ES2052524T3 - Un procedimiento para la preparacion de un compuesto de carbapenem cristalino. - Google Patents

Un procedimiento para la preparacion de un compuesto de carbapenem cristalino.

Info

Publication number
ES2052524T3
ES2052524T3 ES87110992T ES87110992T ES2052524T3 ES 2052524 T3 ES2052524 T3 ES 2052524T3 ES 87110992 T ES87110992 T ES 87110992T ES 87110992 T ES87110992 T ES 87110992T ES 2052524 T3 ES2052524 T3 ES 2052524T3
Authority
ES
Spain
Prior art keywords
procedure
preparation
carbapenem compound
crystalline carbapenem
crystalline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87110992T
Other languages
English (en)
Spanish (es)
Inventor
Makoto Sunagawa
Yutaka Isobe
Yutaka Takeuchi
Haruki Matsumura
Tetsuo Noguchi
Yukio Ozaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
Original Assignee
Sumitomo Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharmaceuticals Co Ltd filed Critical Sumitomo Pharmaceuticals Co Ltd
Application granted granted Critical
Publication of ES2052524T3 publication Critical patent/ES2052524T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES87110992T 1986-07-30 1987-07-29 Un procedimiento para la preparacion de un compuesto de carbapenem cristalino. Expired - Lifetime ES2052524T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP17932186 1986-07-30
JP15776987 1987-06-26

Publications (1)

Publication Number Publication Date
ES2052524T3 true ES2052524T3 (es) 1994-07-16

Family

ID=26485103

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87110992T Expired - Lifetime ES2052524T3 (es) 1986-07-30 1987-07-29 Un procedimiento para la preparacion de un compuesto de carbapenem cristalino.

Country Status (20)

Country Link
US (1) US4888344A (cg-RX-API-DMAC7.html)
EP (1) EP0256377B1 (cg-RX-API-DMAC7.html)
JP (1) JP2665767B2 (cg-RX-API-DMAC7.html)
AR (1) AR243189A1 (cg-RX-API-DMAC7.html)
AU (1) AU596857B2 (cg-RX-API-DMAC7.html)
CA (1) CA1322371C (cg-RX-API-DMAC7.html)
DE (1) DE3781980T2 (cg-RX-API-DMAC7.html)
DK (1) DK172666B1 (cg-RX-API-DMAC7.html)
ES (1) ES2052524T3 (cg-RX-API-DMAC7.html)
FI (1) FI88037C (cg-RX-API-DMAC7.html)
GR (1) GR3006254T3 (cg-RX-API-DMAC7.html)
HK (1) HK169595A (cg-RX-API-DMAC7.html)
HU (1) HU199473B (cg-RX-API-DMAC7.html)
IE (1) IE60588B1 (cg-RX-API-DMAC7.html)
IL (1) IL83372A (cg-RX-API-DMAC7.html)
LU (1) LU88635I2 (cg-RX-API-DMAC7.html)
MX (1) MX173359B (cg-RX-API-DMAC7.html)
NO (2) NO165543C (cg-RX-API-DMAC7.html)
NZ (1) NZ221224A (cg-RX-API-DMAC7.html)
PH (1) PH24710A (cg-RX-API-DMAC7.html)

