EE05442B1 - V„ikeses annuses entekaviiri sisaldav ravimkoostis B-hepatiidi viirusinfektsiooni raviks ning meetod selle valmistamiseks - Google Patents

V„ikeses annuses entekaviiri sisaldav ravimkoostis B-hepatiidi viirusinfektsiooni raviks ning meetod selle valmistamiseks

Info

Publication number
EE05442B1
EE05442B1 EEP200200484A EEP200200484A EE05442B1 EE 05442 B1 EE05442 B1 EE 05442B1 EE P200200484 A EEP200200484 A EE P200200484A EE P200200484 A EEP200200484 A EE P200200484A EE 05442 B1 EE05442 B1 EE 05442B1
Authority
EE
Estonia
Prior art keywords
hepatitis
preparation
treatment
pharmaceutical composition
virus infection
Prior art date
Application number
EEP200200484A
Other languages
English (en)
Estonian (et)
Inventor
J. Colonno Richard
L. Sprockel Omar
Harianawala Abizer
S. Desai Divyakant
G. Fakes Michael
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26881354&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE05442(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of EE200200484A publication Critical patent/EE200200484A/xx
Publication of EE05442B1 publication Critical patent/EE05442B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
EEP200200484A 2000-02-29 2001-01-26 V„ikeses annuses entekaviiri sisaldav ravimkoostis B-hepatiidi viirusinfektsiooni raviks ning meetod selle valmistamiseks EE05442B1 (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18567200P 2000-02-29 2000-02-29
US22131300P 2000-07-28 2000-07-28
PCT/US2001/002630 WO2001064221A1 (en) 2000-02-29 2001-01-26 Low dose entecavir formulation and use

Publications (2)

Publication Number Publication Date
EE200200484A EE200200484A (et) 2004-04-15
EE05442B1 true EE05442B1 (et) 2011-08-15

Family

ID=26881354

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200484A EE05442B1 (et) 2000-02-29 2001-01-26 V„ikeses annuses entekaviiri sisaldav ravimkoostis B-hepatiidi viirusinfektsiooni raviks ning meetod selle valmistamiseks

Country Status (35)

