EP0092918B1
(en)
|
1982-04-22 |
1988-10-19 |
Imperial Chemical Industries Plc |
Continuous release formulations
|
US4522811A
(en)
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
EP0154316B1
(en)
|
1984-03-06 |
1989-09-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified lymphokine and production thereof
|
JPS6147500A
(ja)
|
1984-08-15 |
1986-03-07 |
Res Dev Corp Of Japan |
キメラモノクロ−ナル抗体及びその製造法
|
JPS61122292A
(ja)
|
1984-11-16 |
1986-06-10 |
Teijin Ltd |
新規カルバサイクリン中間体の製法
|
JPS61134325A
(ja)
|
1984-12-04 |
1986-06-21 |
Teijin Ltd |
ハイブリツド抗体遺伝子の発現方法
|
US5128326A
(en)
|
1984-12-06 |
1992-07-07 |
Biomatrix, Inc. |
Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
|
US5374548A
(en)
|
1986-05-02 |
1994-12-20 |
Genentech, Inc. |
Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
|
MX9203291A
(es)
|
1985-06-26 |
1992-08-01 |
Liposome Co Inc |
Metodo para acoplamiento de liposomas.
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
US6548640B1
(en)
|
1986-03-27 |
2003-04-15 |
Btg International Limited |
Altered antibodies
|
EP0276496B1
(en)
|
1987-01-26 |
1992-03-18 |
Ford New Holland N.V. |
Baler feeder mechanism
|
DE3773648D1
(de)
|
1987-01-27 |
1991-11-14 |
Agfa Gevaert Nv |
Verfahren zur erzeugung von radiographischen mehrfachbildern.
|
WO1988007089A1
(en)
|
1987-03-18 |
1988-09-22 |
Medical Research Council |
Altered antibodies
|
US5169938A
(en)
*
|
1987-04-25 |
1992-12-08 |
Kyowa Hakko Kogyo Co., Ltd. |
Anti-T cell receptor γ-chain monoclonal antibody
|
US4880078A
(en)
|
1987-06-29 |
1989-11-14 |
Honda Giken Kogyo Kabushiki Kaisha |
Exhaust muffler
|
US5677425A
(en)
|
1987-09-04 |
1997-10-14 |
Celltech Therapeutics Limited |
Recombinant antibody
|
US5336603A
(en)
|
1987-10-02 |
1994-08-09 |
Genentech, Inc. |
CD4 adheson variants
|
US4975369A
(en)
|
1988-04-21 |
1990-12-04 |
Eli Lilly And Company |
Recombinant and chimeric KS1/4 antibodies directed against a human adenocarcinoma antigen
|
AU631802B2
(en)
|
1988-06-14 |
1992-12-10 |
Cetus Oncology Corporation |
Coupling agents and sterically hindered disulfide linked conjugates prepared therefrom
|
KR900005995A
(ko)
|
1988-10-31 |
1990-05-07 |
우메모또 요시마사 |
변형 인터류킨-2 및 그의 제조방법
|
US5766947A
(en)
*
|
1988-12-14 |
1998-06-16 |
Astra Ab |
Monoclonal antibodies reactive with an epitope of a Vβ3.1 variable region of a T cell receptor
|
US5223426A
(en)
|
1988-12-15 |
1993-06-29 |
T Cell Sciences, Inc. |
Monoclonal antibodies reactive with defined regions of the t-cell antigen receptor
|
WO1990006952A1
(en)
|
1988-12-22 |
1990-06-28 |
Kirin-Amgen, Inc. |
Chemically modified granulocyte colony stimulating factor
|
IL162181A
(en)
|
1988-12-28 |
2006-04-10 |
Pdl Biopharma Inc |
A method of producing humanized immunoglubulin, and polynucleotides encoding the same
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
US5108921A
(en)
|
1989-04-03 |
1992-04-28 |
Purdue Research Foundation |
Method for enhanced transmembrane transport of exogenous molecules
|
ATE92107T1
(de)
|
1989-04-29 |
1993-08-15 |
Delta Biotechnology Ltd |
N-terminale fragmente von menschliches serumalbumin enthaltenden fusionsproteinen.
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
US5112946A
(en)
|
1989-07-06 |
1992-05-12 |
Repligen Corporation |
Modified pf4 compositions and methods of use
|
FR2650598B1
(fr)
|
1989-08-03 |
1994-06-03 |
Rhone Poulenc Sante |
Derives de l'albumine a fonction therapeutique
|
AU6430190A
(en)
|
1989-10-10 |
1991-05-16 |
Pitman-Moore, Inc. |
Sustained release composition for macromolecular proteins
|
WO1991006570A1
(en)
|
1989-10-25 |
1991-05-16 |
The University Of Melbourne |
HYBRID Fc RECEPTOR MOLECULES
|
EP0550436A1
(en)
|
1989-11-06 |
1993-07-14 |
Alkermes Controlled Therapeutics, Inc. |
Protein microspheres and methods of using them
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
US5349053A
(en)
|
1990-06-01 |
1994-09-20 |
Protein Design Labs, Inc. |
Chimeric ligand/immunoglobulin molecules and their uses
|
US5582996A
(en)
|
1990-12-04 |
1996-12-10 |
The Wistar Institute Of Anatomy & Biology |
Bifunctional antibodies and method of preparing same
|
ATE145428T1
(de)
|
1990-12-14 |
1996-12-15 |
Cell Genesys Inc |
Chimärische ketten zur transduktion von rezeptorverbundenen signalwegen
|
DE69232706T2
(de)
|
1991-05-01 |
2002-11-28 |
Jackson H M Found Military Med |
Verfahren zur behandlung infektiöser respiratorischer erkrankungen
|
DE69233482T2
(de)
|
1991-05-17 |
2006-01-12 |
Merck & Co., Inc. |
Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
|
DK0590058T3
(da)
|
1991-06-14 |
2004-03-29 |
Genentech Inc |
Humaniseret heregulin-antistof
|
US5565332A
(en)
|
1991-09-23 |
1996-10-15 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
ES2241710T3
(es)
|
1991-11-25 |
2005-11-01 |
Enzon, Inc. |
Procedimiento para producir proteinas multivalentes de union a antigeno.
|
US5932448A
(en)
|
1991-11-29 |
1999-08-03 |
Protein Design Labs., Inc. |
Bispecific antibody heterodimers
|
US5766886A
(en)
|
1991-12-13 |
1998-06-16 |
Xoma Corporation |
Modified antibody variable domains
|
AU676150B2
(en)
|
1992-01-23 |
1997-03-06 |
Merck Patent Gmbh |
Monomeric and dimeric antibody-fragment fusion proteins
|
US5622929A
(en)
|
1992-01-23 |
1997-04-22 |
Bristol-Myers Squibb Company |
Thioether conjugates
|
FR2686901A1
(fr)
|
1992-01-31 |
1993-08-06 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides antithrombotiques, leur preparation et compositions pharmaceutiques les contenant.
