EE03354B1 - Asendatud sulfoksiidide sünteesi protsess - Google Patents
Asendatud sulfoksiidide sünteesi protsessInfo
- Publication number
- EE03354B1 EE03354B1 EE9700006A EE9700006A EE03354B1 EE 03354 B1 EE03354 B1 EE 03354B1 EE 9700006 A EE9700006 A EE 9700006A EE 9700006 A EE9700006 A EE 9700006A EE 03354 B1 EE03354 B1 EE 03354B1
- Authority
- EE
- Estonia
- Prior art keywords
- synthesis
- substituted sulfoxides
- sulfoxides
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9402510A SE504459C2 (sv) | 1994-07-15 | 1994-07-15 | Förfarande för framställning av substituerade sulfoxider |
PCT/SE1995/000818 WO1996002535A1 (fr) | 1994-07-15 | 1995-07-03 | Procede de synthese de sulfoxydes substitues |
Publications (1)
Publication Number | Publication Date |
---|---|
EE03354B1 true EE03354B1 (et) | 2001-02-15 |
Family
ID=20394753
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EE9700006A EE03354B1 (et) | 1994-07-15 | 1995-07-03 | Asendatud sulfoksiidide sünteesi protsess |
Country Status (42)
Country | Link |
---|---|
US (1) | US5948789A (fr) |
EP (1) | EP0773940B2 (fr) |
JP (1) | JP3795917B2 (fr) |
KR (1) | KR100356252B1 (fr) |
CN (1) | CN1070489C (fr) |
AR (1) | AR003443A1 (fr) |
AT (1) | ATE242233T1 (fr) |
AU (1) | AU688074B2 (fr) |
BR (1) | BR9508292A (fr) |
CA (1) | CA2193994C (fr) |
CZ (1) | CZ297987B6 (fr) |
DE (1) | DE69530987T3 (fr) |
DK (1) | DK0773940T4 (fr) |
DZ (1) | DZ1911A1 (fr) |
EE (1) | EE03354B1 (fr) |
EG (1) | EG24534A (fr) |
ES (1) | ES2199998T5 (fr) |
FI (2) | FI117672B (fr) |
HK (1) | HK1008331A1 (fr) |
HR (1) | HRP950401B1 (fr) |
HU (1) | HU226361B1 (fr) |
IL (1) | IL114477A (fr) |
IS (1) | IS1772B (fr) |
MA (1) | MA23611A1 (fr) |
MX (1) | MX9700358A (fr) |
MY (1) | MY113180A (fr) |
NO (1) | NO312101B1 (fr) |
NZ (1) | NZ289959A (fr) |
PL (1) | PL186342B1 (fr) |
PT (1) | PT773940E (fr) |
RU (1) | RU2157806C2 (fr) |
SA (1) | SA95160294B1 (fr) |
SE (1) | SE504459C2 (fr) |
SI (1) | SI0773940T2 (fr) |
SK (1) | SK284059B6 (fr) |
TN (1) | TNSN95081A1 (fr) |
TR (1) | TR199500861A2 (fr) |
TW (1) | TW372971B (fr) |
UA (1) | UA47409C2 (fr) |
WO (1) | WO1996002535A1 (fr) |
YU (1) | YU49475B (fr) |
ZA (1) | ZA955724B (fr) |
Families Citing this family (153)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9301830D0 (sv) * | 1993-05-28 | 1993-05-28 | Ab Astra | New compounds |
US6875872B1 (en) | 1993-05-28 | 2005-04-05 | Astrazeneca | Compounds |
SE504459C2 (sv) * | 1994-07-15 | 1997-02-17 | Astra Ab | Förfarande för framställning av substituerade sulfoxider |
US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
US6699885B2 (en) | 1996-01-04 | 2004-03-02 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and methods of using same |
US6645988B2 (en) * | 1996-01-04 | 2003-11-11 | Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US6489346B1 (en) * | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US6747155B2 (en) | 1997-05-30 | 2004-06-08 | Astrazeneca Ab | Process |
SE510650C2 (sv) | 1997-05-30 | 1999-06-14 | Astra Ab | Ny förening |
SE510643C2 (sv) * | 1997-06-27 | 1999-06-14 | Astra Ab | Termodynamiskt stabil omeprazol natrium form B |
AU746706B2 (en) | 1997-07-03 | 2002-05-02 | Du Pont Pharmaceuticals Company | Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders |
US6174548B1 (en) | 1998-08-28 | 2001-01-16 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
US6096340A (en) * | 1997-11-14 | 2000-08-01 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
