ECSP19034870A - Péptidos escindibles y proteínas insecticidas y nematicidas que los comprenden - Google Patents

Péptidos escindibles y proteínas insecticidas y nematicidas que los comprenden

Info

Publication number
ECSP19034870A
ECSP19034870A ECSENADI201934870A ECDI201934870A ECSP19034870A EC SP19034870 A ECSP19034870 A EC SP19034870A EC SENADI201934870 A ECSENADI201934870 A EC SENADI201934870A EC DI201934870 A ECDI201934870 A EC DI201934870A EC SP19034870 A ECSP19034870 A EC SP19034870A
Authority
EC
Ecuador
Prior art keywords
peptide
different regions
nematicided
insecticided
slippable
Prior art date
Application number
ECSENADI201934870A
Other languages
English (en)
Inventor
Robert M Kennedy
Alexandra M Haase
Alvar R Carlson
Original Assignee
Vestaron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vestaron Corp filed Critical Vestaron Corp
Publication of ECSP19034870A publication Critical patent/ECSP19034870A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46—N-acyl derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • C07K14/325—Bacillus thuringiensis crystal peptides, i.e. delta-endotoxins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43531—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from mites
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/743—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Agrobacterium; Rhizobium; Bradyrhizobium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8282—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for fungal resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8285—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for nematode resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/04—Fusion polypeptide containing a localisation/targetting motif containing an ER retention signal such as a C-terminal HDEL motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
    • Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Insects & Arthropods (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Pest Control & Pesticides (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Mycology (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Botany (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Peptides Or Proteins (AREA)

Abstract

RESUMEN Un péptido que comprende un péptido binario o terciario, el péptido contiene al menos 4 aminoácidos y hasta un máximo de 16 aminoácidos, y consta de 2 o 3 regiones diferentes, en donde el péptido binario tiene 2 regiones diferentes y el péptido terciario tiene 3 regiones diferentes; en donde, el péptido se puede escindir mediante una proteasa intestinal de animal y una proteasa intestinal de insecto o nematodo. 1. Un péptido que comprende un péptido binario o terciario, que contiene al menos 4 aminoácidos y hasta un máximo de 16 aminoácidos, y consta de 2 o 3 regiones diferentes, en donde el péptido binario tiene 2 regiones diferentes y el péptido terciario tiene 3 regiones diferentes; en donde, el péptido binario y terciario se pueden escindir mediante una proteasa intestinal de animal y una proteasa intestinal de insecto o nematodo.
ECSENADI201934870A 2016-10-21 2019-05-16 Péptidos escindibles y proteínas insecticidas y nematicidas que los comprenden ECSP19034870A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662411117P 2016-10-21 2016-10-21

Publications (1)

Publication Number Publication Date
ECSP19034870A true ECSP19034870A (es) 2019-07-31

Family

ID=62018720

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI201934870A ECSP19034870A (es) 2016-10-21 2019-05-16 Péptidos escindibles y proteínas insecticidas y nematicidas que los comprenden

Country Status (15)