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FR2735474B1 (fr) * 1995-06-13 1997-08-08 Roussel Uclaf Chlorhydrate de zilpaterol sous une forme cristallisee particuliere, son procede de preparation et les produits intermediaires mis en oeuvre
HUP0000952A3 (en) * 1997-02-07 2000-12-28 Kyoto Pharma Ind Carbapenem compounds, process for their preparation and pharmaceutical compositions containing them
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JP4547245B2 (ja) * 2004-12-16 2010-09-22 株式会社パーマケム・アジア ペリンドプリルエルブミンのｉ型結晶、及びその製造方法
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PL1926732T3 (pl) 2005-09-05 2014-01-31 Ranbaxy Laboratories Ltd Sposób wytwarzania związków karbapenemu
BRPI0616563A2 (pt) 2005-09-15 2012-12-25 Orchid Chemicals & Pharm Ltd processo melhorado para a preparaÇço de antibiàtico betalactÂmico
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DK3494960T3 (da) * 2008-03-27 2021-01-25 Helsinn Healthcare Sa Stabiliserede sammensætninger af alkyleringsmidler og fremgangsmåder til anvendelse af samme
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ES2477290T3 (es) * 2009-03-13 2014-07-16 Daewoong Pharmaceutical Co., Ltd. Método mejorado para preparar meropenem usando polvo de zinc
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CN101962383A (zh) * 2010-11-12 2011-02-02 上海巴迪生物医药科技有限公司 一种美罗培南的合成方法
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CN102532140B (zh) * 2010-12-21 2015-03-11 北大方正集团有限公司 一种美罗培南三水合物的制备方法
CN102250096B (zh) * 2011-09-05 2016-04-06 江西华邦药业有限公司 一种美罗培南的制备方法
CN103570720B (zh) * 2012-07-31 2016-02-10 新乡海滨药业有限公司 一种美罗培南原料药、其制备方法及包含其的药物组合物
CN103570719B (zh) * 2012-07-31 2016-03-02 深圳市海滨制药有限公司 一种美罗培南原料药、其制备方法及包含其的药物组合物
CN103570718B (zh) * 2012-07-31 2016-06-29 深圳市海滨制药有限公司 一种美罗培南原料药、其制备方法及包含其的药物组合物
KR101331762B1 (ko) * 2012-12-28 2013-11-20 주식회사 대웅제약 메로페넴의 삼수화물의 제조방법
CN103044429B (zh) * 2013-01-28 2015-04-01 苏州二叶制药有限公司 一种美罗培南的制备方法
US9089560B2 (en) 2013-02-01 2015-07-28 Ocularis Pharma, Llc Methods and compositions for daily ophthalmic administration of phentolamine to improve visual performance
ES2762153T3 (es) 2013-02-01 2020-05-22 Ocuphire Pharma Inc Soluciones oftálmicas acuosas de fentolamina y usos médicos de las mismas
KR102144777B1 (ko) 2013-06-19 2020-08-18 제이더블유중외제약 주식회사 결정형 메로페넴 삼수화물의 제조방법
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JP2022508715A (ja) 2018-10-15 2022-01-19 オキュフィア・ファーマ・インコーポレイテッド 緑内障および関連状態の処置のための方法および組成物
JP7670945B2 (ja) 2018-10-26 2025-05-01 オーパス・ジェネティクス・インコーポレイテッド 老眼、散瞳、および他の眼障害の治療のための方法および組成物
CN115368310B (zh) 2021-05-18 2025-06-27 奥库菲尔医药公司 合成甲磺酸酚妥拉明的方法

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Also Published As

Publication number Publication date
PH24710A (en) 1990-10-01
FI873299L (fi) 1988-01-31
DE3781980D1 (de) 1992-11-05
HK169595A (en) 1995-11-10
MX7534A (es) 1993-10-01
US4888344A (en) 1989-12-19
FI88037B (fi) 1992-12-15
NO873205D0 (no) 1987-07-30
JP2665767B2 (ja) 1997-10-22
LU88635I2 (fr) 1995-12-01
NO165543C (no) 1991-02-27
AU596857B2 (en) 1990-05-17
JPS6434986A (en) 1989-02-06
NO1997013I1 (no) 1997-10-17
AR243189A1 (es) 1993-07-30
NO873205L (no) 1988-02-01
EP0256377B1 (en) 1992-09-30
CA1322371C (en) 1993-09-21
DK172666B1 (da) 1999-05-10
IL83372A0 (en) 1987-12-31
HU199473B (en) 1990-02-28
IE60588B1 (en) 1994-07-27
IL83372A (en) 1992-05-25
AU7619687A (en) 1988-03-03
GR3006254T3 (cg-RX-API-DMAC7.html) 1993-06-21
DK399087D0 (da) 1987-07-30
MX173359B (es) 1994-02-23
DE3781980T2 (de) 1993-02-18
DK399087A (da) 1988-01-31
FI873299A0 (fi) 1987-07-29
NZ221224A (en) 1989-10-27
NO165543B (no) 1990-11-19
HUT44553A (en) 1988-03-28
FI88037C (fi) 1993-03-25
EP0256377A1 (en) 1988-02-24
IE871959L (en) 1988-01-30

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