Country Link
US (1) US6627224B2 (cs)
EP (2) EP1267880B2 (cs)
JP (3) JP5140222B2 (cs)
KR (1) KR100757155B1 (cs)
AR (1) AR027965A1 (cs)
AT (1) ATE312613T1 (cs)
AU (1) AU2001229775A1 (cs)
BG (1) BG65815B1 (cs)
BR (1) BRPI0108435B8 (cs)
CA (1) CA2401569C (cs)
CO (1) CO5261593A1 (cs)
CZ (1) CZ303395B6 (cs)
DE (1) DE60115870T3 (cs)
DK (1) DK1267880T4 (cs)
EA (1) EA006181B1 (cs)
EE (1) EE05442B1 (cs)
EG (1) EG24408A (cs)
ES (1) ES2253403T5 (cs)
GE (1) GEP20053504B (cs)
HK (1) HK1048771A1 (cs)
HR (1) HRP20020649A2 (cs)
HU (1) HU230698B1 (cs)
IL (1) IL150447A0 (cs)
MX (1) MXPA02008359A (cs)
MY (1) MY127422A (cs)
NO (1) NO324014B1 (cs)
NZ (1) NZ520024A (cs)
PE (1) PE20020770A1 (cs)
PL (1) PL201411B1 (cs)
RS (1) RS51561B (cs)
SI (1) SI1267880T2 (cs)
SK (1) SK288008B6 (cs)
TW (1) TWI287988B (cs)
UA (1) UA84534C2 (cs)
WO (1) WO2001064221A1 (cs)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH061291Y2 (ja) 1988-03-04 1994-01-12 株式会社日立工機原町 拘束状態解除装置付き丸鋸式切断機
EP1267880B2 (en) * 2000-02-29 2010-01-20 Bristol-Myers Squibb Company Low dose entecavir formulation and use
US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
KR100820983B1 (ko) 2001-01-26 2008-04-10 쉐링 코포레이션 치환된 아제티딘온 화합물을 포함하는 약제학적 조성물
US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
MEP27808A (en) 2001-01-26 2010-10-10 Schering Corp Combinations of peroxisome proliferator-activated receptor (ppar) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications
US7056906B2 (en) 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
DK1429756T3 (da) 2001-09-21 2007-03-19 Schering Corp Behandling af xanthoma med azetidinonderivater som sterolabsorptionsinhibitorer
US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
MY131488A (en) * 2002-04-08 2007-08-30 Bristol Myers Squibb Co Low dose liquid entecavir formulations and use
AR040588A1 (es) 2002-07-26 2005-04-13 Schering Corp Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
AU2003291719A1 (en) 2002-11-06 2004-06-03 Schering Corporation Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
CN101899063B (zh) * 2002-12-11 2012-12-12 布里斯托尔-迈尔斯斯奎布公司 制备抗病毒药[1S-(1α,3α,4β)]-2-氨基-1,9-二氢-9-[4-羟基-3-(羟甲基)-2-亚甲环戊基]-6H-嘌呤-6-酮的方法
PL408254A1 (pl) 2003-01-14 2014-07-21 Gilead Sciences Inc. Kompozycje i i sposoby wykorzystywane w skojarzonej terapii przeciwwirusowej
WO2004081002A1 (en) 2003-03-07 2004-09-23 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
CN1756756A (zh) 2003-03-07 2006-04-05 先灵公司 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
WO2004081004A1 (en) 2003-03-07 2004-09-23 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
PL3138566T3 (pl) 2003-11-17 2022-03-07 Biomarin Pharmaceutical Inc. Leczenie fenyloketonurii z użyciem bh4
RU2377987C2 (ru) * 2003-11-18 2010-01-10 Бёрингер Ингельхайм Интернациональ Гмбх Твердая лекарственная форма
US7511139B2 (en) * 2004-06-04 2009-03-31 Bristol-Myers Squibb Company Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation
JP4756153B2 (ja) * 2004-08-27 2011-08-24 富士製薬工業株式会社 低成分含量の錠剤の製造方法
WO2006034397A2 (en) * 2004-09-23 2006-03-30 Fmc Corporation Coating composition
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
CN101245068A (zh) * 2007-02-14 2008-08-20 浙江医药股份有限公司新昌制药厂 结晶型态的恩替卡韦及其制备方法和其药物组合物及用途
AR065809A1 (es) 2007-03-22 2009-07-01 Bristol Myers Squibb Co Formulaciones farmaceuticas que contienen un inhibidor sglt2
CN102596183B (zh) * 2009-10-28 2014-09-17 麦克内尔-Ppc股份有限公司 迅速溶出/崩解的包衣组合物
EP2515872A1 (de) * 2009-12-23 2012-10-31 Ratiopharm GmbH Orale darreichungsform umfassend entecavir
DE102009060194A1 (de) 2009-12-23 2011-06-30 ratiopharm GmbH, 89079 Orale Darreichungsform umfassend Entecavir
EP2536411A4 (en) 2010-02-18 2013-08-07 Univ Princeton HEMMER OF THE METABOLISM OF LOW-CHAIN AND VERY LOW-FATTYED FATTY ACIDS AS AN ANTIVIRUS ACTIVE SUBSTANCES WITH A WIDE SPECTRUM
MA34169B1 (fr) 2010-03-31 2013-04-03 Millennium Pharm Inc Dérivés d'acide 1-amino-2-cyclopropyléthylboronique
EP2606895A4 (en) * 2010-10-12 2014-04-02 Univ Wuhan PLASTER FOR THE TRANSDERMAL ABSORPTION OF AN ANTIVIRUS ACTIVE SUBSTANCE AND METHOD FOR THE PRODUCTION THEREOF
EP2508172A1 (en) 2011-04-06 2012-10-10 Zentiva, a.s. Stable and uniform formulations of entecavir and preparation method thereof
KR101594820B1 (ko) * 2011-06-16 2016-02-17 건일제약 주식회사 엔테카비르를 함유하는 미립구 및 이의 제조방법
KR101439635B1 (ko) 2011-11-01 2014-09-11 대원제약주식회사 안정성이 향상된 엔테카비어를 함유하는 약학적 조성물 및 그 제조방법
CA2881119A1 (en) * 2011-11-14 2013-05-23 Hetero Research Foundation Fast release solid oral compositions of entecavir
EP2644197A1 (en) * 2012-03-26 2013-10-02 Sanovel Ilac Sanayi ve Ticaret A.S. Novel Pharmaceutical Compositions of Entecavir
EP2644196B1 (en) * 2012-03-26 2019-09-18 Arven Ilac Sanayi ve Ticaret A.S. Pharmaceutical compositions of Entecavir
KR101285008B1 (ko) * 2012-04-18 2013-07-10 제일약품주식회사 저용량 엔테카비어의 경구투여 제제의 제조방법
CA2779052A1 (en) * 2012-05-31 2013-11-30 Pharmascience Inc. Pharmaceutical composition of entecavir and process of manufacturing
CN103908436B (zh) * 2012-12-29 2016-02-10 安徽贝克生物制药有限公司 一种速释型恩替卡韦组合物
KR101512895B1 (ko) 2013-08-09 2015-04-16 대화제약 주식회사 엔테카비어를 포함하는 약학적 조성물의 제조방법
KR102435064B1 (ko) * 2014-06-20 2022-08-22 주식회사 씨티씨바이오 엔테카비르를 유효성분으로 포함하는 약학 제제 및 이의 제조방법
JP6625878B2 (ja) * 2015-01-26 2019-12-25 沢井製薬株式会社 エンテカビル含有錠剤、その製造方法及びそれを用いた口腔内崩壊錠
EP3357515B1 (en) * 2015-09-30 2025-08-06 Daicel Corporation Particle composition for easy-to-use solid preparation and easy-to-use solid preparation including said particle composition
AU2020355873B2 (en) 2019-09-29 2025-09-25 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Drug combination containing TLR7 agonist
KR20230112817A (ko) 2022-01-21 2023-07-28 한림대학교 산학협력단 피루브산 및 pdk 억제제를 포함하는 뇌질환의 예방 또는 치료용 조성물

