SG11202000055PA - Antibodies that modulate a biological activity expressed by a cell - Google Patents
Antibodies that modulate a biological activity expressed by a cellInfo
- Publication number
- SG11202000055PA SG11202000055PA SG11202000055PA SG11202000055PA SG11202000055PA SG 11202000055P A SG11202000055P A SG 11202000055PA SG 11202000055P A SG11202000055P A SG 11202000055PA SG 11202000055P A SG11202000055P A SG 11202000055PA SG 11202000055P A SG11202000055P A SG 11202000055PA
- Authority
- SG
- Singapore
- Prior art keywords
- utrecht
- yalelaan
- international
- cell
- bind
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau vitivio VIII oviolo OH itio oimIE (43) International Publication Date 10 January 2019 (10.01.2019) W I PO I (10) International Publication Number WO 2019/009728 Al PCT (51) International Patent Classification: C07K 16/28 (2006.01) C07K 16/46 (2006.01) CO7K 16/12 (2006.01) TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (21) International Application Number: PCT/NL2018/050451 (22) International Filing Date: Published: with international search report (Art 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) Filing Language: Publication Language: Priority Data: 17180070.9 06 July 2017 (06.07.2017) EP Applicant: MERUS N.V. [NL/NL]; Yalelaan 62, 3584 CM Utrecht (NL). Inventors: GEUIJEN, Cecilia Ana Wilhelmina; c/o Yale- laan 62, 3584 CM Utrecht (NL). KLOOSTER, Rinse; c/ o Yalelaan 62, 3584 CM Utrecht (NL). DE KRUIF, Cor- nelis Adriaan; c/o Yalelaan 62, 3584 CM Utrecht (NL). TACKEN, Paulus Johannes; c/o Yalelaan 62, 3584 CM Utrecht (NL). THROSBY, Mark; c/o Yalelaan 62, 3584 CM Utrecht (NL). LOGTENBERG, Ton; c/o Yalelaan 62, 3584 CM Utrecht (NL). 06 July 2018 (06.07.2018) English English Agent: JANSEN, C.M.; V.O., Carnegieplein 5, 2517 KJ Den Haag (NL). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (25) (26) (30) (71) (72) (74) (81) (84) 1-1 GC N cr\ O O cr\ O 1-1 O (54) Title: ANTIBODIES THAT MODULATE A BIOLOGICAL ACTIVITY EXPRESSED BY A CELL (57) : The invention provides means and methods for interfering with Programmed Cell Death 1 protein (PD-1) and Lympho- cyte activation 3 (LAG 3) mediated inhibition in a PD- 1 and/or LAG3 positive cell. A method may comprise contacting said cell with an antibody or a functional part, derivative and/or analogue thereof that comprises a variable domain that can bind to an extracellular part of PD- 1 and a variable domain that can bind to an extracellular part of LAG3, thereby inhibiting PD-1 and/or LAG3 mediated activity in said cell. The invention also provides antibodies or variants thereof that comprises a variable domain that can bind to an extracellular part of PD- 1 and a variable domain that can bind to an extracellular part of LAG3.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17180070 | 2017-07-06 | ||
PCT/NL2018/050451 WO2019009728A1 (en) | 2017-07-06 | 2018-07-06 | Antibodies that modulate a biological activity expressed by a cell |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202000055PA true SG11202000055PA (en) | 2020-02-27 |
Family
ID=59295099
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202000055PA SG11202000055PA (en) | 2017-07-06 | 2018-07-06 | Antibodies that modulate a biological activity expressed by a cell |
Country Status (14)
Country | Link |
---|---|
US (2) | US11732043B2 (en) |
EP (1) | EP3649156A1 (en) |
JP (1) | JP2020525533A (en) |
KR (1) | KR20200037250A (en) |
CN (1) | CN111094350A (en) |
AU (1) | AU2018297061B2 (en) |
BR (1) | BR112020000228A2 (en) |
CA (1) | CA3068933A1 (en) |
EA (1) | EA202090005A1 (en) |
IL (1) | IL271833A (en) |
PH (1) | PH12020550010A1 (en) |
SG (1) | SG11202000055PA (en) |
TW (1) | TW201920275A (en) |
WO (1) | WO2019009728A1 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10844119B2 (en) | 2016-10-11 | 2020-11-24 | Agenus Inc. | Anti-LAG-3 antibodies and methods of use thereof |
WO2018127711A1 (en) | 2017-01-06 | 2018-07-12 | Crescendo Biologics Limited | Single Domain Antibodies to Programmed Cell Death (PD-1) |
GB201802573D0 (en) * | 2018-02-16 | 2018-04-04 | Crescendo Biologics Ltd | Therapeutic molecules that bind to LAG3 |
WO2019179422A1 (en) * | 2018-03-20 | 2019-09-26 | Wuxi Biologics (Shanghai) Co., Ltd. | Novel bispecific pd-1/lag-3 antibody molecules |
BR112020019795A2 (en) * | 2018-03-30 | 2021-01-05 | Merus N.V. | MULTIVALENT ANTIBODY |
EP3958900A4 (en) * | 2019-04-26 | 2023-01-25 | WuXi Biologics Ireland Limited | Bispecific antibodies against pd-1 and lag-3 |
MX2021013646A (en) | 2019-05-09 | 2022-01-31 | Merus Nv | Variant domains for multimerizing proteins and separation thereof. |
US11667711B2 (en) | 2020-05-27 | 2023-06-06 | Agilent Technologies, Inc. | Anti-human LAG-3 antibodies and their use in immunohistochemistry (IHC) |
CN113416249B (en) * | 2020-10-21 | 2023-04-07 | 北京智仁美博生物科技有限公司 | Compositions against tetanus toxin |
EP4019633A1 (en) * | 2020-12-23 | 2022-06-29 | Technische Universität München | Conditional cell connectors |
JP2024511871A (en) | 2021-03-31 | 2024-03-15 | メルス ナムローゼ フェンノートシャップ | Novel multispecific antibody |
WO2022211629A1 (en) | 2021-03-31 | 2022-10-06 | Merus N.V. | Novel pd-1 binding domains |
CA3213682A1 (en) | 2021-03-31 | 2022-10-06 | Simon Edward PLYTE | Multispecific binding moieties comprising novel pd-1 binding domains |
WO2024072893A1 (en) * | 2022-09-28 | 2024-04-04 | Incyte Corporation | Anti-pd-1/lag-3 bispecific antibodies and uses thereof |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020062010A1 (en) | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
SI1523496T1 (en) | 2002-07-18 | 2011-11-30 | Merus B V | Recombinant production of mixtures of antibodies |
DK2161336T4 (en) | 2005-05-09 | 2017-04-24 | Ono Pharmaceutical Co | Human monoclonal antibodies for programmed death 1 (PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapies |
EP2860260A1 (en) | 2008-04-11 | 2015-04-15 | Merrimack Pharmaceuticals, Inc. | Human serum albumin linkers and conjugates thereof |
MX2010014542A (en) | 2008-06-27 | 2011-04-05 | Merus B V | Antibody producing non-human mammals. |
AR072999A1 (en) | 2008-08-11 | 2010-10-06 | Medarex Inc | HUMAN ANTIBODIES THAT JOIN GEN 3 OF LYMPHOCYTARY ACTIVATION (LAG-3) AND THE USES OF THESE |
CA2736816C (en) | 2008-09-12 | 2018-05-22 | Isis Innovation Limited | Pd-1 specific antibodies and uses thereof |
WO2010029435A1 (en) | 2008-09-12 | 2010-03-18 | Isis Innovation Limited | Pd-1 specific antibodies and uses thereof |
HUE037651T2 (en) | 2011-04-20 | 2018-09-28 | Medimmune Llc | Antibodies and other molecules that bind b7-h1 and pd-1 |
WO2013022091A1 (en) | 2011-08-11 | 2013-02-14 | 小野薬品工業株式会社 | Therapeutic agent for autoimmune diseases comprising pd-1 agonist |
EA035344B1 (en) | 2012-04-20 | 2020-05-29 | Мерюс Н.В. | Method for producing two antibodies from a single host cell |
