ES2123874T3 - Fraccionamiento de albumina a baja temperatura usando caprilato sodico como agente de reparto. - Google Patents

Fraccionamiento de albumina a baja temperatura usando caprilato sodico como agente de reparto.

Info

Publication number
ES2123874T3
ES2123874T3 ES95112061T ES95112061T ES2123874T3 ES 2123874 T3 ES2123874 T3 ES 2123874T3 ES 95112061 T ES95112061 T ES 95112061T ES 95112061 T ES95112061 T ES 95112061T ES 2123874 T3 ES2123874 T3 ES 2123874T3
Authority
ES
Spain
Prior art keywords
albumin
sodium caprylate
amount
albumine
fractionation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95112061T
Other languages
English (en)
Inventor
Robert A Tenold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Bayer Corp
Original Assignee
Bayer AG
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG, Bayer Corp filed Critical Bayer AG
Application granted granted Critical
Publication of ES2123874T3 publication Critical patent/ES2123874T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SOLUCIONES DE ALBUMINA TERAPEUTICA DERIVADA DE PLASMA ALTAMENTE ESTABLES, QUE TIENEN UN NIVEL DE TURBIEDAD DE 5 NTU O MENOS PUEDEN OBTENERSE MEDIANTE LA ADICION DE CAPRILATO DE SODIO PARA FRACCIONAR EL EFLUENTE DE COHN II+III O IV-1 A RELATIVAMENTE BAJAS TEMPERATURAS. EL CAPRILATO DE SODIO ACTUA COMO UN AGENTE DE DIVISION PARA SEPARAR ALBUMINA DE PROTEINAS NO DESEADAS. EN REALIZACIONES PREFERIDAS, LA TEMPERATURA DE LA SOLUCION DE ORIGEN DE ALBUMINA SE ELEVA, AUMENTA EL PH Y SE HACE REACCIONAR DURANTE APROXIMADAMENTE DURANTE SEIS HORAS BAJO CONDICIONES SUFICIENTES PARA ROMPER EL COLOIDE DE LA SOLUCION INICIAL, Y DIVIDIR EL SOBRANTE QUE CONTIENE ALBUMINA DE LA FASE DE COLOIDAL DISPERSA, QUE RETIENE GLOBULINAS NO DESEADAS Y DESECHOS DE FABRICACION. COMO TIENDE A SER UNA MOLECULA DESPERDICIO, LA ALBUMINA ES SELECTIVAMENTE ESTABILIZADA MEDIANTE UNA DIAFILTRACION CONTRA UN SEPARADOR QUE CONTIENE CAPRILATO DE SODIO, ASEGURANDO ASI UN ALTO CONTENIDO DE MONOMERO DE ALBUMINA Y UN BAJO NIVEL DE TURBIEDAD. LA CANTIDAD DE CAPRILATO DE SODIO REQUERIDA PARA LA ESTABILIZACION SELECTIVA, ESTA DETERMINADA POR LA CANTIDAD DE EMPLAZAMIENTOS DE ENLACE DISPONIBLES EN LA MOLECULA DE ALBUMINA.
ES95112061T 1994-08-10 1995-08-01 Fraccionamiento de albumina a baja temperatura usando caprilato sodico como agente de reparto. Expired - Lifetime ES2123874T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/288,180 US5561115A (en) 1994-08-10 1994-08-10 Low temperature albumin fractionation using sodium caprylate as a partitioning agent

Publications (1)

Publication Number Publication Date
ES2123874T3 true ES2123874T3 (es) 1999-01-16

Family

ID=23106084

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95112061T Expired - Lifetime ES2123874T3 (es) 1994-08-10 1995-08-01 Fraccionamiento de albumina a baja temperatura usando caprilato sodico como agente de reparto.

Country Status (11)

Country Link
US (1) US5561115A (es)
EP (1) EP0696595B1 (es)
JP (1) JP3874029B2 (es)
KR (1) KR100418821B1 (es)
CN (1) CN1150004C (es)
AT (1) ATE172744T1 (es)
AU (1) AU684202B2 (es)
CA (1) CA2155630C (es)
DE (1) DE69505610T2 (es)
DK (1) DK0696595T3 (es)
ES (1) ES2123874T3 (es)

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Also Published As

Publication number Publication date
AU684202B2 (en) 1997-12-04
CN1150004C (zh) 2004-05-19
JP3874029B2 (ja) 2007-01-31
DE69505610D1 (de) 1998-12-03
JPH08176010A (ja) 1996-07-09
CA2155630A1 (en) 1996-02-11
EP0696595B1 (en) 1998-10-28
DE69505610T2 (de) 1999-03-25
US5561115A (en) 1996-10-01
KR100418821B1 (ko) 2004-05-20
EP0696595A1 (en) 1996-02-14
ATE172744T1 (de) 1998-11-15
CN1120439A (zh) 1996-04-17
CA2155630C (en) 2007-10-23
AU2839095A (en) 1996-02-22
DK0696595T3 (da) 1999-07-12
KR960006939A (ko) 1996-03-22

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