EE9700200A - Bis-aminohappe hüdroksüetüülamino-sulfoonamiidsed retroviirusliku proteaasi inhibiitorid - Google Patents

Bis-aminohappe hüdroksüetüülamino-sulfoonamiidsed retroviirusliku proteaasi inhibiitorid

Info

Publication number
EE9700200A
EE9700200A EE9700200A EE9700200A EE9700200A EE 9700200 A EE9700200 A EE 9700200A EE 9700200 A EE9700200 A EE 9700200A EE 9700200 A EE9700200 A EE 9700200A EE 9700200 A EE9700200 A EE 9700200A
Authority
EE
Estonia
Prior art keywords
retroviral
amino acid
protease inhibitors
bis
retroviral protease
Prior art date
Application number
EE9700200A
Other languages
English (en)
Other versions
EE04376B1 (et
Inventor
A. Decrescenzo Gary
N. Freskos John
L. Vazquez Michael
A. Sikorski James
L. Brown David
J. Mcdonald Joseph
P. Getman Daniel
Devadas Balekudru
R. Nagarajan Srinivasan
Original Assignee
G.D. Searle & Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by G.D. Searle & Co. filed Critical G.D. Searle & Co.
Publication of EE9700200A publication Critical patent/EE9700200A/et
Publication of EE04376B1 publication Critical patent/EE04376B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
EE9700200A 1995-03-10 1996-03-07 Bis-aminohappe hüdroksüetüülamino-sulfoonamiidsedretroviirusliku proteaasi inhibiitorid EE04376B1 (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40245095A 1995-03-10 1995-03-10
US08/479,071 US6150556A (en) 1995-03-10 1995-06-07 Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
PCT/US1996/002685 WO1996028464A1 (en) 1995-03-10 1996-03-07 Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Publications (2)

Publication Number Publication Date
EE9700200A true EE9700200A (et) 1998-02-16
EE04376B1 EE04376B1 (et) 2004-10-15

Family

ID=27017890

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9700200A EE04376B1 (et) 1995-03-10 1996-03-07 Bis-aminohappe hüdroksüetüülamino-sulfoonamiidsedretroviirusliku proteaasi inhibiitorid

Country Status (23)

Country Link
US (2) US6150556A (et)
EP (2) EP1076062A1 (et)
JP (1) JPH11501921A (et)
KR (1) KR100428499B1 (et)
CN (1) CN1178954C (et)
AT (1) ATE304550T1 (et)
AU (1) AU704360B2 (et)
BR (1) BR9607543A (et)
CA (1) CA2215025A1 (et)
CZ (1) CZ294966B6 (et)
DE (1) DE69635183T2 (et)
DK (1) DK0813543T3 (et)
EA (1) EA000578B1 (et)
EE (1) EE04376B1 (et)
ES (1) ES2249779T3 (et)
HU (1) HUP9802647A3 (et)
MX (1) MX9706913A (et)
NO (3) NO325230B1 (et)
NZ (1) NZ305544A (et)
PL (2) PL185543B1 (et)
SK (2) SK285930B6 (et)
UA (1) UA55384C2 (et)
WO (1) WO1996028464A1 (et)

