CO2019004886A2 - Péptidos que se pueden desdoblar y proteínas insecticidas y nematicidas que los comprenden - Google Patents

Péptidos que se pueden desdoblar y proteínas insecticidas y nematicidas que los comprenden

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Publication number
CO2019004886A2
CO2019004886A2 CONC2019/0004886A CO2019004886A CO2019004886A2 CO 2019004886 A2 CO2019004886 A2 CO 2019004886A2 CO 2019004886 A CO2019004886 A CO 2019004886A CO 2019004886 A2 CO2019004886 A2 CO 2019004886A2
Authority
CO
Colombia
Prior art keywords
peptide
binary
unfold
insecticidal
peptides
Prior art date
Application number
CONC2019/0004886A
Other languages
English (en)
Inventor
Alvar R Carlson
Alexandra M Haase
Robert M Kennedy
Original Assignee
Vestaron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vestaron Corp filed Critical Vestaron Corp
Publication of CO2019004886A2 publication Critical patent/CO2019004886A2/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46—N-acyl derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • C07K14/325—Bacillus thuringiensis crystal peptides, i.e. delta-endotoxins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43531—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from mites
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/743—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Agrobacterium; Rhizobium; Bradyrhizobium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8282—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for fungal resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8285—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for nematode resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/04—Fusion polypeptide containing a localisation/targetting motif containing an ER retention signal such as a C-terminal HDEL motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
    • Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Insects & Arthropods (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Pest Control & Pesticides (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Mycology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Botany (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Un péptido que comprende un péptido binario o terciario, el péptido contiene al menos 4 aminoácidos y hasta un máximo de 16 aminoácidos, y consta de 2 o 3 regiones diferentes, en donde el péptido binario tiene 2 regiones diferentes y el péptido terciario tiene 3 regiones diferentes; en donde, el péptido se puede escindir mediante una proteasa intestinal de animal y una proteasa intestinal de insecto o nematodo. 1. Un péptido que comprende un péptido binario o terciario, que contiene al menos 4 aminoácidos y hasta un máximo de 16 aminoácidos, y consta de 2 o 3 regiones diferentes, en donde el péptido binario tiene 2 regiones diferentes y el péptido terciario tiene 3 regiones diferentes; en donde, el péptido binario y terciario se pueden escindir mediante una proteasa intestinal de animal y una proteasa intestinal de insecto o nematodo
CONC2019/0004886A 2016-10-21 2019-05-14 Péptidos que se pueden desdoblar y proteínas insecticidas y nematicidas que los comprenden CO2019004886A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662411117P 2016-10-21 2016-10-21
PCT/US2017/055596 WO2018075269A1 (en) 2016-10-21 2017-10-06 Cleavable peptides and insecticidal and nematicidal proteins comprising same

Publications (1)

Publication Number Publication Date
CO2019004886A2 true CO2019004886A2 (es) 2019-07-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2019/0004886A CO2019004886A2 (es) 2016-10-21 2019-05-14 Péptidos que se pueden desdoblar y proteínas insecticidas y nematicidas que los comprenden

Country Status (15)

Country Link
US (3) US11447531B2 (es)
EP (1) EP3528617A4 (es)
JP (1) JP2020500009A (es)
KR (1) KR20190085514A (es)
CN (1) CN110267527A (es)
AR (1) AR109871A1 (es)
AU (1) AU2017347761C1 (es)
BR (1) BR112019008023A2 (es)
CA (1) CA3041303A1 (es)
CL (1) CL2019001089A1 (es)
CO (1) CO2019004886A2 (es)
EC (1) ECSP19034870A (es)
IL (1) IL266130A (es)
MX (1) MX2019004648A (es)
WO (1) WO2018075269A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018187342A1 (en) 2017-04-04 2018-10-11 Baylor University Targeted mosquitocidal toxins
KR102065171B1 (ko) * 2019-02-20 2020-01-13 (주)케어젠 대기오염물질에 의한 피부 손상 방지 및 항노화용 펩타이드와 이의 용도
AR118478A1 (es) * 2019-03-28 2021-10-06 Syngenta Crop Protection Ag Modulación de expresión transgénica
MX2021013026A (es) * 2019-04-24 2022-02-10 Dcm Shriram Ltd Secuencias de nucleótidos sintéticos con codones optimizados que codifican la proteína cry2ai y usos de las mismas.
