IL83372A - Carbapenem compound in crystalline form and pharmaceutical composition comprising it - Google Patents

Carbapenem compound in crystalline form and pharmaceutical composition comprising it

Info

Publication number
IL83372A
IL83372A IL83372A IL8337287A IL83372A IL 83372 A IL83372 A IL 83372A IL 83372 A IL83372 A IL 83372A IL 8337287 A IL8337287 A IL 8337287A IL 83372 A IL83372 A IL 83372A
Authority
IL
Israel
Prior art keywords
pharmaceutical composition
crystalline form
carbapenem compound
carbapenem
compound
Prior art date
Application number
IL83372A
Other languages
English (en)
Other versions
IL83372A0 (en
Original Assignee
Sumitomo Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharma filed Critical Sumitomo Pharma
Publication of IL83372A0 publication Critical patent/IL83372A0/xx
Publication of IL83372A publication Critical patent/IL83372A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL83372A 1986-07-30 1987-07-29 Carbapenem compound in crystalline form and pharmaceutical composition comprising it IL83372A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP17932186 1986-07-30
JP15776987 1987-06-26

Publications (2)

Publication Number Publication Date
IL83372A0 IL83372A0 (en) 1987-12-31
IL83372A true IL83372A (en) 1992-05-25

Family

ID=26485103

Family Applications (1)

Application Number Title Priority Date Filing Date
IL83372A IL83372A (en) 1986-07-30 1987-07-29 Carbapenem compound in crystalline form and pharmaceutical composition comprising it

Country Status (20)

Country Link
US (1) US4888344A (xx)
EP (1) EP0256377B1 (xx)
JP (1) JP2665767B2 (xx)
AR (1) AR243189A1 (xx)
AU (1) AU596857B2 (xx)
CA (1) CA1322371C (xx)
DE (1) DE3781980T2 (xx)
DK (1) DK172666B1 (xx)
ES (1) ES2052524T3 (xx)
FI (1) FI88037C (xx)
GR (1) GR3006254T3 (xx)
HK (1) HK169595A (xx)
HU (1) HU199473B (xx)
IE (1) IE60588B1 (xx)
IL (1) IL83372A (xx)
LU (1) LU88635I2 (xx)
MX (1) MX173359B (xx)
NO (2) NO165543C (xx)
NZ (1) NZ221224A (xx)
PH (1) PH24710A (xx)

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EP0406863B1 (en) * 1989-07-06 1995-05-24 Banyu Pharmaceutical Co., Ltd. Cyclic amidinylthiocarbapenem derivatives
DE69013131T2 (de) * 1989-12-29 1995-05-24 Banyu Pharma Co Ltd 2-(2-Cyclopropylpyrrolidin-4-ylthio)carbapenemderivate.
TW264475B (xx) * 1991-09-20 1995-12-01 Takeda Pharm Industry Co Ltd
JP2696807B2 (ja) * 1992-08-06 1998-01-14 田辺製薬株式会社 カルバペネム誘導体の製法
GB9503717D0 (en) * 1995-02-24 1995-04-12 Smithkline Beecham Plc Novel compounds
FR2735474B1 (fr) * 1995-06-13 1997-08-08 Roussel Uclaf Chlorhydrate de zilpaterol sous une forme cristallisee particuliere, son procede de preparation et les produits intermediaires mis en oeuvre
TR199901887T2 (xx) * 1997-02-07 1999-12-21 Kyoto Pharmaceutical Industries, Ltd. Karbapenem bile�i�i, bu bile�i�in kullan�m� ve bu bile�ik i�in ara bile�ik.
SK16382000A3 (sk) 1998-05-01 2001-05-10 Kyoto Pharmaceutical Industries, Ltd. Karbapénové deriváty, ich vyžitie a ich medziproduktové zlúčeniny
JP4130078B2 (ja) * 1999-06-03 2008-08-06 エーザイ・アール・アンド・ディー・マネジメント株式会社 カルバペネム誘導体結晶と注射製剤
US7041660B2 (en) 1999-07-06 2006-05-09 Sankyo Company, Limited Crystalline 1-methylcarbapenem derivatives
TWI250160B (en) * 1999-07-06 2006-03-01 Sankyo Co Crystalline 1-methylcarbapenem compound
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JP5079190B2 (ja) * 2001-04-27 2012-11-21 大日本住友製薬株式会社 アゼチジノン誘導体およびその製造方法
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US20030236306A1 (en) * 2002-06-20 2003-12-25 Chen Andrew X. Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof
US7229630B2 (en) * 2002-06-20 2007-06-12 Novalar Pharmaceuticals, Inc. Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof
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WO2006035300A2 (en) * 2004-09-30 2006-04-06 Ranbaxy Laboratories Limited A process for the preparation of meropenem
JP4547245B2 (ja) * 2004-12-16 2010-09-22 株式会社パーマケム・アジア ペリンドプリルエルブミンのｉ型結晶、及びその製造方法
US20110039943A1 (en) * 2005-03-14 2011-02-17 Robert Alonso Methods for treating skin disorders with topical nitrogen mustard compositions
US7872050B2 (en) * 2005-03-14 2011-01-18 Yaupon Therapeutics Inc. Stabilized compositions of volatile alkylating agents and methods of using thereof
US8501818B2 (en) * 2005-03-14 2013-08-06 Ceptaris Therapeutics, Inc. Stabilized compositions of alkylating agents and methods of using same
US20070197781A1 (en) * 2005-07-29 2007-08-23 Neera Tewari Processes for the preparation of carbapenems
EP1926732B1 (en) 2005-09-05 2013-11-06 Ranbaxy Laboratories Limited A process for the preparation of carbapenem compounds
WO2007031858A2 (en) * 2005-09-15 2007-03-22 Orchid Chemicals And Pharmaceuticals Limited An improved process for the preparation of beta-lactam antibiotic
CN100497338C (zh) * 2006-01-05 2009-06-10 上海医药工业研究院 4－甲基－7－氧－1－氮杂双环[3.2.0]庚－2－烯－2－羧酸类衍生物的制备方法
KR100781821B1 (ko) * 2006-02-16 2007-12-03 문순구 카르바페넴계 화합물의 제조방법
WO2007111328A1 (ja) * 2006-03-28 2007-10-04 Kaneka Corporation カルバペネム化合物の改良された製造方法
KR20090007572A (ko) * 2006-04-28 2009-01-19 카네카 코포레이션 카르바페넴 항생 물질 중간체의 개량된 정석 방법
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US20090216010A1 (en) * 2008-02-22 2009-08-27 Wei-Hong Tseng Crystalline carbapenem compound and produced method thereof
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CN102036557A (zh) * 2008-03-27 2011-04-27 耀鹏医疗有限公司 烷基化剂的稳定组合物及其使用方法
US8097719B2 (en) * 2008-07-15 2012-01-17 Genesen Labs Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem
AU2009277936B2 (en) * 2008-07-30 2014-11-27 Sun Pharmaceutical Industries Limited Process for the preparation of carbapenem compounds
RU2490270C2 (ru) 2009-03-13 2013-08-20 Даевунг Фармасьютикал Ко., Лтд. Улучшенный способ получения меропенема с применением цинкового порошка
WO2011048583A1 (en) 2009-10-23 2011-04-28 Ranbaxy Laboratories Limited Process for the preparation of carbapenem compounds
WO2011141847A1 (en) * 2010-05-10 2011-11-17 Orchid Chemicals And Pharmaceuticals Limited An improved process for the preparation of meropenem
AU2011319478A1 (en) 2010-10-22 2013-05-23 Sun Pharmaceutical Industries Limited A process for the preparation of pure meropenem trihydrate
CN101962383A (zh) * 2010-11-12 2011-02-02 上海巴迪生物医药科技有限公司 一种美罗培南的合成方法
WO2012081033A2 (en) * 2010-12-06 2012-06-21 Sequent Scientific Limited A process for preparation of imipenem
CN102532140B (zh) * 2010-12-21 2015-03-11 北大方正集团有限公司 一种美罗培南三水合物的制备方法
CN102250096B (zh) * 2011-09-05 2016-04-06 江西华邦药业有限公司 一种美罗培南的制备方法
CN103570718B (zh) * 2012-07-31 2016-06-29 深圳市海滨制药有限公司 一种美罗培南原料药、其制备方法及包含其的药物组合物
CN103570720B (zh) * 2012-07-31 2016-02-10 新乡海滨药业有限公司 一种美罗培南原料药、其制备方法及包含其的药物组合物
CN103570719B (zh) * 2012-07-31 2016-03-02 深圳市海滨制药有限公司 一种美罗培南原料药、其制备方法及包含其的药物组合物
KR101331762B1 (ko) 2012-12-28 2013-11-20 주식회사 대웅제약 메로페넴의 삼수화물의 제조방법
CN103044429B (zh) * 2013-01-28 2015-04-01 苏州二叶制药有限公司 一种美罗培南的制备方法
AU2014212275B2 (en) 2013-02-01 2018-09-06 Ocuphire Pharma, Inc. Methods and compositions for daily ophthalmic administration of phentolamine to improve visual performance
CA2899339C (en) 2013-02-01 2021-07-06 Ocularis Pharma, Llc Aqueous ophthalmic solutions of phentolamine and medical uses thereof
KR102144777B1 (ko) 2013-06-19 2020-08-18 제이더블유중외제약 주식회사 결정형 메로페넴 삼수화물의 제조방법
CN110922405A (zh) * 2014-03-27 2020-03-27 庄信万丰股份有限公司 制备碳青霉烯抗生素的方法
CN113164452A (zh) 2018-10-26 2021-07-23 奥库菲尔制药股份有限公司 治疗老花眼、散瞳和其他眼部疾病的方法和组合物
CN115368310A (zh) 2021-05-18 2022-11-22 奥库菲尔医药公司 合成甲磺酸酚妥拉明的方法

