MA43955B1 - Anticorps anti-bcma et anti-cd3 bispécifiques de format bite - Google Patents
Anticorps anti-bcma et anti-cd3 bispécifiques de format biteInfo
- Publication number
- MA43955B1 MA43955B1 MA43955A MA43955A MA43955B1 MA 43955 B1 MA43955 B1 MA 43955B1 MA 43955 A MA43955 A MA 43955A MA 43955 A MA43955 A MA 43955A MA 43955 B1 MA43955 B1 MA 43955B1
- Authority
- MA
- Morocco
- Prior art keywords
- bcma
- antibodies
- bite
- recombinant antibody
- specific
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
La présente invention concerne des anticorps bi-spécifiques recombinants présentant une modalité fc spécifique, caractérisés par le fait qu'ils comprennent un premier domaine se liant à bcma, un second domaine se liant à un épitope extracellulaire de la chaîne cd3e humaine et/ou du macaque, et un troisième domaine, qui est la modalité fc spécifique. En outre, l'invention concerne un polynucléotide codant pour l'anticorps recombinant, un vecteur comprenant ce polynucléotide, des cellules hôtes exprimant ledit anticorps recombinant, et une composition pharmaceutique contenant ledit anticorps recombinant.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662290831P | 2016-02-03 | 2016-02-03 | |
PCT/EP2017/052202 WO2017134134A1 (fr) | 2016-02-03 | 2017-02-02 | ANTICORPS RECOMBINANTS BISPÉCIFIQUES BiTE (BISPECIFIC T CELL ENGAGING ANTIBODY) ANTI-BCMA ET ANTI-CD3 |
Publications (2)
Publication Number | Publication Date |
---|---|
MA43955A MA43955A (fr) | 2021-04-28 |
MA43955B1 true MA43955B1 (fr) | 2022-02-28 |
Family
ID=57965930
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA43955A MA43955B1 (fr) | 2016-02-03 | 2017-02-02 | Anticorps anti-bcma et anti-cd3 bispécifiques de format bite |
Country Status (37)
Country | Link |
---|---|
US (2) | US10301391B2 (fr) |
EP (2) | EP4039709A1 (fr) |
JP (2) | JP6959011B2 (fr) |
KR (1) | KR20180103084A (fr) |
CN (2) | CN116063544A (fr) |
AR (1) | AR107521A1 (fr) |
AU (2) | AU2017216230B2 (fr) |
BR (1) | BR112018015715A2 (fr) |
CA (1) | CA3010704A1 (fr) |
CL (1) | CL2018002057A1 (fr) |
CO (1) | CO2018007552A2 (fr) |
CR (1) | CR20180420A (fr) |
CY (1) | CY1125277T1 (fr) |
DK (1) | DK3411402T3 (fr) |
EA (1) | EA039594B1 (fr) |
ES (1) | ES2905361T3 (fr) |
HR (1) | HRP20220081T1 (fr) |
HU (1) | HUE057220T2 (fr) |
JO (1) | JOP20170027B1 (fr) |
LT (1) | LT3411402T (fr) |
MA (1) | MA43955B1 (fr) |
MD (1) | MD3411402T2 (fr) |
MX (1) | MX2018009108A (fr) |
MY (1) | MY190421A (fr) |
PE (1) | PE20181536A1 (fr) |
PH (1) | PH12018501536A1 (fr) |
PL (1) | PL3411402T3 (fr) |
PT (1) | PT3411402T (fr) |
RS (1) | RS62841B1 (fr) |
SG (1) | SG11201805770UA (fr) |
SI (1) | SI3411402T1 (fr) |
TN (1) | TN2018000263A1 (fr) |
TW (1) | TWI748984B (fr) |
UA (1) | UA126657C2 (fr) |
UY (1) | UY37106A (fr) |
WO (1) | WO2017134134A1 (fr) |
ZA (1) | ZA201804450B (fr) |
Families Citing this family (51)
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WO2010037838A2 (fr) | 2008-10-01 | 2010-04-08 | Micromet Ag | Anticorps monocaténaire bispécifique à domaine unique, spécifique d'espèces croisées |
TWI679212B (zh) * | 2011-11-15 | 2019-12-11 | 美商安進股份有限公司 | 針對bcma之e3以及cd3的結合分子 |
JO3519B1 (ar) | 2013-01-25 | 2020-07-05 | Amgen Inc | تركيبات أجسام مضادة لأجل cdh19 و cd3 |
GB201317928D0 (en) * | 2013-10-10 | 2013-11-27 | Ucl Business Plc | Molecule |
TW201609812A (zh) | 2014-07-31 | 2016-03-16 | 安美基研究(慕尼黑)公司 | 最佳化之跨物種特異性雙特異性單鏈抗體構築體 |
TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究(慕尼黑)公司 | Msln及cd3抗體構築體 |
TWI744242B (zh) | 2015-07-31 | 2021-11-01 | 德商安美基研究(慕尼黑)公司 | Egfrviii及cd3抗體構築體 |
TW202346349A (zh) * | 2015-07-31 | 2023-12-01 | 德商安美基研究(慕尼黑)公司 | Dll3及cd3抗體構築體 |
TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究(慕尼黑)公司 | Flt3及cd3抗體構築體 |
TWI717375B (zh) | 2015-07-31 | 2021-02-01 | 德商安美基研究(慕尼黑)公司 | Cd70及cd3抗體構築體 |
US11713358B2 (en) | 2015-08-28 | 2023-08-01 | Amunix Pharmaceuticals, Inc. | Chimeric polypeptide assembly and methods of making and using the same |
DK3411402T3 (da) * | 2016-02-03 | 2022-02-07 | Amgen Res Munich Gmbh | Bcma- og cd3-bispecifikke t-celle-engagerende antistofkonstruktioner |
EA039859B1 (ru) | 2016-02-03 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