SE9704183D0 (sv) * | 1997-11-14 | 1997-11-14 | Astra Ab | New process |
CA2320963A1 (fr) * | 1998-01-30 | 1999-08-05 | Sepracor, Inc. | Compositions et procedes d'utilisation du r-lansoprazole |
EP1073332A4 (fr) * | 1998-04-30 | 2005-06-15 | Sepracor Inc | Compositions a base de r-rabeprazole et procedes |
AU3967399A (en) * | 1998-04-30 | 1999-11-16 | Sepracor, Inc. | S-rabeprazole compositions and methods |
US6365589B1 (en) | 1998-07-02 | 2002-04-02 | Bristol-Myers Squibb Pharma Company | Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists |
US6733778B1 (en) | 1999-08-27 | 2004-05-11 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
CN1087739C (zh) * | 1998-12-28 | 2002-07-17 | 中国科学院成都有机化学研究所 | 光学纯的苯并咪唑类抗消化性溃疡药物的包结拆分制备法 |
SE9900274D0 (sv) * | 1999-01-28 | 1999-01-28 | Astra Ab | New compound |
TWI275587B (en) | 1999-06-17 | 2007-03-11 | Takeda Chemical Industries Ltd | A crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole |
DE60020967T2 (de) | 1999-06-30 | 2006-05-04 | Takeda Pharmaceutical Co. Ltd. | Kristalle von lansoprazole |
AU6727700A (en) * | 1999-08-25 | 2001-03-19 | Takeda Chemical Industries Ltd. | Process for the preparation of optically active sulfoxide derivatives |
US6312723B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Pharmaceutical unit dosage form |
US6316020B1 (en) * | 1999-08-26 | 2001-11-13 | Robert R. Whittle | Pharmaceutical formulations |
US6262085B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
US6268385B1 (en) | 1999-08-26 | 2001-07-31 | Robert R. Whittle | Dry blend pharmaceutical formulations |
US6262086B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Pharmaceutical unit dosage form |
US6312712B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Method of improving bioavailability |
US6326384B1 (en) | 1999-08-26 | 2001-12-04 | Robert R. Whittle | Dry blend pharmaceutical unit dosage form |
US6780880B1 (en) | 1999-08-26 | 2004-08-24 | Robert R. Whittle | FT-Raman spectroscopic measurement |
KR100775802B1 (ko) * | 2000-04-28 | 2007-11-12 | 다케다 야쿠힌 고교 가부시키가이샤 | 광학 활성 술폭시드 유도체의 제조 방법 |
CN100562318C (zh) * | 2000-05-15 | 2009-11-25 | 武田药品工业株式会社 | 晶体的制备方法 |
KR100869677B1 (ko) | 2000-05-15 | 2008-11-21 | 다케다 야쿠힌 고교 가부시키가이샤 | 결정의 제조방법 |
AU2001276721A1 (en) * | 2000-08-04 | 2002-02-18 | Takeda Chemical Industries Ltd. | Salts of benzimidazole compound and use thereof |
AU2002218506A1 (en) * | 2000-12-01 | 2002-06-11 | Takeda Chemical Industries Ltd. | Process for the crystallization of (r)- or (s)-lansoprazole |
AU2002338655A1 (en) * | 2001-04-13 | 2002-10-28 | Aspinterm Llc | Methods of preparing sulfinamide and sulfoxides |
GB2376231A (en) * | 2001-06-06 | 2002-12-11 | Cipla Ltd | Benzimidazole-cyclodextrin inclusion complex |
JP2005521662A (ja) * | 2002-01-25 | 2005-07-21 | サンタラス インコーポレイティッド | プロトンポンプ阻害剤の経粘膜送達 |
DE60314105T2 (de) * | 2002-03-05 | 2008-01-24 | Astrazeneca Ab | Alkylammoniumsalze von omeprazol und esomeprazol |
AU2003262375A1 (en) * | 2002-04-22 | 2003-11-03 | Sun Pharmaceutical Industries Limited | Optically active substituted pyridinylmethyl-sulphinyl-benzimidazole and salts |
US7169793B2 (en) | 2002-06-27 | 2007-01-30 | Dr. Reddy's Laboratories Limited | Process for preparation of optically pure or optically enriched sulfoxide compounds, including amorphous esomeprazole and salts thereof |
MY148805A (en) | 2002-10-16 | 2013-05-31 | Takeda Pharmaceutical | Controlled release preparation |
ES2534713T3 (es) * | 2002-10-16 | 2015-04-27 | Takeda Pharmaceutical Company Limited | Preparaciones sólidas estables |
AU2003278406A1 (en) | 2002-10-22 | 2004-05-13 | Ranbaxy Laboratories Limited | Amorphous form of esomeprazole salts |
DE10254167A1 (de) | 2002-11-20 | 2004-06-09 | Icon Genetics Ag | Verfahren zur Kontrolle von zellulären Prozessen in Pflanzen |
US7301030B2 (en) | 2002-12-06 | 2007-11-27 | Nycomed Gmbh | Process for preparing (S)-pantoprazole |
BRPI0310118B1 (pt) | 2002-12-06 | 2015-10-20 | Altana Pharma Ag | processo para a preparação de inibidores de bomba de próton (ppi) opticamente puro possuindo uma estrutura de sulfinila |
WO2004055001A2 (fr) * | 2002-12-16 | 2004-07-01 | Ranbaxy Laboratories Limited | Calcium de rabeprazole |
FR2848555B1 (fr) | 2002-12-16 | 2006-07-28 | Negma Gild | Enantiomere(-)du tenatoprazole et son application en therapeutique |
WO2004056804A2 (fr) | 2002-12-19 | 2004-07-08 | Teva Pharmaceutical Industries Ltd. | Etats solides de sodium de pantoprazole, leurs procedes de preparation et procedes de preparation d'hydrates de sodium de pantoprazole connus |
CN1723208A (zh) * | 2003-01-07 | 2006-01-18 | 兰贝克赛实验室有限公司 | 咪唑衍生物的镁盐 |
JP2006518751A (ja) * | 2003-02-20 | 2006-08-17 | サンタラス インコーポレイティッド | 胃酸の急速かつ持続的な抑制のための新規製剤、オメプラゾール制酸剤複合体−即時放出物 |
US20060247277A1 (en) * | 2003-02-28 | 2006-11-02 | Yatendra Kumar | Polymorphs of s-omeprazole |
WO2004080961A2 (fr) * | 2003-03-12 | 2004-09-23 | Teva Pharmaceutical Industries Ltd. | Formes solides cristallines et amorphes de pantoprazole et procedes de preparation de ces formes |
WO2004080487A1 (fr) * | 2003-03-13 | 2004-09-23 | Eisai Co. Ltd. | Medicament destine a prevenir ou a traiter les grincements de dents |
FR2852956B1 (fr) * | 2003-03-28 | 2006-08-04 | Negma Gild | Procede de preparation enantioselective de derives de sulfoxydes |
JP2006523201A (ja) * | 2003-03-28 | 2006-10-12 | シデム ファーマ | スルホキシド誘導体をエナンチオ選択的に調製する方法 |
US20070060556A1 (en) * | 2003-05-05 | 2007-03-15 | Yatendra Kumar | Barium salt of benzimidazole derivative |
CA2528993A1 (fr) | 2003-06-10 | 2004-12-23 | Teva Pharmaceutical Industries Ltd. | Procede de preparation de benzimidazoles 2-[(pyridinyl)methyl]sulfinyle substitues et nouveau derives chlorures de pantoprazole |
US8993599B2 (en) | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
SE0302381D0 (sv) | 2003-09-04 | 2003-09-04 | Astrazeneca Ab | New salts I |
SE0302382D0 (sv) | 2003-09-04 | 2003-09-04 | Astrazeneca Ab | New salts II |
WO2005054228A1 (fr) * | 2003-12-05 | 2005-06-16 | Hetero Drugs Limited | Procede de preparation d'enantiomeres de pyridinylmethylsulfinyl- benzamide substitues |
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US7176319B2 (en) * | 2004-04-28 | 2007-02-13 | Hetero Drugs Limited | Process for substituted sulfoxides |
US8815916B2 (en) | 2004-05-25 | 2014-08-26 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
US8906940B2 (en) | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
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FR2876101B1 (fr) * | 2004-10-05 | 2007-03-02 | Sidem Pharma Sa Sa | Procede de preparation enantioselective de derives de sulfoxydes |
EP1802584B1 (fr) * | 2004-10-11 | 2009-09-16 | Ranbaxy Laboratories Limited | Procedes de preparation de sulfoxydes substitues |
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CN101098867B (zh) * | 2005-03-25 | 2010-08-11 | 丽珠医药集团股份有限公司 | 取代的亚砜类化合物和其制备方法及用途 |
