FI873299A - Karbapenemfoerening i kristallform och dess framstaellning och anvaendning. - Google Patents
Karbapenemfoerening i kristallform och dess framstaellning och anvaendning. Download PDFInfo
- Publication number
- FI873299A FI873299A FI873299A FI873299A FI873299A FI 873299 A FI873299 A FI 873299A FI 873299 A FI873299 A FI 873299A FI 873299 A FI873299 A FI 873299A FI 873299 A FI873299 A FI 873299A
- Authority
- FI
- Finland
- Prior art keywords
- och
- karbapenemfoerening
- kristallform
- anvaendning
- dess framstaellning
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17932186 | 1986-07-30 | ||
JP17932186 | 1986-07-30 | ||
JP15776987 | 1987-06-26 | ||
JP15776987 | 1987-06-26 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI873299A0 FI873299A0 (fi) | 1987-07-29 |
FI873299A true FI873299A (fi) | 1988-01-31 |
FI88037B FI88037B (fi) | 1992-12-15 |
FI88037C FI88037C (fi) | 1993-03-25 |
Family
ID=26485103
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI873299A FI88037C (fi) | 1986-07-30 | 1987-07-29 | Foerfarande foer framstaellning av farmaceutiskt vaerdefullt kristallint (4r,5s,6s,8r,2's,4's)-3-/4-(2-dimetylaminokarbonyl)-pyrrolidinyltio/-4-metyl-6-(1-hydroxietyl)-1-azabicyklo-/3,2,0/-hept-2-en-7-on-2-karboxylsyratrihydrat |
Country Status (20)
Country | Link |
---|---|
US (1) | US4888344A (fi) |
EP (1) | EP0256377B1 (fi) |
JP (1) | JP2665767B2 (fi) |
AR (1) | AR243189A1 (fi) |
AU (1) | AU596857B2 (fi) |
CA (1) | CA1322371C (fi) |
DE (1) | DE3781980T2 (fi) |
DK (1) | DK172666B1 (fi) |
ES (1) | ES2052524T3 (fi) |
FI (1) | FI88037C (fi) |
GR (1) | GR3006254T3 (fi) |
HK (1) | HK169595A (fi) |
HU (1) | HU199473B (fi) |
IE (1) | IE60588B1 (fi) |
IL (1) | IL83372A (fi) |
LU (1) | LU88635I2 (fi) |
MX (1) | MX173359B (fi) |
NO (2) | NO165543C (fi) |
NZ (1) | NZ221224A (fi) |
PH (1) | PH24710A (fi) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1283906C (en) * | 1983-05-09 | 1991-05-07 | Makoto Sunagawa | .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF |
KR880006244A (ko) * | 1986-11-24 | 1988-07-22 | 후지사와 도모 기찌 로 | 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법 |
EP0406863B1 (en) * | 1989-07-06 | 1995-05-24 | Banyu Pharmaceutical Co., Ltd. | Cyclic amidinylthiocarbapenem derivatives |
EP0435320B1 (en) * | 1989-12-29 | 1994-10-05 | Banyu Pharmaceutical Co., Ltd. | 2(2-Cyclopropylpyrrolidin-4-ylthio)-carbapenem derivatives |
TW264475B (fi) * | 1991-09-20 | 1995-12-01 | Takeda Pharm Industry Co Ltd | |
JP2696807B2 (ja) * | 1992-08-06 | 1998-01-14 | 田辺製薬株式会社 | カルバペネム誘導体の製法 |
GB9503717D0 (en) * | 1995-02-24 | 1995-04-12 | Smithkline Beecham Plc | Novel compounds |
FR2735474B1 (fr) * | 1995-06-13 | 1997-08-08 | Roussel Uclaf | Chlorhydrate de zilpaterol sous une forme cristallisee particuliere, son procede de preparation et les produits intermediaires mis en oeuvre |
YU37299A (sh) * | 1997-02-07 | 2002-06-19 | Kyoto Pharmaceutical Industries Ltd. | Karbapenemsko jedinjenje, njegova primena i njegovo intermedijarno jedinjenje |
AU760386B2 (en) | 1998-05-01 | 2003-05-15 | Kyoto Pharmaceutical Industries, Ltd. | Carbapenem derivatives, utilization thereof and intermediate compounds of the same |
US7084268B1 (en) | 1999-06-03 | 2006-08-01 | Eisai Co., Ltd. | Carbapenem compound crystals and interjection preparations |
US7041660B2 (en) | 1999-07-06 | 2006-05-09 | Sankyo Company, Limited | Crystalline 1-methylcarbapenem derivatives |
TWI250160B (en) * | 1999-07-06 | 2006-03-01 | Sankyo Co | Crystalline 1-methylcarbapenem compound |
DK1280531T3 (da) * | 2000-05-12 | 2007-05-29 | Novalar Pharmaceuticals Inc | Formulering bestående af phentolaminmesylat og anvendelse heraf |
JP5079190B2 (ja) * | 2001-04-27 | 2012-11-21 | 大日本住友製薬株式会社 | アゼチジノン誘導体およびその製造方法 |
NZ530170A (en) * | 2001-05-21 | 2005-09-30 | Kyoto Pharma Ind | Carbapenem compound |
KR100451672B1 (ko) * | 2001-06-05 | 2004-10-08 | 한미약품 주식회사 | 결정성 세프디니르 산부가염, 이의 제조방법 및 이를이용한 세프디니르의 제조방법 |
US20040198973A1 (en) * | 2001-08-13 | 2004-10-07 | Tsujii Masahiko | Process for preparation of carbapenem antibiotics |
MXPA04002797A (es) * | 2001-09-26 | 2004-07-02 | Merck & Co Inc | Procedimiento para elaborar compuestos de carbapenemo. |
AU2002331885B2 (en) * | 2001-09-26 | 2007-07-26 | Merck & Co., Inc. | Crystalline forms of ertapenem sodium |
ITMI20012364A1 (it) * | 2001-11-09 | 2003-05-09 | Antibioticos Spa | Processo di sintesi della cefixima via alchil-o arilsolfonati |
EP2316468A1 (en) | 2002-02-22 | 2011-05-04 | Shire LLC | Delivery system and methods for protecting and administering dextroamphetamine |
US7229630B2 (en) * | 2002-06-20 | 2007-06-12 | Novalar Pharmaceuticals, Inc. | Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof |
US20030236306A1 (en) * | 2002-06-20 | 2003-12-25 | Chen Andrew X. | Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof |
EP1950563A3 (en) | 2002-09-11 | 2008-08-06 | Michio Ishibashi | Method for screening for a substance for promoting regeneration of macrophages |
WO2005118586A1 (en) * | 2004-06-02 | 2005-12-15 | Sandoz Ag | Meropenem intermediate in crystalline form |
WO2006035300A2 (en) * | 2004-09-30 | 2006-04-06 | Ranbaxy Laboratories Limited | A process for the preparation of meropenem |
JP4547245B2 (ja) * | 2004-12-16 | 2010-09-22 | 株式会社パーマケム・アジア | ペリンドプリルエルブミンのi型結晶、及びその製造方法 |
US7872050B2 (en) * | 2005-03-14 | 2011-01-18 | Yaupon Therapeutics Inc. | Stabilized compositions of volatile alkylating agents and methods of using thereof |
US8501818B2 (en) * | 2005-03-14 | 2013-08-06 | Ceptaris Therapeutics, Inc. | Stabilized compositions of alkylating agents and methods of using same |
US20110039943A1 (en) * | 2005-03-14 | 2011-02-17 | Robert Alonso | Methods for treating skin disorders with topical nitrogen mustard compositions |
US20070197781A1 (en) * | 2005-07-29 | 2007-08-23 | Neera Tewari | Processes for the preparation of carbapenems |
PT1926732E (pt) | 2005-09-05 | 2013-12-27 | Ranbaxy Lab Ltd | Processo para a preparação de compostos de carbapenem |
BRPI0616563A2 (pt) * | 2005-09-15 | 2012-12-25 | Orchid Chemicals & Pharm Ltd | processo melhorado para a preparaÇço de antibiàtico betalactÂmico |
CN100497338C (zh) * | 2006-01-05 | 2009-06-10 | 上海医药工业研究院 | 4-甲基-7-氧-1-氮杂双环[3.2.0]庚-2-烯-2-羧酸类衍生物的制备方法 |
KR100781821B1 (ko) * | 2006-02-16 | 2007-12-03 | 문순구 | 카르바페넴계 화합물의 제조방법 |
EP2006290A4 (en) * | 2006-03-28 | 2011-01-05 | Kaneka Corp | IMPROVED PROCESS FOR PRODUCING CARBAPENEM COMPOUND |
KR20090007572A (ko) * | 2006-04-28 | 2009-01-19 | 카네카 코포레이션 | 카르바페넴 항생 물질 중간체의 개량된 정석 방법 |
EP2229944A1 (en) * | 2007-12-12 | 2010-09-22 | Dainippon Sumitomo Pharma Co., Ltd. | Preparation composition |
US20090216010A1 (en) * | 2008-02-22 | 2009-08-27 | Wei-Hong Tseng | Crystalline carbapenem compound and produced method thereof |
EP2098525A1 (en) | 2008-02-26 | 2009-09-09 | Savior Lifetec Corporation | Crystalline carbapenem compound and produced method thereof |
HUE053482T2 (hu) * | 2008-03-27 | 2021-06-28 | Helsinn Healthcare Sa | Alkilezõszerek stabilizált készítményei és alkalmazási eljárásaik |
US8097719B2 (en) * | 2008-07-15 | 2012-01-17 | Genesen Labs | Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem |
AU2009277936B2 (en) * | 2008-07-30 | 2014-11-27 | Sun Pharmaceutical Industries Limited | Process for the preparation of carbapenem compounds |
CN102348710B (zh) * | 2009-03-13 | 2014-12-17 | 株式会社大熊制药 | 利用锌粉制备美罗培南的改进方法 |
WO2011048583A1 (en) | 2009-10-23 | 2011-04-28 | Ranbaxy Laboratories Limited | Process for the preparation of carbapenem compounds |
WO2011141847A1 (en) * | 2010-05-10 | 2011-11-17 | Orchid Chemicals And Pharmaceuticals Limited | An improved process for the preparation of meropenem |
PL2630147T3 (pl) | 2010-10-22 | 2015-08-31 | Ranbaxy Laboratories Ltd | Sposób otrzymywania czystego trihydratu meropenemu |
CN101962383A (zh) * | 2010-11-12 | 2011-02-02 | 上海巴迪生物医药科技有限公司 | 一种美罗培南的合成方法 |
WO2012081033A2 (en) * | 2010-12-06 | 2012-06-21 | Sequent Scientific Limited | A process for preparation of imipenem |
CN102532140B (zh) * | 2010-12-21 | 2015-03-11 | 北大方正集团有限公司 | 一种美罗培南三水合物的制备方法 |
CN102250096B (zh) * | 2011-09-05 | 2016-04-06 | 江西华邦药业有限公司 | 一种美罗培南的制备方法 |
CN103570719B (zh) * | 2012-07-31 | 2016-03-02 | 深圳市海滨制药有限公司 | 一种美罗培南原料药、其制备方法及包含其的药物组合物 |
CN103570718B (zh) * | 2012-07-31 | 2016-06-29 | 深圳市海滨制药有限公司 | 一种美罗培南原料药、其制备方法及包含其的药物组合物 |
CN103570720B (zh) * | 2012-07-31 | 2016-02-10 | 新乡海滨药业有限公司 | 一种美罗培南原料药、其制备方法及包含其的药物组合物 |
KR101331762B1 (ko) | 2012-12-28 | 2013-11-20 | 주식회사 대웅제약 | 메로페넴의 삼수화물의 제조방법 |
CN103044429B (zh) * | 2013-01-28 | 2015-04-01 | 苏州二叶制药有限公司 | 一种美罗培南的制备方法 |
WO2014121027A1 (en) | 2013-02-01 | 2014-08-07 | Oculars Pharma, Llc | Aqueous ophthalmic solutions of phentolamine and medical uses thereof |
ES2835398T3 (es) | 2013-02-01 | 2021-06-22 | Ocuphire Pharma Inc | Métodos y composiciones para la administración oftálmica diaria de fentolamina para mejorar el rendimiento visual |
KR102144777B1 (ko) | 2013-06-19 | 2020-08-18 | 제이더블유중외제약 주식회사 | 결정형 메로페넴 삼수화물의 제조방법 |
CN106459052B (zh) | 2014-03-27 | 2021-07-30 | 庄信万丰股份有限公司 | 制备碳青霉烯抗生素的方法 |
CA3116589A1 (en) | 2018-10-26 | 2020-04-30 | Ocuphire Pharma, Inc. | Methods and compositions for treatment of presbyopia, mydriasis, and other ocular disorders |
CN115368310A (zh) | 2021-05-18 | 2022-11-22 | 奥库菲尔医药公司 | 合成甲磺酸酚妥拉明的方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK153486C (da) * | 1978-07-03 | 1988-11-28 | Merck & Co Inc | Analogifremgangsmaade til fremstilling af krystallinsk n-formimidoyl-thienamycin-monohydrat |
EP0113101A1 (en) * | 1982-12-30 | 1984-07-11 | Merck & Co. Inc. | 6-(1-Hydroxyethyl)-2-SR8-1-methyl-1-carbadethiapen-2-em-3-carboxylic acid esters |
CA1283906C (en) * | 1983-05-09 | 1991-05-07 | Makoto Sunagawa | .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF |
JPS60104088A (ja) * | 1983-11-11 | 1985-06-08 | Sumitomo Chem Co Ltd | 新規なβ−ラクタム化合物およびその製造法 |
US4748238A (en) * | 1984-03-14 | 1988-05-31 | Merck & Co., Inc. | Crystalline 1R,5S,6S,8R-1-methyl-2-(N,N-dimethylcarbamimidoylmethylthio)-6-(1-hydroxyethyl)-1-carbapen-2-em-3-carboxylic acid |
US4713451A (en) * | 1984-04-09 | 1987-12-15 | Merck & Co., Inc. | Crystalline dimethyliminothienamycin |
US4761408A (en) * | 1984-11-02 | 1988-08-02 | Ciba-Geigy Corporation | Crystalline aminomethyl compound |
NZ214691A (en) * | 1984-12-27 | 1988-08-30 | Sumitomo Pharma | The preparation of carbapenem derivatives and beta-lactam intermediates |
US4788282A (en) * | 1985-06-07 | 1988-11-29 | Bristol-Myers Company | Deprotection of allylic esters and ethers |
-
1987
- 1987-07-20 IE IE195987A patent/IE60588B1/en not_active IP Right Cessation
- 1987-07-28 NZ NZ221224A patent/NZ221224A/xx unknown
- 1987-07-28 AU AU76196/87A patent/AU596857B2/en not_active Expired
- 1987-07-29 LU LU88635C patent/LU88635I2/fr unknown
- 1987-07-29 IL IL83372A patent/IL83372A/xx not_active IP Right Cessation
- 1987-07-29 FI FI873299A patent/FI88037C/fi not_active IP Right Cessation
- 1987-07-29 CA CA000543276A patent/CA1322371C/en not_active Expired - Lifetime
- 1987-07-29 EP EP87110992A patent/EP0256377B1/en not_active Expired - Lifetime
- 1987-07-29 ES ES87110992T patent/ES2052524T3/es not_active Expired - Lifetime
- 1987-07-29 DE DE8787110992T patent/DE3781980T2/de not_active Expired - Lifetime
- 1987-07-29 PH PH35599A patent/PH24710A/en unknown
- 1987-07-30 NO NO873205A patent/NO165543C/no not_active IP Right Cessation
- 1987-07-30 DK DK198703990A patent/DK172666B1/da not_active IP Right Cessation
- 1987-07-30 MX MX753487A patent/MX173359B/es unknown
- 1987-07-30 US US07/079,470 patent/US4888344A/en not_active Expired - Lifetime
- 1987-07-30 HU HU873521A patent/HU199473B/hu unknown
- 1987-07-30 AR AR87308307A patent/AR243189A1/es active
-
1988
- 1988-05-16 JP JP63117078A patent/JP2665767B2/ja not_active Expired - Lifetime
-
1992
- 1992-11-16 GR GR920402593T patent/GR3006254T3/el unknown
-
1995
- 1995-11-02 HK HK169595A patent/HK169595A/xx not_active IP Right Cessation
-
1997
- 1997-10-17 NO NO1997013C patent/NO1997013I1/no unknown
Also Published As
Publication number | Publication date |
---|---|
HUT44553A (en) | 1988-03-28 |
JP2665767B2 (ja) | 1997-10-22 |
IE60588B1 (en) | 1994-07-27 |
AU596857B2 (en) | 1990-05-17 |
EP0256377A1 (en) | 1988-02-24 |
IL83372A (en) | 1992-05-25 |
NO165543B (no) | 1990-11-19 |
DK172666B1 (da) | 1999-05-10 |
PH24710A (en) | 1990-10-01 |
NO165543C (no) | 1991-02-27 |
IL83372A0 (en) | 1987-12-31 |
ES2052524T3 (es) | 1994-07-16 |
AU7619687A (en) | 1988-03-03 |
US4888344A (en) | 1989-12-19 |
FI873299A0 (fi) | 1987-07-29 |
MX7534A (es) | 1993-10-01 |
DK399087D0 (da) | 1987-07-30 |
FI88037C (fi) | 1993-03-25 |
DE3781980D1 (de) | 1992-11-05 |
DE3781980T2 (de) | 1993-02-18 |
MX173359B (es) | 1994-02-23 |
NO1997013I1 (no) | 1997-10-17 |
GR3006254T3 (fi) | 1993-06-21 |
LU88635I2 (fr) | 1995-12-01 |
CA1322371C (en) | 1993-09-21 |
NZ221224A (en) | 1989-10-27 |
JPS6434986A (en) | 1989-02-06 |
AR243189A1 (es) | 1993-07-30 |
IE871959L (en) | 1988-01-30 |
FI88037B (fi) | 1992-12-15 |
NO873205D0 (no) | 1987-07-30 |
HU199473B (en) | 1990-02-28 |
HK169595A (en) | 1995-11-10 |
NO873205L (no) | 1988-02-01 |
EP0256377B1 (en) | 1992-09-30 |
DK399087A (da) | 1988-01-31 |
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