EA021424B1 - Тиазолопиридиновые соединения, регулирующие сиртуин - Google Patents
Тиазолопиридиновые соединения, регулирующие сиртуин Download PDFInfo
- Publication number
- EA021424B1 EA021424B1 EA201170847A EA201170847A EA021424B1 EA 021424 B1 EA021424 B1 EA 021424B1 EA 201170847 A EA201170847 A EA 201170847A EA 201170847 A EA201170847 A EA 201170847A EA 021424 B1 EA021424 B1 EA 021424B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- sirtuin
- phenyl
- compound
- thiazolo
- protein
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract description 197
- 102000011990 Sirtuin Human genes 0.000 title claims description 206
- 108050002485 Sirtuin Proteins 0.000 title claims description 206
- WFIHKLWVLPBMIQ-UHFFFAOYSA-N [1,3]thiazolo[5,4-b]pyridine Chemical compound C1=CN=C2SC=NC2=C1 WFIHKLWVLPBMIQ-UHFFFAOYSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 claims abstract description 84
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- 230000001105 regulatory effect Effects 0.000 claims description 85
- -1 methoxypropyl Chemical group 0.000 claims description 70
- 150000003839 salts Chemical class 0.000 claims description 23
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 17
- 239000013543 active substance Substances 0.000 claims description 14
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 12
- 206010022489 Insulin Resistance Diseases 0.000 claims description 12
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 11
- IKMDFBPHZNJCSN-UHFFFAOYSA-N Myricetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC(O)=C(O)C(O)=C1 IKMDFBPHZNJCSN-UHFFFAOYSA-N 0.000 claims description 9
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Classifications
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- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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Landscapes
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- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20315608P | 2008-12-19 | 2008-12-19 | |
| PCT/US2009/068865 WO2010071853A1 (en) | 2008-12-19 | 2009-12-18 | Thiazolopyridine sirtuin modulating compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201170847A1 EA201170847A1 (ru) | 2011-12-30 |
| EA021424B1 true EA021424B1 (ru) | 2015-06-30 |
Family
ID=42269132
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201170847A EA021424B1 (ru) | 2008-12-19 | 2009-12-18 | Тиазолопиридиновые соединения, регулирующие сиртуин |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US8343997B2 (enExample) |
| EP (1) | EP2376502B1 (enExample) |
| JP (1) | JP5628828B2 (enExample) |
| KR (1) | KR20110110194A (enExample) |
| CN (1) | CN102388054B (enExample) |
| BR (1) | BRPI0922435A2 (enExample) |
| CA (1) | CA2747715A1 (enExample) |
| CO (1) | CO6400181A2 (enExample) |
| CR (1) | CR20110353A (enExample) |
| DO (1) | DOP2011000188A (enExample) |
| EA (1) | EA021424B1 (enExample) |
| ES (1) | ES2544258T3 (enExample) |
| IL (1) | IL213217A0 (enExample) |
| MA (1) | MA32909B1 (enExample) |
| MX (1) | MX2011006555A (enExample) |
| MY (1) | MY160006A (enExample) |
| NZ (1) | NZ594122A (enExample) |
| PE (1) | PE20120057A1 (enExample) |
| SG (1) | SG171835A1 (enExample) |
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- 2009-12-18 US US13/139,796 patent/US8343997B2/en not_active Expired - Fee Related
- 2009-12-18 MX MX2011006555A patent/MX2011006555A/es active IP Right Grant
- 2009-12-18 PE PE2011001241A patent/PE20120057A1/es not_active Application Discontinuation
- 2009-12-18 ES ES09833859.3T patent/ES2544258T3/es active Active
- 2009-12-18 SG SG2011038486A patent/SG171835A1/en unknown
- 2009-12-18 CA CA2747715A patent/CA2747715A1/en not_active Abandoned
- 2009-12-18 NZ NZ594122A patent/NZ594122A/xx not_active IP Right Cessation
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2011
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- 2011-06-01 ZA ZA2011/04060A patent/ZA201104060B/en unknown
- 2011-06-15 DO DO2011000188A patent/DOP2011000188A/es unknown
- 2011-06-17 MA MA33955A patent/MA32909B1/fr unknown
- 2011-06-22 CR CR20110353A patent/CR20110353A/es unknown
- 2011-06-23 CO CO11079280A patent/CO6400181A2/es active IP Right Grant
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007019346A1 (en) * | 2005-08-04 | 2007-02-15 | Sirtris Pharmaceuticals, Inc. | Benzothiazoles and thiazolopyridines as sirtuin modulators |
| WO2008156869A2 (en) * | 2007-06-20 | 2008-12-24 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating thiazolopyridine compounds |
| WO2009061453A1 (en) * | 2007-11-08 | 2009-05-14 | Sirtris Pharmaceuticals, Inc. | Solubilized thiazolopyridines |
Also Published As
| Publication number | Publication date |
|---|---|
| US20110306609A1 (en) | 2011-12-15 |
| AU2009327373A1 (en) | 2011-06-30 |
| MY160006A (en) | 2017-02-15 |
| BRPI0922435A2 (pt) | 2018-09-11 |
| NZ594122A (en) | 2013-03-28 |
| EP2376502A1 (en) | 2011-10-19 |
| KR20110110194A (ko) | 2011-10-06 |
| WO2010071853A1 (en) | 2010-06-24 |
| ZA201104060B (en) | 2012-02-29 |
| JP5628828B2 (ja) | 2014-11-19 |
| US8492401B2 (en) | 2013-07-23 |
| ES2544258T3 (es) | 2015-08-28 |
| MA32909B1 (fr) | 2011-12-01 |
| PE20120057A1 (es) | 2012-02-24 |
| EA201170847A1 (ru) | 2011-12-30 |
| CN102388054B (zh) | 2015-03-04 |
| CR20110353A (es) | 2011-10-27 |
| CA2747715A1 (en) | 2010-06-24 |
| CN102388054A (zh) | 2012-03-21 |
| IL213217A0 (en) | 2011-07-31 |
| EP2376502A4 (en) | 2012-07-18 |
| JP2012512907A (ja) | 2012-06-07 |
| UA104447C2 (uk) | 2014-02-10 |
| US8343997B2 (en) | 2013-01-01 |
| DOP2011000188A (es) | 2011-07-31 |
| SG171835A1 (en) | 2011-07-28 |
| EP2376502B1 (en) | 2015-06-17 |
| MX2011006555A (es) | 2011-08-03 |
| US20130085155A1 (en) | 2013-04-04 |
| CO6400181A2 (es) | 2012-03-15 |
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