|
FR2686899B1
(fr)
|
1992-01-31 |
1995-09-01 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
|
GB9203459D0
(en)
|
1992-02-19 |
1992-04-08 |
Scotgen Ltd |
Antibodies with germ-line variable regions
|
US5912015A
(en)
|
1992-03-12 |
1999-06-15 |
Alkermes Controlled Therapeutics, Inc. |
Modulated release from biocompatible polymers
|
US5447851B1
(en)
|
1992-04-02 |
1999-07-06 |
Univ Texas System Board Of |
Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
|
WO1993022332A2
(en)
|
1992-04-24 |
1993-11-11 |
Board Of Regents, The University Of Texas System |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
DK1589107T3
(da)
|
1992-08-21 |
2010-04-26 |
Univ Bruxelles |
Immonuglobuliner uden lette kæder
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
US5934272A
(en)
|
1993-01-29 |
1999-08-10 |
Aradigm Corporation |
Device and method of creating aerosolized mist of respiratory drug
|
US5747654A
(en)
|
1993-06-14 |
1998-05-05 |
The United States Of America As Represented By The Department Of Health And Human Services |
Recombinant disulfide-stabilized polypeptide fragments having binding specificity
|
EP0714409A1
(en)
|
1993-06-16 |
1996-06-05 |
Celltech Therapeutics Limited |
Antibodies
|
US5834252A
(en)
|
1995-04-18 |
1998-11-10 |
Glaxo Group Limited |
End-complementary polymerase reaction
|
US5605793A
(en)
|
1994-02-17 |
1997-02-25 |
Affymax Technologies N.V. |
Methods for in vitro recombination
|
US5837458A
(en)
|
1994-02-17 |
1998-11-17 |
Maxygen, Inc. |
Methods and compositions for cellular and metabolic engineering
|
CZ25697A3
(en)
|
1994-07-29 |
1997-09-17 |
Smithkline Beecham Plc |
Novel compounds
|
US6132764A
(en)
|
1994-08-05 |
2000-10-17 |
Targesome, Inc. |
Targeted polymerized liposome diagnostic and treatment agents
|
EP0805678B1
(en)
|
1995-01-05 |
2003-10-29 |
THE BOARD OF REGENTS acting for and on behalf of THE UNIVERSITY OF MICHIGAN |
Surface-modified nanoparticles and method of making and using same
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
US6121022A
(en)
|
1995-04-14 |
2000-09-19 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
US6019968A
(en)
|
1995-04-14 |
2000-02-01 |
Inhale Therapeutic Systems, Inc. |
Dispersible antibody compositions and methods for their preparation and use
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
EP0871720A2
(en)
|
1995-06-07 |
1998-10-21 |
Athena Neurosciences, Inc. |
Beta-secretase, antibodies to beta-secretase, and assays for detecting beta-secretase inhibition
|
WO1997007788A2
(en)
|
1995-08-31 |
1997-03-06 |
Alkermes Controlled Therapeutics, Inc. |
Composition for sustained release of an agent
|
PT885002E
(pt)
|
1996-03-04 |
2011-07-14 |
Massachusetts Inst Technology |
Materiais e métodos para aumento da internalização celular
|
WO1997034631A1
(en)
|
1996-03-18 |
1997-09-25 |
Board Of Regents, The University Of Texas System |
Immunoglobin-like domains with increased half lives
|
US5985309A
(en)
|
1996-05-24 |
1999-11-16 |
Massachusetts Institute Of Technology |
Preparation of particles for inhalation
|
US5855913A
(en)
|
1997-01-16 |
1999-01-05 |
Massachusetts Instite Of Technology |
Particles incorporating surfactants for pulmonary drug delivery
|
US5874064A
(en)
|
1996-05-24 |
1999-02-23 |
Massachusetts Institute Of Technology |
Aerodynamically light particles for pulmonary drug delivery
|
US6056973A
(en)
|
1996-10-11 |
2000-05-02 |
Sequus Pharmaceuticals, Inc. |
Therapeutic liposome composition and method of preparation
|
WO1998023289A1
(en)
|
1996-11-27 |
1998-06-04 |
The General Hospital Corporation |
MODULATION OF IgG BINDING TO FcRn
|
GB9625640D0
(en)
|
1996-12-10 |
1997-01-29 |
Celltech Therapeutics Ltd |
Biological products
|
CA2277801C
(en)
|
1997-01-16 |
2002-10-15 |
Massachusetts Institute Of Technology |
Preparation of particles for inhalation
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
US20020062010A1
(en)
|
1997-05-02 |
2002-05-23 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
ES2301198T3
(es)
|
1997-06-12 |
2008-06-16 |
Novartis International Pharmaceutical Ltd. |
Polipeptidos artificiales de anticuerpos.
|
GB9720054D0
(en)
|
1997-09-19 |
1997-11-19 |
Celltech Therapeutics Ltd |
Biological products
|
US5989463A
(en)
|
1997-09-24 |
1999-11-23 |
Alkermes Controlled Therapeutics, Inc. |
Methods for fabricating polymer-based controlled release devices
|
SE512663C2
(sv)
|
1997-10-23 |
2000-04-17 |
Biogram Ab |
Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
WO1999054342A1
(en)
|
1998-04-20 |
1999-10-28 |
Pablo Umana |
Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
|
JP2002518432A
(ja)
|
1998-06-24 |
2002-06-25 |
アドバンスト インハレーション リサーチ,インコーポレイテッド |
吸入器から放出される大多孔性粒子
|
BR0007423A
(pt)
|
1999-01-07 |
2002-01-22 |
Zymogenetics Inc |
Métodos para inibir a atividade de ztnf4 em um mamìfero e o acoplamento de receptor-ligando br43x2, taci ou bcma e para produzir um polipeptìdeo, molécula de polinucleotìdeo isolada, vetor de expressão, célula cultivada, e, polipeptìdeo isolado
|
PL209786B1
(pl)
|
1999-01-15 |
2011-10-31 |
Genentech Inc |
Przeciwciało zawierające wariant regionu Fc ludzkiej IgG1, przeciwciało wiążące czynnik wzrostu śródbłonka naczyń oraz immunoadhezyna
|
IL129299A0
(en)
|
1999-03-31 |
2000-02-17 |
Mor Research Applic Ltd |
Monoclonal antibodies antigens and diagnosis of malignant diseases
|
ES2420835T3
(es)
|
1999-04-09 |
2013-08-27 |
Kyowa Hakko Kirin Co., Ltd. |
Procedimiento para controlar la actividad de las moléculas inmunofuncionales
|
EE05673B1
(et)
|
1999-08-17 |
2013-08-15 |
Biogen, Inc. |
BAFF-retseptor (BCMA), immunoregulatoorne agens
|
UA74798C2
(uk)
|
1999-10-06 |
2006-02-15 |
Байоджен Айдек Ма Інк. |
Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами
|
WO2001039722A2
(en)
|
1999-11-30 |
2001-06-07 |
Mayo Foundation For Medical Education And Research |
B7-h1, a novel immunoregulatory molecule
|
US20070042392A1
(en)
|
2000-02-03 |
2007-02-22 |
Nuvelo, Inc. |
Novel nucleic acids and polypeptides
|
JP2003530838A
(ja)
|
2000-04-12 |
2003-10-21 |
ヒューマン ゲノム サイエンシズ インコーポレイテッド |
アルブミン融合タンパク質
|
WO2001087979A2
(en)
|
2000-05-12 |
2001-11-22 |
Amgen Inc. |
Methods and compositions of matter concerning april/g70, bcma, blys/agp-3, and taci
|
GB0020685D0
(en)
|
2000-08-22 |
2000-10-11 |
Novartis Ag |
Organic compounds
|
AU2002218166A1
(en)
|
2000-09-08 |
2002-03-22 |
Universitat Zurich |
Collections of repeat proteins comprising repeat modules
|
US7468365B2
(en)
|
2000-11-17 |
2008-12-23 |
Eli Lilly And Company |
Lactam compound
|
WO2002066516A2
(en)
|
2001-02-20 |
2002-08-29 |
Zymogenetics, Inc. |
Antibodies that bind both bcma and taci
|
EP1243276A1
(en)
|
2001-03-23 |
2002-09-25 |
Franciscus Marinus Hendrikus De Groot |
Elongated and multiple spacers containing activatible prodrugs
|
US20050048512A1
(en)
|
2001-04-26 |
2005-03-03 |
Avidia Research Institute |
Combinatorial libraries of monomer domains
|
ITMI20011483A1
(it)
|
2001-07-11 |
2003-01-11 |
Res & Innovation Soc Coop A R |
Uso di composti come antagonisti funzionali ai recettori centrali deicannabinoidi
|
US6833441B2
(en)
|
2001-08-01 |
2004-12-21 |
Abmaxis, Inc. |
Compositions and methods for generating chimeric heteromultimers
|
GB0120347D0
(en)
|
2001-08-21 |
2001-10-17 |
Merck Sharp & Dohme |
Therapeutic agents
|
MXPA04003798A
(es)
|
2001-10-25 |
2004-07-30 |
Genentech Inc |
Composiciones de glicoproteina.
