SE9403914D0 - Process B - Google Patents
Process BInfo
- Publication number
- SE9403914D0 SE9403914D0 SE9403914A SE9403914A SE9403914D0 SE 9403914 D0 SE9403914 D0 SE 9403914D0 SE 9403914 A SE9403914 A SE 9403914A SE 9403914 A SE9403914 A SE 9403914A SE 9403914 D0 SE9403914 D0 SE 9403914D0
- Authority
- SE
- Sweden
- Prior art keywords
- factor viii
- aqueous solution
- pct
- gel
- present
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 102000001690 Factor VIII Human genes 0.000 abstract 7
- 108010054218 Factor VIII Proteins 0.000 abstract 7
- 229960000301 factor viii Drugs 0.000 abstract 6
- 239000007864 aqueous solution Substances 0.000 abstract 5
- 238000004191 hydrophobic interaction chromatography Methods 0.000 abstract 3
- 208000031220 Hemophilia Diseases 0.000 abstract 2
- 208000009292 Hemophilia A Diseases 0.000 abstract 2
- 239000004094 surface-active agent Substances 0.000 abstract 2
- 239000007853 buffer solution Substances 0.000 abstract 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 abstract 1
- 229940105778 coagulation factor viii Drugs 0.000 abstract 1
- 239000000356 contaminant Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9403914A SE503424C2 (sv) | 1994-11-14 | 1994-11-14 | Process för rening av rekombinant koagulationsfaktor VIII |
JP51599296A JP3871710B2 (ja) | 1994-11-14 | 1995-11-14 | Viii因子の精製方法 |
DE69528471T DE69528471T2 (de) | 1994-11-14 | 1995-11-14 | Verfahren zur reinigung von faktor viii |
CA 2202873 CA2202873C (en) | 1994-11-14 | 1995-11-14 | Process for purification of factor viii |
US08/809,698 US6005082A (en) | 1994-11-14 | 1995-11-14 | Process for purification of factor VIII |
NZ295810A NZ295810A (en) | 1994-11-14 | 1995-11-14 | Method of purifying factor viii using hydrophobic interaction chromatography gel with at least one surfactant in the chromatography solution |
ES95937285T ES2182915T3 (es) | 1994-11-14 | 1995-11-14 | Procedimiento de purificacion del factor viii |
DK95937285T DK0792281T3 (da) | 1994-11-14 | 1995-11-14 | Proces til oprensning af faktor VIII |
PT95937285T PT792281E (pt) | 1994-11-14 | 1995-11-14 | Processo para a purificacao de factor viii |
AU39438/95A AU691993B2 (en) | 1994-11-14 | 1995-11-14 | Process for purification of factor VIII |
PCT/SE1995/001350 WO1996015140A1 (en) | 1994-11-14 | 1995-11-14 | Process for purification of factor viii |
AT95937285T ATE225368T1 (de) | 1994-11-14 | 1995-11-14 | Verfahren zur reinigung von faktor viii |
EP95937285A EP0792281B1 (en) | 1994-11-14 | 1995-11-14 | Process for purification of factor viii |
MXPA/A/1997/003470A MXPA97003470A (en) | 1994-11-14 | 1997-05-12 | Factor v purification process |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9403914A SE503424C2 (sv) | 1994-11-14 | 1994-11-14 | Process för rening av rekombinant koagulationsfaktor VIII |
Publications (3)
Publication Number | Publication Date |
---|---|
SE9403914D0 true SE9403914D0 (sv) | 1994-11-14 |
SE9403914L SE9403914L (sv) | 1996-05-15 |
SE503424C2 SE503424C2 (sv) | 1996-06-10 |
Family
ID=20395963
