LU88635I2 - Meronem - Google Patents

Meronem

Info

Publication number
LU88635I2
LU88635I2 LU88635C LU88635C LU88635I2 LU 88635 I2 LU88635 I2 LU 88635I2 LU 88635 C LU88635 C LU 88635C LU 88635 C LU88635 C LU 88635C LU 88635 I2 LU88635 I2 LU 88635I2
Authority
LU
Luxembourg
Prior art keywords
meronem
Prior art date
Application number
LU88635C
Other languages
English (en)
Original Assignee
Sumitomo Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharma filed Critical Sumitomo Pharma
Publication of LU88635I2 publication Critical patent/LU88635I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
LU88635C 1986-07-30 1987-07-29 Meronem LU88635I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP17932186 1986-07-30
JP15776987 1987-06-26

Publications (1)

Publication Number Publication Date
LU88635I2 true LU88635I2 (fr) 1995-12-01

Family

ID=26485103

Family Applications (1)

Application Number Title Priority Date Filing Date
LU88635C LU88635I2 (fr) 1986-07-30 1987-07-29 Meronem

Country Status (20)

Country Link
US (1) US4888344A (fr)
EP (1) EP0256377B1 (fr)
JP (1) JP2665767B2 (fr)
AR (1) AR243189A1 (fr)
AU (1) AU596857B2 (fr)
CA (1) CA1322371C (fr)
DE (1) DE3781980T2 (fr)
DK (1) DK172666B1 (fr)
ES (1) ES2052524T3 (fr)
FI (1) FI88037C (fr)
GR (1) GR3006254T3 (fr)
HK (1) HK169595A (fr)
HU (1) HU199473B (fr)
IE (1) IE60588B1 (fr)
IL (1) IL83372A (fr)
LU (1) LU88635I2 (fr)
MX (1) MX173359B (fr)
NO (2) NO165543C (fr)
NZ (1) NZ221224A (fr)
PH (1) PH24710A (fr)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1283906C (fr) * 1983-05-09 1991-05-07 Makoto Sunagawa COMPOSE DE .beta.-LACTAM ET PROCEDE DE PRODUCTION
KR880006244A (ko) * 1986-11-24 1988-07-22 후지사와 도모 기찌 로 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법
DE69019610D1 (de) * 1989-07-06 1995-06-29 Banyu Pharma Co Ltd Cyclische Derivate des Amidinylthiocarbapenems.
EP0435320B1 (fr) * 1989-12-29 1994-10-05 Banyu Pharmaceutical Co., Ltd. Dérivés de 2-(2-cyclopropylpyrrolidin-4-ylthio)carbapénème
TW264475B (fr) * 1991-09-20 1995-12-01 Takeda Pharm Industry Co Ltd
JP2696807B2 (ja) * 1992-08-06 1998-01-14 田辺製薬株式会社 カルバペネム誘導体の製法
GB9503717D0 (en) * 1995-02-24 1995-04-12 Smithkline Beecham Plc Novel compounds
FR2735474B1 (fr) * 1995-06-13 1997-08-08 Roussel Uclaf Chlorhydrate de zilpaterol sous une forme cristallisee particuliere, son procede de preparation et les produits intermediaires mis en oeuvre
NZ337532A (en) * 1997-02-07 2001-06-29 Kyoto Pharma Ind Carbapenem derivatives useful as an antibiotic
YU66700A (sh) 1998-05-01 2003-01-31 Kyoto Pharmaceutical Industries Ltd. Derivati karbapenema, njihovo korišćenje i intermedijarna jedinjenja istih
WO2000075143A1 (fr) * 1999-06-03 2000-12-14 Eisai Co., Ltd. Cristaux de derives de carbapenem et preparations pharmaceutiques pour injection
TWI250160B (en) * 1999-07-06 2006-03-01 Sankyo Co Crystalline 1-methylcarbapenem compound
US7041660B2 (en) 1999-07-06 2006-05-09 Sankyo Company, Limited Crystalline 1-methylcarbapenem derivatives
CA2408417C (fr) 2000-05-12 2009-09-15 Novalar Pharmaceuticals, Inc. Methodes et kits d'anesthesie locale
JP5079190B2 (ja) * 2001-04-27 2012-11-21 大日本住友製薬株式会社 アゼチジノン誘導体およびその製造方法
CA2448670A1 (fr) * 2001-05-21 2002-11-28 Kyoto Pharmaceutical Industries, Ltd. Compose de carbapenem
KR100451672B1 (ko) * 2001-06-05 2004-10-08 한미약품 주식회사 결정성 세프디니르 산부가염, 이의 제조방법 및 이를이용한 세프디니르의 제조방법
EP1426376A4 (fr) * 2001-08-13 2004-12-22 Eisai Co Ltd Procede de preparation d'antibiotiques a base de carbapenem
EP1442038A4 (fr) * 2001-09-26 2005-01-05 Merck & Co Inc Formes cristallines d'antibiotiques a base de carbapeneme et procedes de preparation
DK1474426T3 (da) * 2001-09-26 2011-11-21 Merck Sharp & Dohme Fremgangsmåde til fremstilling af carbapenemforbindelser
ITMI20012364A1 (it) * 2001-11-09 2003-05-09 Antibioticos Spa Processo di sintesi della cefixima via alchil-o arilsolfonati
KR20040088519A (ko) 2002-02-22 2004-10-16 뉴 리버 파마슈티칼스, 인크. 활성 제제 전달 시스템 및 활성 제제의 보호 및 투여 방법
US20030236306A1 (en) * 2002-06-20 2003-12-25 Chen Andrew X. Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof
US7229630B2 (en) * 2002-06-20 2007-06-12 Novalar Pharmaceuticals, Inc. Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof
EP1950563A3 (fr) 2002-09-11 2008-08-06 Michio Ishibashi Méthode de criblage une substance pour la promotion-régénération des macrophages
US20070249827A1 (en) * 2004-06-02 2007-10-25 Sandoz Ag Meropenem Intermediatein in Crystalling Form
WO2006035300A2 (fr) * 2004-09-30 2006-04-06 Ranbaxy Laboratories Limited Procede de preparation de meropenem
JP4547245B2 (ja) * 2004-12-16 2010-09-22 株式会社パーマケム・アジア ペリンドプリルエルブミンのｉ型結晶、及びその製造方法
US8501818B2 (en) * 2005-03-14 2013-08-06 Ceptaris Therapeutics, Inc. Stabilized compositions of alkylating agents and methods of using same
