ES2404071T3 - Cristal en forma alfa o en forma beta de derivado de acetanilida - Google Patents

Cristal en forma alfa o en forma beta de derivado de acetanilida Download PDF

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Publication number
ES2404071T3
ES2404071T3 ES10075435T ES10075435T ES2404071T3 ES 2404071 T3 ES2404071 T3 ES 2404071T3 ES 10075435 T ES10075435 T ES 10075435T ES 10075435 T ES10075435 T ES 10075435T ES 2404071 T3 ES2404071 T3 ES 2404071T3
Authority
ES
Spain
Prior art keywords
crystal
ethyl
amino
hydroxy
acetanilide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES10075435T
Other languages
English (en)
Spanish (es)
Inventor
S. Kawazoe
K. Sakamoto
Y. Awamura
T. Maruyama
T. Suzuki
K. Onda
T. Takasu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=19148268&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2404071(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Application granted granted Critical
Publication of ES2404071T3 publication Critical patent/ES2404071T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
ES10075435T 2001-10-30 2002-10-29 Cristal en forma alfa o en forma beta de derivado de acetanilida Expired - Lifetime ES2404071T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001332914 2001-10-30
JP2001332914 2001-10-30

Publications (1)

Publication Number Publication Date
ES2404071T3 true ES2404071T3 (es) 2013-05-23

Family

ID=19148268

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10075435T Expired - Lifetime ES2404071T3 (es) 2001-10-30 2002-10-29 Cristal en forma alfa o en forma beta de derivado de acetanilida

Country Status (17)

Country Link
US (2) US7342117B2 (enExample)
EP (3) EP1932838A3 (enExample)
JP (1) JP3800220B2 (enExample)
KR (1) KR100908796B1 (enExample)
CN (1) CN1243740C (enExample)
AU (1) AU2002344419C1 (enExample)
BR (1) BRPI0213570B8 (enExample)
CA (1) CA2464068C (enExample)
ES (1) ES2404071T3 (enExample)
HU (1) HU230481B1 (enExample)
MX (1) MXPA04003936A (enExample)
NO (1) NO326965B1 (enExample)
PL (1) PL218982B1 (enExample)
RU (1) RU2303033C2 (enExample)
TW (1) TW200300020A (enExample)
WO (1) WO2003037881A1 (enExample)
ZA (1) ZA200403044B (enExample)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
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WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
SI2216021T1 (sl) 2007-11-02 2013-01-31 Astellas Pharma Inc. Farmacevtski sestavek za zdravljenje prekomerno aktivnega sečnega mehurja
ES2627848T3 (es) 2008-06-04 2017-07-31 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
TWI478712B (zh) * 2008-09-30 2015-04-01 Astellas Pharma Inc 釋控性醫藥組成物
US8410284B2 (en) 2008-10-22 2013-04-02 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
WO2010051206A1 (en) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
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CN103068816B (zh) * 2010-06-16 2015-01-07 武田药品工业株式会社 酰胺化合物的结晶
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
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CN103232352B (zh) * 2013-05-11 2015-12-23 苏州永健生物医药有限公司 (r)-4-(2-(2-羟基-2-苯乙胺基)乙基)苯胺基甲酸叔丁基酯
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CN104016877B (zh) * 2014-06-13 2017-02-15 南京海融制药有限公司 一种苯基乙酰胺类化合物及在制备米拉贝隆中的应用
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CN104230840A (zh) * 2014-09-05 2014-12-24 安徽联创药物化学有限公司 米拉贝隆的合成方法
US10149837B2 (en) 2014-09-26 2018-12-11 Universita' Degli Studi Di Bari Selective agonists of beta-adrenergic type 3 receptors (BAR3) and use thereof
WO2016049749A1 (en) * 2014-10-01 2016-04-07 Apotex Inc. Solid forms of mirabegron
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FR3043555B1 (fr) * 2015-11-17 2019-10-25 Centre National De La Recherche Scientifique (Cnrs) Mirabegron pour le traitement de maladies retiniennes
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CN105801438A (zh) * 2016-04-12 2016-07-27 济南大学 一种米拉贝隆中间体的合成方法
CN107963976A (zh) * 2016-10-20 2018-04-27 中国动物疫病预防控制中心 一种苯乙醇胺类化合物中间体的制备方法
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KR20250099259A (ko) 2017-06-06 2025-07-01 유로반트 사이언시즈 게엠베하 과민성 방광의 치료를 위한 비베그론의 용도
KR102398639B1 (ko) 2017-06-20 2022-05-17 (주) 성운파마코피아 아미드 유도체의 염 및 그 제조방법
CN108658797A (zh) * 2018-06-19 2018-10-16 安徽德信佳生物医药有限公司 一种米拉贝隆中间体(r)-2-(4-硝基苯乙基氨基)-1-苯基乙醇盐酸盐的合成
CN108947853A (zh) * 2018-06-29 2018-12-07 黑龙江鑫创生物科技开发有限公司 一种微通道反应器合成米拉贝隆中间体的方法
KR101928987B1 (ko) * 2018-08-28 2018-12-13 (주) 성운파마코피아 신규한 고순도 미라베그론의 결정질 일수화물, 이의 제조방법 또는 용도
TW202038963A (zh) 2018-12-05 2020-11-01 瑞士商優洛凡特科學公司 維貝隆（ｖｉｂｅｇｒｏｎ）於治療患有良性前列腺增生之男性中膀胱過動症症狀之用途
KR20200117091A (ko) 2019-04-02 2020-10-14 제이투에이치바이오텍 (주) 미라베그론 전구체 약물 화합물 및 이의 과민성 방광 질환의 치료 또는 개선을 위한 의약 용도
CN110590699B (zh) * 2019-09-29 2022-11-15 广东先强药业有限公司 一种米拉贝隆的精制方法
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CN113816864B (zh) * 2020-06-18 2024-03-29 南京正大天晴制药有限公司 一种(r)-2-羟基-n-[2-(4-氨基苯基)乙基]-2-苯乙胺的制备方法
CN114539084B (zh) * 2020-11-24 2024-04-02 威智医药股份有限公司 米拉贝隆及其中间体的制备方法
CN114539182B (zh) * 2020-11-24 2024-08-09 威智医药股份有限公司 转晶溶剂及其应用和米拉贝隆α晶型的制备方法
KR20220081033A (ko) 2020-12-08 2022-06-15 주식회사 한서켐 미라베그론 α형 결정의 제조방법
CN112574137A (zh) * 2021-01-19 2021-03-30 南京美瑞制药有限公司 一种α晶型米拉贝隆的制备方法
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Also Published As

Publication number Publication date
HU230481B1 (hu) 2016-07-28
HUP0401665A3 (en) 2008-05-28
JPWO2003037881A1 (ja) 2005-02-17
PL369874A1 (en) 2005-05-02
KR100908796B1 (ko) 2009-07-22
ZA200403044B (en) 2005-06-29
CA2464068A1 (en) 2003-05-08
US20080214633A1 (en) 2008-09-04
BR0213570A (pt) 2004-10-26
HUP0401665A1 (hu) 2004-11-29
TW200300020A (en) 2003-05-01
US7342117B2 (en) 2008-03-11
US20050004190A1 (en) 2005-01-06
NO326965B1 (no) 2009-03-23
BRPI0213570B1 (pt) 2018-02-27
PL218982B1 (pl) 2015-02-27
MXPA04003936A (es) 2004-06-18
RU2303033C2 (ru) 2007-07-20
KR100908796B9 (ko) 2024-07-17
AU2002344419B2 (en) 2007-12-13
JP3800220B2 (ja) 2006-07-26
CN1243740C (zh) 2006-03-01
BRPI0213570B8 (pt) 2021-05-25
US7982049B2 (en) 2011-07-19
EP1932838A3 (en) 2008-07-30
TWI322805B (enExample) 2010-04-01
EP2298752B1 (en) 2013-03-27
RU2004116313A (ru) 2005-03-27
EP1440969A1 (en) 2004-07-28
CA2464068C (en) 2007-10-16
WO2003037881A1 (en) 2003-05-08
EP1440969A4 (en) 2005-01-19
NO20042227L (no) 2004-05-28
AU2002344419C1 (en) 2024-02-01
EP2298752A1 (en) 2011-03-23
CN1575287A (zh) 2005-02-02
KR20050040837A (ko) 2005-05-03
EP1932838A2 (en) 2008-06-18

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