AR243189A1 - Un procedimiento para obtener el acido ( ( ( ( ( - Google Patents

Un procedimiento para obtener el acido ( ( ( ( (

Info

Publication number
AR243189A1
AR243189A1 AR87308307A AR30830787A AR243189A1 AR 243189 A1 AR243189 A1 AR 243189A1 AR 87308307 A AR87308307 A AR 87308307A AR 30830787 A AR30830787 A AR 30830787A AR 243189 A1 AR243189 A1 AR 243189A1
Authority
AR
Argentina
Prior art keywords
microbial
procedure
obtaining
antibiotic acid
antibiotic
Prior art date
Application number
AR87308307A
Other languages
English (en)
Original Assignee
Sumitomo Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharma filed Critical Sumitomo Pharma
Application granted granted Critical
Publication of AR243189A1 publication Critical patent/AR243189A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AR87308307A 1986-07-30 1987-07-30 Un procedimiento para obtener el acido ( ( ( ( ( AR243189A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP17932186 1986-07-30
JP15776987 1987-06-26

Publications (1)

Publication Number Publication Date
AR243189A1 true AR243189A1 (es) 1993-07-30

Family

ID=26485103

Family Applications (1)

Application Number Title Priority Date Filing Date
AR87308307A AR243189A1 (es) 1986-07-30 1987-07-30 Un procedimiento para obtener el acido ( ( ( ( (

Country Status (20)

Country Link
US (1) US4888344A (es)
EP (1) EP0256377B1 (es)
JP (1) JP2665767B2 (es)
AR (1) AR243189A1 (es)
AU (1) AU596857B2 (es)
CA (1) CA1322371C (es)
DE (1) DE3781980T2 (es)
DK (1) DK172666B1 (es)
ES (1) ES2052524T3 (es)
FI (1) FI88037C (es)
GR (1) GR3006254T3 (es)
HK (1) HK169595A (es)
HU (1) HU199473B (es)
IE (1) IE60588B1 (es)
IL (1) IL83372A (es)
LU (1) LU88635I2 (es)
MX (1) MX173359B (es)
NO (2) NO165543C (es)
NZ (1) NZ221224A (es)
PH (1) PH24710A (es)