AU2020319744B2 (en) * 2019-07-30 2023-12-21 Dcm Shriram Limited Synthetic nucleotide sequences encoding insecticidal crystal protein and uses thereof
WO2021093943A1 (en) * 2019-11-12 2021-05-20 KWS SAAT SE & Co. KGaA Gene for resistance to a pathogen of the genus heterodera
CN112279902A (zh) * 2020-01-15 2021-01-29 四川农业大学 一种Bt蛋白Cry1A-like及其编码基因和应用
CA3180326A1 (en) * 2020-04-20 2021-10-28 Vestaron Corporation Proteolytically stable u1-agatoxin-ta1b variant polypeptides for pest control
IL297738A (en) 2020-05-01 2022-12-01 Vestaron Corp Insecticide combinations
CN111961126B (zh) * 2020-08-31 2022-04-08 中国农业科学院作物科学研究所 TaVQ25基因在调控小麦对白粉病和纹枯病抗性中的应用
KR20230078719A (ko) * 2020-09-28 2023-06-02 베스타론 코포레이션 해충 방제용 뮤-디구에톡신-Dc1a 변이형 폴리펩타이드
CN112458138B (zh) * 2020-11-30 2023-05-05 海南医学院 一种紫点海葵酶解多肽的制备方法及其应用
WO2022125639A1 (en) * 2020-12-08 2022-06-16 Monsanto Technology Llc Modified plant-associated bacteria and methods of their use
US20230013686A1 (en) * 2021-07-08 2023-01-19 Monsanto Technology Llc Novel insect inhibitory proteins
US11713341B1 (en) 2022-06-17 2023-08-01 Vestaron Corporation Antimicrobial NCR13 variant peptides
CN116751769B (zh) * 2023-06-16 2024-04-30 河南农业大学 咖啡短体线虫Pc-CL蛋白、编码基因及其应用

Family Cites Families (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US5073632A (en) 1987-04-16 1991-12-17 Ecogen Inc. CryIIB crystal protein gene from Bacillus thuringiensis
TR27832A (tr) 1987-04-29 1995-08-31 Monsanto Co Zararli ucucu hasarata mukavim bitkiler.
US6686149B1 (en) 1987-06-10 2004-02-03 Institut Pasteur Methods for obtaining nucleotide sequences coding for polypeptides specifically active for larvae of S. littoralis
US5281530A (en) 1987-08-12 1994-01-25 Mycogen Corporation Genes encoding nematode-active toxins cloned from bacillus thuringiensis isolate PS17
US5753492A (en) 1987-08-12 1998-05-19 Mycogen Corporation Genes encoding nematode-active toxins from Bacillus thuringiensis strains
US5236843A (en) 1987-08-12 1993-08-17 Mycogen Corporation Gene encoding a nematode-active toxin cloned from a Bacillus thuringiensis isolate
US20010026939A1 (en) 1987-11-18 2001-10-04 Douglas Rice Insecticidal cotton plant cells
US5055294A (en) 1988-03-03 1991-10-08 Mycogen Corporation Chimeric bacillus thuringiensis crystal protein gene comprising hd-73 and berliner 1715 toxin genes, transformed and expressed in pseudomonas fluorescens
US5104974A (en) 1988-03-04 1992-04-14 Mycogen Corporation Bacillus thuringiensis coleopteran-active toxin
US4996155A (en) 1988-03-04 1991-02-26 Mycogen Corporation Bacillus thuringiensis gene encoding a coleopteran-active toxin
GB8823068D0 (en) 1988-09-30 1988-11-09 Ici Plc Recombinant dna
US5045469A (en) 1988-10-27 1991-09-03 Mycogen Corporation Novel bacillus thuringiensis isolate denoted B. T. PS81F, active against lepidopteran pests, and a gene encoding a lepidopteran-active toxin
US5135867A (en) 1988-11-01 1992-08-04 Mycogen Corporation Gene encoding a lepidopteran-active toxin from Bacillus thuringiensis isolate denoted B.t. .PS81GG active against lepidopteran pests
US5683691A (en) 1989-02-15 1997-11-04 Plant Genetic Systems, N.V. Bacillus thuringiensis insecticidal toxins
US6063605A (en) 1989-05-09 2000-05-16 Zeneca Limited Bacillus thuringiensis endotoxin genes and methods of use
US5206166A (en) 1989-05-18 1993-04-27 Mycogen Corporation Genes encoding lepidopteran-active toxins and transformed hosts
EP0400246A1 (en) 1989-05-31 1990-12-05 Plant Genetic Systems, N.V. Prevention of Bt resistance development
US6855873B1 (en) 1989-05-31 2005-02-15 Bayer Bioscience, N.V. Recombinant plant expressing non-competitively binding Bt insecticidal cryatal proteins
US5188960A (en) 1989-06-27 1993-02-23 Mycogen Corporation Bacillus thuringiensis isolate active against lepidopteran pests, and genes encoding novel lepidopteran-active toxins
WO1991000915A1 (en) 1989-07-11 1991-01-24 Biotechnology Research & Development Corporation Aerosol beam microinjector
US5187091A (en) 1990-03-20 1993-02-16 Ecogen Inc. Bacillus thuringiensis cryiiic gene encoding toxic to coleopteran insects
ES2171391T3 (es) 1990-04-26 2002-09-16 Aventis Cropscience Nv Nueva cepa de bacillus thuringiensis y su gen de codificado de toxina insecticida.