HUE042040T2 (en) * | 2012-09-27 | 2019-06-28 | Merus Nv | Bispecific igg antibodies as t cell engagers |
KR20220126813A (en) * | 2014-03-14 | 2022-09-16 | 노파르티스 아게 | Antibody molecules to lag-3 and uses thereof |
TWI693232B (en) * | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | Covalently bonded diabodies having immunoreactivity with pd-1 and lag-3, and methods of use thereof |
WO2016011069A1 (en) | 2014-07-15 | 2016-01-21 | The Board Of Trustees Of The Leland Stanford Junior University | Medical uses of cd38 agonists (antibodies) |
JO3663B1 (en) * | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | Anti-lag3 antibodies and antigen-binding fragments |
JP6974311B2 (en) * | 2015-06-23 | 2021-12-01 | メモリアル スローン ケタリング キャンサー センター | New PD-1 immunomodulator |
KR20180093127A (en) * | 2015-07-30 | 2018-08-20 | 마크로제닉스, 인크. | PD-1-Binding Molecules and Methods of Use Thereof |
WO2017024515A1 (en) * | 2015-08-11 | 2017-02-16 | Wuxi Biologics (Cayman) Inc. | Novel anti-pd-1 antibodies |
WO2017049143A1 (en) | 2015-09-18 | 2017-03-23 | Dana-Farber Cancer Institute, Inc. | Methods of reducing liver pd-1-expressing cd8+t cells using pd-1 fc fusion proteins that bind fc receptors |
TWI756187B (en) | 2015-10-09 | 2022-03-01 | 美商再生元醫藥公司 | Anti-lag3 antibodies and uses thereof |
EP3912998A3 (en) * | 2015-10-23 | 2022-02-23 | Merus N.V. | Binding molecules that inhibit cancer growth |
AU2016355570B2 (en) * | 2015-11-18 | 2020-01-02 | Merck Sharp & Dohme Llc | PD1 and/or LAG3 binders |
SG11201901950TA (en) | 2016-09-19 | 2019-04-29 | Celgene Corp | Methods of treating immune disorders using pd-1 binding proteins |
JP2019534859A (en) | 2016-09-19 | 2019-12-05 | セルジーン コーポレイション | Method for treating vitiligo using PD-1 binding protein |
WO2018056821A1 (en) | 2016-09-23 | 2018-03-29 | Merus N.V. | Binding molecules that modulate a biological activity expressed by a cell |
JP6929951B2 (en) * | 2017-02-22 | 2021-09-01 | アイ−エムエービー バイオファーマ (ハンジョウ) カンパニー リミテッド | Anti-LAG-3 antibody and its use |
CN110366546A (en) | 2017-03-01 | 2019-10-22 | 氟化学有限公司法兰克福 | The savings medium of new material and its manufacture to be used as in sensitive energy-storage system within the scope of low, medium and high temperature |
DE202017102208U1 (en) | 2017-03-03 | 2018-03-07 | Sarah Yanik | Composition, in particular for the treatment of hoof and claw diseases in animals, and their production |
AU2018297058B2 (en) * | 2017-07-06 | 2021-04-29 | Merus N.V. | Bispecific anti PD1-anti TIM3 antibodies |
US11667714B2 (en) * | 2017-07-06 | 2023-06-06 | Merus N.V. | Binding molecules that modulate a biological activity expressed by a cell |
WO2020167122A1 (en) * | 2019-02-14 | 2020-08-20 | Merus N.V. | Producing compositions comprising two or more antibodies. |
EP4157354A1 (en) | 2020-05-27 | 2023-04-05 | Dana-Farber Cancer Institute, Inc. | Bispecific molecules for selectively modulating t cells |
-
2018
- 2018-07-06 BR BR112020000228-3A patent/BR112020000228A2/en unknown
- 2018-07-06 CA CA3068933A patent/CA3068933A1/en active Pending
- 2018-07-06 KR KR1020207003657A patent/KR20200037250A/en not_active Application Discontinuation
- 2018-07-06 EA EA202090005A patent/EA202090005A1/en unknown
- 2018-07-06 US US16/628,939 patent/US11732043B2/en active Active
- 2018-07-06 WO PCT/NL2018/050451 patent/WO2019009728A1/en unknown