|
DE10156482A1
(de)
*
|
2001-11-12 |
2003-05-28 |
Gundram Jung |
Bispezifisches Antikörper-Molekül
|
US20030220297A1
(en)
|
2002-02-01 |
2003-11-27 |
Berstein David L. |
Phosphorus-containing compounds and uses thereof
|
US8188231B2
(en)
|
2002-09-27 |
2012-05-29 |
Xencor, Inc. |
Optimized FC variants
|
US20070274998A1
(en)
*
|
2002-04-29 |
2007-11-29 |
Genpatzz Pharmacogentetics Ag |
Novel Bispecific Molecules For Use In Therapy And Diagnosis
|
IL149820A0
(en)
|
2002-05-23 |
2002-11-10 |
Curetech Ltd |
Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency
|
US7446190B2
(en)
|
2002-05-28 |
2008-11-04 |
Sloan-Kettering Institute For Cancer Research |
Nucleic acids encoding chimeric T cell receptors
|
EP2243493A1
(en)
|
2002-07-03 |
2010-10-27 |
Ono Pharmaceutical Co., Ltd. |
Immunopotentiative composition
|
JP3975850B2
(ja)
|
2002-07-25 |
2007-09-12 |
富士ゼロックス株式会社 |
画像処理装置
|
DK1545613T3
(da)
|
2002-07-31 |
2011-11-14 |
Seattle Genetics Inc |
Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom
|
US8187593B2
(en)
|
2002-08-14 |
2012-05-29 |
Macrogenics, Inc. |
FcγRIIB specific antibodies and methods of use thereof
|
WO2004019993A1
(en)
|
2002-08-30 |
2004-03-11 |
Ramot At Tel Aviv University Ltd. |
Self-immolative dendrimers releasing many active moieties upon a single activating event
|
US20060235208A1
(en)
|
2002-09-27 |
2006-10-19 |
Xencor, Inc. |
Fc variants with optimized properties
|
JP2006507322A
(ja)
|
2002-11-14 |
2006-03-02 |
シンタルガ・ビーブイ |
多重自己脱離放出スペーサーとして構築されたプロドラッグ
|
MXPA05006828A
(es)
|
2002-12-23 |
2005-09-08 |
Wyeth Corp |
Anticuerpos contra pd-1, y sus usos.
|
WO2004073656A2
(en)
|
2003-02-20 |
2004-09-02 |
Seattle Genetics, Inc. |
Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders
|
WO2004079013A1
(en)
|
2003-03-03 |
2004-09-16 |
Arizona Board Of Regents On Behalf Of The University Of Arizona |
Ecto-5’-nucleotidase (cd73) used in the diagnosis and the treatment of pancreatic cancer
|
US8084582B2
(en)
|
2003-03-03 |
2011-12-27 |
Xencor, Inc. |
Optimized anti-CD20 monoclonal antibodies having Fc variants
|
NZ543202A
(en)
|
2003-05-31 |
2008-04-30 |
Micromet Ag |
Pharmaceutical composition comprising a bispecific antibody for epcam
|
GB0315457D0
(en)
|
2003-07-01 |
2003-08-06 |
Celltech R&D Ltd |
Biological products
|
PT1644412E
(pt)
|
2003-07-01 |
2015-12-23 |
Ucb Biopharma Sprl |
Fragmentos de anticorpos fab modificados
|
GB0315450D0
(en)
|
2003-07-01 |
2003-08-06 |
Celltech R&D Ltd |
Biological products
|
US7473531B1
(en)
|
2003-08-08 |
2009-01-06 |
Colora Corporation |
Pancreatic cancer targets and uses thereof
|
EP1660186B1
(en)
|
2003-08-18 |
2013-12-25 |
MedImmune, LLC |
Humanization of antibodies
|
CA2537055A1
(en)
|
2003-08-22 |
2005-04-21 |
Medimmune, Inc. |
Humanization of antibodies
|
KR20070087233A
(ko)
|
2003-09-09 |
2007-08-27 |
에프. 호프만-라 로슈 아게 |
감마-세크리테이즈의 활성을 차단하는 말론아미드 유도체
|
CA2539253A1
(en)
|
2003-09-19 |
2005-03-31 |
Novo Nordisk A/S |
Albumin-binding derivatives of therapeutic peptides
|
ATE493441T1
(de)
|
2003-10-16 |
2011-01-15 |
Micromet Ag |
Multispezifische deimmunisierte cd3-bindende moleküle
|
US20050164301A1
(en)
|
2003-10-24 |
2005-07-28 |
Avidia Research Institute |
LDL receptor class A and EGF domain monomers and multimers
|
RU2364587C2
(ru)
|
2003-10-29 |
2009-08-20 |
Элан Фармасьютикалз, Инк. |
N-замещенные бензолсульфонамиды
|
US7435596B2
(en)
|
2004-11-04 |
2008-10-14 |
St. Jude Children's Research Hospital, Inc. |
Modified cell line and method for expansion of NK cell
|
US7235641B2
(en)
|
2003-12-22 |
2007-06-26 |
Micromet Ag |
Bispecific antibodies
|
US20070161700A1
(en)
|
2004-12-28 |
2007-07-12 |
Kowa Company, Ltd. |
Inhibitor for the formation of y-secretase complex
|
EP1709072A1
(en)
|
2004-01-29 |
2006-10-11 |
Genentech, Inc. |
Variants of the extracellular domain of bcma and uses thereof
|
US7375078B2
(en)
|
2004-02-23 |
2008-05-20 |
Genentech, Inc. |
Heterocyclic self-immolative linkers and conjugates
|
GEP20084420B
(en)
|
2004-03-23 |
2008-07-10 |
Pfizer Prod Inc |
Use of imidazole compounds for the treatment of neurodegenerative disorders
|
WO2005108986A1
(en)
|
2004-05-10 |
2005-11-17 |
Korea Research Institute Of Bioscience And Biotechnology |
A diagnostic method of asthma using baff as a diagnostic marker
|
GB0417487D0
(en)
|
2004-08-05 |
2004-09-08 |
Novartis Ag |
Organic compound
|
JP2008511337A
(ja)
|
2004-09-02 |
2008-04-17 |
ジェネンテック・インコーポレーテッド |
ヘテロ多量体分子
|
ZA200701783B
(en)
|
2004-09-02 |
2009-10-28 |
Genentech Inc |
Anti-Fc-gamma RIIB receptor antibody and uses therefor
|
KR101270829B1
(ko)
|
2004-09-23 |
2013-06-07 |
제넨테크, 인크. |
시스테인 유전자조작 항체 및 접합체
|
CA2587617C
(en)
|
2004-11-12 |
2011-02-01 |
Xencor, Inc. |
Fc variants with altered binding to fcrn
|
US8367805B2
(en)
|
2004-11-12 |
2013-02-05 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
AU2005318086B2
(en)
|
2004-12-23 |
2011-07-07 |
Merck Serono Sa |
BCMA polypeptides and uses thereof
|
PL3520815T3
(pl)
|
2005-02-08 |
2022-04-11 |
Genzyme Corporation |
Przeciwciała przeciwko TGFBETA
|
JP5620626B2
(ja)
|
2005-03-31 |
2014-11-05 |
中外製薬株式会社 |
会合制御によるポリペプチド製造方法
|
SI2161336T1
(sl)
|
2005-05-09 |
2013-11-29 |
Ono Pharmaceutical Co., Ltd. |
Humana monoklonska protitelesa za programirano smrt 1 (PD-1) in postopki za zdravljenje raka ob uporabi anti-PD-1 protiteles samih ali v kombinaciji z drugimi imunoterapevtiki
|
BRPI0613361A2
(pt)
|
2005-07-01 |
2011-01-04 |
Medarex Inc |
anticorpo monoclonal humano isolado, composição, imunoconjugado, molécula biespecìfica, molécula de ácido nucleico isolada, vetor de expressão, célula hospedeira, camundongo transgênico, método para modular uma resposta imune num indivìduo, método para inibir crescimento de células tumorais num indivìduo, método para tratar uma doença infecciosa num indivìduo, método para aumentar uma resposta imune a um antìgeno num indivìduo, método para tratar ou prevenir uma doença inflamatória num indivìduo e método para preparar o anticorpo anti-pd-l1
|
CN101213474B
(zh)
|
2005-07-04 |
2012-06-13 |
株式会社尼康美景 |
距离测量设备
|
AU2006269940C1
(en)
|
2005-07-18 |
2013-11-07 |
Seagen Inc. |
Beta-glucuronide-linker drug conjugates
|
AU2006299429B2
(en)
|
2005-10-03 |
2012-02-23 |
Xencor, Inc. |
Fc variants with optimized Fc receptor binding properties
|
EP3770174A1
(en)
|
2005-10-11 |
2021-01-27 |
Amgen Research (Munich) GmbH |
Compositions comprising cross-species-specific antibodies and uses thereof
|
JP6088723B2
(ja)
|
2005-11-23 |
2017-03-01 |
ジェネンテック, インコーポレイテッド |
B細胞アッセイに関する組成物及び方法。
|
HUE039353T2
(hu)
|
2005-12-13 |
2018-12-28 |
Lilly Co Eli |
Anti-IL-17 ellenanyagok
|
CA2636111C
(en)
|
2006-01-13 |
2018-04-03 |
The Government Of The United States, As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health |
Codon optimized il-15 and il-15r-alpha genes for expression in mammalian cells
|
EP1994000B1
(en)
|
2006-02-02 |
2017-08-23 |
Syntarga B.V. |
Water-soluble cc-1065 analogs and their conjugates
|
AU2007217965A1
(en)
|
2006-02-17 |
2007-08-30 |
Wyeth |
Methods for preparing sulfonamide substituted alcohols and intermediates thereof
|
WO2007129457A1
(ja)
|
2006-04-25 |
2007-11-15 |
The University Of Tokyo |
アルツハイマー病および癌の治療薬
|
KR101571027B1
(ko)
|
2006-06-12 |
2015-11-23 |
이머전트 프로덕트 디벨롭먼트 시애틀, 엘엘씨 |
효과기 기능을 갖는 단일쇄 다가 결합 단백질
|
EP2032159B1
(en)
|
2006-06-26 |
2015-01-07 |
MacroGenics, Inc. |
Combination of fcgammariib antibodies and cd20-specific antibodies and methods of use thereof
|
US7833527B2
(en)
|
2006-10-02 |
2010-11-16 |
Amgen Inc. |
Methods of treating psoriasis using IL-17 Receptor A antibodies
|
ES2523915T5
(es)
|
2006-12-01 |
2022-05-26 |
Seagen Inc |
Agentes de unión a la diana variantes y usos de los mismos
|
CN104497143B
(zh)
|
2007-03-29 |
2020-08-25 |
健玛保 |
双特异性抗体及其制造方法
|
SI2155783T1
(sl)
|
2007-04-03 |
2013-10-30 |
Amgen Research (Munich) Gmbh |
Medvrstno specifiäśna cd3-epsilon vezavna domena
|
HUE040467T2
(hu)
|
2007-04-03 |
2019-03-28 |
Amgen Res Munich Gmbh |
Keresztfaj-specifikus kötõdomén
|
MX2009010611A
(es)
|
2007-04-03 |
2010-03-26 |
Micromet Ag |
Enlazadores biespecificos, especificos para especies.
|
EP1987839A1
(en)
|
2007-04-30 |
2008-11-05 |
I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale |
Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
|
US9244059B2
(en)
|
2007-04-30 |
2016-01-26 |
Immutep Parc Club Orsay |
Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
|
PT2160401E
(pt)
|
2007-05-11 |
2014-10-30 |
Altor Bioscience Corp |
Moléculas de fusão e variantes de il-15
|
EP2535354B1
(en)
|
2007-06-18 |
2017-01-11 |
Merck Sharp & Dohme B.V. |
Antibodies to human programmed death receptor pd-1
|
CN101821241A
(zh)
|
2007-08-07 |
2010-09-01 |
先灵公司 |
γ-分泌酶调节剂
|
EA017286B1
(ru)
|
2007-08-14 |
2012-11-30 |
Эли Лилли Энд Компани |
Ингибиторы гамма-секретазы
|
EP2044949A1
(en)
|
2007-10-05 |
2009-04-08 |
Immutep |
Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
|
US8592498B2
(en)
|
2007-10-22 |
2013-11-26 |
M. Technique Co., Ltd. |
Method for producing organic compound and organic compound obtained by the method
|
US8084477B2
(en)
|
2007-10-31 |
2011-12-27 |
Bristol-Myers Squibb Company |
Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production
|
MX2010005857A
(es)
|
2007-11-28 |
2010-11-22 |
Mersana Therapeutics Inc |
Conjugados de analogos de fumagillina biodegradables biocompatibles.
|
US9266967B2
(en)
|
2007-12-21 |
2016-02-23 |
Hoffmann-La Roche, Inc. |
Bivalent, bispecific antibodies
|
US8802089B2
(en)
|
2008-01-03 |
2014-08-12 |
Genmab A/S |
Monoclonal antibodies against CD32B
|
PL2235064T3
(pl)
|
2008-01-07 |
2016-06-30 |
Amgen Inc |
Sposób otrzymywania cząsteczek przeciwciał z heterodimerycznymi fc z zastosowaniem kierujących efektów elektrostatycznych
|
US8168757B2
(en)
|
2008-03-12 |
2012-05-01 |
Merck Sharp & Dohme Corp. |
PD-1 binding proteins
|
AU2009239437B2
(en)
|
2008-04-25 |
2014-11-13 |
University Of Washington |
Levels of BCMA protein expression on B cells and use in diagnostic methods
|
GB0906579D0
(en)
|
2009-04-16 |
2009-05-20 |
Vernalis R&D Ltd |
Pharmaceuticals, compositions and methods of making and using the same
|
AR072999A1
(es)
|
2008-08-11 |
2010-10-06 |
Medarex Inc |
Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
|
US20110223188A1
(en)
|
2008-08-25 |
2011-09-15 |
Solomon Langermann |
Targeted costimulatory polypeptides and methods of use to treat cancer
|
ES2545609T3
(es)
|
2008-08-25 |
2015-09-14 |
Amplimmune, Inc. |
Composiciones de antagonistas de PD-1 y métodos de uso
|
WO2010027797A1
(en)
|
2008-08-26 |
2010-03-11 |
Macrogenics Inc. |
T-cell receptor antibodies and methods of use thereof
|
US8927697B2
(en)
|
2008-09-12 |
2015-01-06 |
Isis Innovation Limited |
PD-1 specific antibodies and uses thereof
|
AU2009296392B2
(en)
|
2008-09-26 |
2016-06-02 |
Dana-Farber Cancer Institute, Inc. |
Human anti-PD-1, PD-L1, and PD-L2 antibodies and uses therefor
|
WO2010037838A2
(en)
|
2008-10-01 |
2010-04-08 |
Micromet Ag |
Cross-species-specific single domain bispecific single chain antibody
|
US20120034228A1
(en)
|
2008-10-01 |
2012-02-09 |
Micromet Ag |
CROSS-SPECIES-SPECIFIC PSCAxCD3, CD19xCD3, C-METxCD3, ENDOSIALINxCD3, EPCAMxCD3, IGF-1RxCD3 OR FAPALPHAxCD3 BISPECIFIC SINGLE CHAIN ANTIBODY
|
CA2738566C
(en)
|
2008-10-01 |
2024-04-30 |
Micromet Ag |
Bispecific single chain antibodies with specificity for high molecular weight target antigens
|
PL2356153T3
(pl)
|
2008-10-01 |
2016-11-30 |
|
Swoiste międzygatunkowo dwuswoiste przeciwciało jednołańcuchowe PSMAXCD3
|
US8340621B1
(en)
|
2008-11-19 |
2012-12-25 |
Qualcomm Incorporated |
Wireless device using a shared gain stage for simultaneous reception of multiple protocols
|
KR20210060670A
(ko)
|
2008-12-09 |
2021-05-26 |
제넨테크, 인크. |
항-pd-l1 항체 및 t 세포 기능을 향상시키기 위한 그의 용도
|
US20100152725A1
(en)
|
2008-12-12 |
2010-06-17 |
Angiodynamics, Inc. |
Method and system for tissue treatment utilizing irreversible electroporation and thermal track coagulation
|
EP2210891A1
(en)
|
2009-01-26 |
2010-07-28 |
Domain Therapeutics |
New adenosine receptor ligands and uses thereof
|
JP6061469B2
(ja)
|
2009-03-10 |
2017-01-25 |
バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. |
抗bcma抗体
|
PL2408775T3
(pl)
|
2009-03-20 |
2015-10-30 |
Alfasigma Spa |
Utlenione pochodne triazolilopurynowe użyteczne jako ligandy receptora adenozynowego a2a i ich zastosowanie jako leków
|
CN102448469A
(zh)
|
2009-05-28 |
2012-05-09 |
摩萨纳医疗有限公司 |
包括具有可变的释放速率的连接物的聚缩醛(酮)-药物共轭物
|
JP5918129B2
(ja)
|
2009-06-22 |
2016-05-18 |
メディミューン,エルエルシー |
部位特異的共役のための操作されたFc領域
|
US9493578B2
(en)
|
2009-09-02 |
2016-11-15 |
Xencor, Inc. |
Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
|
IT1395574B1
(it)
|
2009-09-14 |
2012-10-16 |
Guala Dispensing Spa |
Dispositivo di erogazione
|
US20130017199A1
(en)
|
2009-11-24 |
2013-01-17 |
AMPLIMMUNE ,Inc. a corporation |
Simultaneous inhibition of pd-l1/pd-l2
|
BR122021025338B1
(pt)
|
2009-11-24 |
2023-03-14 |
Medimmune Limited |
Anticorpo isolado ou fragmento de ligação do mesmo contra b7-h1, composição farmacêutica e seus usos
|
DK2519543T3
(en)
|
2009-12-29 |
2016-09-26 |
Emergent Product Dev Seattle |
HETERODIMER BINDING PROTEINS AND USE THEREOF
|
JP5914361B2
(ja)
|
2010-02-05 |
2016-05-11 |
ヘプタレス セラピューティックス リミテッド |
1,2,4−トリアジン−4−アミン含有誘導体
|
US8993731B2
(en)
|
2010-03-11 |
2015-03-31 |
Ucb Biopharma Sprl |
PD-1 antibody
|
JP2013528665A
(ja)
|
2010-03-26 |
2013-07-11 |
メルサナ セラピューティックス, インコーポレイテッド |
ポリヌクレオチドの送達のための修飾ポリマー、その製造方法、およびその使用方法
|
ES2365960B1
(es)
|
2010-03-31 |
2012-06-04 |
Palobiofarma, S.L |
Nuevos antagonistas de los receptores de adenosina.
|
US20130079280A1
(en)
|
2010-04-13 |
2013-03-28 |
Medlmmune, Llc |
Fibronectin type iii domain-based multimeric scaffolds
|
WO2011131746A2
(en)
|
2010-04-20 |
2011-10-27 |
Genmab A/S |
Heterodimeric antibody fc-containing proteins and methods for production thereof
|
PL2581113T3
(pl)
|
2010-06-11 |
2018-11-30 |
Kyowa Hakko Kirin Co., Ltd. |
Przeciwciało anty-tim-3
|
US9163087B2
(en)
|
2010-06-18 |
2015-10-20 |
The Brigham And Women's Hospital, Inc. |
Bi-specific antibodies against TIM-3 and PD-1 for immunotherapy in chronic immune conditions
|
US8907053B2
(en)
|
2010-06-25 |
2014-12-09 |
Aurigene Discovery Technologies Limited |
Immunosuppression modulating compounds
|
GB201013989D0
(en)
|
2010-08-20 |
2010-10-06 |
Univ Southampton |
Biological materials and methods of using the same
|
EP2448371A1
(de)
|
2010-10-26 |
2012-05-02 |
Belux IP AG |
Verfahren und Schaltungsanordnung zum Betreiben eines LED-Moduls für Beleuchtungszwecke
|
EP2635607B1
(en)
|
2010-11-05 |
2019-09-04 |
Zymeworks Inc. |
Stable heterodimeric antibody design with mutations in the fc domain
|
EP3305798A1
(en)
|
