NO974149L - Bis-aminosyre hydroksyetylamino sulfonamid retrovirale proteaseinhibitorer - Google Patents

Bis-aminosyre hydroksyetylamino sulfonamid retrovirale proteaseinhibitorer

Info

Publication number
NO974149L
NO974149L NO974149A NO974149A NO974149L NO 974149 L NO974149 L NO 974149L NO 974149 A NO974149 A NO 974149A NO 974149 A NO974149 A NO 974149A NO 974149 L NO974149 L NO 974149L
Authority
NO
Norway
Prior art keywords
amino acid
protease inhibitors
bis
retroviral
retroviral protease
Prior art date
Application number
NO974149A
Other languages
English (en)
Other versions
NO325230B1 (no
NO974149D0 (no
Inventor
Daniel P Getman
Gary A Decrescenzo
John N Freskos
Michael L Vasquez
James A Sikorski
Balekudru Devadas
Srivivasan Nagarajan
David L Brown
Joseph J Mcdonald
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of NO974149D0 publication Critical patent/NO974149D0/no
Publication of NO974149L publication Critical patent/NO974149L/no
Publication of NO325230B1 publication Critical patent/NO325230B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
NO19974149A 1995-03-10 1997-09-09 Forbindelser, sammensetninger og anvendelse av slike for fremstilling av preparater egnet for inhibering av en retroviral protease NO325230B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40245095A 1995-03-10 1995-03-10
US08/479,071 US6150556A (en) 1995-03-10 1995-06-07 Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
PCT/US1996/002685 WO1996028464A1 (en) 1995-03-10 1996-03-07 Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Publications (3)

Publication Number Publication Date
NO974149D0 NO974149D0 (no) 1997-09-09
NO974149L true NO974149L (no) 1997-11-05
NO325230B1 NO325230B1 (no) 2008-03-03

Family

ID=27017890

Family Applications (3)

Application Number Title Priority Date Filing Date
NO19974149A NO325230B1 (no) 1995-03-10 1997-09-09 Forbindelser, sammensetninger og anvendelse av slike for fremstilling av preparater egnet for inhibering av en retroviral protease
NO20075806A NO20075806L (no) 1995-03-10 2007-11-12 Aminosyrehydroksyetylaminosulfonamid retrovirale proteaseinhibitorer
NO20075810A NO20075810L (no) 1995-03-10 2007-11-12 Aminosyrehydroksyetylaminosulfonamid retrovirale proteaseinhibitorer

Family Applications After (2)

Application Number Title Priority Date Filing Date
NO20075806A NO20075806L (no) 1995-03-10 2007-11-12 Aminosyrehydroksyetylaminosulfonamid retrovirale proteaseinhibitorer
NO20075810A NO20075810L (no) 1995-03-10 2007-11-12 Aminosyrehydroksyetylaminosulfonamid retrovirale proteaseinhibitorer

Country Status (23)

Country Link
US (2) US6150556A (no)
EP (2) EP1076062A1 (no)
JP (1) JPH11501921A (no)
KR (1) KR100428499B1 (no)
CN (1) CN1178954C (no)
AT (1) ATE304550T1 (no)
AU (1) AU704360B2 (no)
BR (1) BR9607543A (no)
CA (1) CA2215025A1 (no)
CZ (1) CZ294966B6 (no)
DE (1) DE69635183T2 (no)
DK (1) DK0813543T3 (no)
EA (1) EA000578B1 (no)
EE (1) EE04376B1 (no)
ES (1) ES2249779T3 (no)
HU (1) HUP9802647A3 (no)
MX (1) MX9706913A (no)
NO (3) NO325230B1 (no)
NZ (1) NZ305544A (no)
PL (2) PL185543B1 (no)
SK (2) SK285958B6 (no)
UA (1) UA55384C2 (no)
WO (1) WO1996028464A1 (no)

