DK399087D0 - Carbapenemderivater - Google Patents

Carbapenemderivater

Info

Publication number
DK399087D0
DK399087D0 DK399087A DK399087A DK399087D0 DK 399087 D0 DK399087 D0 DK 399087D0 DK 399087 A DK399087 A DK 399087A DK 399087 A DK399087 A DK 399087A DK 399087 D0 DK399087 D0 DK 399087D0
Authority
DK
Denmark
Prior art keywords
carbapenem derivatives
carbapenem
derivatives
Prior art date
Application number
DK399087A
Other languages
English (en)
Other versions
DK399087A (da
DK172666B1 (da
Inventor
Makoto Sunagawa
Yutaka Isobe
Yutaka Takeuchi
Haruki Matsumura
Tetsuo Noguchi
Yukio Ozaki
Original Assignee
Sumitomo Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharma filed Critical Sumitomo Pharma
Publication of DK399087D0 publication Critical patent/DK399087D0/da
Publication of DK399087A publication Critical patent/DK399087A/da
Application granted granted Critical
Publication of DK172666B1 publication Critical patent/DK172666B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK198703990A 1986-07-30 1987-07-30 Krystallinsk trihydrat af (4R,5S,6S,8R,2'S,4'S)-3-[4-[2-dimethylaminocarbonyl)pyrrolidinylthio]-4-methyl-6-(1-hydroxyethyl) DK172666B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP17932186 1986-07-30
JP17932186 1986-07-30
JP15776987 1987-06-26
JP15776987 1987-06-26

Publications (3)

Publication Number Publication Date
DK399087D0 true DK399087D0 (da) 1987-07-30
DK399087A DK399087A (da) 1988-01-31
DK172666B1 DK172666B1 (da) 1999-05-10

Family

ID=26485103

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198703990A DK172666B1 (da) 1986-07-30 1987-07-30 Krystallinsk trihydrat af (4R,5S,6S,8R,2'S,4'S)-3-[4-[2-dimethylaminocarbonyl)pyrrolidinylthio]-4-methyl-6-(1-hydroxyethyl)

Country Status (20)

Country Link
US (1) US4888344A (da)
EP (1) EP0256377B1 (da)
JP (1) JP2665767B2 (da)
AR (1) AR243189A1 (da)
AU (1) AU596857B2 (da)
CA (1) CA1322371C (da)
DE (1) DE3781980T2 (da)
DK (1) DK172666B1 (da)
ES (1) ES2052524T3 (da)
FI (1) FI88037C (da)
GR (1) GR3006254T3 (da)
HK (1) HK169595A (da)
HU (1) HU199473B (da)
IE (1) IE60588B1 (da)
IL (1) IL83372A (da)
LU (1) LU88635I2 (da)
MX (1) MX173359B (da)
NO (2) NO165543C (da)
NZ (1) NZ221224A (da)
PH (1) PH24710A (da)

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KR880006244A (ko) * 1986-11-24 1988-07-22 후지사와 도모 기찌 로 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법
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JP2696807B2 (ja) * 1992-08-06 1998-01-14 田辺製薬株式会社 カルバペネム誘導体の製法
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FR2735474B1 (fr) * 1995-06-13 1997-08-08 Roussel Uclaf Chlorhydrate de zilpaterol sous une forme cristallisee particuliere, son procede de preparation et les produits intermediaires mis en oeuvre
CN1107067C (zh) * 1997-02-07 2003-04-30 京都药品工业株式会社 碳代青霉烯化合物、其用途及其中间体化合物
CA2330641A1 (en) 1998-05-01 1999-11-11 Kyoto Pharmaceutical Industries, Ltd. Carbapenem derivatives, utilization thereof and intermediate compounds of the same
DE60009695T2 (de) * 1999-06-03 2004-09-23 Eisai Co., Ltd. Kristalline cabapenemderivate und pharmazeutische zubereitungen zur injektion
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US7041660B2 (en) 1999-07-06 2006-05-09 Sankyo Company, Limited Crystalline 1-methylcarbapenem derivatives
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KR100451672B1 (ko) * 2001-06-05 2004-10-08 한미약품 주식회사 결정성 세프디니르 산부가염, 이의 제조방법 및 이를이용한 세프디니르의 제조방법
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IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
US20030236306A1 (en) * 2002-06-20 2003-12-25 Chen Andrew X. Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof
US7229630B2 (en) * 2002-06-20 2007-06-12 Novalar Pharmaceuticals, Inc. Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof
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WO2006035300A2 (en) * 2004-09-30 2006-04-06 Ranbaxy Laboratories Limited A process for the preparation of meropenem
JP4547245B2 (ja) * 2004-12-16 2010-09-22 株式会社パーマケム・アジア ペリンドプリルエルブミンのｉ型結晶、及びその製造方法
US7872050B2 (en) * 2005-03-14 2011-01-18 Yaupon Therapeutics Inc. Stabilized compositions of volatile alkylating agents and methods of using thereof
US8501818B2 (en) * 2005-03-14 2013-08-06 Ceptaris Therapeutics, Inc. Stabilized compositions of alkylating agents and methods of using same
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US20070197781A1 (en) * 2005-07-29 2007-08-23 Neera Tewari Processes for the preparation of carbapenems
PL1926732T3 (pl) 2005-09-05 2014-01-31 Ranbaxy Laboratories Ltd Sposób wytwarzania związków karbapenemu
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CN100497338C (zh) * 2006-01-05 2009-06-10 上海医药工业研究院 4－甲基－7－氧－1－氮杂双环[3.2.0]庚－2－烯－2－羧酸类衍生物的制备方法
KR100781821B1 (ko) * 2006-02-16 2007-12-03 문순구 카르바페넴계 화합물의 제조방법
CN101410398B (zh) * 2006-03-28 2013-01-23 株式会社钟化 碳青霉素烯化合物的改良制备方法
US8093378B2 (en) * 2006-04-28 2012-01-10 Kaneka Corporation Crystallization method for intermediates of carbapenem antibiotics
WO2009075309A1 (ja) * 2007-12-12 2009-06-18 Dainippon Sumitomo Pharma Co., Ltd. 製剤組成物
US20090216010A1 (en) * 2008-02-22 2009-08-27 Wei-Hong Tseng Crystalline carbapenem compound and produced method thereof
EP2098525A1 (en) 2008-02-26 2009-09-09 Savior Lifetec Corporation Crystalline carbapenem compound and produced method thereof
SI3494960T1 (sl) * 2008-03-27 2021-04-30 Helsinn Healthcare Sa Stabilizirani sestavki alkilirajočih sredstev in metode uporabe le-teh
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CA2732619A1 (en) * 2008-07-30 2010-02-04 Ranbaxy Laboratories Limited Process for the preparation of carbapenem compounds
MX2011009532A (es) 2009-03-13 2011-10-24 Daewoong Bio Inc Metodo mejorado para preparar meropenem usando polvo de zinc.
WO2011048583A1 (en) 2009-10-23 2011-04-28 Ranbaxy Laboratories Limited Process for the preparation of carbapenem compounds
WO2011141847A1 (en) * 2010-05-10 2011-11-17 Orchid Chemicals And Pharmaceuticals Limited An improved process for the preparation of meropenem
CA2815167A1 (en) 2010-10-22 2012-04-26 Ranbaxy Laboratories Limited A process for the preparation of pure meropenem trihydrate
CN101962383A (zh) * 2010-11-12 2011-02-02 上海巴迪生物医药科技有限公司 一种美罗培南的合成方法
WO2012081033A2 (en) * 2010-12-06 2012-06-21 Sequent Scientific Limited A process for preparation of imipenem
CN102532140B (zh) * 2010-12-21 2015-03-11 北大方正集团有限公司 一种美罗培南三水合物的制备方法
CN102250096B (zh) * 2011-09-05 2016-04-06 江西华邦药业有限公司 一种美罗培南的制备方法
CN103570719B (zh) * 2012-07-31 2016-03-02 深圳市海滨制药有限公司 一种美罗培南原料药、其制备方法及包含其的药物组合物
CN103570718B (zh) * 2012-07-31 2016-06-29 深圳市海滨制药有限公司 一种美罗培南原料药、其制备方法及包含其的药物组合物
CN103570720B (zh) * 2012-07-31 2016-02-10 新乡海滨药业有限公司 一种美罗培南原料药、其制备方法及包含其的药物组合物
KR101331762B1 (ko) 2012-12-28 2013-11-20 주식회사 대웅제약 메로페넴의 삼수화물의 제조방법
CN103044429B (zh) * 2013-01-28 2015-04-01 苏州二叶制药有限公司 一种美罗培南的制备方法
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WO2014121028A1 (en) 2013-02-01 2014-08-07 Ocularis Pharma, Llc Methods and compositions for daily ophthalmic administration of phentolamine to improve visual performance
KR102144777B1 (ko) 2013-06-19 2020-08-18 제이더블유중외제약 주식회사 결정형 메로페넴 삼수화물의 제조방법
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Also Published As

Publication number Publication date
FI88037C (fi) 1993-03-25
IL83372A0 (en) 1987-12-31
NO165543C (no) 1991-02-27
HU199473B (en) 1990-02-28
MX7534A (es) 1993-10-01
NO873205D0 (no) 1987-07-30
NO165543B (no) 1990-11-19
LU88635I2 (fr) 1995-12-01
IE871959L (en) 1988-01-30
HUT44553A (en) 1988-03-28
AU596857B2 (en) 1990-05-17
CA1322371C (en) 1993-09-21
DK399087A (da) 1988-01-31
FI873299A0 (fi) 1987-07-29
AR243189A1 (es) 1993-07-30
NO873205L (no) 1988-02-01
IL83372A (en) 1992-05-25
EP0256377A1 (en) 1988-02-24
JPS6434986A (en) 1989-02-06
PH24710A (en) 1990-10-01
AU7619687A (en) 1988-03-03
HK169595A (en) 1995-11-10
IE60588B1 (en) 1994-07-27
DE3781980D1 (de) 1992-11-05
FI873299A (fi) 1988-01-31
DE3781980T2 (de) 1993-02-18
JP2665767B2 (ja) 1997-10-22
FI88037B (fi) 1992-12-15
GR3006254T3 (da) 1993-06-21
MX173359B (es) 1994-02-23
DK172666B1 (da) 1999-05-10
NZ221224A (en) 1989-10-27
US4888344A (en) 1989-12-19
ES2052524T3 (es) 1994-07-16
EP0256377B1 (en) 1992-09-30
NO1997013I1 (no) 1997-10-17

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired