ES2735355T3 - Inhibidores macrocíclicos y bicíclicos de virus de hepatitis C - Google Patents
Inhibidores macrocíclicos y bicíclicos de virus de hepatitis C Download PDFInfo
- Publication number
- ES2735355T3 ES2735355T3 ES14723582T ES14723582T ES2735355T3 ES 2735355 T3 ES2735355 T3 ES 2735355T3 ES 14723582 T ES14723582 T ES 14723582T ES 14723582 T ES14723582 T ES 14723582T ES 2735355 T3 ES2735355 T3 ES 2735355T3
- Authority
- ES
- Spain
- Prior art keywords
- mmol
- preparation
- concentrated
- vacuo
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 0 *C1(CC1)S(N)(=O)=O Chemical compound *C1(CC1)S(N)(=O)=O 0.000 description 8
- OHNNZOOGWXZCPZ-CYDAGYADSA-N C(C1)C2[C@@H]3O[C@@H]3C1C2 Chemical compound C(C1)C2[C@@H]3O[C@@H]3C1C2 OHNNZOOGWXZCPZ-CYDAGYADSA-N 0.000 description 1
- KZGAXTMNECCEQV-UHFFFAOYSA-N C=CC(c1nc(ccc(OC(F)F)c2)c2nc1O)(F)F Chemical compound C=CC(c1nc(ccc(OC(F)F)c2)c2nc1O)(F)F KZGAXTMNECCEQV-UHFFFAOYSA-N 0.000 description 1
- YCGNJFWMEASNEB-UHFFFAOYSA-N C=CC(c1nc(cccc2)c2nc1Cl)(F)F Chemical compound C=CC(c1nc(cccc2)c2nc1Cl)(F)F YCGNJFWMEASNEB-UHFFFAOYSA-N 0.000 description 1
- SHGPPNKYUMVQPJ-HBIQZDMRSA-N C=CCCCC([C@H]1CC2CC1)[C@@H]2O Chemical compound C=CCCCC([C@H]1CC2CC1)[C@@H]2O SHGPPNKYUMVQPJ-HBIQZDMRSA-N 0.000 description 1
- MZMNEDXVUJLQAF-SFYZADRCSA-N CC(C)(C)OC(N(C[C@@H](C1)O)[C@@H]1C(OC)=O)=O Chemical compound CC(C)(C)OC(N(C[C@@H](C1)O)[C@@H]1C(OC)=O)=O MZMNEDXVUJLQAF-SFYZADRCSA-N 0.000 description 1
- YNKDNGKIJFMWKH-CJNGLKHVSA-N CC(C)(C)OC(N(C[C@@H](C1)Oc2c(C(C=C)(F)F)nc(cccc3)c3n2)[C@@H]1C(OC)=O)=O Chemical compound CC(C)(C)OC(N(C[C@@H](C1)Oc2c(C(C=C)(F)F)nc(cccc3)c3n2)[C@@H]1C(OC)=O)=O YNKDNGKIJFMWKH-CJNGLKHVSA-N 0.000 description 1
- CAXRCRDDEDHEIB-SLCMMARKSA-N CC(C)(C)[C@@H](C(N(C[C@@H](C1)Oc2nc(cc(cc3)OC)c3nc2CCCCC[C@H](CC2=N[C@H]22)[C@@H]2O2)[C@@H]1C(N[C@@](C1)(C(NS(C3(C)CC3)(=O)=O)=O)C1=C(F)F)=O)=O)NC2=O Chemical compound CC(C)(C)[C@@H](C(N(C[C@@H](C1)Oc2nc(cc(cc3)OC)c3nc2CCCCC[C@H](CC2=N[C@H]22)[C@@H]2O2)[C@@H]1C(N[C@@](C1)(C(NS(C3(C)CC3)(=O)=O)=O)C1=C(F)F)=O)=O)NC2=O CAXRCRDDEDHEIB-SLCMMARKSA-N 0.000 description 1
- HXLQQSUFBGPABO-IALVXYMDSA-N CC(C/C(/O[C@H](C1)CN[C@@H]1C(OC)=O)=N\c1c(C)cccc1)(C=C)F Chemical compound CC(C/C(/O[C@H](C1)CN[C@@H]1C(OC)=O)=N\c1c(C)cccc1)(C=C)F HXLQQSUFBGPABO-IALVXYMDSA-N 0.000 description 1
- JWLZDNDLXFFVDL-UHFFFAOYSA-N CCOC(C(C(C=C)(F)F)O)=O Chemical compound CCOC(C(C(C=C)(F)F)O)=O JWLZDNDLXFFVDL-UHFFFAOYSA-N 0.000 description 1
- HJTXXQZTAPAGEW-UHFFFAOYSA-N CCOC(C(C(C=C)F)(O)O)=O Chemical compound CCOC(C(C(C=C)F)(O)O)=O HJTXXQZTAPAGEW-UHFFFAOYSA-N 0.000 description 1
- YMIAJALIVUPLFE-UHFFFAOYSA-N COc(cc1)cc2c1NC(C(C=C)(F)F)C(O)=N2 Chemical compound COc(cc1)cc2c1NC(C(C=C)(F)F)C(O)=N2 YMIAJALIVUPLFE-UHFFFAOYSA-N 0.000 description 1
- QFMJFXFXQAFGBO-UHFFFAOYSA-N COc(cc1[N+]([O-])=O)ccc1N Chemical compound COc(cc1[N+]([O-])=O)ccc1N QFMJFXFXQAFGBO-UHFFFAOYSA-N 0.000 description 1