2010-12-09 |
2018-04-11 |
The Trustees of The University of Pennsylvania |
Use of chimeric antigen receptor-modified t cells to treat cancer
|
US20120213768A1
(en)
|
2011-02-19 |
2012-08-23 |
Baylor Research Institute |
Diagnostic and Therapeutic Uses for B Cell Maturation Antigen
|
CA2830254C
(en)
|
2011-03-16 |
2019-09-10 |
Amgen Inc. |
Fc variants
|
TWI530489B
(zh)
|
2011-03-22 |
2016-04-21 |
必治妥美雅史谷比公司 |
雙(氟烷基)-1,4-苯二氮呯酮化合物
|
KR101970025B1
(ko)
|
2011-04-20 |
2019-04-17 |
메디뮨 엘엘씨 |
B7-h1 및 pd-1과 결합하는 항체 및 다른 분자들
|
US20130101599A1
(en)
|
2011-04-21 |
2013-04-25 |
Boehringer Ingelheim International Gmbh |
Bcma-based stratification and therapy for multiple myeloma patients
|
HUE063461T2
(hu)
|
2011-05-27 |
2024-01-28 |
Glaxo Group Ltd |
BCMA (CD269/TNFRSF17)-kötõ fehérjék
|
UA112434C2
(uk)
*
|
2011-05-27 |
2016-09-12 |
Ґлаксо Ґруп Лімітед |
Антигензв'язувальний білок, який специфічно зв'язується з всма
|
ES2894398T3
(es)
|
2011-06-03 |
2022-02-14 |
Xoma Technology Ltd |
Anticuerpos específicos para TGF-beta
|
EP2537933A1
(en)
|
2011-06-24 |
2012-12-26 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
An IL-15 and IL-15Ralpha sushi domain based immunocytokines
|
WO2013006490A2
(en)
|
2011-07-01 |
2013-01-10 |
Cellerant Therapeutics, Inc. |
Antibodies that specifically bind to tim3
|
BR112013032552A2
(pt)
|
2011-07-24 |
2017-12-12 |
Curetech Ltd |
variantes de anticorpos monoclonais humanizados imunomoduladores
|
EP2753623A4
(en)
|
2011-09-09 |
2015-01-28 |
Merck Sharp & Dohme |
GAMMA SECRETASE INHIBITORS
|
SI2771364T1
(sl)
|
2011-10-27 |
2019-10-30 |
Genmab As |
Produkcija heterodimernih proteinov
|
US9096582B2
(en)
|
2011-10-31 |
2015-08-04 |
Merck Sharp & Dohme Corp |
Gamma secretase modulators
|
TWI679212B
(zh)
|
2011-11-15 |
2019-12-11 |
美商安進股份有限公司 |
針對bcma之e3以及cd3的結合分子
|
HUE051954T2
(hu)
|
2011-11-28 |
2021-03-29 |
Merck Patent Gmbh |
ANTI-PD-L1 ellenanyagok és alkalmazásaik
|
IN2014CN04961A
(es)
|
2011-12-05 |
2015-09-18 |
Igenica Biotherapeutics Inc |
|
CN104024236A
(zh)
|
2011-12-23 |
2014-09-03 |
摩萨那医疗公司 |
烟曲霉素衍生物-phf结合物的药物配制品
|
SG11201406414WA
(en)
|
2012-04-11 |
2014-11-27 |
Us Health |
Chimeric antigen receptors targeting b-cell maturation antigen
|
US9504756B2
(en)
|
2012-05-15 |
2016-11-29 |
Seattle Genetics, Inc. |
Self-stabilizing linker conjugates
|
WO2013181634A2
(en)
|
2012-05-31 |
2013-12-05 |
Sorrento Therapeutics Inc. |
Antigen binding proteins that bind pd-l1
|
JP6321633B2
(ja)
|
2012-06-04 |
2018-05-09 |
ノバルティス アーゲー |
部位特異的標識法およびそれによって生成される分子
|
JO3300B1
(ar)
|
2012-06-06 |
2018-09-16 |
Novartis Ag |
مركبات وتركيبات لتعديل نشاط egfr
|
UY34887A
(es)
|
2012-07-02 |
2013-12-31 |
Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware |
Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos
|
US20140017265A1
(en)
|
2012-07-05 |
2014-01-16 |
Mersana Therapeutics, Inc. |
Terminally Modified Polymers and Conjugates Thereof
|
WO2014022758A1
(en)
|
2012-08-03 |
2014-02-06 |
Dana-Farber Cancer Institute, Inc. |
Single agent anti-pd-l1 and pd-l2 dual binding antibodies and methods of use
|
KR101947702B1
(ko)
|
2012-10-04 |
2019-02-14 |
다나-파버 캔서 인스티튜트 인크. |
인간 단클론 항-pd-l1 항체 및 사용 방법
|
NZ630790A
(en)
|
2012-10-24 |
2016-11-25 |
Admune Therapeutics Llc |
Il-15r alpha forms, cells expressing il-15r alpha forms, and therapeutic uses of il-15r alpha and il-15/il-15r alpha complexes
|
EP3508503B1
(en)
|
2012-11-01 |
2022-11-02 |
Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft |
Antibody against cd269 (bcma)
|
KR102545617B1
(ko)
|
2012-11-28 |
2023-06-20 |
자임워크스 비씨 인코포레이티드 |
가공된 면역글로불린 중쇄-경쇄 쌍 및 이들의 용도
|
WO2014085211A2
(en)
|
2012-11-29 |
2014-06-05 |
Merck Sharp & Dohme Corp. |
Spirocyclic sulfones as gamma secretase inhibitors
|
TW201425336A
(zh)
|
2012-12-07 |
2014-07-01 |
Amgen Inc |
Bcma抗原結合蛋白質
|
US10226535B2
(en)
|
2012-12-10 |
2019-03-12 |
Mersana Therapeutics, Inc. |
Auristatin compounds and conjugates thereof
|
CA2892863C
(en)
|
2012-12-10 |
2022-03-15 |
Mersana Therapeutics, Inc. |
Polymeric scaffold based on phf for targeted drug delivery
|
EP2931316B1
(en)
|
2012-12-12 |
2019-02-20 |
Mersana Therapeutics, Inc. |
Hydroxyl-polymer-drug-protein conjugates
|
AR093984A1
(es)
|
2012-12-21 |
2015-07-01 |
Merck Sharp & Dohme |
Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano
|
AU2014205086B2
(en)
*
|
2013-01-14 |
2019-04-18 |
Xencor, Inc. |
Novel heterodimeric proteins
|
EP2762497A1
(en)
|
2013-02-05 |
2014-08-06 |
EngMab AG |
Bispecific antibodies against CD3epsilon and BCMA
|
US9963513B2
(en)
*
|
2013-02-05 |
2018-05-08 |
Engmab Sàrl |
Method for the selection of antibodies against BCMA
|
PL2953969T3
(pl)
|
2013-02-08 |
2020-02-28 |
Novartis Ag |
Przeciwciała anty-il-17a i ich zastosowanie w leczeniu zaburzeń autoimmunologicznych i zapalnych
|
CN115925957A
(zh)
|
2013-02-08 |
2023-04-07 |
Irm责任有限公司 |
用于修饰抗体以制备免疫缀合物的特定位点
|
CA2900529A1
(en)
|
2013-02-08 |
2014-08-14 |
Institute For Myeloma & Bone Cancer Research |
Improved diagnostic, prognostic, and monitoring methods for multiple myeloma, chronic lymphocytic leukemia, and b-cell non-hodgkin lymphoma
|
WO2014124258A2
(en)
|
2013-02-08 |
2014-08-14 |
Irm Llc |
Specific sites for modifying antibodies to make immunoconjugates
|
EP2968296B1
(en)
|
2013-03-12 |
2020-09-02 |
The Regents of the University of California |
Gamma-secretase modulators
|
US9090697B2