CA2042868A1 (en) 1990-06-11 1991-12-12 Kenneth E. Narva Bacillus thuringiensis microbes active against nematodes, and genes encoding novel nematode-active toxins cloned from bacillus thuringiensis isolates
US5831011A (en) 1990-07-27 1998-11-03 Mycogen Corporation Bacillus thuringiensis genes encoding nematode-active toxins
US5436002A (en) 1991-01-29 1995-07-25 Mycogen Corporation Bacillus thuringiensisisolate PS201T6 toxin
US5264364A (en) 1991-01-31 1993-11-23 Ecogen Inc. Bacillus thuringiensis cryIIIc(B) toxin gene and protein toxic to coleopteran insects
US5596071A (en) 1991-05-22 1997-01-21 Mycogen Corporation Bacillus thuringiensis toxins active against hymenopteran pests
US5723758A (en) 1991-09-13 1998-03-03 Mycogen Corporation Bacillus thuringiensis genes encoding lepidopteran-active toxins
UA48104C2 (uk) 1991-10-04 2002-08-15 Новартіс Аг Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника
US5763568A (en) 1992-01-31 1998-06-09 Zeneca Limited Insecticidal toxins derived from funnel web (atrax or hadronyche) spiders
HU221339B1 (en) 1992-08-27 2002-09-28 Plant Genetic Systems Nv New bacillus thuringiensis strains and their insecticidal proteins
US5743477A (en) 1992-08-27 1998-04-28 Dowelanco Insecticidal proteins and method for plant protection
US5356623A (en) 1993-03-17 1994-10-18 Ecogen Inc. Bacillus thuringiensis cryET1 toxin gene and protein toxic to lepidopteran insects
WO1994024264A1 (en) 1993-04-09 1994-10-27 Plant Genetic Systems N.V. New bacillus thuringiensis strains and their insecticidal proteins
US5322687A (en) 1993-07-29 1994-06-21 Ecogen Inc. Bacillus thuringiensis cryet4 and cryet5 toxin genes and proteins toxic to lepidopteran insects
US6780408B1 (en) 1993-09-02 2004-08-24 Syngenta Participations Ag Genes encoding hybrid bacillus thuringiensis toxins
US5593881A (en) 1994-05-06 1997-01-14 Mycogen Corporation Bacillus thuringiensis delta-endotoxin
US5530195A (en) 1994-06-10 1996-06-25 Ciba-Geigy Corporation Bacillus thuringiensis gene encoding a toxin active against insects
US6150589A (en) 1995-05-23 2000-11-21 Mycogen Corporation Genes encoding lepidopteran-active toxins from Bacillus thuringiensis isolate PS158C2
MX9606262A (es) 1995-05-30 1998-01-31 Novartis Ag Novedosos genes de bacillus thuringiensis que codifican toxinas activas contra plagas de lepidopteros.
US5670365A (en) 1995-10-06 1997-09-23 Mycogen Corporation Identification of, and uses for, nematicidal bacillus thuringiensis genes, toxins, and isolates
US6083499A (en) 1996-04-19 2000-07-04 Mycogen Corporation Pesticidal toxins
US6570005B1 (en) 1996-07-01 2003-05-27 Mycogen Corporation Toxins active against pests
US6063756A (en) 1996-09-24 2000-05-16 Monsanto Company Bacillus thuringiensis cryET33 and cryET34 compositions and uses therefor
US6093695A (en) 1996-09-26 2000-07-25 Monsanto Company Bacillus thuringiensis CryET29 compositions toxic to coleopteran insects and ctenocephalides SPP
US6110668A (en) 1996-10-07 2000-08-29 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Gene synthesis method
US6017534A (en) 1996-11-20 2000-01-25 Ecogen, Inc. Hybrid Bacillus thuringiensis δ-endotoxins with novel broad-spectrum insecticidal activity
US6713063B1 (en) 1996-11-20 2004-03-30 Monsanto Technology, Llc Broad-spectrum δ-endotoxins
ID25530A (id) 1996-11-20 2000-10-12 Ecogen Inc δ-ENDOTOKSIN BERSPEKTRUM-LEBAR
US5942664A (en) 1996-11-27 1999-08-24 Ecogen, Inc. Bacillus thuringiensis Cry1C compositions toxic to lepidopteran insects and methods for making Cry1C mutants
JP2001522233A (ja) 1997-03-13 2001-11-13 マイコーゲン コーポレーション バチルス・チューリンギエンシス毒素
JP2001515355A (ja) 1997-03-13 2001-09-18 マイコーゲン コーポレーション 殺虫性バチルス・チューリンギエンシス菌株
CN1068767C (zh) 1997-05-19 2001-07-25 纪宏城 滋血粥
US5874288A (en) 1997-07-31 1999-02-23 Mycogen Corporation Bacillus thuringiensis toxins with improved activity
GB9725556D0 (en) 1997-12-03 1998-02-04 Ciba Geigy Ag Organic compounds
US6060594A (en) 1997-12-18 2000-05-09 Ecogen, Inc. Nucleic acid segments encoding modified bacillus thuringiensis coleopteran-toxic crystal proteins
US5973231A (en) 1998-05-12 1999-10-26 Mycogen Corporation Bacillus thuringiensis isolates, toxins, and genes for controlling certain coleopteran pests
US6468523B1 (en) 1998-11-02 2002-10-22 Monsanto Technology Llc Polypeptide compositions toxic to diabrotic insects, and methods of use
US6489542B1 (en) 1998-11-04 2002-12-03 Monsanto Technology Llc Methods for transforming plants to express Cry2Ab δ-endotoxins targeted to the plastids
GB9909796D0 (en) 1999-04-28 1999-06-23 Plant Bioscience Ltd Pesticidal fumes
WO2001014562A1 (en) 1999-08-19 2001-03-01 Syngenta Participations Ag Hybrid insecticidal toxins and nucleic acid sequences coding therefor
CN1111600C (zh) 1999-08-26 2003-06-18 中国科学院遗传研究所 杀虫蛋白基因及其应用
CA2384967A1 (en) 1999-09-15 2001-03-22 Monsanto Technology Llc Lepidopteran-active bacillus thuringiensis .delta.-endotoxin compositions and methods of use
US6551800B1 (en) 1999-10-26 2003-04-22 The Board Of Regents, The University Texas System Recombinant materials for production of a protein toxic to fire ants
EP1099760A1 (en) 1999-11-09 2001-05-16 Centrum Voor Plantenveredelings- En Reproduktieonderzoek (Cpro) Bacillus thuringiensis Cry1Ia-Cry1Ba hybrid toxins
ATE538205T1 (de) 1999-11-29 2012-01-15 Midwest Oilseeds Inc Verfahren, medien und vorrichtung zur einführung von molekülen in pflanzenzellen und bakterien mittels aerosolstrahlen
AU784649B2 (en) 1999-12-28 2006-05-18 Bayer Cropscience Nv Insecticidal proteins from Bacillus thuringiensis
