ES2122610T3 - Procedimiento perfeccionado de preparacion de un compuesto derivado del aspartamo como agente edulcorante. - Google Patents

Procedimiento perfeccionado de preparacion de un compuesto derivado del aspartamo como agente edulcorante.

Info

Publication number
ES2122610T3
ES2122610T3 ES95919484T ES95919484T ES2122610T3 ES 2122610 T3 ES2122610 T3 ES 2122610T3 ES 95919484 T ES95919484 T ES 95919484T ES 95919484 T ES95919484 T ES 95919484T ES 2122610 T3 ES2122610 T3 ES 2122610T3
Authority
ES
Spain
Prior art keywords
sweetening agent
aspartamo
preparation
compound derived
platinum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95919484T
Other languages
English (en)
Inventor
Claude Nofre
Jean-Marie Tinti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2122610T3 publication Critical patent/ES2122610T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid

Abstract

PROCEDIMIENTO DE PREPARACION DEL N [ N ( 3,3-DIMETILBUTIL{-L{AL}-ASPARTIL{[}-L-HEXAHIDROFENILALANINA 1-METIL ESTER DE FORMULA (I) UTIL COMO AGENTE EDULCORANTE, PROCEDIMIENTO CARACTERIZADO PORQUE SE TRATA UNA SOLUCION HIDROALCOHOLICA DE PH4,5-5 DE ASPARTAMO Y DE 3,3-DIMETILBUTIRALDEHIDO A TEMPERATURA AMBIENTE POR HIDROGENO A UNA PRESION INFERIOR O IGUAL A 1 BAR EN PRESENCIA DE UN CATALIZADOR A ELEGIDO EN EL GRUPO QUE COMPRENDE PLATINO O PALADIO SOBRE CABONO ACTIVADO, O EN FORMA DE NEGRO DE PLATINO O DE PALADIO, Y PORQUE EL PRODUCTO FORMADO ES PURIFICADO POR PRECIPITACION Y FILTRACION TRAS LA ELIMINACION AL VACIO DE LA PARTE ALCOHOLICA DEL SOLVENTE.
ES95919484T 1994-05-09 1995-05-05 Procedimiento perfeccionado de preparacion de un compuesto derivado del aspartamo como agente edulcorante. Expired - Lifetime ES2122610T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9405674A FR2719590B1 (fr) 1994-05-09 1994-05-09 Procédé perfectionné de préparation d'un composé dérivé de l'aspartame utile comme agent édulcorant.

Publications (1)

Publication Number Publication Date
ES2122610T3 true ES2122610T3 (es) 1998-12-16

Family

ID=9463024

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95919484T Expired - Lifetime ES2122610T3 (es) 1994-05-09 1995-05-05 Procedimiento perfeccionado de preparacion de un compuesto derivado del aspartamo como agente edulcorante.

Country Status (30)

Country Link
US (1) US5510508A (es)
EP (1) EP0759031B1 (es)
JP (1) JP3303921B2 (es)
KR (1) KR100304320B1 (es)
CN (1) CN1114615C (es)
AT (1) ATE169636T1 (es)
AU (1) AU681523B2 (es)
BG (1) BG62813B1 (es)
BR (1) BR9507635A (es)
CA (1) CA2187901C (es)
CZ (1) CZ285612B6 (es)
DE (1) DE69504059T2 (es)
DK (1) DK0759031T3 (es)
EE (1) EE03402B1 (es)
ES (1) ES2122610T3 (es)
FI (1) FI114313B (es)
FR (1) FR2719590B1 (es)
GE (1) GEP19991647B (es)
HK (1) HK1012406A1 (es)
HU (1) HU219829B (es)
MD (1) MD1175G2 (es)
NO (1) NO313832B1 (es)
NZ (1) NZ285777A (es)
OA (1) OA10334A (es)
PL (1) PL180471B1 (es)
RO (1) RO115732B1 (es)
RU (1) RU2138510C1 (es)
SK (1) SK280376B6 (es)
UA (1) UA41403C2 (es)
WO (1) WO1995030689A1 (es)