EP3411404B1 (fr) | 2016-02-03 | 2022-11-09 | Amgen Research (Munich) GmbH | Constructions d'anticorps impliquant des cellules t bispécifiques psma et cd3 |
WO2017143069A1 (fr) | 2016-02-17 | 2017-08-24 | Seattle Genetics, Inc. | Anticorps bcma et leur utilisation pour traiter le cancer et les troubles immunologiques |
US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
WO2017201488A1 (fr) | 2016-05-20 | 2017-11-23 | Harpoon Therapeutics, Inc. | Protéine de liaison à l'albumine sérique à domaine unique |
JOP20190189A1 (ar) * | 2017-02-02 | 2019-08-01 | Amgen Res Munich Gmbh | تركيبة صيدلانية ذات درجة حموضة منخفضة تتضمن بنيات جسم مضاد يستهدف الخلية t |
US11535668B2 (en) | 2017-02-28 | 2022-12-27 | Harpoon Therapeutics, Inc. | Inducible monovalent antigen binding protein |
CN113896792A (zh) | 2017-05-12 | 2022-01-07 | 哈普恩治疗公司 | 间皮素结合蛋白质 |
CA3063905A1 (fr) | 2017-05-16 | 2018-11-22 | The Johns Hopkins University | Manabodies et procedes d'utilisation |
JP7079171B2 (ja) | 2017-08-03 | 2022-06-01 | アムジエン・インコーポレーテツド | インターロイキン-21ムテイン及び治療方法 |
CA3075046A1 (fr) | 2017-09-08 | 2019-03-14 | Amgen Inc. | Inhibiteurs de kras g12c et leurs procedes d'utilisation |
MX2020003915A (es) | 2017-10-13 | 2020-10-08 | Harpoon Therapeutics Inc | Proteinas trispecificas y metodos de uso. |
MX2020003856A (es) | 2017-10-13 | 2020-08-13 | Harpoon Therapeutics Inc | Proteinas de union a antigenos de maduracion de celulas b. |
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MA53732A (fr) | 2018-09-28 | 2022-01-05 | Amgen Inc | Anticorps dirigés contre bcma soluble |
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DK3411402T3 (da) * | 2016-02-03 | 2022-02-07 | Amgen Res Munich Gmbh | Bcma- og cd3-bispecifikke t-celle-engagerende antistofkonstruktioner |
EP3411404B1 (fr) | 2016-02-03 | 2022-11-09 | Amgen Research (Munich) GmbH | Constructions d'anticorps impliquant des cellules t bispécifiques psma et cd3 |
EP3535295A1 (fr) | 2016-11-02 | 2019-09-11 | EngMab Sàrl | Anticorps bispécifique contre bcma et cd3 et médicament immunologique pour une utilisation combinée dans le traitement du myélome multiple |
KR20190141243A (ko) | 2017-05-05 | 2019-12-23 | 암젠 인크 | 개선된 저장 및 투여를 위한 이중특이적 항체 구축물을 포함하는 약제학적 조성물 |
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2017
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- 2017-02-02 EP EP21214955.3A patent/EP4039709A1/fr active Pending
- 2017-02-02 RS RS20220071A patent/RS62841B1/sr unknown
- 2017-02-02 TN TNP/2018/000263A patent/TN2018000263A1/en unknown
- 2017-02-02 EP EP17703376.8A patent/EP3411402B1/fr active Active
- 2017-02-02 MX MX2018009108A patent/MX2018009108A/es unknown
- 2017-02-02 CN CN202211231024.9A patent/CN116063544A/zh active Pending
- 2017-02-02 KR KR1020187022265A patent/KR20180103084A/ko active IP Right Grant
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- 2017-02-02 JO JOP/2017/0027A patent/JOP20170027B1/ar active
- 2017-02-02 MA MA43955A patent/MA43955B1/fr unknown
- 2017-02-02 UA UAA201809054A patent/UA126657C2/uk unknown
- 2017-02-02 MD MDE20181178T patent/MD3411402T2/ro unknown
- 2017-02-02 WO PCT/EP2017/052202 patent/WO2017134134A1/fr active Application Filing
- 2017-02-02 CN CN201780010011.XA patent/CN109219617A/zh active Pending
- 2017-02-02 AU AU2017216230A patent/AU2017216230B2/en active Active
- 2017-02-02 TW TW106103580A patent/TWI748984B/zh active
- 2017-02-02 BR BR112018015715A patent/BR112018015715A2/pt unknown
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- 2017-02-02 PE PE2018001287A patent/PE20181536A1/es unknown
- 2017-02-02 HU HUE17703376A patent/HUE057220T2/hu unknown
- 2017-02-02 SI SI201731056T patent/SI3411402T1/sl unknown
- 2017-02-02 CR CR20180420A patent/CR20180420A/es unknown
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2018
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2019
- 2019-04-02 US US16/373,083 patent/US11352433B2/en active Active
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2021
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2022
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2023
- 2023-10-02 AU AU2023237216A patent/AU2023237216A1/en not_active Abandoned
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