BR0007854A - Sulfonamide compounds bis-amino acids hiv protease inhibitors, pharmaceutical composition and method of treatment of hiv infections - Google Patents

Sulfonamide compounds bis-amino acids hiv protease inhibitors, pharmaceutical composition and method of treatment of hiv infections

Info

Publication number
BR0007854A
BR0007854A BR0007854-9A BR0007854A BR0007854A BR 0007854 A BR0007854 A BR 0007854A BR 0007854 A BR0007854 A BR 0007854A BR 0007854 A BR0007854 A BR 0007854A
Authority
BR
Brazil
Prior art keywords
hiv
treatment
amino acids
pharmaceutical composition
protease inhibitors
Prior art date
Application number
BR0007854-9A
Other languages
Portuguese (pt)
Inventor
Robert F Kaltenbach
George L Trainor
Original Assignee
Du Pont Pharm Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Pharm Co filed Critical Du Pont Pharm Co
Publication of BR0007854A publication Critical patent/BR0007854A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

"COMPOSTOS SULFONAMIDAS BIS-AMINOáCIDOS INIBIDORES DE PROTEASE DE HIV, COMPOSIçãO FARMACêUTICA E MéTODO DE TRATAMENTO DE INFECçõES POR HIV". A presente invenção refere-se, de forma geral, a sulfonamidas bis-aminoácidos que contêm benzilaminas substituídas da fórmula (I) ou suas formas estereoisoméricas, misturas estereoisoméricas ou suas formas de sais farmaceuticamente aceitáveis, que são úteis como inibidores da protease de HIV, composições farmacêuticas e "kits" de diagnóstico que os compreendem, métodos de sua utilização para o tratamento de infecções virais ou como reagentes ou padrões de ensaios, intermediários e processos de sua fabricação."SISPHONAMID COMPOUNDS BIS-AMINO ACIDS INHIBITORS OF HIV PROTEASE, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATING HIV INFECTIONS". The present invention relates in general to bis-amino acid sulfonamides containing substituted benzylamines of formula (I) or their stereoisomeric forms, stereoisomeric mixtures or their pharmaceutically acceptable salt forms, which are useful as HIV protease inhibitors, pharmaceutical compositions and diagnostic kits that comprise them, methods of their use for the treatment of viral infections or as reagents or test standards, intermediates and manufacturing processes.

BR0007854-9A 1999-01-13 2000-01-13 Sulfonamide compounds bis-amino acids hiv protease inhibitors, pharmaceutical composition and method of treatment of hiv infections BR0007854A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11574699P 1999-01-13 1999-01-13
PCT/US2000/000820 WO2000042060A1 (en) 1999-01-13 2000-01-13 Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors

Publications (1)

Publication Number Publication Date
BR0007854A true BR0007854A (en) 2002-01-15

Family

ID=22363180

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0007854-9A BR0007854A (en) 1999-01-13 2000-01-13 Sulfonamide compounds bis-amino acids hiv protease inhibitors, pharmaceutical composition and method of treatment of hiv infections

Country Status (15)

Country Link
EP (1) EP1140983A1 (en)
JP (1) JP2002536298A (en)
KR (1) KR20010101478A (en)
CN (1) CN1336934A (en)
AU (1) AU2725700A (en)
BR (1) BR0007854A (en)
CA (1) CA2353088A1 (en)
CZ (1) CZ20012435A3 (en)
HU (1) HUP0105235A3 (en)
IL (1) IL143763A0 (en)
NO (1) NO20013338L (en)
PL (1) PL349774A1 (en)
SK (1) SK9522001A3 (en)
TR (1) TR200102033T2 (en)
WO (1) WO2000042060A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7339078B2 (en) 1995-03-10 2008-03-04 G.D. Searle Llc Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6861539B1 (en) 1995-03-10 2005-03-01 G. D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
EP1188766A1 (en) 1995-03-10 2002-03-20 G.D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US20020022742A1 (en) * 2000-07-19 2002-02-21 Harris Gregory D. Salt forms of an HIV protease inhibitor
US6617310B2 (en) 2000-07-19 2003-09-09 Bristol-Myers Squibb Pharma Company Phosphate esters of bis-amino acid sulfonamides containing substituted benzyl amines
US20020022659A1 (en) * 2000-07-19 2002-02-21 Harris Gregory D. Crystalline and salt forms of an HIV protease inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2140929C (en) * 1992-08-25 2006-09-12 Michael L. Vazquez Hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
AU7669794A (en) * 1993-08-24 1995-03-21 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
US6150556A (en) * 1995-03-10 2000-11-21 G. D. Dearle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Also Published As

Publication number Publication date
EP1140983A1 (en) 2001-10-10
WO2000042060A1 (en) 2000-07-20
CA2353088A1 (en) 2000-07-20
JP2002536298A (en) 2002-10-29
KR20010101478A (en) 2001-11-14
NO20013338L (en) 2001-09-13
CN1336934A (en) 2002-02-20
AU2725700A (en) 2000-08-01
HUP0105235A3 (en) 2002-08-28
NO20013338D0 (en) 2001-07-05
HUP0105235A2 (en) 2002-04-29
SK9522001A3 (en) 2002-03-05
CZ20012435A3 (en) 2002-02-13
PL349774A1 (en) 2002-09-09
IL143763A0 (en) 2002-04-21
TR200102033T2 (en) 2001-12-21

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved
B25G Requested change of headquarter approved
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008.