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FR2719591B1 (fr) * 1994-05-09 1996-07-26 Claude Nofre Nouveau composé utile comme agent édulcorant, son procédé de préparation.
FR2744454B1 (fr) * 1996-02-07 1998-04-24 Nofre Claude Acide n-(3,3-dimethylbutyl)-l-aspartyl-d-alpha- aminoalcanoique n-(s)-1-phenyl-1-alcanamide utile comme agent edulcorant
US5728862A (en) * 1997-01-29 1998-03-17 The Nutrasweet Company Method for preparing and purifying an N-alkylated aspartame derivative
US5770775A (en) * 1997-02-10 1998-06-23 The Nutrasweet Company Method for preparing 3,3-dimethylbutyraldehyde
US5973209A (en) * 1997-07-11 1999-10-26 The Nutrasweet Company Method for preparing 3, 3-dimethybutyraldehyde
US6146680A (en) * 1997-09-11 2000-11-14 The Nutrasweet Company Metal complexes of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester
US6291004B1 (en) 1997-09-11 2001-09-18 The Nutrasweet Company Basic salts of n-[n-(3,3-dimethylbutyl)-l-α-aspartyl]-l-phenylalanine 1-methyl ester
US6180156B1 (en) 1997-09-11 2001-01-30 The Nutrasweet Company Acid salts of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester
US6129942A (en) * 1997-09-11 2000-10-10 The Nutrasweet Company Sweetener salts of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester
JPH1180108A (ja) * 1997-09-12 1999-03-26 Ajinomoto Co Inc 甘味料の精製法
JPH11130794A (ja) * 1997-10-23 1999-05-18 Ajinomoto Co Inc アスパルテーム誘導体の精製方法
JPH11171895A (ja) * 1997-12-11 1999-06-29 Ajinomoto Co Inc アスパルテームとアスパルテーム誘導体の分離精製方法
JPH11169132A (ja) * 1997-12-15 1999-06-29 Ajinomoto Co Inc アスパルテームとアスパルテーム誘導体の混晶及びその製造方法
JPH11169133A (ja) * 1997-12-15 1999-06-29 Ajinomoto Co Inc アスパルテーム及びアスパルテーム誘導体を含有する甘味料組成物
AU1936499A (en) * 1997-12-17 1999-07-05 Nutrasweet Company, The Use of n-{n-(3,3-dimethylbutyl)-l-alpha-aspartyl}-l-phenylalanine 1-methyl esterin dairy and dairy analogue products
AU1924899A (en) * 1997-12-17 1999-07-05 Nutrasweet Company, The Tabletop sweetener compositions comprising sweetener with extremely high potency
AR014129A1 (es) * 1997-12-17 2001-02-07 Nutrasweet Co Bebida que comprende fundamentalmente un ester n-[n-(3,3-dimetilbutil)-l- alfa-aspartil]-l-fenilamina 1 - metilico, bebida sin alcohol carbonatada,bebida de jugo, bebida envasada caliente y bebida deportiva de bajas calorias.
JPH11322788A (ja) * 1998-05-08 1999-11-24 Ajinomoto Co Inc 新規アスパルテーム誘導体結晶及びその製造方法
JP2000026496A (ja) 1998-05-08 2000-01-25 Ajinomoto Co Inc 新規アスパルテーム誘導体結晶及びその製造法
US5905175A (en) * 1998-05-20 1999-05-18 The Nutrasweet Company Synthesis and purification of 3,3-dimethylbutyraldehyde via oxidation of 1-chloro-3,3-dimethylbutane with dimethyl sulfoxide
US6692778B2 (en) * 1998-06-05 2004-02-17 Wm. Wrigley Jr. Company Method of controlling release of N-substituted derivatives of aspartame in chewing gum
AU7822398A (en) * 1998-06-05 1999-12-20 Wm. Wrigley Jr. Company Method of controlling release of n-substituted derivatives of aspartame in chewing gum and gum produced thereby
AU752473B2 (en) * 1998-06-26 2002-09-19 Ajinomoto Co., Inc. Novel aspartyl dipeptide ester derivatives and sweeteners
US5977415A (en) * 1998-08-20 1999-11-02 The Nutrasweet Company Preparation of 3, 3-dimethylbutyraldehyde from a tert-butyl cation precursor, vinyl chloride and an acidic catalyst
NL1010063C2 (nl) * 1998-09-10 2000-03-13 Holland Sweetener Co Werkwijze voor de bereiding van neotaam.
US5994593A (en) * 1998-09-17 1999-11-30 The Nutrasweet Company Synthesis and purification of 3,3-dimethylbutyraldehyde via hydrolysis of 1,1-dichloro-3,3-dimethylbutane or 1-bromo-1-chloro-3,3-dimethylbutane
US6214402B1 (en) 1998-09-17 2001-04-10 The Nutrasweet Company Co-crystallization of sugar and n-[n-(3,3-dimethylbutyl)-l αaspartyl]-l-phenylalanine 1-methyl ester
CA2348162A1 (en) * 1998-10-30 2000-05-11 Ajinomoto Co., Inc. Method for preparing crystal of aspartame derivative excellent in stability
US6844465B2 (en) 1998-10-30 2005-01-18 Ajinomoto Co., Inc. Method for preparing highly stable crystals of aspartame derivative
KR20010075419A (ko) 1998-10-30 2001-08-09 에가시라 구니오 안정성이 우수한 아스파르탐 유도체 결정의 결정 석출법
US6465677B1 (en) 1998-11-19 2002-10-15 The Nutrasweet Company Method for the preparation of N-neohexyl-α-aspartyl-L-phenylalanine methyl ester from imidazolidin-4-one intermediates
AU1628700A (en) * 1998-11-20 2000-06-13 Nutrasweet Company, The Amorphous N-(N-(3,3-dimethylbutyl)-l-alpha-aspartyl)-l-phenylalanine 1-methyl ester
WO2000032622A1 (en) 1998-11-25 2000-06-08 The Nutrasweet Company PURIFICATION OF N-[N-(3,3-DIMETHYLBUTYL)-L-α-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER VIA CRYSTALLIZATION
WO2000036924A1 (en) * 1998-12-18 2000-06-29 The Nutrasweet Company N-[N-(3,3-DIMETHYLBUTYL)-L-α-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER AS A SWEETENER IN CHEWING GUM
US6077962A (en) * 1998-12-24 2000-06-20 The Nutrasweet Company N-3, 3-dimethylbutyl-L-aspartic acid and esters thereof, the process of preparing the same, and the process for preparing N-(N-(3,3-dimethylbutyl) -α L-aspartyl)-L- phenylalanine 1-methyl ester therefrom
US6048999A (en) * 1999-01-25 2000-04-11 The Nutrasweet Company N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester synergistic sweetener blends
US6180157B1 (en) 1999-02-18 2001-01-30 The Nutrasweet Company Process for preparing an N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester agglomerate
EP1164872A1 (en) 1999-03-26 2002-01-02 The NutraSweet Company PARTICLES OF N- N-(3,3-DIMETHYLBUTYL)-L-$g(a)-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER
US6726922B1 (en) 1999-06-28 2004-04-27 Minu, L.L.C. Process and composition for temporarily suppressing pain
US6573409B1 (en) * 1999-07-02 2003-06-03 The Nutrasweet Company Process for the preparation of 3,3-dimethylbutanal
AU4459400A (en) 1999-07-28 2001-02-19 Nutrasweet Company, The A method for the purification of n-[n-(3,3-dimethylbutyl)-l-alpha-aspartyl]-l-phenylalanine 1-methyl ester
AU7627800A (en) 1999-08-06 2001-03-05 Nutrasweet Company, The Process for coating n-[n-(3,3-dimethylbutyl)-l-alpha-aspartyl]-l-phenylalanine 1-methyl ester onto a carrier
WO2001010236A1 (en) * 1999-08-11 2001-02-15 The Nutrasweet Company CONFECTIONERY FOOD PRODUCTS SWEETENED WITH N-[N-(3,3-DIMETHYLBUTYL)-1-α-ASPARTYL]-L-PHENYLALANINE METHYL ESTER
AU6727300A (en) * 1999-09-07 2001-04-10 Ajinomoto Co., Inc. Process for producing aspartame derivative, method of purifying the same, crystals thereof and use of the same
KR20020038797A (ko) * 1999-10-08 2002-05-23 에가시라 구니오 아스파탐 유도체의 제조방법, 이의 결정, 이를 위한신규한 제조 중간체 및 당해 중간체의 제조방법
US6627431B1 (en) 2000-05-12 2003-09-30 The Nutrasweet Company Chemoenzymatic synthesis of neotame
EP1403276B1 (en) * 2000-05-18 2005-11-16 The NutraSweet Company Synthesis of N-[N-(3,3-dimethylbutyl)-L-alpha-aspartyl]-L-phenylalanine 1-methyl ester using L-alpha-aspartyl-L-phenylalanine 1-methyl ester precursors
WO2001087927A2 (en) * 2000-05-18 2001-11-22 The Nutrasweet Company gYNTHESIS OF N-[N-(3,3-DIMETHYLBUTYL)-L-α-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER USING L-α-ASPARTYL-L-PHENYLALANINE 1-METHYL ESTER PRECURSORS
ES2233647T3 (es) * 2000-05-19 2005-06-16 The Nutrasweet Company Sintesis de n- n-(3,3-dimetilbutil)-l-alfa- aspartil-l- fenilalanina 1-metil ester utilizando "nuevos derivados de laoxazolidinona".
US7326430B2 (en) * 2000-07-18 2008-02-05 The Nutrasweet Company Method of preparing liquid compositions for delivery of N-[N- (3,3-dimethylbutyl-L-α-aspartyl]-L-phenylalanine 1-methyl ester in food and beverage systems
WO2002065853A2 (en) * 2000-11-06 2002-08-29 The Nutrasweet Company Catalyst modification to enhance neotame production
CN100482681C (zh) * 2003-05-06 2009-04-29 纽特拉斯威特公司 使用3,3-二甲基丁醛前体合成N-[N-(3,3-二甲基丁基)-L-α-天冬氨酰基]-L-苯基丙氨酸1-甲基酯的方法
CA2558683A1 (en) * 2004-03-05 2005-09-22 Sunil Srivastava High-intensity sweetener-polyol compositions
US20060188629A1 (en) * 2005-01-21 2006-08-24 Greg Liesen Method for the purification of sucralose
EP1971217A2 (en) * 2005-12-02 2008-09-24 The Coca-Cola Company Reduced calorie frozen beverage
CN101270092B (zh) * 2008-04-30 2010-12-08 厦门大学 一种合成纽甜的方法
US20100125146A1 (en) * 2008-11-19 2010-05-20 Johnson Matthey Public Limited Company Method for making pharmaceutical compounds
CN105131081A (zh) * 2015-09-08 2015-12-09 南京工业大学 一种廉价高效的纽甜制备方法
FR3102041A1 (fr) 2019-10-22 2021-04-23 Aroma Sens Edulcorant pour liquides de cigarette électronique