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US20040122000A1 (en) 1981-01-07 2004-06-24 Vertex Pharmaceuticals Incorporated. Inhibitors of aspartyl protease
US7339078B2 (en) * 1995-03-10 2008-03-04 G.D. Searle Llc Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6861539B1 (en) 1995-03-10 2005-03-01 G. D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
EP1188766A1 (en) 1995-03-10 2002-03-20 G.D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
WO2000002862A1 (en) 1998-07-08 2000-01-20 G.D. Searle & Co. Retroviral protease inhibitors
EP1140983A1 (en) * 1999-01-13 2001-10-10 Bristol-Myers Squibb Pharma Company Bis-amino acid sulfonamides containing n-terminally a fluoro-substituted benzyl group as hiv protease inhibitors
AR031520A1 (es) * 1999-06-11 2003-09-24 Vertex Pharma Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
US6391919B1 (en) 2000-01-12 2002-05-21 Bristol-Myers Squibb Pharma Company Bis-amino acid sulfonamides containing substituted benzyl amines HIV protease inhibitors
US20020022742A1 (en) * 2000-07-19 2002-02-21 Harris Gregory D. Salt forms of an HIV protease inhibitor
US20020022659A1 (en) * 2000-07-19 2002-02-21 Harris Gregory D. Crystalline and salt forms of an HIV protease inhibitor
US6617310B2 (en) 2000-07-19 2003-09-09 Bristol-Myers Squibb Pharma Company Phosphate esters of bis-amino acid sulfonamides containing substituted benzyl amines
ATE343567T1 (de) 2001-02-14 2006-11-15 Tibotec Pharm Ltd Breitspektrum 2-(substituierte-amino)- benzothiazol-sulfonamide hiv protease inhibitoren
PL367084A1 (en) * 2001-04-09 2005-02-21 Tibotec Pharmaceuticals Ltd. Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide hiv protease inhibitors
AU2002310818B2 (en) * 2001-05-11 2007-12-13 Tibotec Pharmaceuticals Ltd. Broadspectrum 2-amino-benzoxazole sulfonamide HIV protease inhibitors
WO2003024932A1 (en) 2001-09-18 2003-03-27 Bristol-Myers Squibb Company Bis-amino acid sulfonamides as hiv protease inhibitors
HUP0500164A3 (en) 2001-12-21 2009-03-30 Tibotec Pharm Ltd Heterocyclic substituted benzenesulfonamides as hiv protease inhibitors and pharmaceutical compositions containing them
MY142238A (en) * 2002-03-12 2010-11-15 Tibotec Pharm Ltd Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
PL373425A1 (en) * 2002-05-17 2005-08-22 Tibotec Pharmaceuticals Ltd. Broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors
KR100994759B1 (ko) 2002-08-14 2010-11-16 티보텍 파마슈티컬즈 광역스펙트럼의 치환된 옥신돌 설폰아미드 ｈｉｖ프로테아제 저해제
US20060128634A1 (en) * 2002-11-14 2006-06-15 Carini David J Alpha, alpha-disubstituted benzylglycine derivatives as HIV protease inhibitors
US6943170B2 (en) * 2002-11-14 2005-09-13 Bristol-Myers Squibb Company N-cycloalkylglycines as HIV protease inhibitors
US7897179B2 (en) * 2003-08-06 2011-03-01 Nostrum Pharmaceuticals, Inc. Pharmaceutical composition containing water soluble drug
US20050131042A1 (en) * 2003-12-11 2005-06-16 Flentge Charles A. HIV protease inhibiting compounds
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UA85567C2 (en) 2003-12-23 2009-02-10 Тиботек Фармасьютикелз Лтд. Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate
AU2004309122B2 (en) 2003-12-23 2011-07-21 Janssen Sciences Ireland Unlimited Company Process for the preparation of (3R,3aS,6AR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate
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Also Published As

Publication number Publication date
SK285958B6 (sk) 2007-12-06
NO325230B1 (no) 2008-03-03
US6316496B1 (en) 2001-11-13
EP0813543A1 (en) 1997-12-29
EA199700220A1 (ru) 1998-02-26
NZ305544A (en) 1999-04-29
EE04376B1 (et) 2004-10-15
EP0813543B1 (en) 2005-09-14
DE69635183T2 (de) 2006-06-29
CZ282597A3 (cs) 1998-02-18
US6150556A (en) 2000-11-21
PL185108B1 (pl) 2003-02-28
EP1076062A1 (en) 2001-02-14
EA000578B1 (ru) 1999-12-29
NO20075806L (no) 1997-11-05
BR9607543A (pt) 1997-12-23
SK122297A3 (en) 1998-02-04
MX9706913A (es) 1997-11-29
CN1196732A (zh) 1998-10-21
DK0813543T3 (da) 2006-01-16
EE9700200A (et) 1998-02-16
DE69635183D1 (de) 2005-10-20
KR100428499B1 (ko) 2004-11-16
HUP9802647A3 (en) 2000-10-30
UA55384C2 (uk) 2003-04-15
CZ294966B6 (cs) 2005-04-13
JPH11501921A (ja) 1999-02-16
AU704360B2 (en) 1999-04-22
PL322163A1 (en) 1998-01-19
NO974149D0 (no) 1997-09-09
PL185543B1 (pl) 2003-05-30
HUP9802647A2 (hu) 1999-02-01
CN1178954C (zh) 2004-12-08
AU5356196A (en) 1996-10-02
CA2215025A1 (en) 1996-09-19
ATE304550T1 (de) 2005-09-15
KR19980702908A (ko) 1998-09-05
SK285930B6 (sk) 2007-11-02
WO1996028464A1 (en) 1996-09-19
NO20075810L (no) 1997-11-05
ES2249779T3 (es) 2006-04-01

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Free format text: I PATENTTIDENDE NR 10/08 BLE PATENTNUMMER 325230 (19974149) KUNNGJORT MED FEIL INTERNASJONAL INNGIVELSESDAG OG LOPEDAG. RIKTIG INTERNASJONAL INNGIVELSESDAG OG LOPEDAG ER 19960307