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3836618A (en) * 1971-12-23 1974-09-17 American Home Prod Process for the uniform distribution of a drug on a granulated base
US4513008A (en) * 1982-07-30 1985-04-23 The Vinoxen Company, Inc. Virucidal compositions and therapy
US4489026A (en) † 1982-09-07 1984-12-18 The Upjohn Company Process for preparing solid unit dosage forms of ultra-low dose drugs
US4631284A (en) * 1984-11-19 1986-12-23 Mallinckrodt, Inc. Acetaminophen compositions containing low doses of chlorpheniramine maleate, method for preparing same and tablets formed therefrom
US5206244A (en) * 1990-10-18 1993-04-27 E. R. Squibb & Sons, Inc. Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines
JPH08208478A (ja) * 1994-10-14 1996-08-13 Japan Energy Corp 抗エイズ薬製剤およびその製造方法
PT929294E (pt) * 1996-04-04 2003-11-28 Felix Specht Processo para a preparacao de sistemas em po fluidos e/ou directamente compressiveis de baixa dosagem
WO1998009964A1 (en) 1996-09-03 1998-03-12 Bristol-Myers Squibb Company IMPROVED PROCESS FOR PREPARING THE ANTIVIRAL AGENT [1S-(1α, 3α, 4β)]-2-AMINO-1,9-DIHYDRO-9-[4-HYDROXY-3-(HYDROXYMETHYL)-2-METHYLENECYCLOPENTYL]-6H-PURIN-6-ONE
ES2531928T3 (es) * 1998-08-10 2015-03-20 Novartis Ag Beta-L-2'-desoxi-nucleósidos para el tratamiento de la hepatitis B
US5997905A (en) * 1998-09-04 1999-12-07 Mcneil-Ppc Preparation of pharmaceutically active particles
GB9820416D0 (en) 1998-09-18 1998-11-11 Glaxo Group Ltd Antiviral combinations
GB9820417D0 (en) 1998-09-18 1998-11-11 Glaxo Group Ltd Antiviral combinations
GB9820420D0 (en) 1998-09-18 1998-11-11 Glaxo Group Ltd Antiviral combinations
US6432966B2 (en) * 1999-10-29 2002-08-13 Smithkline Beecham Corporation Antiviral combinations
EP1267880B2 (en) * 2000-02-29 2010-01-20 Bristol-Myers Squibb Company Low dose entecavir formulation and use

