DE69114635D1 - 1,3-Diphenyl-2-propin-1-one. - Google Patents

1,3-Diphenyl-2-propin-1-one.

Info

Publication number
DE69114635D1
DE69114635D1 DE69114635T DE69114635T DE69114635D1 DE 69114635 D1 DE69114635 D1 DE 69114635D1 DE 69114635 T DE69114635 T DE 69114635T DE 69114635 T DE69114635 T DE 69114635T DE 69114635 D1 DE69114635 D1 DE 69114635D1
Authority
DE
Germany
Prior art keywords
propyne
diphenyl
phenyl
thrombocytes
leukocytes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69114635T
Other languages
English (en)
Other versions
DE69114635T2 (de
Inventor
Robert Joseph Dinerstein
Jeffrey Stephen Sabol
Keith Allen Diekema
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69114635D1 publication Critical patent/DE69114635D1/de
Publication of DE69114635T2 publication Critical patent/DE69114635T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/207—Unsaturated compounds containing keto groups bound to acyclic carbon atoms with only carbon-to-carbon triple bonds as unsaturation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/298—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/76—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and etherified hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/794—Ketones containing a keto group bound to a six-membered aromatic ring having unsaturation outside an aromatic ring
    • C07C49/796—Ketones containing a keto group bound to a six-membered aromatic ring having unsaturation outside an aromatic ring polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Cosmetics (AREA)
  • Steroid Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
DE69114635T 1990-09-20 1991-09-19 1,3-Diphenyl-2-propin-1-one. Expired - Lifetime DE69114635T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58575990A 1990-09-20 1990-09-20

Publications (2)

Publication Number Publication Date
DE69114635D1 true DE69114635D1 (de) 1995-12-21
DE69114635T2 DE69114635T2 (de) 1996-04-18

Family

ID=24342836

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69114635T Expired - Lifetime DE69114635T2 (de) 1990-09-20 1991-09-19 1,3-Diphenyl-2-propin-1-one.

Country Status (17)

Country Link
EP (1) EP0476658B1 (de)
JP (1) JP3296836B2 (de)
KR (1) KR100217806B1 (de)
CN (1) CN1059901A (de)
AT (1) ATE130289T1 (de)
AU (1) AU635156B2 (de)
CA (1) CA2051501C (de)
DE (1) DE69114635T2 (de)
ES (1) ES2082074T3 (de)
FI (1) FI914408A7 (de)
HU (1) HUT59076A (de)
IE (1) IE913298A1 (de)
IL (1) IL99511A0 (de)
NO (1) NO913683L (de)
NZ (1) NZ239865A (de)
PT (1) PT99012A (de)
ZA (1) ZA917369B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2767526B1 (fr) * 1997-08-21 2002-10-04 Galderma Rech Dermatologique Composes bi-aromatiques relies par un radical heteroethynylene et compositions pharmaceutiques et cosmetiques les contenant
EP0634927B1 (de) * 1992-03-06 2001-07-04 Lica Pharmaceuticals A/S Behandlung und prophylaxe von durch parasiten oder bakterien verursachten erkrankungen
TW312688B (de) * 1993-08-02 1997-08-11 Mitsubishi Chem Corp
FR2713635B1 (fr) * 1993-12-15 1996-01-05 Cird Galderma Nouveaux composés propynyl bi-aromatiques, compositions pharmaceutiques et cosmétiques les contenant et utilisations.
FR2764604B1 (fr) * 1997-06-13 1999-09-10 Cird Galderma Composes bi-aromatiques relies par un radical propynylene ou allenylene et compositions pharmaceutiques et cosmetiques les contenant
JP2004525109A (ja) 2001-02-15 2004-08-19 キング・ファーマシューティカルズ・インコーポレイティッド 安定化された甲状腺ホルモン医薬組成物、及びその製法
US7101569B2 (en) 2001-08-14 2006-09-05 Franz G Andrew Methods of administering levothyroxine pharmaceutical compositions
CN1596240A (zh) 2001-12-19 2005-03-16 阿特罗吉尼克斯公司 查耳酮衍生物及其治疗疾病的用途
WO2003053359A2 (en) 2001-12-19 2003-07-03 Atherogenics, Inc. 1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders
WO2009135178A2 (en) 2008-05-02 2009-11-05 Flower Robert W Methods for production and use of substance-loaded erythrocytes (s-les) for observation and treatment of microvascular hemodynamics

