ES2312090T3 - Camptotecinas con un anillo de lactona modificado. - Google Patents

Camptotecinas con un anillo de lactona modificado. Download PDF

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Publication number
ES2312090T3
ES2312090T3 ES06116366T ES06116366T ES2312090T3 ES 2312090 T3 ES2312090 T3 ES 2312090T3 ES 06116366 T ES06116366 T ES 06116366T ES 06116366 T ES06116366 T ES 06116366T ES 2312090 T3 ES2312090 T3 ES 2312090T3
Authority
ES
Spain
Prior art keywords
alkyl
branched
linear
group
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES06116366T
Other languages
English (en)
Spanish (es)
Inventor
Mauro Marzi
Elena Marastoni
Sergio Penco
Claudio Sigma-Tau Inds. Farma Riunite S.P.A Pisano
Maria Ornella Tinti
Loredana Vesci
Franco Zunino
Domenico Sigma-Tau Inds. Farma. Riunite Vergani
Walter Cabri
Marco Alpegiani
Martin Patricio
Tamara Sigma-Tau Inds. Farma Riunite S.P.A Danelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto Nazionale per lo Studio e la Cura die Tumori
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Istituto Nazionale per lo Studio e la Cura die Tumori
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Nazionale per lo Studio e la Cura die Tumori, Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Istituto Nazionale per lo Studio e la Cura die Tumori
Application granted granted Critical
Publication of ES2312090T3 publication Critical patent/ES2312090T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)
ES06116366T 2002-05-31 2003-05-28 Camptotecinas con un anillo de lactona modificado. Expired - Lifetime ES2312090T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM02A0305 2002-05-31
IT2002RM000305A ITRM20020305A1 (it) 2002-05-31 2002-05-31 Camptotecine con anello lattonico modificato.

Publications (1)

Publication Number Publication Date
ES2312090T3 true ES2312090T3 (es) 2009-02-16

Family

ID=11456338

Family Applications (2)

Application Number Title Priority Date Filing Date
ES03730480T Active ES2273002T7 (es) 2002-05-31 2003-05-28 Camptotecinas con un anillo lactona modificado.
ES06116366T Expired - Lifetime ES2312090T3 (es) 2002-05-31 2003-05-28 Camptotecinas con un anillo de lactona modificado.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES03730480T Active ES2273002T7 (es) 2002-05-31 2003-05-28 Camptotecinas con un anillo lactona modificado.

Country Status (22)

Country Link
US (1) US7273873B2 (enExample)
EP (2) EP1719775B1 (enExample)
JP (1) JP4693410B2 (enExample)
KR (1) KR101042042B1 (enExample)
CN (1) CN1656100A (enExample)
AR (1) AR040139A1 (enExample)
AT (2) ATE403659T1 (enExample)
AU (2) AU2003241160B2 (enExample)
BR (2) BR0311333A (enExample)
CA (2) CA2485201C (enExample)
CY (2) CY1107311T1 (enExample)
DE (2) DE60322754D1 (enExample)
DK (2) DK1719775T3 (enExample)
ES (2) ES2273002T7 (enExample)
IT (1) ITRM20020305A1 (enExample)
MX (1) MXPA04011682A (enExample)
PE (1) PE20050120A1 (enExample)
PL (1) PL374346A1 (enExample)
PT (2) PT1511752E (enExample)
SI (2) SI1511752T1 (enExample)
TW (1) TWI325866B (enExample)
WO (1) WO2003101995A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2852606A1 (fr) * 2003-03-18 2004-09-24 Inst Nat Sante Rech Med Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie
ITRM20030344A1 (it) * 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
PL2170900T3 (pl) * 2007-08-01 2013-04-30 Sigma Tau Ind Farmaceuti Krystaliczna forma II 7-(dimetoksymetylo)kamptotecyny, jej zastosowanie jako związek pośredni oraz otrzymane z niej produkty
CN102746314B (zh) * 2011-04-18 2016-07-06 华东师范大学 含有稳定7元内酯环的喜树碱类化合物、制备方法和用途
CN104530066A (zh) * 2015-01-06 2015-04-22 华东师范大学 一类新型高喜树碱衍生物、制备方法和用途
CN112566666A (zh) 2018-05-14 2021-03-26 努瓦申生物公司 靶向抗癌核激素受体的化合物
AU2020274113A1 (en) 2019-05-14 2021-11-11 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
TW202131930A (zh) 2019-11-13 2021-09-01 美商諾維雪碧歐公司 抗癌核荷爾蒙受體標靶化合物
IL306010A (en) 2021-03-23 2023-11-01 Nuvation Bio Inc Anticancer compounds against the nuclear hormone receptor
CA3218577A1 (en) 2021-05-03 2022-11-10 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
WO2024073626A2 (en) * 2022-09-28 2024-04-04 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57116076A (en) * 1981-01-09 1982-07-19 Yakult Honsha Co Ltd Novel camptothecin derivative and its preparation
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
FR2532591A1 (fr) 1982-09-02 1984-03-09 Hutchinson Nouveau dispositif de securite pour pneumatiques de vehicules ou autres engins
EP1251125B1 (fr) * 1995-06-21 2005-12-07 Société de Conseils et de Recherches d'Applications Scientifiques (S.C.R.A.S.) Nouveaux analogues de la camptoth-cine, des proc-d-s de pr-paration, leur application comme m-dicaments et les compositions pharmaceutiques les contenant
DK1044977T3 (da) * 1999-03-09 2002-07-08 Sigma Tau Ind Farmaceuti Camptothecinderivater med antitumoraktivitet

Also Published As

Publication number Publication date
ES2273002T7 (es) 2011-08-01
EP1719775B1 (en) 2008-08-06
WO2003101995A2 (en) 2003-12-11
PT1719775E (pt) 2008-09-30
SI1511752T1 (sl) 2007-02-28
EP1719775A1 (en) 2006-11-08
BR0311329A (pt) 2005-02-22
AU2009236044A1 (en) 2009-12-03
EP1511752A2 (en) 2005-03-09
ITRM20020305A1 (it) 2003-12-01
AU2003241160A1 (en) 2003-12-19
JP2005531602A (ja) 2005-10-20
CY1108793T1 (el) 2014-04-09
AU2009236044B2 (en) 2011-03-24
AU2009236044A8 (en) 2011-07-21
DE60308368T3 (de) 2010-09-16
EP1511752B3 (en) 2010-03-10
EP1511752B8 (en) 2007-04-18
DE60308368D1 (de) 2006-10-26
EP1511752B1 (en) 2006-09-13
ATE339422T1 (de) 2006-10-15
AU2009236044B8 (en) 2011-07-21
PL374346A1 (en) 2005-10-17
WO2003101995A8 (en) 2004-12-23
ATE403659T1 (de) 2008-08-15
SI1719775T1 (sl) 2009-04-30
CA2485201A1 (en) 2003-12-11
JP4693410B2 (ja) 2011-06-01
US20050154003A1 (en) 2005-07-14
DK1511752T5 (da) 2010-06-14
DE60322754D1 (de) 2008-09-18
BR0311333A (pt) 2005-03-15
PT1511752E (pt) 2007-01-31
TWI325866B (en) 2010-06-11
CY1107311T1 (el) 2012-11-21
ITRM20020305A0 (it) 2002-05-31
TW200404806A (en) 2004-04-01
CA2706635A1 (en) 2003-12-11
PE20050120A1 (es) 2005-03-04
CN1656100A (zh) 2005-08-17
KR20050036909A (ko) 2005-04-20
DE60308368T2 (de) 2007-09-06
DK1719775T3 (da) 2008-11-17
CA2485201C (en) 2010-11-02
AU2003241160B2 (en) 2009-08-20
ES2273002T3 (es) 2007-05-01
KR101042042B1 (ko) 2011-06-16
AR040139A1 (es) 2005-03-16
MXPA04011682A (es) 2005-03-31
WO2003101995A3 (en) 2004-02-19
US7273873B2 (en) 2007-09-25
DK1511752T3 (da) 2007-01-29

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