 (de)
IT (1) ITMI20040367A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20040367A1 (it) 2004-03-01 2004-06-01 Ind Chimica Srl Processo per la preparazione di drospirenone
ITMI20042338A1 (it) * 2004-12-06 2005-03-06 Ind Chimica Srl Processo per la preparazione di drospirenone
EP1910403B1 (de) * 2005-07-21 2016-04-27 Bayer Pharma Aktiengesellschaft Verfahren zur herstellung von 3-oxopregn-4-en-21,17-carbolactonen durch metallfreie oxidation von 17-(hydroxypropyl)-3,17-dihydroxyandrostanen
US7319154B2 (en) 2005-07-21 2008-01-15 Bayer Schering Pharma Ag Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes
DK1746101T4 (da) 2005-07-21 2014-08-11 Bayer Pharma AG Fremgangsmåde til fremstilling af 3-oxo-pregn-4-en-21,17-carbolactoner ved metalfri oxidation af 17-(3-hydroxypropyl)-3,17-dihydroxyandrostaner
EP2253641A2 (de) * 2007-05-01 2010-11-24 Sicor, Inc. Verfahren zur herstellung von Drospirenon und Zwischenprodukten davon
DE102007030596B3 (de) * 2007-06-28 2009-03-12 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Herstellung von 17-(3-Hydroxypropyl)-17-hydroxysteroiden
CN101343306B (zh) * 2007-07-12 2011-06-08 江苏希迪制药有限公司 合成6,7-亚甲基甾体化合物的方法
CN101343308B (zh) * 2007-07-12 2012-05-02 江苏希迪制药有限公司 制备7α-溴代甾体化合物的方法
PL2019114T3 (pl) * 2007-07-26 2011-05-31 Newchem S P A Sposób wytwarzania Drospirenonu
EP2265629B1 (de) * 2008-03-05 2015-06-24 Evestra, Inc. Bismethylen-17-carbolactone und damit in zusammenhang stehende anwendungen
EP2367808A4 (de) * 2008-11-25 2012-05-09 Evestra Inc PROGESTATIVE 3-(6,6-ETHYLEN-17b-HYDROXY-3-OXO-17a-PREGNA-4-EN-17a-YL) PROPIONSÄURE-g-LACTONE
US8334375B2 (en) * 2009-04-10 2012-12-18 Evestra, Inc. Methods for the preparation of drospirenone
EP2266998B1 (de) 2009-06-16 2013-07-24 Crystal Pharma, S.A.U. Verfahren zum Erhalten von 17-Spirolactonen in Steroiden
DE102009031907B4 (de) 2009-07-01 2017-02-09 Heyl Chemisch-Pharmazeutische Fabrik Gmbh & Co. Kg Verfahren zur Herstellung von Drospirenon aus Androstendion
DE102009031908B4 (de) 2009-07-01 2017-02-09 Heyl Chemisch-Pharmazeutische Fabrik Gmbh & Co. Kg Verfahren zur Herstellung von Drospirenon aus 15-Hydroxyandrostendion
ES2419663T3 (es) 2010-08-03 2013-08-21 Newchem S.P.A. Métodos para la preparación de Drospirenona y productos intermedios de la misma
WO2012107513A1 (en) 2011-02-10 2012-08-16 Crystal Pharma, S.A.U. Process for obtaining drospirenone
ITMI20120146A1 (it) * 2012-02-03 2013-08-04 Ind Chimica Srl Processo per la preparazione di composti policiclici insaturi dotati di attivita' farmacologica
PL2782924T3 (pl) 2011-11-22 2017-07-31 Industriale Chimica S.R.L. Proces otrzymywania drospirenonu
MX356791B (es) * 2013-04-12 2018-06-12 Ind Chimica Srl Procedimiento para la preparacion de drospirenona.
CN110407905B (zh) * 2019-08-22 2021-09-28 武汉九珑人福药业有限责任公司 一种屈螺酮及其中间体的制备方法
CN110780001B (zh) * 2019-11-05 2022-04-08 兰州东立龙信息技术有限公司 气相色谱柱及其制备方法
CN115850359B (zh) * 2022-12-14 2024-06-11 梯尔希（南京）药物研发有限公司 一种孕二烯酮杂质i的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2652761C2 (de) * 1976-11-16 1985-11-21 Schering AG, 1000 Berlin und 4709 Bergkamen 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE3111950A1 (de) * 1981-03-23 1982-09-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen 7(alpha)-alkoxycarbonyl-15(beta).16(beta)-methylen-4-androsten-3-one, verfahren zu ihrer herstellung und verwendung als arzneimittel
DE3265852D1 (en) * 1981-09-21 1985-10-03 Schering Ag 3-beta,7-beta,15-alpha-trihydroxy-5-androsten-17-one, its 3,15-dipivalate, and its preparation
EP0134529B1 (de) * 1983-08-17 1990-03-21 Schering Aktiengesellschaft 7-alpha-Substituierte 3-Oxo-17alpha-pregn-4-en-21.17-carbolactone, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
DE19633685C1 (de) 1996-08-12 1997-10-09 Schering Ag Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens
ITMI20040367A1 (it) 2004-03-01 2004-06-01 Ind Chimica Srl Processo per la preparazione di drospirenone

Also Published As

Publication number Publication date
EP2433951A3 (de) 2013-07-03
CA2761534C (en) 2013-03-26
ATE486885T1 (de) 2010-11-15
CA2498634A1 (en) 2005-09-01
EP1571153A2 (de) 2005-09-07
EP2433951A2 (de) 2012-03-28
EP1571153A3 (de) 2005-12-07
CA2761534A1 (en) 2005-09-01
US20050192450A1 (en) 2005-09-01
CA2498634C (en) 2012-03-20
US7585971B2 (en) 2009-09-08
ITMI20040367A1 (it) 2004-06-01
EP1571153B1 (de) 2010-11-03

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