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE9403914A SE503424C2 (sv) | 1994-11-14 | 1994-11-14 | Process för rening av rekombinant koagulationsfaktor VIII |
Country Status (12)
Country | Link |
---|---|
US (1) | US6005082A (sv) |
EP (1) | EP0792281B1 (sv) |
JP (1) | JP3871710B2 (sv) |
AT (1) | ATE225368T1 (sv) |
AU (1) | AU691993B2 (sv) |
DE (1) | DE69528471T2 (sv) |
DK (1) | DK0792281T3 (sv) |
ES (1) | ES2182915T3 (sv) |
NZ (1) | NZ295810A (sv) |
PT (1) | PT792281E (sv) |
SE (1) | SE503424C2 (sv) |
WO (1) | WO1996015140A1 (sv) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT2130554E (pt) | 1999-02-22 | 2012-11-19 | Univ Connecticut | Formulações de factor viii isentas de albumina |
US6822081B2 (en) * | 2000-01-13 | 2004-11-23 | Max-Planck Gesellschaft zur Förderung der Wissenschaften e.V. | Process for the isolation and/or purification of a proteinaceous material |
ES2343023T3 (es) | 2000-03-27 | 2010-07-21 | Genetics Institute, Llc | Procedimientos para purificar proteinas altamente anionicas. |
ATE421536T1 (de) * | 2001-06-05 | 2009-02-15 | Genetics Inst Llc | Verfahren zur reinigung stark anionischer proteine |
CA2542951C (en) * | 2003-10-24 | 2016-08-30 | Abhinav A. Shukla | Process for purifying proteins in a hydrophobic interaction chromatography flow-through fraction |
JP5323072B2 (ja) * | 2007-07-11 | 2013-10-23 | ノボ・ノルデイスク・エー/エス | 混合方式又は多様式樹脂を使用する第viii因子の精製 |
US20100168018A1 (en) | 2008-11-07 | 2010-07-01 | Baxter International Inc. | Factor viii formulations |
US8716448B2 (en) | 2009-02-03 | 2014-05-06 | Amunix Operating Inc. | Coagulation factor VII compositions and methods of making and using same |
RU2012151132A (ru) | 2010-05-19 | 2014-06-27 | Ф. Хоффманн-Ля Рош Аг | Хроматография с гиброфобным взаимодействием |
SG191186A1 (en) | 2010-12-15 | 2013-07-31 | Baxter Int | Eluate collection using conductivity gradient |
BRPI1105317A2 (pt) | 2011-01-24 | 2013-04-30 | Fundacco Hemoct De Ribeirco Preto | produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1 |
WO2012149197A2 (en) | 2011-04-27 | 2012-11-01 | Abbott Laboratories | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
CN111548418A (zh) | 2012-02-15 | 2020-08-18 | 比奥贝拉蒂治疗公司 | 因子viii组合物及其制备和使用方法 |
KR20190094480A (ko) | 2012-02-15 | 2019-08-13 | 바이오버라티브 테라퓨틱스 인크. | 재조합 인자 viii 단백질 |
US9334319B2 (en) | 2012-04-20 | 2016-05-10 | Abbvie Inc. | Low acidic species compositions |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
SG11201507230PA (en) | 2013-03-12 | 2015-10-29 | Abbvie Inc | Human antibodies that bind human tnf-alpha and methods of preparing the same |
US10023608B1 (en) | 2013-03-13 | 2018-07-17 | Amgen Inc. | Protein purification methods to remove impurities |
WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
TW202003554A (zh) | 2013-08-14 | 2020-01-16 | 美商百歐維拉提夫治療公司 | 因子viii-xten融合物及其用途 |
US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
WO2015073884A2 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
JP6909203B2 (ja) | 2015-08-03 | 2021-07-28 | バイオベラティブ セラピューティクス インコーポレイテッド | 第ix因子融合タンパク質及びそれらの製造方法及び使用方法 |
