EA029088B1 - Макроциклические и бициклические ингибиторы вируса гепатита c - Google Patents
Макроциклические и бициклические ингибиторы вируса гепатита c Download PDFInfo
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- EA029088B1 EA029088B1 EA201591456A EA201591456A EA029088B1 EA 029088 B1 EA029088 B1 EA 029088B1 EA 201591456 A EA201591456 A EA 201591456A EA 201591456 A EA201591456 A EA 201591456A EA 029088 B1 EA029088 B1 EA 029088B1
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/02—Preparation by ring-closure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| PCT/US2014/029765 WO2014145095A1 (en) | 2013-03-15 | 2014-03-14 | Macrocyclic and bicyclic inhibitors of hepatitis c virus |
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| UA119315C2 (uk) | 2012-07-03 | 2019-06-10 | Гіліад Фармассет Елелсі | Інгібітори вірусу гепатиту с |
| JP7381190B2 (ja) | 2014-12-26 | 2023-11-15 | エモリー・ユニバーシテイ | N4-ヒドロキシシチジン及び誘導体並びにそれに関連する抗ウイルス用途 |
| CN105503751B (zh) * | 2015-12-22 | 2018-06-05 | 广西师范大学 | 一种喹喔啉衍生物的高效合成方法 |
| KR102626210B1 (ko) | 2017-12-07 | 2024-01-18 | 에모리 유니버시티 | N4-하이드록시사이티딘 및 유도체 및 이와 관련된 항-바이러스 용도 |
| CN108329332A (zh) * | 2018-03-16 | 2018-07-27 | 安徽华昌高科药业有限公司 | 一种制备Glecaprevir的方法 |
| CN111004188B (zh) * | 2019-12-18 | 2021-04-20 | 安徽红杉生物医药科技有限公司 | Ns3/4a蛋白酶抑制剂中间体及其合成方法、应用 |
| CN111018795B (zh) * | 2019-12-25 | 2023-03-28 | 上海彩迩文生化科技有限公司 | 一种碱性条件下合成喹喔啉-3-酮的方法 |
| US12083099B2 (en) | 2020-10-28 | 2024-09-10 | Accencio LLC | Methods of treating symptoms of coronavirus infection with viral protease inhibitors |
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2014
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- 2014-03-14 CN CN201480015589.0A patent/CN105073758B/zh active Active
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- 2014-03-14 KR KR1020157028437A patent/KR102215400B1/ko active Active
- 2014-03-14 EP EP14723582.4A patent/EP2970335B1/en active Active
- 2014-03-14 SG SG11201507223TA patent/SG11201507223TA/en unknown
- 2014-03-14 MX MX2015013224A patent/MX2015013224A/es unknown
- 2014-03-14 BR BR112015021768A patent/BR112015021768A2/pt not_active Application Discontinuation
-
2015
- 2015-08-18 IL IL240662A patent/IL240662A0/en unknown
-
2017
- 2017-03-10 US US15/455,508 patent/US20170313745A1/en not_active Abandoned
-
2018
- 2018-12-13 JP JP2018233621A patent/JP2019059775A/ja not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007131966A1 (en) * | 2006-05-15 | 2007-11-22 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Macrocyclic compounds as antiviral agents |
| WO2009005676A2 (en) * | 2007-06-29 | 2009-01-08 | Gilead Sciences, Inc. | Antiviral compounds |
| WO2010011566A1 (en) * | 2008-07-22 | 2010-01-28 | Merck & Co., Inc. | Macrocyclic quinoxaline compounds as hcv ns3 protease inhibitors |
| WO2012040040A1 (en) * | 2010-09-21 | 2012-03-29 | Merck Sharp & Dohme Corp. | Hcv ns3 protease inhibitors |
| WO2014008285A1 (en) * | 2012-07-03 | 2014-01-09 | Gilead Sciences, Inc. | Inhibitors of hepatitis c virus |
Non-Patent Citations (5)
| Title |
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| WO -A1-2007131966 * |
| WO -A1-2010011566 * |
| WO -A1-2012040040 * |
| WO -A1-2014008285 * |
| WO -A2-2009005676 * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR102215400B1 (ko) | 2021-02-10 |
| KR20150130456A (ko) | 2015-11-23 |
| BR112015021768A2 (pt) | 2016-02-02 |
| US20140274884A1 (en) | 2014-09-18 |
| EP2970335A1 (en) | 2016-01-20 |
| US9617310B2 (en) | 2017-04-11 |
| EA201591456A1 (ru) | 2016-02-29 |
| US20170313745A1 (en) | 2017-11-02 |
| AU2014233390A1 (en) | 2015-09-03 |
| JP2019059775A (ja) | 2019-04-18 |
| MX2015013224A (es) | 2015-12-11 |
| ES2735355T3 (es) | 2019-12-18 |
| WO2014145095A1 (en) | 2014-09-18 |
| EP2970335B1 (en) | 2019-05-08 |
| CN105073758B (zh) | 2017-08-11 |
| SG11201507223TA (en) | 2015-10-29 |
| HK1217196A1 (en) | 2016-12-30 |
| CN105073758A (zh) | 2015-11-18 |
| JP6511432B2 (ja) | 2019-05-15 |
| JP2016516069A (ja) | 2016-06-02 |
| CA2902569A1 (en) | 2014-09-18 |
| AU2014233390B2 (en) | 2018-03-01 |
| IL240662A0 (en) | 2015-10-29 |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
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