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Also Published As

Publication number Publication date
ES2052524T3 (es) 1994-07-16
IE871959L (en) 1988-01-30
NZ221224A (en) 1989-10-27
IL83372A0 (en) 1987-12-31
DK399087D0 (da) 1987-07-30
HU199473B (en) 1990-02-28
DK172666B1 (da) 1999-05-10
NO873205D0 (no) 1987-07-30
GR3006254T3 (xx) 1993-06-21
AU596857B2 (en) 1990-05-17
DK399087A (da) 1988-01-31
EP0256377A1 (en) 1988-02-24
HUT44553A (en) 1988-03-28
AU7619687A (en) 1988-03-03
MX173359B (es) 1994-02-23
DE3781980D1 (de) 1992-11-05
PH24710A (en) 1990-10-01
US4888344A (en) 1989-12-19
NO165543C (no) 1991-02-27
LU88635I2 (fr) 1995-12-01
JP2665767B2 (ja) 1997-10-22
AR243189A1 (es) 1993-07-30
FI873299A0 (fi) 1987-07-29
HK169595A (en) 1995-11-10
CA1322371C (en) 1993-09-21
IE60588B1 (en) 1994-07-27
NO1997013I1 (no) 1997-10-17
FI88037C (fi) 1993-03-25
NO165543B (no) 1990-11-19
FI873299A (fi) 1988-01-31
JPS6434986A (en) 1989-02-06
EP0256377B1 (en) 1992-09-30
MX7534A (es) 1993-10-01
FI88037B (fi) 1992-12-15
DE3781980T2 (de) 1993-02-18
NO873205L (no) 1988-02-01

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