SG11201909017XA - Targeted mosquitocidal toxins - Google Patents

Targeted mosquitocidal toxins

Info

Publication number
SG11201909017XA
SG11201909017XA SG11201909017XA SG11201909017XA SG 11201909017X A SG11201909017X A SG 11201909017XA SG 11201909017X A SG11201909017X A SG 11201909017XA SG 11201909017X A SG11201909017X A SG 11201909017XA
Authority
SG
Singapore
Prior art keywords
international
toxin
waco
neff
hall
Prior art date
Application number
Inventor
Christopher Kearney
Grace Pruett
Original Assignee
Univ Baylor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Baylor filed Critical Univ Baylor
Publication of SG11201909017XA publication Critical patent/SG11201909017XA/en

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/18—Togaviridae; Flaviviridae
    • C07K14/1816—Flaviviridae, e.g. pestivirus, mucosal disease virus, bovine viral diarrhoea virus, classical swine fever virus (hog cholera virus), border disease virus
    • C07K14/1825—Flaviviruses or Group B arboviruses, e.g. yellow fever virus, japanese encephalitis, tick-borne encephalitis, dengue
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Insects & Arthropods (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pest Control & Pesticides (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Toxicology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 11 October 2018 (11.10.2018) WIPO I PCT o 1E1 oio 0111OH oI0IIIOH01Omuumuu° o (10) International Publication Number WO 2018/187342 Al (51) International Patent Classification: C12N 15/82 (2006.01) C07K 14/18 (2006.01) A01N 63/00 (2006.01) CO7K 14/435 (2006.01) (21) International Application Number: PCT/US2018/025907 (22) International Filing Date: 03 April 2018 (03.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/481,199 04 April 2017 (04.04.2017) US (71) Applicant: BAYLOR UNIVERSITY [US/US]; 213 Pat Neff Hall, One Bear Place, Box 97034, Waco, TX 76798-7034 (US). (72) Inventors: KEARNEY, Christopher, Michel; c/o Baylor University, 213 Pat Neff Hall, One Bear Place, Box 97034, Waco, TX 76798-7034 (US). PRUETT, Grace; c/o Baylor University, 213 Pat Neff Hall, One Bear Place, Box 97034, Waco, TX 76798-7034 (US). (74) Agent: BORRELLI, Sara, K. et al.; Jackson Walker LLP, 2323 Ross Avenue, Suite 600, Dallas, TX 75201 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with amended claims (Art. 19(1)) with sequence listing part of description (Rule 5.2(a)) (54) Title: TARGETED MOSQUITOCIDAL TOXINS 100 -0 Toxin = To z -13- Deng ue/Toxin 4- Buffer 50 a) a. ‘ cr 0 0 1 2 3 4 Time (Days) FIG. 6 (57) : Insecticidal toxins described herein are fused toxin peptides made up of a targeting domain fused to a toxin domain. The targeting peptide generates a specific association with mosquitoes by causing the fused toxin peptide to bind mosquitoes in a way that leads to the insecticidal activity. Transgenic plants described herein are mosquitocidal by expressing an insecticidal toxin protein in nectar that includes a targeting peptide to ensure specificity against mosquitoes. These transgenic plants serve as role models for safety, since they are non-crop plants and specific to one mosquito species.
SG11201909017X 2017-04-04 2018-04-03 Targeted mosquitocidal toxins SG11201909017XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762481199P 2017-04-04 2017-04-04
PCT/US2018/025907 WO2018187342A1 (en) 2017-04-04 2018-04-03 Targeted mosquitocidal toxins

Publications (1)

Publication Number Publication Date
SG11201909017XA true SG11201909017XA (en) 2019-10-30

Family

ID=62028149

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201909017X SG11201909017XA (en) 2017-04-04 2018-04-03 Targeted mosquitocidal toxins

Country Status (11)

Country Link
US (2) US11479583B2 (en)
EP (1) EP3607075A1 (en)
JP (1) JP7112757B2 (en)
CN (1) CN110475867A (en)
AU (1) AU2018250153A1 (en)
BR (1) BR112019020245A2 (en)
CA (1) CA3057881A1 (en)
EA (1) EA201992362A1 (en)
MX (1) MX2019011917A (en)
SG (1) SG11201909017XA (en)
WO (1) WO2018187342A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201909017XA (en) 2017-04-04 2019-10-30 Univ Baylor Targeted mosquitocidal toxins