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US20040122000A1 (en) 1981-01-07 2004-06-24 Vertex Pharmaceuticals Incorporated. Inhibitors of aspartyl protease
US7339078B2 (en) * 1995-03-10 2008-03-04 G.D. Searle Llc Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6861539B1 (en) 1995-03-10 2005-03-01 G. D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
EP1188766A1 (en) * 1995-03-10 2002-03-20 G.D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
WO2000002862A1 (en) 1998-07-08 2000-01-20 G.D. Searle & Co. Retroviral protease inhibitors
HUP0105235A3 (en) * 1999-01-13 2002-08-28 Pont Pharmaceuticals Company W Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors, pharmaceutical compositions comprising thereof and their use
AR031520A1 (es) * 1999-06-11 2003-09-24 Vertex Pharma Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
US6391919B1 (en) 2000-01-12 2002-05-21 Bristol-Myers Squibb Pharma Company Bis-amino acid sulfonamides containing substituted benzyl amines HIV protease inhibitors
US20020022742A1 (en) * 2000-07-19 2002-02-21 Harris Gregory D. Salt forms of an HIV protease inhibitor
US6617310B2 (en) * 2000-07-19 2003-09-09 Bristol-Myers Squibb Pharma Company Phosphate esters of bis-amino acid sulfonamides containing substituted benzyl amines
US20020022659A1 (en) * 2000-07-19 2002-02-21 Harris Gregory D. Crystalline and salt forms of an HIV protease inhibitor
ES2275866T3 (es) 2001-02-14 2007-06-16 Tibotec Pharmaceuticals Ltd. 2-(aminosustituido)-benzotiazol-sulfonamidas de amplio esprecto inhibidoras de la proteasa de vih.
AP1544A (en) * 2001-04-09 2006-01-12 Tibotec Pharm Ltd Broadspectrum 2- (substituted-amino) -benzoxazole sulfonamide HIV protease inhibitors.
EA009590B1 (ru) * 2001-05-11 2008-02-28 Тиботек Фармасьютикалз Лтд. 2-аминобензоксазолсульфонамидные ингибиторы вич-протеазы широкого спектра
US6562848B1 (en) 2001-09-18 2003-05-13 Bristol-Myers Squibb Company Bis-amino acid sulfonamides as HIV protease inhibitors
JP4578101B2 (ja) 2001-12-21 2010-11-10 テイボテク・フアーマシユーチカルズ・リミテツド 幅広いスペクトルのｈｉｖプロテアーゼ阻害剤である複素環置換フェニル含有スルホンアミド
MY142238A (en) 2002-03-12 2010-11-15 Tibotec Pharm Ltd Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
ATE371652T1 (de) * 2002-05-17 2007-09-15 Tibotec Pharm Ltd Substituierte benzisoxazolsulfonamide mit breitbändiger hiv-protease hemmender wirkung
JP4681296B2 (ja) 2002-08-14 2011-05-11 テイボテク・フアーマシユーチカルズ・リミテツド スペクトルの広い置換オキシインドールスルホンアミドｈｉｖプロテアーゼ阻害剤
US20060128634A1 (en) * 2002-11-14 2006-06-15 Carini David J Alpha, alpha-disubstituted benzylglycine derivatives as HIV protease inhibitors
US6943170B2 (en) * 2002-11-14 2005-09-13 Bristol-Myers Squibb Company N-cycloalkylglycines as HIV protease inhibitors
EP1651192A1 (en) * 2003-08-06 2006-05-03 Nirmal Mulye Pharmaceutical composition containing water soluble drug
US8193227B2 (en) 2003-12-11 2012-06-05 Abbott Laboratories HIV protease inhibiting compounds
US20050131042A1 (en) * 2003-12-11 2005-06-16 Flentge Charles A. HIV protease inhibiting compounds
DK1725566T3 (da) 2003-12-23 2009-10-05 Tibotec Pharm Ltd Fremgangsmåde til fremstilling af (3R,3AS, 6AR)-hexahydrofuro [2,3.B] furan-3-yl (1S,2R)-3-3[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamat
US7772411B2 (en) 2003-12-23 2010-08-10 Tibotec Pharmaceuticals Ltd. Process for the preparation of (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate
KR101192127B1 (ko) 2006-11-03 2012-10-17 쉐링-프라우 리미티드 개 라임병 백신
BRPI0819883A2 (pt) 2007-11-28 2017-05-23 Sequoia Pharmaceuticals Inc composições e métodos para inibir citocromo p450 2d6
WO2013009923A1 (en) * 2011-07-13 2013-01-17 Creighton University Methods of promoting neuron growth
US20150113867A1 (en) 2013-10-24 2015-04-30 Basf Se Use of an alkoxylated polytetrahydrofuran to reduce fuel consumption
CN104478830B (zh) * 2014-12-31 2016-06-22 中国医学科学院医药生物技术研究所 一组叔胺类拟肽衍生物及其在抑制hiv-1蛋白酶中的应用

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Also Published As

Publication number Publication date
US6150556A (en) 2000-11-21
EA199700220A1 (ru) 1998-02-26
NZ305544A (en) 1999-04-29
NO974149L (no) 1997-11-05
SK285958B6 (sk) 2007-12-06
AU704360B2 (en) 1999-04-22
CN1196732A (zh) 1998-10-21
EA000578B1 (ru) 1999-12-29
KR100428499B1 (ko) 2004-11-16
HUP9802647A3 (en) 2000-10-30
MX9706913A (es) 1997-11-29
EP1076062A1 (en) 2001-02-14
NO20075806L (no) 1997-11-05
EE04376B1 (et) 2004-10-15
WO1996028464A1 (en) 1996-09-19
UA55384C2 (uk) 2003-04-15
PL185543B1 (pl) 2003-05-30
NO974149D0 (no) 1997-09-09
US6316496B1 (en) 2001-11-13
JPH11501921A (ja) 1999-02-16
HUP9802647A2 (hu) 1999-02-01
DE69635183D1 (de) 2005-10-20
CN1178954C (zh) 2004-12-08
PL322163A1 (en) 1998-01-19
DK0813543T3 (da) 2006-01-16
AU5356196A (en) 1996-10-02
NO325230B1 (no) 2008-03-03
KR19980702908A (ko) 1998-09-05
SK285930B6 (sk) 2007-11-02
PL185108B1 (pl) 2003-02-28
NO20075810L (no) 1997-11-05
BR9607543A (pt) 1997-12-23
EP0813543A1 (en) 1997-12-29
DE69635183T2 (de) 2006-06-29
CZ282597A3 (cs) 1998-02-18
ATE304550T1 (de) 2005-09-15
CA2215025A1 (en) 1996-09-19
ES2249779T3 (es) 2006-04-01
EP0813543B1 (en) 2005-09-14
CZ294966B6 (cs) 2005-04-13
SK122297A3 (en) 1998-02-04

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