CN111183151A (zh) * | 2017-06-23 | 2020-05-19 | 百深公司 | 因子viii亚种的纯化 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI86885C (sv) * | 1984-04-20 | 1992-10-26 | Genentech Inc | Förfarande för framställning av human rekombinantfaktor VIII och nukle insyrasekvenser och vektorer använd därtill |
US4743680A (en) * | 1985-02-01 | 1988-05-10 | New York University | Method for purifying antihemophilic factor |
SE8501050D0 (sv) * | 1985-03-05 | 1985-03-05 | Kabivitrum Ab | Biologically active fragments of human antihemophilic factor and method for preparation thereof |
US4758657A (en) * | 1985-07-11 | 1988-07-19 | Armour Pharmaceutical Company | Method of purifying Factor VIII:C |
US5595886A (en) * | 1986-01-27 | 1997-01-21 | Chiron Corporation | Protein complexes having Factor VIII:C activity and production thereof |
CA1339946C (en) * | 1987-03-31 | 1998-07-07 | Michael J. Griffith | Ultrapurification process for polypeptides |
SE465222C5 (sv) * | 1989-12-15 | 1998-02-10 | Pharmacia & Upjohn Ab | Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning |
FR2662166A1 (fr) * | 1990-05-18 | 1991-11-22 | Fondation Nale Transfusion San | Procede de preparation de facteur viii de tres haute purete comprenant une etape rapide d'immunoadsorption. |
GB9211538D0 (en) * | 1992-06-01 | 1992-07-15 | Blake David R | Antiinflammatory agent |
JP3905921B2 (ja) * | 1992-10-02 | 2007-04-18 | ジェネティクス インスチチュート リミテッド ライアビリティー カンパニー | 凝固第▲viii▼因子を含む組成物及びその製造方法並びに安定剤としての界面活性剤の使用方法 |
JP3133338B2 (ja) * | 1992-12-16 | 2001-02-05 | イムノ・アクチエンゲゼルシャフト | ウイルス的に安全な生物学的組成物の調製方法 |
-
1994
- 1994-11-14 SE SE9403914A patent/SE503424C2/sv not_active IP Right Cessation
-
1995
- 1995-11-14 PT PT95937285T patent/PT792281E/pt unknown
- 1995-11-14 EP EP95937285A patent/EP0792281B1/en not_active Expired - Lifetime
- 1995-11-14 WO PCT/SE1995/001350 patent/WO1996015140A1/en active IP Right Grant
- 1995-11-14 NZ NZ295810A patent/NZ295810A/en not_active IP Right Cessation
- 1995-11-14 DK DK95937285T patent/DK0792281T3/da active
- 1995-11-14 DE DE69528471T patent/DE69528471T2/de not_active Expired - Lifetime
- 1995-11-14 ES ES95937285T patent/ES2182915T3/es not_active Expired - Lifetime
- 1995-11-14 AT AT95937285T patent/ATE225368T1/de active
- 1995-11-14 JP JP51599296A patent/JP3871710B2/ja not_active Expired - Lifetime
- 1995-11-14 US US08/809,698 patent/US6005082A/en not_active Expired - Lifetime
- 1995-11-14 AU AU39438/95A patent/AU691993B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
SE503424C2 (sv) | 1996-06-10 |
US6005082A (en) | 1999-12-21 |
PT792281E (pt) | 2003-02-28 |
JP3871710B2 (ja) | 2007-01-24 |
ATE225368T1 (de) | 2002-10-15 |
DE69528471D1 (de) | 2002-11-07 |
ES2182915T3 (es) | 2003-03-16 |
WO1996015140A1 (en) | 1996-05-23 |
MX9703470A (es) | 1997-07-31 |
DK0792281T3 (da) | 2003-02-03 |
SE9403914L (sv) | 1996-05-15 |
EP0792281A1 (en) | 1997-09-03 |
AU3943895A (en) | 1996-06-06 |
JPH10508841A (ja) | 1998-09-02 |
NZ295810A (en) | 1998-08-26 |
EP0792281B1 (en) | 2002-10-02 |
DE69528471T2 (de) | 2003-07-10 |
AU691993B2 (en) | 1998-05-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
NUG | Patent has lapsed |