AU2014233390B2 - Macrocyclic and bicyclic inhibitors of hepatitis C virus - Google Patents
Macrocyclic and bicyclic inhibitors of hepatitis C virus Download PDFInfo
- Publication number
- AU2014233390B2 AU2014233390B2 AU2014233390A AU2014233390A AU2014233390B2 AU 2014233390 B2 AU2014233390 B2 AU 2014233390B2 AU 2014233390 A AU2014233390 A AU 2014233390A AU 2014233390 A AU2014233390 A AU 2014233390A AU 2014233390 B2 AU2014233390 B2 AU 2014233390B2
- Authority
- AU
- Australia
- Prior art keywords
- alkyl
- optionally substituted
- carbocyclyl
- groups
- membered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/02—Preparation by ring-closure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361798961P | 2013-03-15 | 2013-03-15 | |
| US61/798,961 | 2013-03-15 | ||
| PCT/US2014/029765 WO2014145095A1 (en) | 2013-03-15 | 2014-03-14 | Macrocyclic and bicyclic inhibitors of hepatitis c virus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2014233390A1 AU2014233390A1 (en) | 2015-09-03 |
| AU2014233390B2 true AU2014233390B2 (en) | 2018-03-01 |
Family
ID=50694007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2014233390A Active AU2014233390B2 (en) | 2013-03-15 | 2014-03-14 | Macrocyclic and bicyclic inhibitors of hepatitis C virus |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9617310B2 (enExample) |
| EP (1) | EP2970335B1 (enExample) |
| JP (2) | JP6511432B2 (enExample) |
| KR (1) | KR102215400B1 (enExample) |
| CN (1) | CN105073758B (enExample) |
| AU (1) | AU2014233390B2 (enExample) |
| BR (1) | BR112015021768A2 (enExample) |
| CA (1) | CA2902569A1 (enExample) |
| EA (1) | EA029088B1 (enExample) |
| ES (1) | ES2735355T3 (enExample) |
| IL (1) | IL240662A0 (enExample) |
| MX (1) | MX2015013224A (enExample) |
| SG (1) | SG11201507223TA (enExample) |
| WO (1) | WO2014145095A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA119315C2 (uk) | 2012-07-03 | 2019-06-10 | Гіліад Фармассет Елелсі | Інгібітори вірусу гепатиту с |
| WO2016106050A1 (en) | 2014-12-26 | 2016-06-30 | Emory University | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
| CN105503751B (zh) * | 2015-12-22 | 2018-06-05 | 广西师范大学 | 一种喹喔啉衍生物的高效合成方法 |
| RU2020116571A (ru) | 2017-12-07 | 2021-11-22 | Эмори Юниверсити | N4-гидроксицитидин и производные и связанные с этим противовирусные применения |
| CN108329332A (zh) * | 2018-03-16 | 2018-07-27 | 安徽华昌高科药业有限公司 | 一种制备Glecaprevir的方法 |
| CN111004188B (zh) * | 2019-12-18 | 2021-04-20 | 安徽红杉生物医药科技有限公司 | Ns3/4a蛋白酶抑制剂中间体及其合成方法、应用 |
| CN111018795B (zh) * | 2019-12-25 | 2023-03-28 | 上海彩迩文生化科技有限公司 | 一种碱性条件下合成喹喔啉-3-酮的方法 |
| US12083099B2 (en) | 2020-10-28 | 2024-09-10 | Accencio LLC | Methods of treating symptoms of coronavirus infection with viral protease inhibitors |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010011566A1 (en) * | 2008-07-22 | 2010-01-28 | Merck & Co., Inc. | Macrocyclic quinoxaline compounds as hcv ns3 protease inhibitors |
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| AU3659102A (en) | 2000-12-12 | 2002-06-24 | Schering Corp | Diaryl peptides as ns3-serine protease inhibitors of hepatits c virus |
| IL161576A0 (en) | 2001-10-26 | 2004-09-27 | Aventis Pharma Inc | Benzimidazoles and analogues and their use as protein kinases inhibitors |
| ES2315568T3 (es) | 2002-05-20 | 2009-04-01 | Bristol-Myers Squibb Company | Inhibidores del virus de la hepatitis c basados en cicloalquilo p1' sustituido. |
| AU2003248535A1 (en) | 2002-05-20 | 2003-12-12 | Bristol-Myers Squibb Company | Heterocyclicsulfonamide hepatitis c virus inhibitors |
| PL215228B1 (pl) | 2002-05-20 | 2013-11-29 | Bristol Myers Squibb Co | Zwiazki tripeptydowe, ich zastosowanie i kompozycja farmaceutyczna je zawierajaca oraz jej zastosowanie |
| ATE422895T1 (de) | 2003-04-16 | 2009-03-15 | Bristol Myers Squibb Co | Makrocyclische isochinolinpeptidinhibitoren des hepatitis-c-virus |
| WO2004093798A2 (en) | 2003-04-18 | 2004-11-04 | Enanta Pharmaceuticals, Inc. | Quinoxalinyl macrocyclic hepatitis c serine protease inhibitors |
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| KR20140003521A (ko) | 2010-12-30 | 2014-01-09 | 이난타 파마슈티칼스, 인코포레이티드 | 페난트리딘 매크로사이클릭 ｃ형 간염 세린 프로테아제 억제제 |
| US8957203B2 (en) | 2011-05-05 | 2015-02-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
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| US8691757B2 (en) | 2011-06-15 | 2014-04-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
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| WO2012176149A1 (en) | 2011-06-23 | 2012-12-27 | Panmed Ltd. | Treatment of hepatitis c virus |
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| WO2013066753A1 (en) | 2011-10-31 | 2013-05-10 | Merck Sharp & Dohme Corp. | Compositions useful for the treatment of viral diseases |
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-
2014
- 2014-03-14 JP JP2016503218A patent/JP6511432B2/ja active Active
- 2014-03-14 WO PCT/US2014/029765 patent/WO2014145095A1/en not_active Ceased
- 2014-03-14 BR BR112015021768A patent/BR112015021768A2/pt not_active Application Discontinuation
- 2014-03-14 EA EA201591456A patent/EA029088B1/ru not_active IP Right Cessation
- 2014-03-14 SG SG11201507223TA patent/SG11201507223TA/en unknown
- 2014-03-14 CN CN201480015589.0A patent/CN105073758B/zh active Active
- 2014-03-14 KR KR1020157028437A patent/KR102215400B1/ko active Active
- 2014-03-14 US US14/214,477 patent/US9617310B2/en active Active
- 2014-03-14 CA CA2902569A patent/CA2902569A1/en not_active Abandoned
- 2014-03-14 EP EP14723582.4A patent/EP2970335B1/en active Active
- 2014-03-14 AU AU2014233390A patent/AU2014233390B2/en active Active
- 2014-03-14 ES ES14723582T patent/ES2735355T3/es active Active
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2015
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2017
- 2017-03-10 US US15/455,508 patent/US20170313745A1/en not_active Abandoned
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2018
- 2018-12-13 JP JP2018233621A patent/JP2019059775A/ja not_active Withdrawn
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2010011566A1 (en) * | 2008-07-22 | 2010-01-28 | Merck & Co., Inc. | Macrocyclic quinoxaline compounds as hcv ns3 protease inhibitors |
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| Publication number | Publication date |
|---|---|
| US20170313745A1 (en) | 2017-11-02 |
| US9617310B2 (en) | 2017-04-11 |
| EP2970335B1 (en) | 2019-05-08 |
| JP2019059775A (ja) | 2019-04-18 |
| MX2015013224A (es) | 2015-12-11 |
| JP6511432B2 (ja) | 2019-05-15 |
| AU2014233390A1 (en) | 2015-09-03 |
| KR102215400B1 (ko) | 2021-02-10 |
| JP2016516069A (ja) | 2016-06-02 |
| IL240662A0 (en) | 2015-10-29 |
| BR112015021768A2 (pt) | 2016-02-02 |
| HK1217196A1 (en) | 2016-12-30 |
| CA2902569A1 (en) | 2014-09-18 |
| WO2014145095A1 (en) | 2014-09-18 |
| EA029088B1 (ru) | 2018-02-28 |
| SG11201507223TA (en) | 2015-10-29 |
| EP2970335A1 (en) | 2016-01-20 |
| CN105073758A (zh) | 2015-11-18 |
| EA201591456A1 (ru) | 2016-02-29 |
| US20140274884A1 (en) | 2014-09-18 |
| ES2735355T3 (es) | 2019-12-18 |
| CN105073758B (zh) | 2017-08-11 |
| KR20150130456A (ko) | 2015-11-23 |
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