Country Link
US (3) US11535653B2 (es)
EP (1) EP3528617A4 (es)
JP (1) JP2020500009A (es)
KR (1) KR20190085514A (es)
CN (1) CN110267527A (es)
AR (1) AR109871A1 (es)
AU (1) AU2017347761C1 (es)
BR (1) BR112019008023A2 (es)
CA (1) CA3041303A1 (es)
CL (1) CL2019001089A1 (es)
CO (1) CO2019004886A2 (es)
EC (1) ECSP19034870A (es)
IL (1) IL266130A (es)
MX (1) MX2019004648A (es)
WO (1) WO2018075269A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201909017XA (en) 2017-04-04 2019-10-30 Univ Baylor Targeted mosquitocidal toxins
KR102065171B1 (ko) * 2019-02-20 2020-01-13 (주)케어젠 대기오염물질에 의한 피부 손상 방지 및 항노화용 펩타이드와 이의 용도
AR118478A1 (es) * 2019-03-28 2021-10-06 Syngenta Crop Protection Ag Modulación de expresión transgénica
SG11202111786RA (en) * 2019-04-24 2021-11-29 Dcm Shriram Ltd Codon optimized synthetic nucleotide sequences encoding cry2ai protein and uses thereof
BR112022000385A2 (pt) * 2019-07-30 2022-03-03 Dcm Shriram Ltd Sequência de nucleotídeos sintéticos otimizada por códons; molécula de ácido nucleico; dna recombinante que compreende a sequência de nucleotídeos sintéticos otimizada por códons; construção de dna para expressão de uma proteína inseticida em planta; vetor plasmídico; célula hospedeira; método para conferir uma resistência a insetos em uma planta; planta transgênica; tecido, semente ou progênie obtida a partir da planta transgênica; amostra biológica derivada a partir dos tecidos ou semente ou progênie; produto primário derivado a partir da planta trangênica; composição que compreende bacillus thuringiensis; e método de controle de infestação de insetos em uma planta de cultura e de fornecimento de gerenciamento de resistência a insetos
CA3157872A1 (en) * 2019-11-12 2021-05-20 Otto Torjek Gene for resistance to a pathogen of the genus heterodera
CN112279902A (zh) * 2020-01-15 2021-01-29 四川农业大学 一种Bt蛋白Cry1A-like及其编码基因和应用
AU2021260878A1 (en) 2020-04-20 2022-11-17 Vestaron Corporation Proteolytically stable U1-agatoxin-Ta1b variant polypeptides for pest control
AU2021265277A1 (en) 2020-05-01 2022-12-08 Vestaron Corporation Insecticidal combinations
CN111961126B (zh) * 2020-08-31 2022-04-08 中国农业科学院作物科学研究所 TaVQ25基因在调控小麦对白粉病和纹枯病抗性中的应用
AU2021350195A1 (en) * 2020-09-28 2023-05-04 Vestaron Corporation Mu-diguetoxin-dc1a variant polypeptides for pest control
CN112458138B (zh) * 2020-11-30 2023-05-05 海南医学院 一种紫点海葵酶解多肽的制备方法及其应用
WO2022125639A1 (en) * 2020-12-08 2022-06-16 Monsanto Technology Llc Modified plant-associated bacteria and methods of their use
US20230013686A1 (en) * 2021-07-08 2023-01-19 Monsanto Technology Llc Novel insect inhibitory proteins
US11713341B1 (en) 2022-06-17 2023-08-01 Vestaron Corporation Antimicrobial NCR13 variant peptides
CN116751769B (zh) * 2023-06-16 2024-04-30 河南农业大学 咖啡短体线虫Pc-CL蛋白、编码基因及其应用

Family Cites Families (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US5073632A (en) 1987-04-16 1991-12-17 Ecogen Inc. CryIIB crystal protein gene from Bacillus thuringiensis
TR27832A (tr) 1987-04-29 1995-08-31 Monsanto Co Zararli ucucu hasarata mukavim bitkiler.
US6686149B1 (en) 1987-06-10 2004-02-03 Institut Pasteur Methods for obtaining nucleotide sequences coding for polypeptides specifically active for larvae of S. littoralis
US5281530A (en) 1987-08-12 1994-01-25 Mycogen Corporation Genes encoding nematode-active toxins cloned from bacillus thuringiensis isolate PS17
US5236843A (en) 1987-08-12 1993-08-17 Mycogen Corporation Gene encoding a nematode-active toxin cloned from a Bacillus thuringiensis isolate
US5753492A (en) 1987-08-12 1998-05-19 Mycogen Corporation Genes encoding nematode-active toxins from Bacillus thuringiensis strains
US20010026939A1 (en) 1987-11-18 2001-10-04 Douglas Rice Insecticidal cotton plant cells
US5055294A (en) 1988-03-03 1991-10-08 Mycogen Corporation Chimeric bacillus thuringiensis crystal protein gene comprising hd-73 and berliner 1715 toxin genes, transformed and expressed in pseudomonas fluorescens
US4996155A (en) 1988-03-04 1991-02-26 Mycogen Corporation Bacillus thuringiensis gene encoding a coleopteran-active toxin
US5104974A (en) 1988-03-04 1992-04-14 Mycogen Corporation Bacillus thuringiensis coleopteran-active toxin
GB8823068D0 (en) 1988-09-30 1988-11-09 Ici Plc Recombinant dna
US5045469A (en) 1988-10-27 1991-09-03 Mycogen Corporation Novel bacillus thuringiensis isolate denoted B. T. PS81F, active against lepidopteran pests, and a gene encoding a lepidopteran-active toxin
US5135867A (en) 1988-11-01 1992-08-04 Mycogen Corporation Gene encoding a lepidopteran-active toxin from Bacillus thuringiensis isolate denoted B.t. .PS81GG active against lepidopteran pests
US5683691A (en) 1989-02-15 1997-11-04 Plant Genetic Systems, N.V. Bacillus thuringiensis insecticidal toxins
US6063605A (en) 1989-05-09 2000-05-16 Zeneca Limited Bacillus thuringiensis endotoxin genes and methods of use
US5206166A (en) 1989-05-18 1993-04-27 Mycogen Corporation Genes encoding lepidopteran-active toxins and transformed hosts
US6855873B1 (en) 1989-05-31 2005-02-15 Bayer Bioscience, N.V. Recombinant plant expressing non-competitively binding Bt insecticidal cryatal proteins
EP0400246A1 (en) 1989-05-31 1990-12-05 Plant Genetic Systems, N.V. Prevention of Bt resistance development
US5188960A (en) 1989-06-27 1993-02-23 Mycogen Corporation Bacillus thuringiensis isolate active against lepidopteran pests, and genes encoding novel lepidopteran-active toxins
EP0482125A1 (en) 1989-07-11 1992-04-29 Biotechnology Research And Development Corporation Aerosol beam microinjection
US5187091A (en) 1990-03-20 1993-02-16 Ecogen Inc. Bacillus thuringiensis cryiiic gene encoding toxic to coleopteran insects
WO1991016433A1 (en) 1990-04-26 1991-10-31 Plant Genetic Systems N.V. New bacillus thuringiensis strains and their genes encoding insecticidal toxins
CA2042868A1 (en) 1990-06-11 1991-12-12 Kenneth E. Narva Bacillus thuringiensis microbes active against nematodes, and genes encoding novel nematode-active toxins cloned from bacillus thuringiensis isolates
US5831011A (en) 1990-07-27 1998-11-03 Mycogen Corporation Bacillus thuringiensis genes encoding nematode-active toxins
US5436002A (en) 1991-01-29 1995-07-25 Mycogen Corporation Bacillus thuringiensisisolate PS201T6 toxin
US5264364A (en) 1991-01-31 1993-11-23 Ecogen Inc. Bacillus thuringiensis cryIIIc(B) toxin gene and protein toxic to coleopteran insects
US5596071A (en) 1991-05-22 1997-01-21 Mycogen Corporation Bacillus thuringiensis toxins active against hymenopteran pests
US5723758A (en) 1991-09-13 1998-03-03 Mycogen Corporation Bacillus thuringiensis genes encoding lepidopteran-active toxins
UA48104C2 (uk) 1991-10-04 2002-08-15 Новартіс Аг Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника
US5763568A (en) 1992-01-31 1998-06-09 Zeneca Limited Insecticidal toxins derived from funnel web (atrax or hadronyche) spiders
EP0654075B1 (en) 1992-08-27 2005-10-26 Bayer BioScience N.V. New bacillus thuringiensis strains and their insecticidal proteins
US5743477A (en) 1992-08-27 1998-04-28 Dowelanco Insecticidal proteins and method for plant protection
US5356623A (en) 1993-03-17 1994-10-18 Ecogen Inc. Bacillus thuringiensis cryET1 toxin gene and protein toxic to lepidopteran insects
CA2160131C (en) 1993-04-09 2000-07-25 Bart Lambert New bacillus thuringiensis strains and their insecticidal proteins
US5322687A (en) 1993-07-29 1994-06-21 Ecogen Inc. Bacillus thuringiensis cryet4 and cryet5 toxin genes and proteins toxic to lepidopteran insects
US6780408B1 (en) 1993-09-02 2004-08-24 Syngenta Participations Ag Genes encoding hybrid bacillus thuringiensis toxins
US5593881A (en) 1994-05-06 1997-01-14 Mycogen Corporation Bacillus thuringiensis delta-endotoxin
US5530195A (en) 1994-06-10 1996-06-25 Ciba-Geigy Corporation Bacillus thuringiensis gene encoding a toxin active against insects
US6150589A (en) 1995-05-23 2000-11-21 Mycogen Corporation Genes encoding lepidopteran-active toxins from Bacillus thuringiensis isolate PS158C2
MX9606262A (es) 1995-05-30 1998-01-31 Novartis Ag Novedosos genes de bacillus thuringiensis que codifican toxinas activas contra plagas de lepidopteros.
US5670365A (en) 1995-10-06 1997-09-23 Mycogen Corporation Identification of, and uses for, nematicidal bacillus thuringiensis genes, toxins, and isolates
US6083499A (en) 1996-04-19 2000-07-04 Mycogen Corporation Pesticidal toxins
US6570005B1 (en) 1996-07-01 2003-05-27 Mycogen Corporation Toxins active against pests
US6063756A (en) 1996-09-24 2000-05-16 Monsanto Company Bacillus thuringiensis cryET33 and cryET34 compositions and uses therefor
US6093695A (en) 1996-09-26 2000-07-25 Monsanto Company Bacillus thuringiensis CryET29 compositions toxic to coleopteran insects and ctenocephalides SPP
US6110668A (en) 1996-10-07 2000-08-29 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Gene synthesis method
US6713063B1 (en) 1996-11-20 2004-03-30 Monsanto Technology, Llc Broad-spectrum δ-endotoxins
US6017534A (en) 1996-11-20 2000-01-25 Ecogen, Inc. Hybrid Bacillus thuringiensis δ-endotoxins with novel broad-spectrum insecticidal activity
AP9901541A0 (en) 1996-11-20 1999-06-30 Ecogen Inc Broad-spectrum delta-endotoxins.
US5942664A (en) 1996-11-27 1999-08-24 Ecogen, Inc. Bacillus thuringiensis Cry1C compositions toxic to lepidopteran insects and methods for making Cry1C mutants
CA2281914A1 (en) 1997-03-13 1998-09-17 Mycogen Corporation Pesticidal bacillus thuringiensis strains
JP2001522233A (ja) 1997-03-13 2001-11-13 マイコーゲン コーポレーション バチルス・チューリンギエンシス毒素
CN1068767C (zh) 1997-05-19 2001-07-25 纪宏城 滋血粥
US5874288A (en) 1997-07-31 1999-02-23 Mycogen Corporation Bacillus thuringiensis toxins with improved activity
GB9725556D0 (en) 1997-12-03 1998-02-04 Ciba Geigy Ag Organic compounds
US6060594A (en) 1997-12-18 2000-05-09 Ecogen, Inc. Nucleic acid segments encoding modified bacillus thuringiensis coleopteran-toxic crystal proteins
US5973231A (en) 1998-05-12 1999-10-26 Mycogen Corporation Bacillus thuringiensis isolates, toxins, and genes for controlling certain coleopteran pests
US6468523B1 (en) 1998-11-02 2002-10-22 Monsanto Technology Llc Polypeptide compositions toxic to diabrotic insects, and methods of use
US6489542B1 (en) 1998-11-04 2002-12-03 Monsanto Technology Llc Methods for transforming plants to express Cry2Ab δ-endotoxins targeted to the plastids
GB9909796D0 (en) 1999-04-28 1999-06-23 Plant Bioscience Ltd Pesticidal fumes
AU6702300A (en) 1999-08-19 2001-03-19 Syngenta Participations Ag Hybrid insecticidal toxins and nucleic acid sequences coding therefor
CN1111600C (zh) 1999-08-26 2003-06-18 中国科学院遗传研究所 杀虫蛋白基因及其应用