- VMTGPNORNAXZBK-UHFFFAOYSA-N COc(ccc1n2)cc1nc(C(C=C)(F)F)c2O Chemical compound COc(ccc1n2)cc1nc(C(C=C)(F)F)c2O VMTGPNORNAXZBK-UHFFFAOYSA-N 0.000 description 1
- QKQRSVWXCZPVOD-LCYFTJDESA-N CS/C(/Nc1cccc2ccccc12)=C\[N+]([O-])=O Chemical compound CS/C(/Nc1cccc2ccccc12)=C\[N+]([O-])=O QKQRSVWXCZPVOD-LCYFTJDESA-N 0.000 description 1
- MFHCHQCAGVHOLU-UHFFFAOYSA-N CSc(nc(c1ccccc1cc1)c1n1)c1Cl Chemical compound CSc(nc(c1ccccc1cc1)c1n1)c1Cl MFHCHQCAGVHOLU-UHFFFAOYSA-N 0.000 description 1
- FPAKXBHHKVXYQL-UHFFFAOYSA-N Cc1nc(cc(cc2)OC(F)F)c2nc1C(C=C)(F)F Chemical compound Cc1nc(cc(cc2)OC(F)F)c2nc1C(C=C)(F)F FPAKXBHHKVXYQL-UHFFFAOYSA-N 0.000 description 1
- RWZUYAHDGINOQQ-UHFFFAOYSA-N Cc1nc(cc(cc2)OC)c2nc1C(C=C)(F)F Chemical compound Cc1nc(cc(cc2)OC)c2nc1C(C=C)(F)F RWZUYAHDGINOQQ-UHFFFAOYSA-N 0.000 description 1
- NPHZYAUZXKZURW-UHFFFAOYSA-N Cc1nc2ccc(cccc3)c3c2nc1S(C)(=O)=O Chemical compound Cc1nc2ccc(cccc3)c3c2nc1S(C)(=O)=O NPHZYAUZXKZURW-UHFFFAOYSA-N 0.000 description 1
- GRBDLKBKKHPPQX-UHFFFAOYSA-N Nc(ccc(OC(F)F)c1)c1N Chemical compound Nc(ccc(OC(F)F)c1)c1N GRBDLKBKKHPPQX-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/02—Preparation by ring-closure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361798961P | 2013-03-15 | 2013-03-15 | |
| PCT/US2014/029765 WO2014145095A1 (en) | 2013-03-15 | 2014-03-14 | Macrocyclic and bicyclic inhibitors of hepatitis c virus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2735355T3 true ES2735355T3 (es) | 2019-12-18 |
Family
ID=50694007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14723582T Active ES2735355T3 (es) | 2013-03-15 | 2014-03-14 | Inhibidores macrocíclicos y bicíclicos de virus de hepatitis C |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9617310B2 (enExample) |
| EP (1) | EP2970335B1 (enExample) |
| JP (2) | JP6511432B2 (enExample) |
| KR (1) | KR102215400B1 (enExample) |
| CN (1) | CN105073758B (enExample) |
| AU (1) | AU2014233390B2 (enExample) |
| BR (1) | BR112015021768A2 (enExample) |
| CA (1) | CA2902569A1 (enExample) |
| EA (1) | EA029088B1 (enExample) |
| ES (1) | ES2735355T3 (enExample) |
| IL (1) | IL240662A0 (enExample) |
| MX (1) | MX2015013224A (enExample) |
| SG (1) | SG11201507223TA (enExample) |
| WO (1) | WO2014145095A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA119315C2 (uk) | 2012-07-03 | 2019-06-10 | Гіліад Фармассет Елелсі | Інгібітори вірусу гепатиту с |
| LT3236972T (lt) | 2014-12-26 | 2021-11-10 | Emory University | Antivirusiniai n4-hidroksicitidino dariniai |
| CN105503751B (zh) * | 2015-12-22 | 2018-06-05 | 广西师范大学 | 一种喹喔啉衍生物的高效合成方法 |
| LT3706762T (lt) | 2017-12-07 | 2024-12-27 | Emory University | N4-hidroksicitidinas ir jo dariniai bei susiję naudojimo prieš virusus būdai |
| CN108329332A (zh) * | 2018-03-16 | 2018-07-27 | 安徽华昌高科药业有限公司 | 一种制备Glecaprevir的方法 |
| CN111004188B (zh) * | 2019-12-18 | 2021-04-20 | 安徽红杉生物医药科技有限公司 | Ns3/4a蛋白酶抑制剂中间体及其合成方法、应用 |
| CN111018795B (zh) * | 2019-12-25 | 2023-03-28 | 上海彩迩文生化科技有限公司 | 一种碱性条件下合成喹喔啉-3-酮的方法 |
| US12083099B2 (en) | 2020-10-28 | 2024-09-10 | Accencio LLC | Methods of treating symptoms of coronavirus infection with viral protease inhibitors |
Family Cites Families (107)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0303436A2 (hu) | 2000-12-12 | 2004-01-28 | Schering Corp. | Diaril-peptidek mint a hepatitis C vírus NS3-szerin proteáz inhibitorai, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk |
| EP1441725A1 (en) | 2001-10-26 | 2004-08-04 | Aventis Pharmaceuticals Inc. | Benzimidazoles and analogues and their use as protein kinases inhibitors |
| JP4312711B2 (ja) | 2002-05-20 | 2009-08-12 | ブリストル−マイヤーズ スクイブ カンパニー | ヘテロ環式スルホンアミドｃ型肝炎ウイルス阻害剤 |
| ES2361011T3 (es) | 2002-05-20 | 2011-06-13 | Bristol-Myers Squibb Company | Inhibidores del virus de la hepatitis c. |
| ES2315568T3 (es) | 2002-05-20 | 2009-04-01 | Bristol-Myers Squibb Company | Inhibidores del virus de la hepatitis c basados en cicloalquilo p1' sustituido. |
| ATE422895T1 (de) | 2003-04-16 | 2009-03-15 | Bristol Myers Squibb Co | Makrocyclische isochinolinpeptidinhibitoren des hepatitis-c-virus |
| DE602004023924D1 (en) | 2003-04-18 | 2009-12-17 | Enanta Pharm Inc | Ease-hemmer |
| US7176208B2 (en) | 2003-04-18 | 2007-02-13 | Enanta Pharmaceuticals, Inc. | Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors |
| CL2004001161A1 (es) | 2003-05-21 | 2005-04-08 | Boehringer Ingelheim Int | Compuestos describe compuestos derivados de quinolina; composicion farmaceutica; y su uso para tratar una enfermedad causada por el virus de la hepatitis c. |
| WO2005018330A1 (en) * | 2003-08-18 | 2005-03-03 | Pharmasset, Inc. | Dosing regimen for flaviviridae therapy |
| US7135462B2 (en) | 2003-11-20 | 2006-11-14 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| AR050174A1 (es) | 2004-07-16 | 2006-10-04 | Gilead Sciences Inc | Derivados de fosfonatos con actividad antiviral. composiciones farmaceuticas |
| UY29016A1 (es) | 2004-07-20 | 2006-02-24 | Boehringer Ingelheim Int | Analogos de dipeptidos inhibidores de la hepatitis c |
| WO2007001406A2 (en) | 2004-10-05 | 2007-01-04 | Chiron Corporation | Aryl-containing macrocyclic compounds |
| AU2006242475B2 (en) | 2005-05-02 | 2011-07-07 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
| AR057456A1 (es) | 2005-07-20 | 2007-12-05 | Merck & Co Inc | Inhibidores de la proteasa ns3 del vhc |
| CN101263156A (zh) | 2005-07-25 | 2008-09-10 | 因特蒙公司 | C型肝炎病毒复制的新颖大环抑制剂 |
| PE20070211A1 (es) | 2005-07-29 | 2007-05-12 | Medivir Ab | Compuestos macrociclicos como inhibidores del virus de hepatitis c |
| RU2008107972A (ru) | 2005-08-01 | 2009-09-10 | Мерк энд Ко., Инк. (US) | Макроциклические пептиды в качестве ингибиторов ns3-протеазы hcv |
| CN101415705B (zh) | 2005-10-11 | 2011-10-26 | 因特蒙公司 | 抑制丙型肝炎病毒复制的化合物和方法 |
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| GB0609492D0 (en) * | 2006-05-15 | 2006-06-21 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| GB0612423D0 (en) | 2006-06-23 | 2006-08-02 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| KR20090024834A (ko) | 2006-07-05 | 2009-03-09 | 인터뮨, 인크. | Ｃ형 간염 바이러스 복제의 신규 억제제 |
| US8138164B2 (en) | 2006-10-24 | 2012-03-20 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
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| US20080287449A1 (en) | 2007-04-26 | 2008-11-20 | Deqiang Niu | Aza-tripeptide hepatitis c serine protease inhibitors |
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-
2014
- 2014-03-14 US US14/214,477 patent/US9617310B2/en active Active
- 2014-03-14 ES ES14723582T patent/ES2735355T3/es active Active
- 2014-03-14 BR BR112015021768A patent/BR112015021768A2/pt not_active Application Discontinuation
- 2014-03-14 AU AU2014233390A patent/AU2014233390B2/en active Active
- 2014-03-14 EP EP14723582.4A patent/EP2970335B1/en active Active
- 2014-03-14 JP JP2016503218A patent/JP6511432B2/ja active Active
- 2014-03-14 MX MX2015013224A patent/MX2015013224A/es unknown
- 2014-03-14 CA CA2902569A patent/CA2902569A1/en not_active Abandoned
- 2014-03-14 WO PCT/US2014/029765 patent/WO2014145095A1/en not_active Ceased
- 2014-03-14 CN CN201480015589.0A patent/CN105073758B/zh active Active
- 2014-03-14 EA EA201591456A patent/EA029088B1/ru not_active IP Right Cessation
- 2014-03-14 KR KR1020157028437A patent/KR102215400B1/ko active Active
- 2014-03-14 SG SG11201507223TA patent/SG11201507223TA/en unknown
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2015
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2017
- 2017-03-10 US US15/455,508 patent/US20170313745A1/en not_active Abandoned
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2018
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Also Published As
| Publication number | Publication date |
|---|---|
| BR112015021768A2 (pt) | 2016-02-02 |
| EA029088B1 (ru) | 2018-02-28 |
| US9617310B2 (en) | 2017-04-11 |
| IL240662A0 (en) | 2015-10-29 |
| CN105073758A (zh) | 2015-11-18 |
| CA2902569A1 (en) | 2014-09-18 |
| MX2015013224A (es) | 2015-12-11 |
| CN105073758B (zh) | 2017-08-11 |
| HK1217196A1 (en) | 2016-12-30 |
| AU2014233390B2 (en) | 2018-03-01 |
| KR20150130456A (ko) | 2015-11-23 |
| US20170313745A1 (en) | 2017-11-02 |
| JP6511432B2 (ja) | 2019-05-15 |
| KR102215400B1 (ko) | 2021-02-10 |
| JP2016516069A (ja) | 2016-06-02 |
| WO2014145095A1 (en) | 2014-09-18 |
| AU2014233390A1 (en) | 2015-09-03 |
| EP2970335B1 (en) | 2019-05-08 |
| EP2970335A1 (en) | 2016-01-20 |
| EA201591456A1 (ru) | 2016-02-29 |
| JP2019059775A (ja) | 2019-04-18 |
| US20140274884A1 (en) | 2014-09-18 |
| SG11201507223TA (en) | 2015-10-29 |
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