(en)
|
2013-03-15 |
2015-07-28 |
Bayer Healthcare Llc |
Methods for treating bleeding disorders
|
AR095374A1
(es)
|
2013-03-15 |
2015-10-14 |
Amgen Res (Munich) Gmbh |
Moléculas de unión para bcma y cd3
|
EP2970435B1
(en)
|
2013-03-15 |
2020-08-12 |
Eli Lilly and Company |
Methods for producing fabs and bi-specific antibodies
|
CA2902831C
(en)
|
2013-03-15 |
2023-04-25 |
Glaxosmithkline Intellectual Property Development Limited |
Anti-lag-3 binding proteins
|
EP2951203B1
(en)
|
2013-03-15 |
2019-05-22 |
Xencor, Inc. |
Heterodimeric proteins
|
UY35468A
(es)
|
2013-03-16 |
2014-10-31 |
Novartis Ag |
Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19
|
DK2992017T3
(da)
|
2013-05-02 |
2021-01-25 |
Anaptysbio Inc |
Antistoffer rettet mod programmeret død-1 (pd-1)
|
CN111423511B
(zh)
|
2013-05-31 |
2024-02-23 |
索伦托药业有限公司 |
与pd-1结合的抗原结合蛋白
|
WO2014209804A1
(en)
|
2013-06-24 |
2014-12-31 |
Biomed Valley Discoveries, Inc. |
Bispecific antibodies
|
AR096687A1
(es)
|
2013-06-24 |
2016-01-27 |
Genentech Inc |
Anticuerpos anti-fcrh5
|
FR3008408B1
(fr)
|
2013-07-11 |
2018-03-09 |
Mc Saf |
Nouveaux conjugues anticorps-medicament et leur utilisation en therapie
|
KR102236367B1
(ko)
|
2013-07-26 |
2021-04-05 |
삼성전자주식회사 |
DARPin을 포함하는 이중 특이 키메라 단백질
|
CN107011441B
(zh)
|
2013-09-13 |
2020-12-01 |
百济神州(广州)生物科技有限公司 |
抗pd1抗体及其作为治疗剂与诊断剂的用途
|
GB201317929D0
(en)
|
2013-10-10 |
2013-11-27 |
Ucl Business Plc |
Chimeric antigen receptor
|
EP3060581A4
(en)
|
2013-10-25 |
2017-06-07 |
Dana-Farber Cancer Institute, Inc. |
Anti-pd-l1 monoclonal antibodies and fragments thereof
|
WO2015081158A1
(en)
|
2013-11-26 |
2015-06-04 |
Bristol-Myers Squibb Company |
Method of treating hiv by disrupting pd-1/pd-l1 signaling
|
PT3081576T
(pt)
|
2013-12-12 |
2019-10-15 |
Jiangsu Hengrui Medicine Co |
Anticorpo pd-1, fragmento de ligação ao antigénio do mesmo e aplicação médica do mesmo
|
CN113603788A
(zh)
|
2014-01-15 |
2021-11-05 |
卡德门企业有限公司 |
免疫调节剂
|
CA2936244A1
(en)
|
2014-01-21 |
2015-07-30 |
Medimmune, Llc |
Compositions and methods for modulating and redirecting immune responses
|
TWI681969B
(zh)
|
2014-01-23 |
2020-01-11 |
美商再生元醫藥公司 |
針對pd-1的人類抗體
|
TWI680138B
(zh)
|
2014-01-23 |
2019-12-21 |
美商再生元醫藥公司 |
抗pd-l1之人類抗體
|
JOP20200094A1
(ar)
|
2014-01-24 |
2017-06-16 |
Dana Farber Cancer Inst Inc |
جزيئات جسم مضاد لـ pd-1 واستخداماتها
|
DK3556775T3
(da)
|
2014-01-28 |
2022-01-03 |
Bristol Myers Squibb Co |
Anti-lag-3 antistoffer til behandling af hæmatologiske maligniteter
|
JOP20200096A1
(ar)
|
2014-01-31 |
2017-06-16 |
Children’S Medical Center Corp |
جزيئات جسم مضاد لـ tim-3 واستخداماتها
|
JP2017509337A
(ja)
|
2014-03-12 |
2017-04-06 |
ノバルティス アーゲー |
イムノコンジュゲートを作製する抗体を修飾するための特定部位
|
CR20160425A
(es)
|
2014-03-14 |
2017-05-26 |
Novartis Ag |
Moléculas de anticuerpos que se unen a lag-3 y usos de las mismas
|
NZ725701A
(en)
|
2014-04-30 |
2023-09-29 |
Max Delbrueck Centrum Fuer Molekulare Medizin Helmholtz Gemeinschaft |
Humanized antibodies against cd269 (bcma)
|
CA2947932C
(en)
|
2014-05-29 |
2021-03-30 |
Spring Bioscience Corporation |
Pd-l1 antibodies and uses thereof
|
US10941182B2
(en)
|
2014-06-10 |
2021-03-09 |
Amgen Inc. |
Apelin polypeptides
|
WO2015195163A1
(en)
|
2014-06-20 |
2015-12-23 |
R-Pharm Overseas, Inc. |
Pd-l1 antagonist fully human antibody
|
US10588980B2
(en)
|
2014-06-23 |
2020-03-17 |
Novartis Ag |
Fatty acids and their use in conjugation to biomolecules
|
TWI693232B
(zh)
|
2014-06-26 |
2020-05-11 |
美商宏觀基因股份有限公司 |
與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法
|
KR102003754B1
(ko)
|
2014-07-03 |
2019-07-25 |
베이진 엘티디 |
Pd-l1 항체와 이를 이용한 치료 및 진단
|
KR102612313B1
(ko)
|
2014-07-21 |
2023-12-12 |
노파르티스 아게 |
인간화 항-bcma 키메라 항원 수용체를 사용한 암의 치료
|
KR102523934B1
(ko)
|
2014-07-24 |
2023-04-20 |
2세븐티 바이오, 인코포레이티드 |
Bcma 키메릭 항원 수용체
|
EP2982692A1
(en)
|
2014-08-04 |
2016-02-10 |
EngMab AG |
Bispecific antibodies against CD3epsilon and BCMA
|
KR102377818B1
(ko)
|
2014-08-05 |
2022-03-24 |
바스프 에스이 |
안정화제로서의 3-페닐-벤조푸란-2-온 디포스파이트 유도체
|
JO3663B1
(ar)
|
2014-08-19 |
2020-08-27 |
Merck Sharp & Dohme |
الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
|
CN106852149B
(zh)
|
2014-10-10 |
2021-08-27 |
依奈特制药公司 |
Cd73阻断
|
ES2952717T3
(es)
|
2014-10-14 |
2023-11-03 |
Novartis Ag |
Moléculas de anticuerpos contra PD-L1 y usos de las mismas
|
MX2017005920A
(es)
|
2014-11-06 |
2017-06-27 |
Hoffmann La Roche |
Anticuerpos anti-tim3 y metodos de uso.
|
BR112017009398A2
(pt)
|
2014-11-10 |
2018-05-15 |
Medimmune Ltd |
moléculas de ligação específicas para cd73 e seus usos
|
GB2538120A
(en)
|
2014-11-11 |
2016-11-09 |
Medimmune Ltd |
Therapeutic combinations comprising anti-CD73 antibodies and uses thereof
|
EP3023437A1
(en)
|
2014-11-20 |
2016-05-25 |
EngMab AG |
Bispecific antibodies against CD3epsilon and BCMA
|
TWI758928B
(zh)
|
2014-11-21 |
2022-03-21 |
美商必治妥美雅史谷比公司 |
抗cd73抗體及其用途
|
WO2016086186A2
(en)
|
2014-11-26 |
2016-06-02 |
Xencor, Inc. |
Heterodimeric antibodies including binding to cd8
|
PE20171324A1
(es)
|
2014-11-26 |
2017-09-11 |
Xencor Inc |
Anticuerpos heterodimericos que se unen a cd3 y a antigenos tumorales
|
US10259887B2
(en)
|
2014-11-26 |
2019-04-16 |
Xencor, Inc. |
Heterodimeric antibodies that bind CD3 and tumor antigens
|
MX2017006918A
(es)
|
2014-11-26 |
2018-01-25 |
Xencor Inc |
Anticuerpos heterodimericos que se unen a cd3 y cd38.