Also Published As

Publication number Publication date
EG24408A (en) 2009-05-20
HUP0500558A2 (hu) 2005-09-28
KR100757155B1 (ko) 2007-09-07
JP5140222B2 (ja) 2013-02-06
EP1642582A1 (en) 2006-04-05
HRP20020649A2 (en) 2004-12-31
MY127422A (en) 2006-11-30
NO20024099D0 (no) 2002-08-28
EP1267880A1 (en) 2003-01-02
JP2012255017A (ja) 2012-12-27
US6627224B2 (en) 2003-09-30
CZ303395B6 (cs) 2012-08-29
PL366102A1 (en) 2005-01-24
DE60115870T2 (de) 2006-08-17
ATE312613T1 (de) 2005-12-15
BRPI0108435B1 (pt) 2019-02-05
YU63002A (sh) 2005-03-15
EP1267880B1 (en) 2005-12-14
SK288008B6 (sk) 2012-10-02
GEP20053504B (en) 2005-05-10
SI1267880T1 (sl) 2006-06-30
DK1267880T4 (da) 2010-05-17
HU230698B1 (hu) 2017-09-28
BG65815B1 (bg) 2010-01-29
HUP0500558A3 (en) 2012-08-28
NO20024099L (no) 2002-08-28
DE60115870D1 (de) 2006-01-19
CA2401569A1 (en) 2001-09-07
JP5921746B2 (ja) 2016-05-24
JP2004503467A (ja) 2004-02-05
SK11652002A3 (sk) 2003-09-11
AR027965A1 (es) 2003-04-16
CO5261593A1 (es) 2003-03-31
JP2015178523A (ja) 2015-10-08
ES2253403T3 (es) 2006-06-01
US20010033864A1 (en) 2001-10-25
EE200200484A (et) 2004-04-15
AU2001229775A1 (en) 2001-09-12
EA200200812A1 (ru) 2003-12-25
CA2401569C (en) 2009-08-18
KR20020082230A (ko) 2002-10-30
PE20020770A1 (es) 2002-09-06
EP1267880B2 (en) 2010-01-20
DK1267880T3 (da) 2006-03-06
NO324014B1 (no) 2007-07-30
NZ520024A (en) 2005-03-24
MXPA02008359A (es) 2003-02-12
RS51561B (sr) 2011-08-31
WO2001064221A1 (en) 2001-09-07
BRPI0108435B8 (pt) 2021-05-25
SI1267880T2 (sl) 2010-04-30
ES2253403T5 (es) 2010-04-22
PL201411B1 (pl) 2009-04-30
EA006181B1 (ru) 2005-10-27
IL150447A0 (en) 2002-12-01
UA84534C2 (uk) 2008-11-10
DE60115870T3 (de) 2010-07-29
BG106905A (bg) 2003-04-30
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BR0108435A (pt) 2004-06-15
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