US7279547B2 (en) 2000-02-10 2007-10-09 University Of Connecticut Insecticidal compounds and methods for selection thereof
US6583264B2 (en) 2000-02-10 2003-06-24 University Of Connecticut Insecticidal compounds and methods for selection thereof
US20110131679A2 (en) 2000-04-19 2011-06-02 Thomas La Rosa Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
WO2001087940A2 (en) 2000-05-15 2001-11-22 Monsanto Technology Llc Polypeptide composionns toxic to anthonomus insects, and use thereof
JP4608059B2 (ja) 2000-08-03 2011-01-05 株式会社エス・ディー・エス バイオテック 殺虫活性を有する蛋白質、その蛋白質をコードするｄｎａ、有害生物防除剤及び防除方法。
AU2000269030A1 (en) 2000-08-11 2002-02-25 Monsanto Technology Llc Broad-spectrum delta-endotoxins
WO2002015701A2 (en) 2000-08-25 2002-02-28 Syngenta Participations Ag Bacillus thuringiensis crystal protein hybrids
AR030718A1 (es) 2000-09-12 2003-09-03 Monsanto Technology Llc Proteinas de bacillus thuringiensis inhibidoras de insectos fusiones y metodos de uso de las mismas
EP1988099B1 (en) 2001-01-09 2012-11-14 Bayer CropScience NV Bacillus thuringiensis insecticidal proteins
BRPI0206346B1 (pt) 2001-01-09 2018-04-03 Bayer Cropscience Nv Dna que codifica uma proteína inseticida cry2ae, gene quimérico compreendendo o mesmo, proteína inseticida, uso da mesma, micro-organismo, bem como processo para tornar uma planta resistente a um inseto lepidóptero
CN1199569C (zh) 2001-07-18 2005-05-04 湖南师范大学 一种双效工程菌生物杀虫剂及其生产方法
CN1181202C (zh) 2001-08-20 2004-12-22 中国农业科学院植物保护研究所 苏云金芽孢杆菌cryl基因、基因组合及表达载体
US20030134310A1 (en) * 2001-11-13 2003-07-17 Cujec Thomas P. Cellular kinase targets and inhibitors, and methods for their use
US7053266B2 (en) 2002-03-27 2006-05-30 Council Of Scientfic And Industrial Research Chimeric cry1E δendotoxin and methods of controlling insects
JP4472998B2 (ja) 2002-04-22 2010-06-02 ダウ グローバル テクノロジーズ インコーポレイティド 低コストのペプチド製造
US20060173162A1 (en) 2002-08-15 2006-08-03 Rene Djurup Bactericidak anti-apoptotic, pro-inflammatory and anti-inflammatory peptides of heparin-binding protein (hbp)
WO2004020636A1 (en) 2002-08-29 2004-03-11 Monsanto Technology, Llc Nucleotide sequences encoding cry1bb proteins for enhanced expression in plants
MXPA02008705A (es) 2002-09-06 2004-12-06 Consejo Del Sist Nac De Educac Tecnologia para encapsular delta endotoxina de bacillus thuringiensis variedad israelensis para prolongar su actividad sobre larvas de mosquitos.
CA2410153C (en) 2002-12-05 2013-04-23 Jean-Charles Cote A novel bacillus thuringiensis strain, crystal gene and crystal protein and uses thereof
US7355099B2 (en) 2003-02-20 2008-04-08 Athenix Corporation AXMI-004, a delta-endotoxin gene and methods for its use
US7951557B2 (en) 2003-04-27 2011-05-31 Protalix Ltd. Human lysosomal proteins from plant cell culture
JP4645087B2 (ja) 2003-10-15 2011-03-09 住友化学株式会社 有害生物防除組成物
EP1708561B1 (en) 2003-12-16 2010-11-10 Monsanto Technology LLC Secreted insecticidal protein and gene compositions from bacillus thuringiensis and uses therefor
US7629504B2 (en) 2003-12-22 2009-12-08 Pioneer Hi-Bred International, Inc. Bacillus thuringiensis cry9 nucleic acids
CN1942582A (zh) 2004-02-25 2007-04-04 先锋高级育种国际公司 新的苏云金芽孢杆菌晶体多肽、多核苷酸及其组合物
ES2318576T3 (es) 2004-11-04 2009-05-01 University Of Connecticut Polipeptidos insecticidas y procedimientos para su uso.
CN1323159C (zh) 2004-11-16 2007-06-27 中国农业科学院植物保护研究所 对鞘翅目害虫高效的苏云金芽孢杆菌菌株和基因
RU2278161C1 (ru) 2004-12-28 2006-06-20 Сергей Ананьевич Тюрин РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК, КОДИРУЮЩАЯ СИНТЕЗ ДЕЛЬТА-ЭНДОТОКСИНА Cry IIIA, И ШТАММ BACILLUS THURINGIENSIS SSP. KURSTAKI, ПОЛУЧЕННЫЙ НА ОСНОВЕ РЕКОМБИНАНТНОЙ ПЛАЗМИДНОЙ ДНК
AU2006284856B2 (en) 2005-08-31 2011-06-02 Monsanto Technology Llc Insecticidal compositions and methods for making insect-resistant transgenic plants
EP3508582B1 (en) 2005-09-16 2021-01-13 Monsanto Technology LLC Methods for genetic control of insect infestations in plants and compositions thereof
CN100510081C (zh) 2005-10-17 2009-07-08 华中农业大学 苏云金芽胞杆菌的杀虫晶体蛋白基因cry7Bal
US20100024075A1 (en) 2005-11-23 2010-01-28 Aroian Raffi V Method for Controlling Plant-Parasitic Nematode Infections in Plants
WO2007087567A2 (en) 2006-01-25 2007-08-02 Pioneer Hi-Bred International, Inc. Antifungal polypeptides
WO2007107302A2 (en) 2006-03-21 2007-09-27 Bayer Bioscience N.V. Novel genes encoding insecticidal proteins
US7449552B2 (en) 2006-04-14 2008-11-11 Pioneer Hi-Bred International, Inc. Bacillus thuringiensis cry gene and protein
US7329736B2 (en) 2006-04-14 2008-02-12 Pioneer Hi-Bred International, Inc. Bacillus thuringiensis cry gene and protein
SG171689A1 (en) 2006-05-25 2011-06-29 Hexima Ltd Multi-gene expression vehicle
US20070281864A1 (en) 2006-06-06 2007-12-06 King Glenn F Methods of identifying insect-specific spider toxin mimics
MX2008015580A (es) 2006-06-06 2009-01-13 Univ Connecticut Metodos para identificar imitadores de toxina de araña especificos para insectos.
EP2046375B1 (en) 2006-07-20 2017-04-05 The General Hospital Corporation Methods and compositions for the selective activation of protoxins through combinatorial targeting
CN101511864B (zh) 2006-07-21 2013-03-27 先锋高级育种国际公司 具有抗鳞翅目活性的苏云金芽孢杆菌毒素
CN101003789B (zh) 2006-11-17 2011-09-07 湖南师范大学 蜘蛛毒肽基因重组的工程菌菌剂
US8541366B2 (en) 2007-09-14 2013-09-24 Athenix Corporation Synthetic AXMI-004 delta-endotoxin genes and methods for their use
WO2009073133A1 (en) * 2007-11-29 2009-06-11 Vaxinnate Corporation Compositions of toll-like receptor agonists and papillomavirus antigens and uses thereof
US20090183278A1 (en) 2008-01-10 2009-07-16 Pioneer Hi-Bred International, Inc. Novel Bacillus Thuringiensis Gene with Coleopteran Activity
JP5448135B2 (ja) 2008-05-27 2014-03-19 クミアイ化学工業株式会社 有害生物防除組成物
MX2010014091A (es) 2008-06-20 2011-03-21 Solae Llc Composiciones de hidrolizado de proteinas estables en condiciones acidas.
PL2334177T3 (pl) 2008-10-01 2016-10-31 Preparat toksyny peptydowej
WO2010133644A2 (en) 2009-05-19 2010-11-25 Danisco A/S Amylase polypeptides
MX348226B (es) 2009-12-16 2017-05-29 Dow Agrosciences Llc Uso de v1p3ab en combinacion con cry1ca para el manejo de insectos resistentes.
WO2013040142A2 (en) * 2011-09-16 2013-03-21 Iogenetics, Llc Bioinformatic processes for determination of peptide binding
WO2012038950A1 (en) * 2010-09-20 2012-03-29 Ramot At Tel-Aviv University Ltd. Activatable toxin complexes comprising a cleavable inhibitory peptide
MX356526B (es) 2012-03-09 2018-06-01 Vestaron Corp Produccion de peptidos toxicos, expresion de peptido en plantas y combinaciones de peptidos ricos en cisteina.
US9163263B2 (en) 2012-05-02 2015-10-20 The Goodyear Tire & Rubber Company Identification of isoprene synthase variants with improved properties for the production of isoprene
US20160132631A1 (en) 2013-06-10 2016-05-12 Iogenetics, Llc Bioinformatic processes for determination of peptide binding
CN106367361B (zh) 2016-10-08 2019-08-06 天津大学 一种酿酒酵母工程菌株及其构建方法、应用
WO2018207036A1 (en) 2017-05-11 2018-11-15 King Abdullah University Of Science And Technology A peptide capable of forming a gel for use in tissue engineering and bioprinting

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