ATE225368T1 - Verfahren zur reinigung von faktor viii - Google Patents

Verfahren zur reinigung von faktor viii

Info

Publication number
ATE225368T1
ATE225368T1 AT95937285T AT95937285T ATE225368T1 AT E225368 T1 ATE225368 T1 AT E225368T1 AT 95937285 T AT95937285 T AT 95937285T AT 95937285 T AT95937285 T AT 95937285T AT E225368 T1 ATE225368 T1 AT E225368T1
Authority
AT
Austria
Prior art keywords
factor viii
aqueous solution
pct
gel
present
Prior art date
Application number
AT95937285T
Other languages
English (en)
Inventor
Anna-Lisa Smeds
Original Assignee
Inst Genetics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Genetics Llc filed Critical Inst Genetics Llc
Application granted granted Critical
Publication of ATE225368T1 publication Critical patent/ATE225368T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Liquid Crystal Substances (AREA)
  • Steroid Compounds (AREA)
AT95937285T 1994-11-14 1995-11-14 Verfahren zur reinigung von faktor viii ATE225368T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9403914A SE503424C2 (sv) 1994-11-14 1994-11-14 Process för rening av rekombinant koagulationsfaktor VIII
PCT/SE1995/001350 WO1996015140A1 (en) 1994-11-14 1995-11-14 Process for purification of factor viii

Publications (1)

Publication Number Publication Date
ATE225368T1 true ATE225368T1 (de) 2002-10-15

Family

ID=20395963

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95937285T ATE225368T1 (de) 1994-11-14 1995-11-14 Verfahren zur reinigung von faktor viii

Country Status (12)

Country Link
US (1) US6005082A (de)
EP (1) EP0792281B1 (de)
JP (1) JP3871710B2 (de)
AT (1) ATE225368T1 (de)
AU (1) AU691993B2 (de)
DE (1) DE69528471T2 (de)
DK (1) DK0792281T3 (de)
ES (1) ES2182915T3 (de)
NZ (1) NZ295810A (de)
PT (1) PT792281E (de)
SE (1) SE503424C2 (de)
WO (1) WO1996015140A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5149470B2 (ja) 1999-02-22 2013-02-20 バクスター・インターナショナル・インコーポレイテッド 新規のアルブミンを含有していない第ｖｉｉｉ因子処方物
US6822081B2 (en) * 2000-01-13 2004-11-23 Max-Planck Gesellschaft zur Förderung der Wissenschaften e.V. Process for the isolation and/or purification of a proteinaceous material
WO2001072769A2 (en) 2000-03-27 2001-10-04 Genetics Institute, Llc Methods for purifying highly anionic proteins
ES2321539T3 (es) * 2001-06-05 2009-06-08 Genetics Institute, Llc Procedimientos relativos a la purificacion de proteinas altamente anionicas.
EP1687328B1 (de) * 2003-10-24 2010-03-31 Amgen, Inc. Verfahren zur aufreinigung von proteinen in einer durchflussfraktion aus der chromatographie mit hydrophoben wechselwirkungen
DE602008005885D1 (de) * 2007-07-11 2011-05-12 Novo Nordisk As Aufreinigung von faktor viii unter verwendung eine
CA2742328C (en) 2008-11-07 2019-02-26 Baxter International Inc. Factor viii formulations
US20120263701A1 (en) 2009-08-24 2012-10-18 Volker Schellenberger Coagulation factor vii compositions and methods of making and using same
ES2534562T3 (es) 2010-05-19 2015-04-24 F. Hoffmann-La Roche Ag Procedimiento de cromatografía de interacción hidrófoba
CA2821711C (en) 2010-12-15 2017-10-10 Baxter International Inc. Eluate collection using conductivity gradient
BRPI1105317A2 (pt) 2011-01-24 2013-04-30 Fundacco Hemoct De Ribeirco Preto produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1
WO2012149197A2 (en) 2011-04-27 2012-11-01 Abbott Laboratories Methods for controlling the galactosylation profile of recombinantly-expressed proteins
SG11201404885RA (en) 2012-02-15 2014-09-26 Amunix Operating Inc Factor viii compositions and methods of making and using same
US10370430B2 (en) 2012-02-15 2019-08-06 Bioverativ Therapeutics Inc. Recombinant factor VIII proteins
US9181572B2 (en) 2012-04-20 2015-11-10 Abbvie, Inc. Methods to modulate lysine variant distribution
US9150645B2 (en) 2012-04-20 2015-10-06 Abbvie, Inc. Cell culture methods to reduce acidic species
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
WO2014143205A1 (en) 2013-03-12 2014-09-18 Abbvie Inc. Human antibodies that bind human tnf-alpha and methods of preparing the same
US10023608B1 (en) 2013-03-13 2018-07-17 Amgen Inc. Protein purification methods to remove impurities
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
WO2014151878A2 (en) 2013-03-14 2014-09-25 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
US10548953B2 (en) 2013-08-14 2020-02-04 Bioverativ Therapeutics Inc. Factor VIII-XTEN fusions and uses thereof
EP3052640A2 (de) 2013-10-04 2016-08-10 AbbVie Inc. Verwendung von metallionen zur modulation von proteinglykosylierungsprofilen rekombinanter proteine
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
WO2015073884A2 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
AU2016301303B2 (en) 2015-08-03 2021-10-07 Bioverativ Therapeutics Inc. Factor IX fusion proteins and methods of making and using same
WO2018234543A1 (en) * 2017-06-23 2018-12-27 Baxalta Incorporated PURIFICATION OF FACTOR VIII SUBSPECIES

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL74909A (en) * 1984-04-20 1992-01-15 Genentech Inc Preparation of functional human factor viii and dna sequences,expression vectors,transformed microorganisms and cell lines used therein
US4743680A (en) * 1985-02-01 1988-05-10 New York University Method for purifying antihemophilic factor
SE8501050D0 (sv) * 1985-03-05 1985-03-05 Kabivitrum Ab Biologically active fragments of human antihemophilic factor and method for preparation thereof
US4758657A (en) * 1985-07-11 1988-07-19 Armour Pharmaceutical Company Method of purifying Factor VIII:C
US5595886A (en) * 1986-01-27 1997-01-21 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
CA1339946C (en) * 1987-03-31 1998-07-07 Michael J. Griffith Ultrapurification process for polypeptides
SE465222C5 (sv) * 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
FR2662166A1 (fr) * 1990-05-18 1991-11-22 Fondation Nale Transfusion San Procede de preparation de facteur viii de tres haute purete comprenant une etape rapide d'immunoadsorption.
GB9211538D0 (en) * 1992-06-01 1992-07-15 Blake David R Antiinflammatory agent
CA2124690C (en) * 1992-10-02 2007-09-11 Thomas Osterberg Composition comprising coagulation factor viii formulation, process for its preparation and use of a surfactant as stabilizer
EP0674531A1 (de) * 1992-12-16 1995-10-04 IMMUNO Aktiengesellschaft Verfahren zur herstellung eines virussicheren biologischen präparates

Also Published As

Publication number Publication date
EP0792281B1 (de) 2002-10-02
ES2182915T3 (es) 2003-03-16
SE9403914D0 (sv) 1994-11-14
SE9403914L (sv) 1996-05-15
DE69528471D1 (de) 2002-11-07
JP3871710B2 (ja) 2007-01-24
DE69528471T2 (de) 2003-07-10
US6005082A (en) 1999-12-21
PT792281E (pt) 2003-02-28
EP0792281A1 (de) 1997-09-03
MX9703470A (es) 1997-07-31
SE503424C2 (sv) 1996-06-10
AU3943895A (en) 1996-06-06
NZ295810A (en) 1998-08-26
AU691993B2 (en) 1998-05-28
JPH10508841A (ja) 1998-09-02
WO1996015140A1 (en) 1996-05-23
DK0792281T3 (da) 2003-02-03

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