KR910016339A - Pp4-델타, 이의 제조방법 및 용도 - Google Patents
Pp4-델타, 이의 제조방법 및 용도 Download PDFInfo
- Publication number
- KR910016339A KR910016339A KR1019900004149A KR900004149A KR910016339A KR 910016339 A KR910016339 A KR 910016339A KR 1019900004149 A KR1019900004149 A KR 1019900004149A KR 900004149 A KR900004149 A KR 900004149A KR 910016339 A KR910016339 A KR 910016339A
- Authority
- KR
- South Korea
- Prior art keywords
- delta
- protein
- medicament
- preparation
- terminal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4721—Lipocortins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (6)
- 트롬보플라스틴 억제 시험에서 PP4 보다 활성이 높고, C-말단 아미노산이 결실된 단백질 PP4-델타.
- 제1항에 있어서, C-말단의 13개 아미노산이 결실된 단백질 PP4-델타.
- 제1항 또는 2항에 있어서, 약제로서의 단백질 PP4-델타.
- 제1항 또는 2항에 따른 단백질 PP4-델타 및 불활성 비이클을 함유하는 치료용 조성물.
- 단백질 PP4-델타를 암호화하는 cDNA를 발현 시스템내에 도입한후 이 시스템내에서 발현시킴을 특징으로 하여, 제1항 또는 2항에 따른 단백질 PP4-델타를 제조하는 방법.
- 응고 장애 치료용 약제의 제조를 위한 제1항 또는 2항에 따른 단백질 PP4-델타의 용도.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3910240A DE3910240A1 (de) | 1989-03-30 | 1989-03-30 | Pp4-delta, seine herstellung und verwendung |
| DEP39102408 | 1989-03-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR910016339A true KR910016339A (ko) | 1991-11-05 |
Family
ID=6377434
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019900004149A KR910016339A (ko) | 1989-03-30 | 1990-03-28 | Pp4-델타, 이의 제조방법 및 용도 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0390067A1 (ko) |
| JP (1) | JPH03109399A (ko) |
| KR (1) | KR910016339A (ko) |
| AU (1) | AU624930B2 (ko) |
| CA (1) | CA2013403A1 (ko) |
| DE (1) | DE3910240A1 (ko) |
| PT (1) | PT93596A (ko) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT87083B (pt) * | 1987-03-28 | 1992-07-31 | Boehringer Ingelheim Int | Processo para a preparacao de uma proteina anticoagulante vascular, de adn que codifica para esta proteina e de composicoes farmaceuticas que a contem |
| AU3231189A (en) * | 1988-03-31 | 1989-10-05 | Rorer International (Overseas) Inc. | Recombinant endonexin ii |
| DE4003773A1 (de) * | 1990-02-08 | 1991-08-14 | Behringwerke Ag | Verfahren zur reinigung von lipocortinen |
-
1989
- 1989-03-30 DE DE3910240A patent/DE3910240A1/de not_active Withdrawn
-
1990
- 1990-03-27 EP EP90105799A patent/EP0390067A1/de not_active Withdrawn
- 1990-03-28 KR KR1019900004149A patent/KR910016339A/ko not_active Application Discontinuation
- 1990-03-29 PT PT93596A patent/PT93596A/pt not_active Application Discontinuation
- 1990-03-29 AU AU52354/90A patent/AU624930B2/en not_active Ceased
- 1990-03-29 CA CA002013403A patent/CA2013403A1/en not_active Abandoned
- 1990-03-30 JP JP2084776A patent/JPH03109399A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2013403A1 (en) | 1990-09-30 |
| DE3910240A1 (de) | 1990-10-04 |
| PT93596A (pt) | 1990-11-20 |
| AU5235490A (en) | 1990-10-04 |
| AU624930B2 (en) | 1992-06-25 |
| JPH03109399A (ja) | 1991-05-09 |
| EP0390067A1 (de) | 1990-10-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |