DE69505610D1 - Fraktionierung des Albumins bei niedriger Temperatur unter Verwendung von Sodiumcaprylat als Trennwirkstoff - Google Patents

Fraktionierung des Albumins bei niedriger Temperatur unter Verwendung von Sodiumcaprylat als Trennwirkstoff

Info

Publication number
DE69505610D1
DE69505610D1 DE69505610T DE69505610T DE69505610D1 DE 69505610 D1 DE69505610 D1 DE 69505610D1 DE 69505610 T DE69505610 T DE 69505610T DE 69505610 T DE69505610 T DE 69505610T DE 69505610 D1 DE69505610 D1 DE 69505610D1
Authority
DE
Germany
Prior art keywords
albumin
sodium caprylate
amount
molecule
fractionation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69505610T
Other languages
English (en)
Other versions
DE69505610T2 (de
Inventor
Robert A Tenold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Bayer Corp
Original Assignee
Bayer AG
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG, Bayer Corp filed Critical Bayer AG
Publication of DE69505610D1 publication Critical patent/DE69505610D1/de
Application granted granted Critical
Publication of DE69505610T2 publication Critical patent/DE69505610T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum
DE69505610T 1994-08-10 1995-08-01 Fraktionierung des Albumins bei niedriger Temperatur unter Verwendung von Sodiumcaprylat als Trennwirkstoff Expired - Lifetime DE69505610T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/288,180 US5561115A (en) 1994-08-10 1994-08-10 Low temperature albumin fractionation using sodium caprylate as a partitioning agent

Publications (2)

Publication Number Publication Date
DE69505610D1 true DE69505610D1 (de) 1998-12-03
DE69505610T2 DE69505610T2 (de) 1999-03-25

Family

ID=23106084

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69505610T Expired - Lifetime DE69505610T2 (de) 1994-08-10 1995-08-01 Fraktionierung des Albumins bei niedriger Temperatur unter Verwendung von Sodiumcaprylat als Trennwirkstoff

Country Status (11)

Country Link
US (1) US5561115A (de)
EP (1) EP0696595B1 (de)
JP (1) JP3874029B2 (de)
KR (1) KR100418821B1 (de)
CN (1) CN1150004C (de)
AT (1) ATE172744T1 (de)
AU (1) AU684202B2 (de)
CA (1) CA2155630C (de)
DE (1) DE69505610T2 (de)
DK (1) DK0696595T3 (de)
ES (1) ES2123874T3 (de)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2103236B1 (es) * 1996-01-30 1998-04-16 Grifols Grupo Sa Albumina humana terapeutica con baja capacidad para la fijacion de aluminio.
AT403989B (de) * 1996-09-16 1998-07-27 Immuno Ag Verfahren zur herstellung eines plasmaprotein-hältigen arzneimittels
US6955917B2 (en) * 1997-06-20 2005-10-18 Bayer Healthcare Llc Chromatographic method for high yield purification and viral inactivation of antibodies
US5886154A (en) 1997-06-20 1999-03-23 Lebing; Wytold R. Chromatographic method for high yield purification and viral inactivation of antibodies
AUPP521298A0 (en) * 1998-08-12 1998-09-03 Life Therapeutics Limited Purification of fibrinogen
AUPP790698A0 (en) * 1998-12-23 1999-01-28 Life Therapeutics Limited Separation of microorganisms
US20050224355A1 (en) * 1999-12-23 2005-10-13 Brendon Conlan Removal of biological contaminants
AUPP790898A0 (en) 1998-12-23 1999-01-28 Life Therapeutics Limited Renal dialysis
GB9902000D0 (en) 1999-01-30 1999-03-17 Delta Biotechnology Ltd Process
WO2000056768A2 (en) * 1999-03-19 2000-09-28 Bayer Corporation Chromatographic albumin process
US7077942B1 (en) * 1999-12-23 2006-07-18 Gradipore Limited Removal of biological contaminants
AUPQ691400A0 (en) * 2000-04-14 2000-05-11 Life Therapeutics Limited Separation of micromolecules
ATE449200T1 (de) 2000-04-18 2009-12-15 Gradipore Ltd Trennung und behandlung von proben durch elektrophorese
AUPQ697300A0 (en) * 2000-04-18 2000-05-11 Life Therapeutics Limited Separation apparatus
BR0112969A (pt) 2000-08-04 2004-06-22 Dmi Biosciences Inc Método de utilização de dicetopiperazinas e composições contendo-as
US6923896B2 (en) * 2000-09-22 2005-08-02 The Texas A&M University System Electrophoresis apparatus and method
WO2002028516A1 (en) * 2000-10-06 2002-04-11 Gradipore Limited Multi-port separation apparatus and method
AUPR222300A0 (en) * 2000-12-21 2001-01-25 Life Therapeutics Limited Electrophoresis device and method
US20020124526A1 (en) * 2001-03-12 2002-09-12 Lewis James D. Albumin in a flexible polymeric container
PL2537524T3 (pl) 2003-05-15 2017-01-31 Ampio Pharmaceuticals, Inc. Leczenie chorób mediowanych przez komórki T
CN100376598C (zh) * 2004-01-20 2008-03-26 中国人民解放军军事医学科学院野战输血研究所 犬静脉注射白蛋白、其制备方法以及犬静脉注射白蛋白制剂
CN1314447C (zh) * 2004-04-12 2007-05-09 爱华生物科技(香港)有限公司 一种具有抑制蛋白酶作用的药物的制备方法
US20070219131A1 (en) * 2004-04-15 2007-09-20 Ben-Sasson Shmuel A Compositions capable of facilitating penetration across a biological barrier
CN101084016A (zh) * 2004-04-15 2007-12-05 克艾思马有限公司 能够容易穿透生物学障碍的组合物
CN1313488C (zh) * 2004-12-29 2007-05-02 三九集团湛江开发区双林药业有限公司 从组分沉淀123中回收白蛋白的方法
US8293242B2 (en) * 2005-09-01 2012-10-23 Plasma Technologies, Llc Ultra-high yield of alpha-1-anti-trypsin
US7879332B2 (en) * 2005-09-01 2011-02-01 Plasma Technologies, Llc Ultra-high yield intravenous immune globulin preparation
US20070049732A1 (en) * 2005-09-01 2007-03-01 Zurlo Eugene J Ultra-high yield intravenous immune globulin preparation
US20100168000A1 (en) 2005-12-22 2010-07-01 Peter Kiessling Octanoate-Reduced Human Albumin
US7735167B2 (en) * 2006-06-07 2010-06-15 Posey Company Bed enclosure
ES2294976B1 (es) 2007-11-12 2008-12-16 Grifols, S.A. "procedimiento de obtencion de albumina humana de alta eficacia para su uso en terapia de detoxificacion".
JP5856843B2 (ja) 2008-05-27 2016-02-10 アンピオ ファーマシューティカルズ，インコーポレイテッド ジケトピペラジンを用いた医薬組成物
SI2343982T1 (sl) * 2008-09-17 2017-08-31 Chiasma Inc. Farmacevtski sestavki in metode povezane z dostavo
CN101367865B (zh) * 2008-09-26 2012-01-04 广州倍绣生物技术有限公司 一种高纯度猪血白蛋白的生产工艺及其应用
CN101927011B (zh) * 2009-06-23 2014-03-19 武汉生物制品研究所有限责任公司 一种球蛋白溶液的病毒灭活方法
NZ599783A (en) 2009-11-03 2013-10-25 Grifols Therapeutics Inc Composition and use for alpha-1 proteinase inhibitor
CA2781120C (en) 2009-11-24 2015-01-27 Jianxin Guo Lyophilization methods, compositions, and kits
CN102127164B (zh) 2010-12-20 2013-01-30 武汉禾元生物科技有限公司 一种从水稻种子中提取重组人血清白蛋白的方法
CN102532254B (zh) * 2010-12-24 2015-06-24 武汉禾元生物科技股份有限公司 一种从水稻种子中分离纯化重组人血清白蛋白的方法
WO2013055749A1 (en) 2011-10-10 2013-04-18 Ampio Pharmaceuticals, Inc. Implantable medical devices with increased immune tolerance, and methods for making and implanting
ES2795803T3 (es) 2011-10-10 2020-11-24 Ampio Pharmaceuticals Inc Tratamiento de artropatía degenerativa
EA201490737A1 (ru) 2011-10-28 2014-09-30 Ампио Фармасьютикалз, Инк. Лечение ринита
AU2013205138B2 (en) * 2012-08-09 2015-06-25 Grifols, S.A. Caprylate Viral Deactivation
CN103880947B (zh) 2012-12-21 2016-01-13 武汉禾元生物科技股份有限公司 一种分离纯化高纯度重组人血清白蛋白的层析方法
SG11201505715RA (en) * 2013-02-01 2015-08-28 Ampio Pharmaceuticals Inc Methods for producing diketopiperazines and compositions containing diketopiperazines
CA2906864A1 (en) 2013-03-15 2014-09-18 Ampio Pharmaceuticals, Inc. Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
US9956217B2 (en) 2014-08-18 2018-05-01 Ampio Pharmaceuticals, Inc. Treatment of joint conditions
CN104356231B (zh) * 2014-11-10 2017-08-08 北海开元生物科技有限公司 一种有效去除人免疫球蛋白多聚体的方法
CN104447987A (zh) * 2014-11-22 2015-03-25 贵州中泰生物科技有限公司 辛酸法血浆免疫球蛋白分离工艺
WO2016126830A1 (en) 2015-02-03 2016-08-11 Chiasma Inc. Method of treating diseases
WO2016209969A1 (en) 2015-06-22 2016-12-29 Ampio Pharmaceuticals, Inc. Use of low molecular weight fractions of human serum albumin in treating diseases
ES2770860T3 (es) * 2015-06-26 2020-07-03 Ferring Bv Métodos de purificación y/o inactivación viral
WO2017084682A1 (en) 2015-11-20 2017-05-26 Hepa Wash Gmbh Method for extracorporeal carbon dioxide removal
WO2017084683A1 (en) 2015-11-20 2017-05-26 Hepa Wash Gmbh Method for extracorporeal lung support
CN109069719B (zh) 2016-03-14 2021-11-26 阿德维托斯有限公司 用于进行透析的系统或设备和方法
KR20220107322A (ko) * 2016-08-18 2022-08-02 알카헤스트 인코포레이티드 노화-관련된 인지 장애 치료제로서의 혈장 분획
WO2018165766A1 (en) * 2017-03-16 2018-09-20 Therapure Biopharma Inc. Method for purification of albumin
JP7302873B2 (ja) * 2017-03-28 2023-07-04 アドビトス ゲーエムベーハー 輸送蛋白質含有マルチプルパス透析流体を再生するための新規組成物および方法
EP3634530A1 (de) 2017-05-22 2020-04-15 Hepa Wash GmbH Verfahren und system zur entfernung von kohlendioxid
CN107312082B (zh) * 2017-07-06 2020-09-01 四川新健康成生物股份有限公司 一种从血清中获取天然前白蛋白的方法
CN111195351A (zh) * 2020-01-20 2020-05-26 华兰生物工程重庆有限公司 5%低浓度人血白蛋白的制备方法
CN114605519B (zh) * 2020-12-03 2023-10-31 四川远大蜀阳药业有限责任公司 提取h因子的方法
CN112521488A (zh) * 2020-12-26 2021-03-19 郑州伊美诺生物技术有限公司 牛血清白蛋白的制备方法
US11141457B1 (en) 2020-12-28 2021-10-12 Amryt Endo, Inc. Oral octreotide therapy and contraceptive methods

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2710293A (en) 1953-10-30 1955-06-07 Olin Mathieson Blood fractionation
US2710294A (en) 1953-11-02 1955-06-07 Olin Mathieson Blood fractionation
FR2190437B1 (de) * 1972-07-05 1975-08-08 Merieux Inst
US3926939A (en) * 1973-08-24 1975-12-16 Mikhail Ivanovich Ivanov Method of extracting pure serum albumin from biological fluids using a salt of a carboxylic aliphatic acid
CH583745A5 (en) * 1973-09-13 1977-01-14 Ts I Gematologii I Perelivania Pure serum albumin isolated from biological liquids - by treatment with alcohol and aliphatic carboxylic acid salt
US4156681A (en) * 1974-03-28 1979-05-29 Plasmesco Ag Process for isolating albumin from blood
DK25877A (da) * 1977-01-21 1978-08-15 Nordisk Insulinlab Fremgangsmaade til udvinding af renset albumin fra blodplasma
US4222934A (en) * 1979-04-12 1980-09-16 American National Red Cross Preparation of albumin using ethanol
AT363190B (de) * 1979-05-28 1981-07-10 Oesterr Rotes Kreuz Herstellung von albumin aus plasma
US4378346A (en) * 1979-08-15 1983-03-29 Tankersley Donald L Intravenously injectable solution of plasma protein fraction free from bradykinin, kininogen and prekallikrein activators and processes for its production
JPS62294621A (ja) * 1986-06-13 1987-12-22 Green Cross Corp:The アルブミンの回収方法
US4990447A (en) * 1988-06-24 1991-02-05 Gist-Brocades Nv Process for the purification of serum albumin
US4939176A (en) 1988-12-20 1990-07-03 Miles Inc. Viral inactivation process
JPH0671434B2 (ja) * 1989-09-18 1994-09-14 株式会社ミドリ十字 ヒト血清アルブミンの製造方法
EP0452753B1 (de) * 1990-04-19 2004-06-23 Bayer Corporation Methode zur Herstellung von im Wesentlichen monomeren normalen menschlichen Serum-Albumin

Also Published As

Publication number Publication date
KR960006939A (ko) 1996-03-22
DK0696595T3 (da) 1999-07-12
CN1120439A (zh) 1996-04-17
CN1150004C (zh) 2004-05-19
JPH08176010A (ja) 1996-07-09
US5561115A (en) 1996-10-01
AU2839095A (en) 1996-02-22
DE69505610T2 (de) 1999-03-25
KR100418821B1 (ko) 2004-05-20
CA2155630A1 (en) 1996-02-11
CA2155630C (en) 2007-10-23
JP3874029B2 (ja) 2007-01-31
AU684202B2 (en) 1997-12-04
EP0696595B1 (de) 1998-10-28
ATE172744T1 (de) 1998-11-15
ES2123874T3 (es) 1999-01-16
EP0696595A1 (de) 1996-02-14

Similar Documents

Publication Publication Date Title
DE69505610T2 (de) Fraktionierung des Albumins bei niedriger Temperatur unter Verwendung von Sodiumcaprylat als Trennwirkstoff
DE69807679T2 (de) Zusammensetzungen aus konjugaten des stabilen, aktiven, menschlichen ob proteins mit der fc kette von immunoglobulinen und damit zusammenhängende verfahren
ATE290590T1 (de) Stabilisierung von proteinen in lösung
CA2067653A1 (en) Modified Complement System Regulator
DE69634726D1 (de) Menschliche ctla-8 und verwendung von ctla-8 ähnlichen proteinen
SE8901687D0 (sv) Fibronectin binding protein as well as its preparation
DE69329877T2 (de) Von L Protein abgeleitete Immunoglobulin-bindende Proteine und deren anwendungen
DE69535795D1 (de) Polynukleinsäuren und proteine aus einem "porcine reproductive and respiratory syndrome virus" und ihre verwendung
ATE267255T1 (de) Ob proteinderivate mit verlängerter halbwertzeit
DE59510905D1 (de) Hochmolekulare und niedermolekulare Fraktionen des von Willebrand-Faktors
DK0410207T3 (da) Stabilisering af højrensede proteiner.
DE69029540D1 (de) Oxidative Denaturierung von Eiweissanalyten
DK0567448T3 (da) Fremgangsmåde til fremstilling af faktor VIII
DE69433400D1 (de) Neue proteine von parasitischen würmern
DE69617885D1 (de) Stabilisierung von nichthalogenierten 3-Isothiazolonen in aggressiven Systemen
DE69126727D1 (de) Warm-behandelte IGM-Antikörper-Zusammensetzungen
KR960701659A (ko) 정맥 주사용 글로블린 액상 조성물, 그 제조방법 및 상기 조성물중에서 글로블린 이량체의 증가를 억제시키는 방법(liquid globulin composition for intrave nous injection, process for producing the same, and method of inhibiting globulin dimer increase in said compisition)
DK0914148T3 (da) Behandling af partielt væksthormonoverfølsomhedssyndrom
KR890002388A (ko) 트롬빈 결합물질 및 그의 제조방법
DE59101882D1 (de) Inhibitor der proliferation von endothelzellen.
DK0512087T3 (da) Fremgangsmåde til reaktivering af denaturerede proteiner
Sasaki et al. Chemical studies on the isolated collagen-like and globular fragments of complement component C1q comparative studies on bovine and human C1q
Kondo et al. Improvement of proteolytic resistance of immunoadsorbents by chemical modification with polyethylene glycol
EP0524737A3 (en) Protein s. polypeptides and anti-peptide antibodies that inhibit protein s binding to c4b binding protein, diagnostic systems and therapeutic methods
DE58909261D1 (de) Ancrod-proteine, ihre herstellung und verwendung.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition