JPS6479180A - Carbapenem compound in crystal form, production thereof and composition containing said compound for injection - Google Patents

Carbapenem compound in crystal form, production thereof and composition containing said compound for injection

Info

Publication number
JPS6479180A
JPS6479180A JP62188857A JP18885787A JPS6479180A JP S6479180 A JPS6479180 A JP S6479180A JP 62188857 A JP62188857 A JP 62188857A JP 18885787 A JP18885787 A JP 18885787A JP S6479180 A JPS6479180 A JP S6479180A
Authority
JP
Japan
Prior art keywords
compound
injection
crystal form
production
composition containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP62188857A
Other languages
Japanese (ja)
Other versions
JP2522671B2 (en
Inventor
Jun Sunakawa
Yutaka Takeuchi
Haruki Matsumura
Minoru Isobe
Tetsuo Noguchi
Yukio Ozaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharmaceuticals Co Ltd
Original Assignee
Sumitomo Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharmaceuticals Co Ltd filed Critical Sumitomo Pharmaceuticals Co Ltd
Priority to JP62188857A priority Critical patent/JP2522671B2/en
Publication of JPS6479180A publication Critical patent/JPS6479180A/en
Application granted granted Critical
Publication of JP2522671B2 publication Critical patent/JP2522671B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Abstract

NEW MATERIAL:A (4R,5S,6S,8R,2'S,4'S)-3-[4-(2-Dimethylaminocarbonyl)pyrroli-dinylthio] -4-methyl-6-(1-hydroxyethyl)-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carbox ylic acid in a crystal form expressed by the formula. USE:An antimicrocbial agent for injection. PREPARATION:(4R,5S,6S,8R,2'S,4'S)-3-[4-(2-Dimethylaminocarbonyl)pyrrol idinyl thio]-4-methyl-6-(1-hydroxyethyl)-1-azabicyclo[3.2.-0]hept-2-en-7-one- 2-carboxylic acid in a noncrystal form is dissolved in water or a hydrous organic solvent and cooled or an organic solvent compatible with water is added to dilute the above-mentioned solution. Alternatively, both the cooling and diluting are combined to crystalline the afore-mentioned compound.
JP62188857A 1986-07-30 1987-07-30 Crystalline carbapenem compound, method for producing the same and injectable antibacterial agent containing the compound Expired - Lifetime JP2522671B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62188857A JP2522671B2 (en) 1986-07-30 1987-07-30 Crystalline carbapenem compound, method for producing the same and injectable antibacterial agent containing the compound

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP17932186 1986-07-30
JP61-179321 1986-07-30
JP15776987 1987-06-26
JP62-157769 1987-06-26
JP62188857A JP2522671B2 (en) 1986-07-30 1987-07-30 Crystalline carbapenem compound, method for producing the same and injectable antibacterial agent containing the compound

Publications (2)

Publication Number Publication Date
JPS6479180A true JPS6479180A (en) 1989-03-24
JP2522671B2 JP2522671B2 (en) 1996-08-07

Family

ID=27321227

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62188857A Expired - Lifetime JP2522671B2 (en) 1986-07-30 1987-07-30 Crystalline carbapenem compound, method for producing the same and injectable antibacterial agent containing the compound

Country Status (1)

Country Link
JP (1) JP2522671B2 (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995029913A1 (en) * 1994-05-02 1995-11-09 Shionogi & Co., Ltd. Crystal of pyrrolidylthiocarbapenem derivative, lyophilized preparation containing said crystal, and process for producing the same
JP2002326985A (en) * 2001-04-27 2002-11-15 Sumitomo Pharmaceut Co Ltd Azetidinone derivative and method for producing the same
JP2006169169A (en) * 2004-12-16 2006-06-29 Permachem Asia Ltd Type i crystal of perindopril erbumine and method for producing the same
WO2007111328A1 (en) * 2006-03-28 2007-10-04 Kaneka Corporation Improved process for producing carbapenem compound
WO2007125788A1 (en) * 2006-04-28 2007-11-08 Kaneka Corporation Improved method for the crystallization of intermediates of carbapenem antibiotics
WO2007142212A1 (en) * 2006-06-08 2007-12-13 Dainippon Sumitomo Pharma Co., Ltd. Preparation composition
JP2008501657A (en) * 2004-06-02 2008-01-24 サンド・アクチエンゲゼルシヤフト Crystalline meropenem intermediate
JP2009508840A (en) * 2005-09-15 2009-03-05 オーキッド ケミカルズ アンド ファーマシューティカルズ リミテッド Improved process for preparing β-lactam antibiotics
WO2010087159A1 (en) * 2009-01-28 2010-08-05 株式会社カネカ Method of producing organic compound having carboxyl group, hydroxy group, and carboxylic acid derivative in same molecule
US7932381B2 (en) 2005-02-15 2011-04-26 Shionogi & Co., Ltd. Process for producing carbapenem derivative and intermediate crystal therefor
JP2012153686A (en) * 2011-01-24 2012-08-16 Savior Lifetec Corp Method for preparing antibiotic compound

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60104088A (en) * 1983-11-11 1985-06-08 Sumitomo Chem Co Ltd Novel beta-lactam compound and its preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60104088A (en) * 1983-11-11 1985-06-08 Sumitomo Chem Co Ltd Novel beta-lactam compound and its preparation

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100314558B1 (en) * 1994-05-02 2002-02-28 시오노 호히코 Crystals of pyrrolidylthiocarbapenem derivatives, and freeze-drying preparations containing the crystals and preparation methods thereof
WO1995029913A1 (en) * 1994-05-02 1995-11-09 Shionogi & Co., Ltd. Crystal of pyrrolidylthiocarbapenem derivative, lyophilized preparation containing said crystal, and process for producing the same
JP2002326985A (en) * 2001-04-27 2002-11-15 Sumitomo Pharmaceut Co Ltd Azetidinone derivative and method for producing the same
JP2008501657A (en) * 2004-06-02 2008-01-24 サンド・アクチエンゲゼルシヤフト Crystalline meropenem intermediate
JP2006169169A (en) * 2004-12-16 2006-06-29 Permachem Asia Ltd Type i crystal of perindopril erbumine and method for producing the same
US7932381B2 (en) 2005-02-15 2011-04-26 Shionogi & Co., Ltd. Process for producing carbapenem derivative and intermediate crystal therefor
JP2009508840A (en) * 2005-09-15 2009-03-05 オーキッド ケミカルズ アンド ファーマシューティカルズ リミテッド Improved process for preparing β-lactam antibiotics
JP5373390B2 (en) * 2006-03-28 2013-12-18 株式会社カネカ Improved process for the preparation of carbapenem compounds
WO2007111328A1 (en) * 2006-03-28 2007-10-04 Kaneka Corporation Improved process for producing carbapenem compound
WO2007125788A1 (en) * 2006-04-28 2007-11-08 Kaneka Corporation Improved method for the crystallization of intermediates of carbapenem antibiotics
JP5671204B2 (en) * 2006-04-28 2015-02-18 株式会社カネカ Improved crystallization method for carbapenem antibiotic intermediates
US8093378B2 (en) 2006-04-28 2012-01-10 Kaneka Corporation Crystallization method for intermediates of carbapenem antibiotics
WO2007142212A1 (en) * 2006-06-08 2007-12-13 Dainippon Sumitomo Pharma Co., Ltd. Preparation composition
WO2010087159A1 (en) * 2009-01-28 2010-08-05 株式会社カネカ Method of producing organic compound having carboxyl group, hydroxy group, and carboxylic acid derivative in same molecule
JP2012153686A (en) * 2011-01-24 2012-08-16 Savior Lifetec Corp Method for preparing antibiotic compound

Also Published As

Publication number Publication date
JP2522671B2 (en) 1996-08-07

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