ES2270515T3 - Arginina deiminasa modificada. - Google Patents
Arginina deiminasa modificada. Download PDFInfo
- Publication number
- ES2270515T3 ES2270515T3 ES98922197T ES98922197T ES2270515T3 ES 2270515 T3 ES2270515 T3 ES 2270515T3 ES 98922197 T ES98922197 T ES 98922197T ES 98922197 T ES98922197 T ES 98922197T ES 2270515 T3 ES2270515 T3 ES 2270515T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- adi
- polyethylene glycol
- arginine deiminase
- succinimidyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A61P35/00—Antineoplastic agents
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
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- C—CHEMISTRY; METALLURGY
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Applications Claiming Priority (4)
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| US4620097P | 1997-05-12 | 1997-05-12 | |
| US46200P | 1997-05-12 | ||
| US23809 | 1998-02-13 | ||
| US09/023,809 US6183738B1 (en) | 1997-05-12 | 1998-02-13 | Modified arginine deiminase |
Publications (1)
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| ES2270515T3 true ES2270515T3 (es) | 2007-04-01 |
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Family Applications (1)
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| ES98922197T Expired - Lifetime ES2270515T3 (es) | 1997-05-12 | 1998-05-12 | Arginina deiminasa modificada. |
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| TWI847958B (zh) | 2016-07-05 | 2024-07-11 | 英屬開曼群島商北極星藥業集團股份有限公司 | 用精胺酸耗盡劑進行之組合癌症免疫療法 |
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| WO2019042628A1 (en) | 2017-08-31 | 2019-03-07 | Erytech Pharma | ARGININE DEIMINASE ENCAPSULATED WITHIN ERYTHROCYTES AND THEIR USE IN THE TREATMENT OF CANCER AND ARGINASE-1 DEFICIENCY |
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| US5080891A (en) | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
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-
1998
- 1998-02-13 US US09/023,809 patent/US6183738B1/en not_active Expired - Lifetime
- 1998-05-12 JP JP54937598A patent/JP4456184B2/ja not_active Expired - Lifetime
- 1998-05-12 DE DE69835515T patent/DE69835515T2/de not_active Expired - Lifetime
- 1998-05-12 AT AT98922197T patent/ATE335814T1/de active
- 1998-05-12 EP EP98922197A patent/EP0981607B1/en not_active Expired - Lifetime
- 1998-05-12 PT PT98922197T patent/PT981607E/pt unknown
- 1998-05-12 CN CNB988050668A patent/CN1169951C/zh not_active Expired - Lifetime
- 1998-05-12 CA CA002288948A patent/CA2288948C/en not_active Expired - Lifetime
- 1998-05-12 AU AU74798/98A patent/AU724907B2/en not_active Expired
- 1998-05-12 ES ES98922197T patent/ES2270515T3/es not_active Expired - Lifetime
- 1998-05-12 TW TW087107257A patent/TW368504B/zh not_active IP Right Cessation
- 1998-05-12 WO PCT/US1998/009575 patent/WO1998051784A1/en not_active Ceased
- 1998-05-12 DK DK98922197T patent/DK0981607T3/da active
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2000
- 2000-11-28 US US09/723,546 patent/US6737259B1/en not_active Expired - Lifetime
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2004
- 2004-01-15 US US10/757,843 patent/US7323167B2/en not_active Expired - Lifetime
-
2006
- 2006-11-03 CY CY20061101590T patent/CY1105758T1/el unknown
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|---|---|
| US20050129706A1 (en) | 2005-06-16 |
| US6737259B1 (en) | 2004-05-18 |
| CA2288948C (en) | 2007-10-30 |
| AU7479898A (en) | 1998-12-08 |
| DE69835515T2 (de) | 2007-08-09 |
| US7323167B2 (en) | 2008-01-29 |
| CN1169951C (zh) | 2004-10-06 |
| AU724907B2 (en) | 2000-10-05 |
| WO1998051784A1 (en) | 1998-11-19 |
| DE69835515D1 (de) | 2006-09-21 |
| EP0981607A4 (en) | 2004-09-01 |
| PT981607E (pt) | 2006-11-30 |
| CY1105758T1 (el) | 2010-12-22 |
| JP2001524836A (ja) | 2001-12-04 |
| EP0981607A1 (en) | 2000-03-01 |
| EP0981607B1 (en) | 2006-08-09 |
| US6183738B1 (en) | 2001-02-06 |
| JP4456184B2 (ja) | 2010-04-28 |
| TW368504B (en) | 1999-09-01 |
| CA2288948A1 (en) | 1998-11-19 |
| DK0981607T3 (da) | 2006-12-11 |
| CN1255944A (zh) | 2000-06-07 |
| ATE335814T1 (de) | 2006-09-15 |
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