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Publication number Priority date Publication date Assignee Title
FR2533210A1 (fr) * 1982-09-17 1984-03-23 Lyon I Universite Claude Edulcorants de synthese
FR2630304B1 (fr) * 1988-04-22 1990-08-31 Bernard Lyon I Universite Clau Derives n-hydrocarbones des acides aspartique et glutamique alpha-monoamides utiles comme agents edulcorants
FR2697844B1 (fr) * 1992-11-12 1995-01-27 Claude Nofre Nouveaux composés dérivés de dipeptides ou d'analogues dipeptidiques utiles comme agents édulcorants, leur procédé de préparation.

Also Published As

Publication number Publication date
AU681523B2 (en) 1997-08-28
CN1147817A (zh) 1997-04-16
PL180471B1 (pl) 2001-02-28
OA10334A (fr) 1997-10-07
DE69504059D1 (de) 1998-09-17
CA2187901C (en) 2003-09-09
UA41403C2 (uk) 2001-09-17
FI964106A (fi) 1996-10-14
KR100304320B1 (ko) 2001-11-30
NO964745D0 (no) 1996-11-08
CZ285612B6 (cs) 1999-09-15
HUT75087A (en) 1997-04-28
HK1012406A1 (en) 1999-07-30
RU2138510C1 (ru) 1999-09-27
BR9507635A (pt) 1997-09-23
BG100967A (en) 1998-01-30
MD1175G2 (ro) 2000-02-29
HU219829B (hu) 2001-08-28
NZ285777A (en) 1997-04-24
CA2187901A1 (en) 1995-11-16
MD1175F1 (en) 1999-03-31
GEP19991647B (en) 1999-06-14
MX9605244A (es) 1997-09-30
NO964745L (no) 1996-11-08
FI964106A0 (fi) 1996-10-14
CN1114615C (zh) 2003-07-16
AU2528595A (en) 1995-11-29
DK0759031T3 (da) 1999-05-17
FR2719590A1 (fr) 1995-11-10
SK280376B6 (sk) 1999-12-10
NO313832B1 (no) 2002-12-09
HU9602990D0 (en) 1997-01-28
CZ329996A3 (en) 1997-02-12
EP0759031A1 (fr) 1997-02-26
US5510508A (en) 1996-04-23
FR2719590B1 (fr) 1996-07-26
JP3303921B2 (ja) 2002-07-22
JPH09512809A (ja) 1997-12-22
RO115732B1 (ro) 2000-05-30
WO1995030689A1 (fr) 1995-11-16
EE9600179A (et) 1997-06-16
FI114313B (fi) 2004-09-30
ATE169636T1 (de) 1998-08-15
PL317053A1 (en) 1997-03-03
EE03402B1 (et) 2001-04-16
EP0759031B1 (fr) 1998-08-12
SK144996A3 (en) 1997-05-07
DE69504059T2 (de) 1999-02-25
BG62813B1 (bg) 2000-08-31

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