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1111336A (en) * 1964-07-24 1968-04-24 Fisons Pharmaceuticals Ltd Aryl ketones
BE758735A (fr) * 1969-11-14 1971-05-10 Hoffmann La Roche Composes acetyleniques
CA1137082A (en) * 1979-05-23 1982-12-07 Isao Umeda Substituted acetophenones and process therefor
JPS6385526A (ja) * 1986-09-30 1988-04-16 Nippon Oil & Fats Co Ltd 非線形光学材料
JPH0669386B2 (ja) * 1987-03-18 1994-09-07 協和醗酵工業株式会社 ５′−イノシン酸の製造法
US4753965A (en) * 1987-04-09 1988-06-28 Merrell Dow Pharmaceuticals, Inc. Method of treating multiple sclerosis with chalcone derivatives

Also Published As

Publication number Publication date
JP3296836B2 (ja) 2002-07-02
NZ239865A (en) 1993-12-23
HU913011D0 (en) 1992-01-28
CN1059901A (zh) 1992-04-01
PT99012A (pt) 1992-08-31
ES2082074T3 (es) 1996-03-16
KR100217806B1 (ko) 1999-09-01
NO913683D0 (no) 1991-09-19
CA2051501C (en) 2004-02-17
JPH0725812A (ja) 1995-01-27
ZA917369B (en) 1992-06-24
IL99511A0 (en) 1992-08-18
HUT59076A (en) 1992-04-28
IE913298A1 (en) 1992-02-25
FI914408L (fi) 1992-03-21
FI914408A0 (fi) 1991-09-19
AU635156B2 (en) 1993-03-11
AU8452891A (en) 1992-03-26
EP0476658B1 (de) 1995-11-15
CA2051501A1 (en) 1992-03-21
FI914408A7 (fi) 1992-03-21
DE69114635T2 (de) 1996-04-18
NO913683L (no) 1992-03-23
EP0476658A1 (de) 1992-03-25
KR920006277A (ko) 1992-04-27
ATE130289T1 (de) 1995-12-15

Similar Documents

Publication Publication Date Title
FI914409A0 (fi) Kalciumupptagande inhibitorer.
IE842979L (en) Desulfatohirudins
EP0275005A3 (en) Complex compounds of bioflavonoids with phospholipids, their preparation and use, and pharmaceutical and cosmetic compositions containing them
EE02962B1 (et) Mometasoonfuroaadi monohüdraat, selle valmistamismeetod ja farmatseutilised kompositsioonid
SE8404065D0 (sv) Novel biologically active compounds
ATE130289T1 (de) 1,3-diphenyl-2-propin-1-one.
IT8323058A0 (it) Derivati di 2,5-piperazindione biologicamente attivi, processi per la loro preparazione e composizioni farmaceutiche che licontengono.
DE69104083D1 (de) Neue Antiulcus-Substanz.
FI914410A0 (fi) Kalciumupptagande inhibitorer.
IL61989A (en) 1-(1,3,4-oxadiazolyl-phenoxy)-3-(phenylpiperazino)propan-2-ols and their derivatives,their preparation and pharmaceutical compositions containing them
ITMI912738A1 (it) Complessi del ferro con la conalbumina e i suoi derivati
DK576887A (da) Farmaceutiske midler
EP0316639A3 (en) Azelastin embonate, process for its preparation and pharmaceutical compositions containing azelastin embonate as the active ingredient
IT8421627A0 (it) Composizione farmaceutica contenente come ingrediente attivo 24,25-diidrossicolecalciferolo.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition