DK0792281T3 - Proces til oprensning af faktor VIII - Google Patents

Proces til oprensning af faktor VIII

Info

Publication number
DK0792281T3
DK0792281T3 DK95937285T DK95937285T DK0792281T3 DK 0792281 T3 DK0792281 T3 DK 0792281T3 DK 95937285 T DK95937285 T DK 95937285T DK 95937285 T DK95937285 T DK 95937285T DK 0792281 T3 DK0792281 T3 DK 0792281T3
Authority
DK
Denmark
Prior art keywords
factor viii
aqueous solution
pct
gel
present
Prior art date
Application number
DK95937285T
Other languages
Danish (da)
English (en)
Inventor
Anna-Lisa Smeds
Original Assignee
Inst Genetics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Genetics Llc filed Critical Inst Genetics Llc
Application granted granted Critical
Publication of DK0792281T3 publication Critical patent/DK0792281T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Liquid Crystal Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
DK95937285T 1994-11-14 1995-11-14 Proces til oprensning af faktor VIII DK0792281T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9403914A SE503424C2 (sv) 1994-11-14 1994-11-14 Process för rening av rekombinant koagulationsfaktor VIII
PCT/SE1995/001350 WO1996015140A1 (en) 1994-11-14 1995-11-14 Process for purification of factor viii

Publications (1)

Publication Number Publication Date
DK0792281T3 true DK0792281T3 (da) 2003-02-03

Family

ID=20395963

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95937285T DK0792281T3 (da) 1994-11-14 1995-11-14 Proces til oprensning af faktor VIII

Country Status (12)

Country Link
US (1) US6005082A (de)
EP (1) EP0792281B1 (de)
JP (1) JP3871710B2 (de)
AT (1) ATE225368T1 (de)
AU (1) AU691993B2 (de)
DE (1) DE69528471T2 (de)
DK (1) DK0792281T3 (de)
ES (1) ES2182915T3 (de)
NZ (1) NZ295810A (de)
PT (1) PT792281E (de)
SE (1) SE503424C2 (de)
WO (1) WO1996015140A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101810854A (zh) 1999-02-22 2010-08-25 巴克斯特国际公司 新的无白蛋白的因子viii制剂
US6822081B2 (en) * 2000-01-13 2004-11-23 Max-Planck Gesellschaft zur Förderung der Wissenschaften e.V. Process for the isolation and/or purification of a proteinaceous material
EP1681299B1 (de) 2000-03-27 2009-11-11 Genetics Institute, LLC Verfahren zur Reinigung stark anionischer Proteine
EP1404428B1 (de) * 2001-06-05 2006-07-19 Genetics Institute, LLC Verfahren zur reinigung hochanionischer proteine
AU2004285928B2 (en) * 2003-10-24 2012-02-02 Amgen, Inc. Process for purifying proteins in a hydrophobic interaction chromatography flow-through fraction
CA2692814A1 (en) * 2007-07-11 2009-01-15 Novo Nordisk A/S Purification of factor viii using a mixed-mode or multimodal resin
JP5779780B2 (ja) 2008-11-07 2015-09-16 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 第ｖｉｉｉ因子製剤
WO2011028229A1 (en) 2009-08-24 2011-03-10 Amunix Operating Inc. Coagulation factor ix compositions and methods of making and using same
JP5635682B2 (ja) 2010-05-19 2014-12-03 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 疎水性相互作用クロマトグラフィー法
WO2012082933A1 (en) 2010-12-15 2012-06-21 Baxter International, Inc. Eluate collection using conductivity gradient
BRPI1105317A2 (pt) 2011-01-24 2013-04-30 Fundacco Hemoct De Ribeirco Preto produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1
WO2012149197A2 (en) 2011-04-27 2012-11-01 Abbott Laboratories Methods for controlling the galactosylation profile of recombinantly-expressed proteins
EP3549953A1 (de) 2012-02-15 2019-10-09 Bioverativ Therapeutics Inc. Rekombinante faktor-viii-proteine
CA2864904C (en) 2012-02-15 2023-04-25 Amunix Operating Inc. Factor viii compositions and methods of making and using same
WO2013158279A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Protein purification methods to reduce acidic species
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
US9181572B2 (en) 2012-04-20 2015-11-10 Abbvie, Inc. Methods to modulate lysine variant distribution
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
EP2830651A4 (de) 2013-03-12 2015-09-02 Abbvie Inc An humanes tnf-alpha bindende humane antikörper und verfahren zur herstellung davon
US10023608B1 (en) 2013-03-13 2018-07-17 Amgen Inc. Protein purification methods to remove impurities
WO2014151878A2 (en) 2013-03-14 2014-09-25 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
US10548953B2 (en) 2013-08-14 2020-02-04 Bioverativ Therapeutics Inc. Factor VIII-XTEN fusions and uses thereof
US9598667B2 (en) 2013-10-04 2017-03-21 Abbvie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
WO2017024060A1 (en) 2015-08-03 2017-02-09 Biogen Ma Inc. Factor ix fusion proteins and methods of making and using same
SG11201912962RA (en) 2017-06-23 2020-01-30 Baxalta Inc Purification of factor viii subspecies

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI86885C (fi) * 1984-04-20 1992-10-26 Genentech Inc Foerfarande foer framstaellning av human rekombinantfaktor viii och nukleinsyrasekvenser och vektorer anvaend daertill
US4743680A (en) * 1985-02-01 1988-05-10 New York University Method for purifying antihemophilic factor
SE8501050D0 (sv) * 1985-03-05 1985-03-05 Kabivitrum Ab Biologically active fragments of human antihemophilic factor and method for preparation thereof
US4758657A (en) * 1985-07-11 1988-07-19 Armour Pharmaceutical Company Method of purifying Factor VIII:C
US5595886A (en) * 1986-01-27 1997-01-21 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
CA1339946C (en) * 1987-03-31 1998-07-07 Michael J. Griffith Ultrapurification process for polypeptides
SE465222C5 (sv) * 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
FR2662166A1 (fr) * 1990-05-18 1991-11-22 Fondation Nale Transfusion San Procede de preparation de facteur viii de tres haute purete comprenant une etape rapide d'immunoadsorption.
GB9211538D0 (en) * 1992-06-01 1992-07-15 Blake David R Antiinflammatory agent
SK282483B6 (sk) * 1992-10-02 2002-02-05 Genetics Institute, Inc. Stabilná kompozícia koagulačného faktora VIII, spôsob jej prípravy a stabilizácie
WO1994013329A1 (de) * 1992-12-16 1994-06-23 Immuno Aktiengesellschaft Verfahren zur herstellung eines virussicheren biologischen präparates

Also Published As

Publication number Publication date
ES2182915T3 (es) 2003-03-16
NZ295810A (en) 1998-08-26
SE9403914D0 (sv) 1994-11-14
US6005082A (en) 1999-12-21
AU691993B2 (en) 1998-05-28
DE69528471D1 (de) 2002-11-07
PT792281E (pt) 2003-02-28
SE503424C2 (sv) 1996-06-10
MX9703470A (es) 1997-07-31
WO1996015140A1 (en) 1996-05-23
ATE225368T1 (de) 2002-10-15
SE9403914L (sv) 1996-05-15
EP0792281B1 (de) 2002-10-02
JP3871710B2 (ja) 2007-01-24
EP0792281A1 (de) 1997-09-03
AU3943895A (en) 1996-06-06
JPH10508841A (ja) 1998-09-02
DE69528471T2 (de) 2003-07-10

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