US20110039943A1 (en) * 2005-03-14 2011-02-17 Robert Alonso Methods for treating skin disorders with topical nitrogen mustard compositions
US7872050B2 (en) * 2005-03-14 2011-01-18 Yaupon Therapeutics Inc. Stabilized compositions of volatile alkylating agents and methods of using thereof
US20070197781A1 (en) * 2005-07-29 2007-08-23 Neera Tewari Processes for the preparation of carbapenems
PL1926732T3 (pl) 2005-09-05 2014-01-31 Ranbaxy Laboratories Ltd Sposób wytwarzania związków karbapenemu
US8148520B2 (en) 2005-09-15 2012-04-03 Orchid Chemicals And Pharmaceuticals Limited Process for the preparation of beta-lactam antibiotic meropenem trihydrate
CN100497338C (zh) * 2006-01-05 2009-06-10 上海医药工业研究院 4－甲基－7－氧－1－氮杂双环[3.2.0]庚－2－烯－2－羧酸类衍生物的制备方法
KR100781821B1 (ko) * 2006-02-16 2007-12-03 문순구 카르바페넴계 화합물의 제조방법
EP2006290A4 (fr) * 2006-03-28 2011-01-05 Kaneka Corp Procédé amélioré de production d'un composé de carbapenem
TW200815442A (en) * 2006-04-28 2008-04-01 Kaneka Corp Improved method for the crystallization of intermediates of carbapenem antibiotics
JPWO2009075309A1 (ja) * 2007-12-12 2011-04-28 大日本住友製薬株式会社 製剤組成物
US20090216010A1 (en) * 2008-02-22 2009-08-27 Wei-Hong Tseng Crystalline carbapenem compound and produced method thereof
EP2098525A1 (fr) 2008-02-26 2009-09-09 Savior Lifetec Corporation Composé de carbapenem cristallin et son procédé de production
EP3494960B1 (fr) * 2008-03-27 2020-11-25 Helsinn Healthcare SA Compositions stabilisées d'agents d'alkylation et leurs procédés d'utilisation
US8097719B2 (en) * 2008-07-15 2012-01-17 Genesen Labs Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem
DK2326648T3 (da) * 2008-07-30 2012-10-15 Ranbaxy Lab Ltd Fremgangsmåde til fremstillingen af carbapenemforbindelser
WO2010104336A2 (fr) * 2009-03-13 2010-09-16 주식회사 대웅제약 Procédé amélioré pour la préparation de meropenem à l'aide de poudre de zinc
WO2011048583A1 (fr) 2009-10-23 2011-04-28 Ranbaxy Laboratories Limited Procédé pour la préparation de composés de carbapénème
WO2011141847A1 (fr) * 2010-05-10 2011-11-17 Orchid Chemicals And Pharmaceuticals Limited Procédé amélioré pour la préparation de méropénem
WO2012052978A1 (fr) 2010-10-22 2012-04-26 Ranbaxy Laboratories Limited Procédé de préparation de méropénème trihydraté pur
CN101962383A (zh) * 2010-11-12 2011-02-02 上海巴迪生物医药科技有限公司 一种美罗培南的合成方法
WO2012081033A2 (fr) * 2010-12-06 2012-06-21 Sequent Scientific Limited Procédé de préparation d'imipénem
CN102532140B (zh) * 2010-12-21 2015-03-11 北大方正集团有限公司 一种美罗培南三水合物的制备方法
CN102250096B (zh) * 2011-09-05 2016-04-06 江西华邦药业有限公司 一种美罗培南的制备方法
CN103570719B (zh) * 2012-07-31 2016-03-02 深圳市海滨制药有限公司 一种美罗培南原料药、其制备方法及包含其的药物组合物
CN103570718B (zh) * 2012-07-31 2016-06-29 深圳市海滨制药有限公司 一种美罗培南原料药、其制备方法及包含其的药物组合物
CN103570720B (zh) * 2012-07-31 2016-02-10 新乡海滨药业有限公司 一种美罗培南原料药、其制备方法及包含其的药物组合物
KR101331762B1 (ko) 2012-12-28 2013-11-20 주식회사 대웅제약 메로페넴의 삼수화물의 제조방법
CN103044429B (zh) * 2013-01-28 2015-04-01 苏州二叶制药有限公司 一种美罗培南的制备方法
JP6335927B2 (ja) 2013-02-01 2018-05-30 オキュラリス・ファーマ・リミテッド・ライアビリティ・カンパニーＯｃｕｌａｒｉｓ Ｐｈａｒｍａ， Ｌｌｃ フェントラミンの水性点眼液およびそれらの医学的用途
EP2950800B1 (fr) 2013-02-01 2020-09-09 Ocuphire Pharma, Inc. Procédés et compositions pour l'administration ophtalmique quotidienne de phentolamine pour améliorer les performances visuelles
KR102144777B1 (ko) 2013-06-19 2020-08-18 제이더블유중외제약 주식회사 결정형 메로페넴 삼수화물의 제조방법
WO2015145161A1 (fr) * 2014-03-27 2015-10-01 Johnson Matthey Public Limited Company Procédé de préparation d'un antibiotique carbapénème
KR20210096096A (ko) 2018-10-26 2021-08-04 오큐파이어 파마, 인크. 노안, 산동, 및 기타 안구 장애의 치료를 위한 방법 및 조성물
CN115368310A (zh) 2021-05-18 2022-11-22 奥库菲尔医药公司 合成甲磺酸酚妥拉明的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK153486C (da) * 1978-07-03 1988-11-28 Merck & Co Inc Analogifremgangsmaade til fremstilling af krystallinsk n-formimidoyl-thienamycin-monohydrat
EP0113101A1 (fr) * 1982-12-30 1984-07-11 Merck & Co. Inc. Esters d'acides 6-(1-hydroxyéthyl)-2-SR8-1-méthyl-1-carbadéthiapén-2-ème-3-carboxyliques
JPS60104088A (ja) * 1983-11-11 1985-06-08 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物およびその製造法
CA1283906C (fr) * 1983-05-09 1991-05-07 Makoto Sunagawa COMPOSE DE .beta.-LACTAM ET PROCEDE DE PRODUCTION
US4748238A (en) * 1984-03-14 1988-05-31 Merck & Co., Inc. Crystalline 1R,5S,6S,8R-1-methyl-2-(N,N-dimethylcarbamimidoylmethylthio)-6-(1-hydroxyethyl)-1-carbapen-2-em-3-carboxylic acid
US4713451A (en) * 1984-04-09 1987-12-15 Merck & Co., Inc. Crystalline dimethyliminothienamycin
US4761408A (en) * 1984-11-02 1988-08-02 Ciba-Geigy Corporation Crystalline aminomethyl compound
NZ214691A (en) * 1984-12-27 1988-08-30 Sumitomo Pharma The preparation of carbapenem derivatives and beta-lactam intermediates
US4788282A (en) * 1985-06-07 1988-11-29 Bristol-Myers Company Deprotection of allylic esters and ethers

Also Published As

Publication number Publication date
MX7534A (es) 1993-10-01
AU7619687A (en) 1988-03-03
NO165543B (no) 1990-11-19
MX173359B (es) 1994-02-23
JP2665767B2 (ja) 1997-10-22
CA1322371C (fr) 1993-09-21
DK399087A (da) 1988-01-31
EP0256377A1 (fr) 1988-02-24
AU596857B2 (en) 1990-05-17
AR243189A1 (es) 1993-07-30
JPS6434986A (en) 1989-02-06
ES2052524T3 (es) 1994-07-16
NO1997013I1 (no) 1997-10-17
GR3006254T3 (fr) 1993-06-21
FI873299A0 (fi) 1987-07-29
IE60588B1 (en) 1994-07-27
EP0256377B1 (fr) 1992-09-30
IL83372A0 (en) 1987-12-31
PH24710A (en) 1990-10-01
HK169595A (en) 1995-11-10
DE3781980D1 (de) 1992-11-05
DK399087D0 (da) 1987-07-30
US4888344A (en) 1989-12-19
FI88037B (fi) 1992-12-15
NZ221224A (en) 1989-10-27
FI873299A (fi) 1988-01-31
IE871959L (en) 1988-01-30
DK172666B1 (da) 1999-05-10
HUT44553A (en) 1988-03-28
NO873205L (no) 1988-02-01
IL83372A (en) 1992-05-25
FI88037C (fi) 1993-03-25
NO165543C (no) 1991-02-27
DE3781980T2 (de) 1993-02-18
HU199473B (en) 1990-02-28
NO873205D0 (no) 1987-07-30

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