|
EP3029068A1
(en)
|
2014-12-03 |
2016-06-08 |
EngMab AG |
Bispecific antibodies against CD3epsilon and BCMA for use in the treatment of diseases
|
KR20170108944A
(ko)
|
2014-12-05 |
2017-09-27 |
메모리얼 슬로안-케터링 캔서 센터 |
B-세포 성숙화 항원을 표적화하는 항체 및 사용 방법
|
KR20170108946A
(ko)
|
2014-12-05 |
2017-09-27 |
메모리얼 슬로안-케터링 캔서 센터 |
Fc 수용체-유사 5를 표적화하는 키메라 항원 수용체 및 그의 용도
|
TWI595006B
(zh)
|
2014-12-09 |
2017-08-11 |
禮納特神經系統科學公司 |
抗pd-1抗體類和使用彼等之方法
|
EP3230321B1
(en)
|
2014-12-12 |
2019-08-28 |
Bluebird Bio, Inc. |
Bcma chimeric antigen receptors
|
WO2016105450A2
(en)
|
2014-12-22 |
2016-06-30 |
Xencor, Inc. |
Trispecific antibodies
|
US20160200815A1
(en)
|
2015-01-05 |
2016-07-14 |
Jounce Therapeutics, Inc. |
Antibodies that inhibit tim-3:lilrb2 interactions and uses thereof
|
WO2016130598A1
(en)
|
2015-02-09 |
2016-08-18 |
University Of Florida Research Foundation, Inc. |
Bi-specific chimeric antigen receptor and uses thereof
|
WO2016141378A1
(en)
|
2015-03-05 |
2016-09-09 |
Think Surgical, Inc. |
Methods for locating and tracking a tool axis
|
CA2978892A1
(en)
|
2015-03-06 |
2016-09-15 |
Sorrento Therapeutics, Inc. |
Antibody therapeutics that bind tim3
|
US10428149B2
(en)
|
2015-03-18 |
2019-10-01 |
Universitat Stuttgart |
Single-chain tumor necrosis factor (TNF) ligand family molecules, fusion proteins and derivatives thereof
|
MA41867A
(fr)
|
2015-04-01 |
2018-02-06 |
Anaptysbio Inc |
Anticorps dirigés contre l'immunoglobuline de cellule t et protéine 3 de mucine (tim-3)
|
KR20170134642A
(ko)
|
2015-04-08 |
2017-12-06 |
노파르티스 아게 |
Cd20 요법, cd22 요법, 및 cd19 키메라 항원 수용체 (car) - 발현 세포와의 조합 요법
|
EP3283106B1
(en)
|
2015-04-13 |
2021-12-22 |
Pfizer Inc. |
Therapeutic antibodies and their uses
|
CN107980046B
(zh)
|
2015-04-13 |
2021-12-24 |
辉瑞公司 |
靶向b细胞成熟抗原的嵌合抗原受体
|
CR20170511A
(es)
|
2015-05-08 |
2018-01-22 |
Xencor Inc |
Anticuerpos heterodiméricos que se unen a cd3 y a antígenos tumorales.
|
AU2016280102B2
(en)
|
2015-06-16 |
2022-06-16 |
Genentech, Inc. |
Humanized and affinity matured antibodies to FcRH5 and methods of use
|
WO2017013136A1
(en)
|
2015-07-20 |
2017-01-26 |
Scil Proteins Gmbh |
Novel binding proteins based on di-ubiquitin muteins and methods for generation
|
MX2018000999A
(es)
|
2015-07-24 |
2018-11-09 |
Oncotracker Inc |
Moduladores de gamma secretasa para el tratamiento de disfuncion del sistema inmunologico.
|
EP3670535A1
(en)
|
2015-08-03 |
2020-06-24 |
EngMab Sàrl |
Monoclonal antibodies against bcma
|
BR112018002585A2
(pt)
|
2015-08-11 |
2018-10-16 |
Novartis Ag |
5-bromo-2,6-di-(1h-pirazol-1-il)pirimidin-4-amina para uso no tratamento de câncer
|
IL298041A
(en)
*
|
2015-08-17 |
2023-01-01 |
Janssen Pharmaceutica Nv |
Anti-bcma antibodies, bispecific antigen-binding molecules that bind bcma and cd3 and their uses
|
EP3150636A1
(en)
|
2015-10-02 |
2017-04-05 |
F. Hoffmann-La Roche AG |
Tetravalent multispecific antibodies
|
BR112018011336A2
(pt)
|
2015-12-04 |
2018-12-04 |
Memorial Sloan-Kettering Cancer Center |
anticorpo anti-fcrl5 isolado ou um fragmento de ligação ao antígeno do mesmo, anticorpo scfv anti-fcrl5 isolado, anticorpo isolado ou porção de ligação ao antígeno do mesmo, composição, imunoconjugado, molécula biespecífica, ácido nucleico isolado, vetor de expressão, célula hospedeira, método para detectar fcrl5 em uma célula ou tecido inteiro, método para tratar câncer em um indivíduo, uso do anticorpo ou fragmento de ligação ao antígeno do mesmo, kit para tratar câncer
|
WO2017103895A1
(en)
|
2015-12-18 |
2017-06-22 |
Novartis Ag |
Antibodies targeting cd32b and methods of use thereof
|
CN109562162A
(zh)
|
2016-01-13 |
2019-04-02 |
指南针制药有限责任公司 |
多特异性免疫调节性抗原结合构建体
|
JOP20170017B1
(ar)
|
2016-01-25 |
2021-08-17 |
Amgen Res Munich Gmbh |
تركيب صيدلي يتضمن تركيبات جسم مضاد ثنائي الاختصاص
|
MA43955B1
(fr)
|
2016-02-03 |
2022-02-28 |
Amgen Inc |
Anticorps anti-bcma et anti-cd3 bispécifiques de format bite
|
US11596699B2
(en)
|
2016-04-29 |
2023-03-07 |
CureVac SE |
RNA encoding an antibody
|
RU2767357C2
(ru)
*
|
2016-06-14 |
2022-03-17 |
Ксенкор, Инк. |
Биспецифические антитела-ингибиторы контрольных точек
|
KR20190053835A
(ko)
|
2016-06-21 |
2019-05-20 |
테네오바이오, 인코포레이티드 |
Cd3 결합 항체
|
CN110167964B
(zh)
|
2016-11-02 |
2023-12-01 |
百时美施贵宝公司 |
组合用于治疗多发性骨髓瘤的针对bcma和cd3的双特异性抗体和免疫药物
|
IL267485B2
(en)
|
2016-12-21 |
2024-01-01 |
Teneobio Inc |
Antibodies against BCMA containing only heavy chains and their uses
|
BR112019014986A8
(pt)
|
2017-01-23 |
2022-10-18 |
Carsgen Therapeutics Co Ltd |
Anticorpo que alveja bcma e uso do mesmo
|
ES2949364T3
(es)
|
2017-02-17 |
2023-09-28 |
Fred Hutchinson Cancer Center |
Terapias de combinación para el tratamiento de cánceres y trastornos autoinmunitarios relacionados con BCMA
|
EP3615068A1
(en)
|
2017-04-28 |
2020-03-04 |
Novartis AG |
Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor
|
SG11201909547TA
(en)
|
2017-05-05 |
2019-11-28 |
Amgen Inc |
Pharmaceutical composition comprising bispecific antibody constructs for improved storage and administration
|
BR112019026907A2
(pt)
|
2017-06-20 |
2020-06-30 |
Teneobio, Inc. |
Anticorpos apenas de cadeia pesadaanti-bcma, polinucleotídeo, vetor, célula,composição farmacêutica, seus usos e método paraproduzir os mesmos
|
CN117567624A
(zh)
|
2017-06-20 |
2024-02-20 |
特纳奥尼股份有限公司 |
仅有重链的抗bcma抗体
|
WO2019000223A1
(en)
|
2017-06-27 |
2019-01-03 |
Nanjing Legend Biotech Co., Ltd. |
ENABLERS OF IMMUNE EFFECTOR CELLS OF CHIMERIC ANTIBODIES AND METHODS OF USE THEREOF
|
WO2019035938A1
(en)
|
2017-08-16 |
2019-02-21 |
Elstar Therapeutics, Inc. |
MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF
|
AU2018346955A1
(en)
|
2017-10-13 |
2020-04-30 |
Harpoon Therapeutics, Inc. |
B cell maturation antigen binding proteins
|
CN111630070A
(zh)
|
2017-10-13 |
2020-09-04 |
哈普恩治疗公司 |
三特异性蛋白质及使用方法
|
EP3697434A1
(en)
|
2017-10-18 |
2020-08-26 |
Vivia Biotech, S.L. |
Bite-activated car-t cells
|
US11623961B2
(en)
|
2017-11-01 |
2023-04-11 |
Juno Therapeutics, Inc. |
Antibodies and chimeric antigen receptors specific for B-cell maturation antigen
|