AU7491600A (en) 1999-09-15 2001-04-17 Monsanto Technology Llc Lepidopteran-active bacillus thuringiensis delta-endotoxin compositions and methods of use
US6551800B1 (en) 1999-10-26 2003-04-22 The Board Of Regents, The University Texas System Recombinant materials for production of a protein toxic to fire ants
EP1099760A1 (en) 1999-11-09 2001-05-16 Centrum Voor Plantenveredelings- En Reproduktieonderzoek (Cpro) Bacillus thuringiensis Cry1Ia-Cry1Ba hybrid toxins
ATE538205T1 (de) 1999-11-29 2012-01-15 Midwest Oilseeds Inc Verfahren, medien und vorrichtung zur einführung von molekülen in pflanzenzellen und bakterien mittels aerosolstrahlen
CN101348793A (zh) 1999-12-28 2009-01-21 拜尔生物科学公司 苏云金芽孢杆菌的杀虫蛋白
AU2001238152A1 (en) 2000-02-10 2001-08-20 University Of Connecticut Insecticidal compounds and methods for selection thereof
US7279547B2 (en) 2000-02-10 2007-10-09 University Of Connecticut Insecticidal compounds and methods for selection thereof
US20110131679A2 (en) 2000-04-19 2011-06-02 Thomas La Rosa Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
WO2001087940A2 (en) 2000-05-15 2001-11-22 Monsanto Technology Llc Polypeptide composionns toxic to anthonomus insects, and use thereof
JP4608059B2 (ja) 2000-08-03 2011-01-05 株式会社エス・ディー・エス バイオテック 殺虫活性を有する蛋白質、その蛋白質をコードするｄｎａ、有害生物防除剤及び防除方法。
WO2002014517A1 (en) 2000-08-11 2002-02-21 Monsanto Technology Llc BROAD-SPECTRUM δ-ENDOTOXINS
CN100353846C (zh) 2000-08-25 2007-12-12 辛根塔参与股份公司 新的来自苏云金芽孢杆菌杀虫晶体蛋白的杀虫毒素
AU2001290919A1 (en) 2000-09-12 2002-03-26 Monsanto Technology Llc Insect inhibitory bacillus thuringiensis proteins, fusions, and methods of use therefor
AU2002252974B2 (en) 2001-01-09 2006-12-14 BASF Agricultural Solutions Seed US LLC Bacillus thuringiensis insecticidal proteins
PT1988099E (pt) 2001-01-09 2013-01-31 Bayer Cropscience Nv Proteínas inseticidas de bacillus thuringiensis
CN1199569C (zh) 2001-07-18 2005-05-04 湖南师范大学 一种双效工程菌生物杀虫剂及其生产方法
CN1181202C (zh) 2001-08-20 2004-12-22 中国农业科学院植物保护研究所 苏云金芽孢杆菌cryl基因、基因组合及表达载体
US20030134310A1 (en) * 2001-11-13 2003-07-17 Cujec Thomas P. Cellular kinase targets and inhibitors, and methods for their use
US7053266B2 (en) 2002-03-27 2006-05-30 Council Of Scientfic And Industrial Research Chimeric cry1E δendotoxin and methods of controlling insects
WO2003089455A2 (en) 2002-04-22 2003-10-30 Dow Global Technologies Inc. Low-cost production of peptides
WO2004016653A2 (en) 2002-08-15 2004-02-26 Leukotech A/S Bactericidal, anti-apoptotic, pro-inflammatory and anti-inflammatory peptides of heparin-binding protein (hbp) or human neutrophil elastase
WO2004020636A1 (en) 2002-08-29 2004-03-11 Monsanto Technology, Llc Nucleotide sequences encoding cry1bb proteins for enhanced expression in plants
MXPA02008705A (es) 2002-09-06 2004-12-06 Consejo Del Sist Nac De Educac Tecnologia para encapsular delta endotoxina de bacillus thuringiensis variedad israelensis para prolongar su actividad sobre larvas de mosquitos.
CA2410153C (en) 2002-12-05 2013-04-23 Jean-Charles Cote A novel bacillus thuringiensis strain, crystal gene and crystal protein and uses thereof
US7355099B2 (en) 2003-02-20 2008-04-08 Athenix Corporation AXMI-004, a delta-endotoxin gene and methods for its use
US7951557B2 (en) 2003-04-27 2011-05-31 Protalix Ltd. Human lysosomal proteins from plant cell culture
JP4645087B2 (ja) 2003-10-15 2011-03-09 住友化学株式会社 有害生物防除組成物
MXPA06007005A (es) 2003-12-16 2008-02-14 Monsanto Technology Llc Composiciones de proteinas y genes secretados de bacillus thuringiensis y usos de las mismas.
US7629504B2 (en) 2003-12-22 2009-12-08 Pioneer Hi-Bred International, Inc. Bacillus thuringiensis cry9 nucleic acids
BRPI0508068B1 (pt) 2004-02-25 2017-11-28 Pioneer Hi-Bred International, Inc. Molecule of nucleic acid isolated, vector understanding, polyepeptide isolated, composition understanding the same and methods of transgenic plant production and increased insect resistance in transgenic plants