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US20070043085A1 (en) * | 2005-08-19 | 2007-02-22 | Glenmark Pharmaceuticals Limited | Process for the preparation of amorphous form of neutral esomeprazole |
NZ568471A (en) * | 2005-12-05 | 2010-09-30 | Astrazeneca Ab | New process for the preparation of esomeprazole non-salt form |
EP1801110A1 (fr) | 2005-12-22 | 2007-06-27 | KRKA, tovarna zdravil, d.d., Novo mesto | Sel d'arginine d'ésoméprazole |
DE102005061720B3 (de) * | 2005-12-22 | 2006-10-19 | Ratiopharm Gmbh | Enantioselektive Herstellung von Benzimidazolderivaten und ihren Salzen |
US7553857B2 (en) | 2005-12-23 | 2009-06-30 | Lek Pharmaceuticals D.D. | S-omeprazole magnesium |
SI1973896T1 (sl) | 2005-12-28 | 2009-08-31 | Union Quimico Farma | Postopek priprave (S) - enantiomere omeprazola |
CN1810803B (zh) * | 2006-02-17 | 2010-11-17 | 中国科学院上海有机化学研究所 | 高对映体选择性制备(s)-奥美拉唑的方法 |
US7579476B2 (en) * | 2006-02-24 | 2009-08-25 | Praktikatalyst Pharma, Llc | Transition metal mediated oxidation of hetero atoms in organic molecules coordinated to transition metals |
US8063074B2 (en) * | 2006-05-04 | 2011-11-22 | Dr. Reddy's Laboratories Limited | Polymorphic forms of esomeprazole sodium |
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BRPI0621832A2 (pt) | 2006-07-05 | 2013-03-19 | Lupin Ltd | processo para a preparaÇço de enantiâmeros oticamente puros ou oticamente enriquecidos de compostos de sulfàxido |
WO2008018091A1 (fr) * | 2006-08-08 | 2008-02-14 | Jubilant Organosys Limited | Procédé de production de composés de sulfoxyde |
JP2009196894A (ja) * | 2006-10-13 | 2009-09-03 | Eisai R & D Management Co Ltd | スルフィニルベンズイミダゾール化合物またはその塩の製造方法 |
JP5492417B2 (ja) | 2006-10-13 | 2014-05-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 胃酸分泌抑制作用を有するベンズイミダゾール化合物 |
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JP2010519284A (ja) | 2007-02-21 | 2010-06-03 | シプラ・リミテッド | エソメプラゾールマグネシウム二水和物の調製方法 |
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CN102014638A (zh) | 2007-10-12 | 2011-04-13 | 武田制药北美公司 | 与食物摄入无关的治疗胃肠病症的方法 |
FR2925899B1 (fr) * | 2007-12-27 | 2012-12-21 | Sidem Pharma Sa | Procede de preparation enantioselective de sulfoxydes. |
CN101492459B (zh) * | 2008-01-25 | 2011-04-27 | 山东轩竹医药科技有限公司 | 含烷氧乙酰基二氢异噁唑并吡啶化合物 |
CN101497603B (zh) * | 2008-01-30 | 2012-11-07 | 山东轩竹医药科技有限公司 | 含有被烷氧烷胺氧基取代的吡啶的苯并咪唑衍生物 |
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EP2265605A4 (fr) * | 2008-03-18 | 2011-08-03 | Reddys Lab Ltd Dr | Procédé de préparation du dexlansoprazole et autres formes polymorphes |
CN101538264A (zh) * | 2008-03-19 | 2009-09-23 | 中国科学院成都有机化学有限公司 | 手性亚砜类化合物的制备新方法 |
WO2009145368A1 (fr) * | 2008-05-27 | 2009-12-03 | Sk Chemicals Co., Ltd. | Procédé amélioré de préparation de (s)-oméprazole à partir d'un racémate d'oméprazole à l’aide d'un agent de résolution optique |
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SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
GB2189698A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
DE4035455A1 (de) * | 1990-11-08 | 1992-05-14 | Byk Gulden Lomberg Chem Fab | Enantiomerentrennung |
SE9301830D0 (sv) * | 1993-05-28 | 1993-05-28 | Ab Astra | New compounds |
SE504459C2 (sv) * | 1994-07-15 | 1997-02-17 | Astra Ab | Förfarande för framställning av substituerade sulfoxider |
GB9423968D0 (en) * | 1994-11-28 | 1995-01-11 | Astra Ab | Resolution |
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