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KR880006244A (ko) * 1986-11-24 1988-07-22 후지사와 도모 기찌 로 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법
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JP2696807B2 (ja) * 1992-08-06 1998-01-14 田辺製薬株式会社 カルバペネム誘導体の製法
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FR2735474B1 (fr) * 1995-06-13 1997-08-08 Roussel Uclaf Chlorhydrate de zilpaterol sous une forme cristallisee particuliere, son procede de preparation et les produits intermediaires mis en oeuvre
BR9807187A (pt) * 1997-02-07 2000-01-25 Kyoto Pharma Ind Composto de carbapenem, seu uso e composto intermediário para o mesmo
DE69932927D1 (de) 1998-05-01 2006-10-05 Kyoto Pharma Ind Cabapenemderivate, ihre anwendung und ihre zwischenprodukte
JP4130078B2 (ja) 1999-06-03 2008-08-06 エーザイ・アール・アンド・ディー・マネジメント株式会社 カルバペネム誘導体結晶と注射製剤
US7041660B2 (en) 1999-07-06 2006-05-09 Sankyo Company, Limited Crystalline 1-methylcarbapenem derivatives
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EP1398314A4 (en) * 2001-05-21 2004-10-20 Kyoto Pharma Ind CARBAPENEM CONNECTION
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JP4547245B2 (ja) * 2004-12-16 2010-09-22 株式会社パーマケム・アジア ペリンドプリルエルブミンのｉ型結晶、及びその製造方法
US8501818B2 (en) * 2005-03-14 2013-08-06 Ceptaris Therapeutics, Inc. Stabilized compositions of alkylating agents and methods of using same
US7872050B2 (en) * 2005-03-14 2011-01-18 Yaupon Therapeutics Inc. Stabilized compositions of volatile alkylating agents and methods of using thereof
US20110039943A1 (en) * 2005-03-14 2011-02-17 Robert Alonso Methods for treating skin disorders with topical nitrogen mustard compositions
US20070197781A1 (en) * 2005-07-29 2007-08-23 Neera Tewari Processes for the preparation of carbapenems
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US8148520B2 (en) 2005-09-15 2012-04-03 Orchid Chemicals And Pharmaceuticals Limited Process for the preparation of beta-lactam antibiotic meropenem trihydrate
CN100497338C (zh) * 2006-01-05 2009-06-10 上海医药工业研究院 4－甲基－7－氧－1－氮杂双环[3.2.0]庚－2－烯－2－羧酸类衍生物的制备方法
KR100781821B1 (ko) * 2006-02-16 2007-12-03 문순구 카르바페넴계 화합물의 제조방법
EP2006290A4 (en) * 2006-03-28 2011-01-05 Kaneka Corp IMPROVED PROCESS FOR PRODUCING CARBAPENEM COMPOUND
JP5671204B2 (ja) * 2006-04-28 2015-02-18 株式会社カネカ カルバペネム抗生物質中間体の改良された晶析方法
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US20090216010A1 (en) * 2008-02-22 2009-08-27 Wei-Hong Tseng Crystalline carbapenem compound and produced method thereof
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PL2273876T3 (pl) * 2008-03-27 2019-09-30 Helsinn Healthcare Sa Stabilizowane kompozycje środków alkilujących i sposoby ich zastosowania
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RU2490270C2 (ru) * 2009-03-13 2013-08-20 Даевунг Фармасьютикал Ко., Лтд. Улучшенный способ получения меропенема с применением цинкового порошка
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WO2011141847A1 (en) * 2010-05-10 2011-11-17 Orchid Chemicals And Pharmaceuticals Limited An improved process for the preparation of meropenem
US9000150B2 (en) 2010-10-22 2015-04-07 Ranbaxy Laboratories Limited Process for the preparation of pure meropenem trihydrate
CN101962383A (zh) * 2010-11-12 2011-02-02 上海巴迪生物医药科技有限公司 一种美罗培南的合成方法
WO2012081033A2 (en) * 2010-12-06 2012-06-21 Sequent Scientific Limited A process for preparation of imipenem
CN102532140B (zh) * 2010-12-21 2015-03-11 北大方正集团有限公司 一种美罗培南三水合物的制备方法
CN102250096B (zh) * 2011-09-05 2016-04-06 江西华邦药业有限公司 一种美罗培南的制备方法
CN103570719B (zh) * 2012-07-31 2016-03-02 深圳市海滨制药有限公司 一种美罗培南原料药、其制备方法及包含其的药物组合物
CN103570720B (zh) * 2012-07-31 2016-02-10 新乡海滨药业有限公司 一种美罗培南原料药、其制备方法及包含其的药物组合物
CN103570718B (zh) * 2012-07-31 2016-06-29 深圳市海滨制药有限公司 一种美罗培南原料药、其制备方法及包含其的药物组合物
KR101331762B1 (ko) 2012-12-28 2013-11-20 주식회사 대웅제약 메로페넴의 삼수화물의 제조방법
CN103044429B (zh) * 2013-01-28 2015-04-01 苏州二叶制药有限公司 一种美罗培南的制备方法
JP6335927B2 (ja) 2013-02-01 2018-05-30 オキュラリス・ファーマ・リミテッド・ライアビリティ・カンパニーＯｃｕｌａｒｉｓ Ｐｈａｒｍａ， Ｌｌｃ フェントラミンの水性点眼液およびそれらの医学的用途
WO2014121028A1 (en) 2013-02-01 2014-08-07 Ocularis Pharma, Llc Methods and compositions for daily ophthalmic administration of phentolamine to improve visual performance
KR102144777B1 (ko) 2013-06-19 2020-08-18 제이더블유중외제약 주식회사 결정형 메로페넴 삼수화물의 제조방법
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Also Published As

Publication number Publication date
HU199473B (en) 1990-02-28
DE3781980T2 (de) 1993-02-18
AU7619687A (en) 1988-03-03
DK399087A (da) 1988-01-31
FI88037B (fi) 1992-12-15
FI873299A0 (fi) 1987-07-29
MX173359B (es) 1994-02-23
DK399087D0 (da) 1987-07-30
HUT44553A (en) 1988-03-28
NO1997013I1 (no) 1997-10-17
NO165543B (no) 1990-11-19
JPS6434986A (en) 1989-02-06
IL83372A0 (en) 1987-12-31
CA1322371C (en) 1993-09-21
LU88635I2 (fr) 1995-12-01
NZ221224A (en) 1989-10-27
NO873205D0 (no) 1987-07-30
NO165543C (no) 1991-02-27
DE3781980D1 (de) 1992-11-05
PH24710A (en) 1990-10-01
EP0256377B1 (en) 1992-09-30
FI88037C (fi) 1993-03-25
MX7534A (es) 1993-10-01
GR3006254T3 (es) 1993-06-21
EP0256377A1 (en) 1988-02-24
NO873205L (no) 1988-02-01
JP2665767B2 (ja) 1997-10-22
IL83372A (en) 1992-05-25
HK169595A (en) 1995-11-10
FI873299A (fi) 1988-01-31
IE60588B1 (en) 1994-07-27
US4888344A (en) 1989-12-19
ES2052524T3 (es) 1994-07-16
AU596857B2 (en) 1990-05-17
DK172666B1 (da) 1999-05-10
IE871959L (en) 1988-01-30

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