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9106185D0 (en) 1991-03-22 1991-05-08 Wellcome Found Biological control agents
US5674846A (en) 1996-09-04 1997-10-07 Nps Pharmaceuticals, Inc. Insecticidal peptides from Segestria sp. spider venom
US7279547B2 (en) 2000-02-10 2007-10-09 University Of Connecticut Insecticidal compounds and methods for selection thereof
AU2001238152A1 (en) 2000-02-10 2001-08-20 University Of Connecticut Insecticidal compounds and methods for selection thereof
ES2318576T3 (en) 2004-11-04 2009-05-01 University Of Connecticut INSPECTED POLYPEPTIDES AND PROCEDURES FOR USE.
NZ566879A (en) * 2005-09-16 2011-08-26 Univ Connecticut Acaricidal compositions comprising an omega-ACTX peptide
US20090023183A1 (en) 2005-10-18 2009-01-22 Seoul National University Industry Foundation Method For Preparing Recombinant Peptide From Spider Venom and Analgesic Composition Containing The Peptide
US20080300210A1 (en) 2007-05-16 2008-12-04 Wisconsin Alumni Research Foundation Method of Controlling Insects and Virus Transmission
SI2334177T1 (en) 2008-10-01 2016-08-31 Vestaron Corporation Peptide toxin formulation
WO2010077672A2 (en) 2008-12-08 2010-07-08 University Of Florida Research Foundation, Inc. Control of mosquito larvae with bti toxins and tmof
US8334366B1 (en) 2009-04-29 2012-12-18 The United States Of America, As Represented By The Secretary Of Agriculture Mutant lycotoxin-1 peptide sequences for insecticidal and cell membrane altering properties
WO2011158242A2 (en) 2010-06-16 2011-12-22 Futuragene Israel Ltd. Pest -resistant plants containing a combination of a spider toxin and a chitinase
GB201105418D0 (en) 2011-03-31 2011-05-18 Univ Durham Pesticide
US20130097729A1 (en) 2011-06-08 2013-04-18 Bryony Claire Bonning Aphicidal Toxins and Methods
US11692016B2 (en) 2012-03-09 2023-07-04 Vestaron Corporation High gene expression yeast strain
EP2822963A2 (en) 2012-03-09 2015-01-14 Vestaron Corporation Toxic peptide production, peptide expression in plants and combinations of cysteine rich peptides
US20200255482A1 (en) 2012-03-09 2020-08-13 Vestaron Corporation Insecticidal combinations
US9388428B2 (en) 2012-11-21 2016-07-12 The Board Of Regents Of The University Of Texas System Compositions and methods related to viruses of the genus Negevirus
CN110172466A (en) 2013-03-07 2019-08-27 巴斯夫农业解决方案种子美国有限责任公司 Toxin gene and its application method
GB201321938D0 (en) 2013-12-11 2014-01-22 Univ Durham Pesticidal fusion protein improvements
EP3483274A1 (en) 2014-03-28 2019-05-15 Monsanto Technology LLC Pesticidal toxin proteins active against coleopteran insects
WO2017011863A1 (en) 2015-07-17 2017-01-26 The University Of Queensland Neuroprotective agents derived from spider venom peptides
US11140902B2 (en) 2016-09-27 2021-10-12 University Of Florida Research Foundation, Inc. Insect toxin delivery mediated by a densovirus coat protein
MX2019004648A (en) 2016-10-21 2019-05-23 Vestaron Corp Cleavable peptides and insecticidal and nematicidal proteins comprising same.
CA3056903A1 (en) 2017-03-24 2018-09-27 Novozymes Bioag A/S Combinations of yersinia entomophaga and pesticides or other substances
SG11201909017XA (en) 2017-04-04 2019-10-30 Univ Baylor Targeted mosquitocidal toxins

Also Published As

Publication number Publication date
US11479583B2 (en) 2022-10-25
EP3607075A1 (en) 2020-02-12
CN110475867A (en) 2019-11-19
MX2019011917A (en) 2020-01-09
US20230002452A1 (en) 2023-01-05
AU2018250153A1 (en) 2019-10-10
JP7112757B2 (en) 2022-08-04
JP2020515628A (en) 2020-05-28
US20180282757A1 (en) 2018-10-04
WO2018187342A1 (en) 2018-10-11
BR112019020245A2 (en) 2020-05-12
EA201992362A1 (en) 2020-02-28
CA3057881A1 (en) 2018-10-11

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