ES2318576T3 (es) 2004-11-04 2009-05-01 University Of Connecticut Polipeptidos insecticidas y procedimientos para su uso.
CN1323159C (zh) 2004-11-16 2007-06-27 中国农业科学院植物保护研究所 对鞘翅目害虫高效的苏云金芽孢杆菌菌株和基因
RU2278161C1 (ru) 2004-12-28 2006-06-20 Сергей Ананьевич Тюрин РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК, КОДИРУЮЩАЯ СИНТЕЗ ДЕЛЬТА-ЭНДОТОКСИНА Cry IIIA, И ШТАММ BACILLUS THURINGIENSIS SSP. KURSTAKI, ПОЛУЧЕННЫЙ НА ОСНОВЕ РЕКОМБИНАНТНОЙ ПЛАЗМИДНОЙ ДНК
ATE505548T1 (de) 2005-08-31 2011-04-15 Monsanto Technology Llc Insektizidzusammensetzungen und verfahren zur herstellung von insektenbeständigen transgenen pflanzen
PT2431473T (pt) 2005-09-16 2017-02-15 Monsanto Technology Llc Métodos para o controlo genético de infestações por insetos em plantas e suas composições
CN100510081C (zh) 2005-10-17 2009-07-08 华中农业大学 苏云金芽胞杆菌的杀虫晶体蛋白基因cry7Bal
US20100024075A1 (en) 2005-11-23 2010-01-28 Aroian Raffi V Method for Controlling Plant-Parasitic Nematode Infections in Plants
US7589176B2 (en) 2006-01-25 2009-09-15 Pioneer Hi-Bred International, Inc. Antifungal polypeptides
CA2646471C (en) 2006-03-21 2016-05-31 Bayer Bioscience N.V. Novel genes encoding insecticidal proteins
US7449552B2 (en) 2006-04-14 2008-11-11 Pioneer Hi-Bred International, Inc. Bacillus thuringiensis cry gene and protein
US7329736B2 (en) 2006-04-14 2008-02-12 Pioneer Hi-Bred International, Inc. Bacillus thuringiensis cry gene and protein
WO2007137329A2 (en) 2006-05-25 2007-12-06 Hexima Limited Multi-gene expression vehicle
AU2007297872A1 (en) 2006-06-06 2008-03-27 University Of Connecticut Methods of identifying insect-specific spider toxin mimics
US20070281864A1 (en) 2006-06-06 2007-12-06 King Glenn F Methods of identifying insect-specific spider toxin mimics
US8993295B2 (en) * 2006-07-20 2015-03-31 The General Hospital Corporation Methods, compositions, and kits for the selective activation of protoxins through combinatorial targeting
ATE455189T1 (de) 2006-07-21 2010-01-15 Pioneer Hi Bred Int Verfahren zur identifizierung neuer gene
CN101003789B (zh) 2006-11-17 2011-09-07 湖南师范大学 蜘蛛毒肽基因重组的工程菌菌剂
US8541366B2 (en) 2007-09-14 2013-09-24 Athenix Corporation Synthetic AXMI-004 delta-endotoxin genes and methods for their use
WO2009073133A1 (en) * 2007-11-29 2009-06-11 Vaxinnate Corporation Compositions of toll-like receptor agonists and papillomavirus antigens and uses thereof
US20090183278A1 (en) 2008-01-10 2009-07-16 Pioneer Hi-Bred International, Inc. Novel Bacillus Thuringiensis Gene with Coleopteran Activity
JP5448135B2 (ja) 2008-05-27 2014-03-19 クミアイ化学工業株式会社 有害生物防除組成物
WO2009155557A2 (en) 2008-06-20 2009-12-23 Solae, Llc Protein hydrolysate compositions stable under acidic conditions
SI2334177T1 (sl) 2008-10-01 2016-08-31 Vestaron Corporation Peptidna toksinska formulacija
EP3412771B1 (en) 2009-05-19 2020-12-02 DuPont Nutrition Biosciences ApS Amylase polypeptides
AR079624A1 (es) 2009-12-16 2012-02-08 Dow Agrosciences Llc Uso de vip3ab en combinacion con cry1ca para control de insectos resisten-tes
US9321847B2 (en) 2010-09-20 2016-04-26 Ramot At Tel Aviv University Ltd. Activatable toxin complexes comprising a cleavable inhibitory peptide
EP2771349B1 (en) * 2011-09-16 2020-02-26 Iogenetics, LLC. Bioinformatic processes for determination of peptide binding
EP2822963A2 (en) 2012-03-09 2015-01-14 Vestaron Corporation Toxic peptide production, peptide expression in plants and combinations of cysteine rich peptides
US9163263B2 (en) 2012-05-02 2015-10-20 The Goodyear Tire & Rubber Company Identification of isoprene synthase variants with improved properties for the production of isoprene
WO2014200910A2 (en) 2013-06-10 2014-12-18 Iogenetics, Llc Bioinformatic processes for determination of peptide binding
CN106367361B (zh) 2016-10-08 2019-08-06 天津大学 一种酿酒酵母工程菌株及其构建方法、应用
US11472839B2 (en) 2017-05-11 2022-10-18 King Abdullah University Of Science And Technology Peptide capable of forming a gel for use in tissue engineering and bioprinting

Also Published As

Publication number Publication date
CA3041303A1 (en) 2018-04-26
US20220380417A1 (en) 2022-12-01
US11535653B2 (en) 2022-12-27
AU2017347761A1 (en) 2019-05-16
WO2018075269A1 (en) 2018-04-26
JP2020500009A (ja) 2020-01-09
US11447531B2 (en) 2022-09-20
KR20190085514A (ko) 2019-07-18
AU2017347761B2 (en) 2023-12-14
IL266130A (en) 2019-06-30
CN110267527A (zh) 2019-09-20
US20180362598A1 (en) 2018-12-20
AR109871A1 (es) 2019-01-30
CO2019004886A2 (es) 2019-07-31
BR112019008023A2 (pt) 2019-07-09
EP3528617A4 (en) 2020-11-25
EP3528617A1 (en) 2019-08-28
AU2017347761C1 (en) 2024-03-28
CL2019001089A1 (es) 2019-09-06
MX2019004648A (es) 2019-05-23
US20190261634A1 (en) 2019-08-29

Similar Documents

Publication Publication Date Title
ECSP19034870A (es) Péptidos escindibles y proteínas insecticidas y nematicidas que los comprenden
CY1124309T1 (el) Τροποποιημενα πολυπεπτιδια fgf-21 και χρησεις εξ αυτων
CL2019000259A1 (es) Anticuerpos, antimiostatina, polipéptidos que contienen regiones fc variantes y métodos de uso.(divisional solicitud 201701584)
CL2022000448A1 (es) Autoinyector (divisional solicitud no. 201903061)
CY1117797T1 (el) Μεθοδοι ενδοκυτταρικης μετατροπης πρωτεϊνων μονης αλυσιδας προς τη μορφη διπλης αλυσιδας αυτων
BR112019012342A2 (pt) anticorpos il-11
EA201990229A1 (ru) Новый ботулинический нейротоксин и его производные
CL2018000226A1 (es) Mezcla de péptidos (divisional solicitud 201601405)
BR112019012343A2 (pt) anticorpos il-11ra
DOP2016000051A (es) Polipéptido para la escisión hidrolítica de la zearalenona y/o derivados de la zearalenona, polinucleótido aislado de la misma y poliéptido que contiene aditivo, uso y procedimiento de los mismos.
CL2017001883A1 (es) Compuestos antisenescentes y usos de los mismos
ES2721309T3 (es) Composición para preparar tagatosa y método para preparar tagatosa a partir de fructosa
EA202090974A1 (ru) Вариантные иммуномодулирующие белки лиганда icos и сопутствующие композиции и способы
ES2722773T3 (es) Polipéptidos de fHbp meningocócicos modificados
DK3660146T3 (da) Ydelsesforbedrede og opbevaringsstabile proteasevarianter
AR103672A1 (es) Proteína resistente a los herbicidas, gen codificador y su uso
NI201900052A (es) Formulaciones farmacéuticas
CL2017003228A1 (es) Fragmentos mutantes de proteína ras
CO2017011816A2 (es) Sistema direccionable de creación de túneles mediante ácido en tiempo real
AR067980A1 (es) Peptidos de cdh3 y agentes que los comprenden
CL2020003277A1 (es) Métodos de fabricación de composiciones de aminoácidos
UY35397A (es) INHIBIDORES POTENTES Y SELECTIVOS DE NaV1.7
PE20170955A1 (es) Nuevas proteinas inhibidoras de insectos
EA202091366A1 (ru) Обесцвеченный изолят рапсового белка
CL2017000200A1 (es) Célula huésped mejorada para producir proteinas