HUP0105235A3 - Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors, pharmaceutical compositions comprising thereof and their use - Google Patents

Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors, pharmaceutical compositions comprising thereof and their use

Info

Publication number
HUP0105235A3
HUP0105235A3 HU0105235A HUP0105235A HUP0105235A3 HU P0105235 A3 HUP0105235 A3 HU P0105235A3 HU 0105235 A HU0105235 A HU 0105235A HU P0105235 A HUP0105235 A HU P0105235A HU P0105235 A3 HUP0105235 A3 HU P0105235A3
Authority
HU
Hungary
Prior art keywords
terminally
bis
amino acid
pharmaceutical compositions
benzyl group
Prior art date
Application number
HU0105235A
Other languages
Hungarian (hu)
Original Assignee
Pont Pharmaceuticals Company W
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pont Pharmaceuticals Company W filed Critical Pont Pharmaceuticals Company W
Publication of HUP0105235A2 publication Critical patent/HUP0105235A2/en
Publication of HUP0105235A3 publication Critical patent/HUP0105235A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
HU0105235A 1999-01-13 2000-01-13 Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors, pharmaceutical compositions comprising thereof and their use HUP0105235A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11574699P 1999-01-13 1999-01-13
PCT/US2000/000820 WO2000042060A1 (en) 1999-01-13 2000-01-13 Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors

Publications (2)

Publication Number Publication Date
HUP0105235A2 HUP0105235A2 (en) 2002-04-29
HUP0105235A3 true HUP0105235A3 (en) 2002-08-28

Family

ID=22363180

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0105235A HUP0105235A3 (en) 1999-01-13 2000-01-13 Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors, pharmaceutical compositions comprising thereof and their use

Country Status (15)

Country Link
EP (1) EP1140983A1 (en)
JP (1) JP2002536298A (en)
KR (1) KR20010101478A (en)
CN (1) CN1336934A (en)
AU (1) AU2725700A (en)
BR (1) BR0007854A (en)
CA (1) CA2353088A1 (en)
CZ (1) CZ20012435A3 (en)
HU (1) HUP0105235A3 (en)
IL (1) IL143763A0 (en)
NO (1) NO20013338L (en)
PL (1) PL349774A1 (en)
SK (1) SK9522001A3 (en)
TR (1) TR200102033T2 (en)
WO (1) WO2000042060A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7339078B2 (en) 1995-03-10 2008-03-04 G.D. Searle Llc Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6861539B1 (en) 1995-03-10 2005-03-01 G. D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
EP1188766A1 (en) * 1995-03-10 2002-03-20 G.D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6617310B2 (en) 2000-07-19 2003-09-09 Bristol-Myers Squibb Pharma Company Phosphate esters of bis-amino acid sulfonamides containing substituted benzyl amines
US20020022659A1 (en) * 2000-07-19 2002-02-21 Harris Gregory D. Crystalline and salt forms of an HIV protease inhibitor
US20020022742A1 (en) * 2000-07-19 2002-02-21 Harris Gregory D. Salt forms of an HIV protease inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0656887T3 (en) * 1992-08-25 1999-07-05 Searle & Co Hydroxyethylaminosulfonamides for use as inhibitors of retroviral proteases
DE69415326T2 (en) * 1993-08-24 1999-06-02 Searle & Co HYDROXYAMINOSULPHONAMIDES USED AS INHIBITORS OF RETROVIRAL PROTEASES
US6150556A (en) * 1995-03-10 2000-11-21 G. D. Dearle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Also Published As

Publication number Publication date
CN1336934A (en) 2002-02-20
TR200102033T2 (en) 2001-12-21
NO20013338L (en) 2001-09-13
IL143763A0 (en) 2002-04-21
BR0007854A (en) 2002-01-15
KR20010101478A (en) 2001-11-14
NO20013338D0 (en) 2001-07-05
WO2000042060A1 (en) 2000-07-20
SK9522001A3 (en) 2002-03-05
PL349774A1 (en) 2002-09-09
JP2002536298A (en) 2002-10-29
AU2725700A (en) 2000-08-01
CA2353088A1 (en) 2000-07-20
HUP0105235A2 (en) 2002-04-29
EP1140983A1 (en) 2001-10-10
CZ20012435A3 (en) 2002-02-13

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