- 2018-07-06 CN CN201880057358.4A patent/CN111094350A/en active Pending
- 2018-07-06 JP JP2020500187A patent/JP2020525533A/en active Pending
- 2018-07-06 TW TW107123603A patent/TW201920275A/en unknown
- 2018-07-06 AU AU2018297061A patent/AU2018297061B2/en active Active
- 2018-07-06 EP EP18749181.6A patent/EP3649156A1/en active Pending
- 2018-07-06 SG SG11202000055PA patent/SG11202000055PA/en unknown
-
2020
- 2020-01-05 IL IL271833A patent/IL271833A/en unknown
- 2020-01-06 PH PH12020550010A patent/PH12020550010A1/en unknown
-
2023
- 2023-04-27 US US18/308,232 patent/US20230406932A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2019009728A8 (en) | 2020-01-09 |
AU2018297061B2 (en) | 2021-05-06 |
BR112020000228A2 (en) | 2020-07-14 |
EP3649156A1 (en) | 2020-05-13 |
US20200216540A1 (en) | 2020-07-09 |
PH12020550010A1 (en) | 2020-10-12 |
CN111094350A (en) | 2020-05-01 |
US20230406932A1 (en) | 2023-12-21 |
TW201920275A (en) | 2019-06-01 |
US11732043B2 (en) | 2023-08-22 |
CA3068933A1 (en) | 2019-01-10 |
EA202090005A1 (en) | 2020-06-18 |
WO2019009728A1 (en) | 2019-01-10 |
JP2020525533A (en) | 2020-08-27 |
IL271833A (en) | 2020-02-27 |
AU2018297061A1 (en) | 2020-01-30 |
KR20200037250A (en) | 2020-04-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG11202000055PA (en) | Antibodies that modulate a biological activity expressed by a cell | |
SG11201903857UA (en) | Antibodies to pd-1 and uses thereof | |
SG11201805888SA (en) | Cyclic dinucleotides for treating conditions associated with sting activity such as cancer | |
SG11201908813QA (en) | Anti-sirp alpha antibodies | |
SG11201811431VA (en) | Multispecific antibodies against cd40 and cd137 | |
SG11201810933QA (en) | Anti-c5 antibodies and uses thereof | |
SG11201901700UA (en) | Biaryl compounds useful as immunomodulators | |
SG11201901899PA (en) | Bispecific trivalent antibodies binding to claudin6 or claudin18.2 and cd3 for treatment of claudin expressing cancer diseases | |
SG11201909955XA (en) | Formulations of anti-lag3 antibodies and co-formulations of anti-lag3 antibodies and anti-pd-1 antibodies | |
SG11201910027YA (en) | Bispecific antibody against ox40 and ctla-4 | |
SG11201805532XA (en) | Multivalent and multispecific 41bb-binding fusion proteins | |
SG11201811184UA (en) | Lag -3 binding members | |
SG11201908088RA (en) | Antibodies against pd-l1 | |
SG11201909949XA (en) | Targeted immunotolerance | |
SG11201805870YA (en) | Bispecific t cell engaging antibody constructs | |
SG11201806496SA (en) | Antigen binding proteins that bind pd-l1 | |
SG11201806624XA (en) | Deposition of molybdenum thin films using a molybdenum carbonyl precursor | |
SG11201910134SA (en) | Stable formulations of anti-ctla4 antibodies alone and in combination with programmed death receptor 1 (pd-1) antibodies and methods of use thereof | |
SG11201803703UA (en) | Anti-complement factor c1q fab fragments and uses thereof | |
SG11201908056QA (en) | Anti-par2 antibodies and uses thereof | |
SG11201806267QA (en) | Organic reactions carried out in aqueous solution in the presence of a hydroxyalkyl(alkyl)cellulose or an alkylcellulose | |
SG11201908238SA (en) | Anti-c5 antibodies and uses thereof | |
SG11201907364WA (en) | Anti-tryptase antibodies, compositions thereof, and uses thereof | |
SG11201906961UA (en) | Polypeptide variants and uses thereof | |
SG11201908325PA (en) | Process for the preparation of glucuronide drug-linkers and intermediates thereof |