JPS6426580A - Production of carbapenem derivative - Google Patents

Production of carbapenem derivative

Info

Publication number
JPS6426580A
JPS6426580A JP62181580A JP18158087A JPS6426580A JP S6426580 A JPS6426580 A JP S6426580A JP 62181580 A JP62181580 A JP 62181580A JP 18158087 A JP18158087 A JP 18158087A JP S6426580 A JPS6426580 A JP S6426580A
Authority
JP
Japan
Prior art keywords
compound
expressed
formula
carbamoyl
protecting group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62181580A
Other languages
Japanese (ja)
Inventor
Masao Sugimura
Kimio Iino
Teruo Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP62181580A priority Critical patent/JPS6426580A/en
Publication of JPS6426580A publication Critical patent/JPS6426580A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PURPOSE:To obtain the titled compound exhibiting excellent antibacterial activity and having a carbamoyl substituted pyrrolidinylthio group at 2-position, reacting a 2-phenylthio-, 2-phenylsulfinylcarbapenem derivative with a thiol compound. CONSTITUTION:A compound [e.g. ( 5R, 6S )-6-[(R)-1-hydroxyethyl]-2-(p-nitrophe nylthio)-2-carbapenem-3-carboxylic acid p-nitrobenzyl ester] expressed by formula I [R<1> is (substituted)phenyl; R<2> is protecting group of carboxyl; m is 0-2] is reacted with a thiol compound [e.g. (2S,4S)-2-carbamoyl-1-(N-p- nitrobenzyloxycarbonyl) acetoimidoyl-4-mercaptopyridine] expressed by formula II (R<4> and R<5> are H, alkyl or alkoxy; R<6> is H, amino protecting group, etc.) to provide the compound (e.g. compound expressed by formula IV) expressed by formula III.
JP62181580A 1987-07-21 1987-07-21 Production of carbapenem derivative Pending JPS6426580A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62181580A JPS6426580A (en) 1987-07-21 1987-07-21 Production of carbapenem derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62181580A JPS6426580A (en) 1987-07-21 1987-07-21 Production of carbapenem derivative

Publications (1)

Publication Number Publication Date
JPS6426580A true JPS6426580A (en) 1989-01-27

Family

ID=16103292

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62181580A Pending JPS6426580A (en) 1987-07-21 1987-07-21 Production of carbapenem derivative

Country Status (1)

Country Link
JP (1) JPS6426580A (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58157788A (en) * 1982-03-16 1983-09-19 Sankyo Co Ltd Preparation of beta-lactam compound
JPS6019787A (en) * 1983-07-12 1985-01-31 Sumitomo Chem Co Ltd Novel beta-lactam compound and its preparation
JPS61275279A (en) * 1984-12-25 1986-12-05 Sankyo Co Ltd Carbapenem compound

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58157788A (en) * 1982-03-16 1983-09-19 Sankyo Co Ltd Preparation of beta-lactam compound
JPS6019787A (en) * 1983-07-12 1985-01-31 Sumitomo Chem Co Ltd Novel beta-lactam compound and its preparation
JPS61275279A (en) * 1984-12-25 1986-12-05 Sankyo Co Ltd Carbapenem compound

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