CA2747715A1 - Thiazolopyridine sirtuin modulating compounds - Google Patents
Thiazolopyridine sirtuin modulating compounds Download PDFInfo
- Publication number
- CA2747715A1 CA2747715A1 CA2747715A CA2747715A CA2747715A1 CA 2747715 A1 CA2747715 A1 CA 2747715A1 CA 2747715 A CA2747715 A CA 2747715A CA 2747715 A CA2747715 A CA 2747715A CA 2747715 A1 CA2747715 A1 CA 2747715A1
- Authority
- CA
- Canada
- Prior art keywords
- sirtuin
- compound
- activity
- protein
- modulating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Landscapes
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- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US61/203,156 | 2008-12-19 | ||
| PCT/US2009/068865 WO2010071853A1 (en) | 2008-12-19 | 2009-12-18 | Thiazolopyridine sirtuin modulating compounds |
Publications (1)
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| US20070014833A1 (en) * | 2005-03-30 | 2007-01-18 | Sirtris Pharmaceuticals, Inc. | Treatment of eye disorders with sirtuin modulators |
| ES2586459T3 (es) | 2008-05-01 | 2016-10-14 | Glaxosmithkline Llc | Quinolinas y análogos relacionados como moduladores de sirtuina |
| JP5758292B2 (ja) * | 2008-07-03 | 2015-08-05 | サートリス ファーマシューティカルズ， インコーポレイテッド | サーチュイン調節薬としてのベンズイミダゾールおよび関連する類似体 |
| AU2009295946B2 (en) | 2008-09-29 | 2013-03-21 | Sirtris Pharmaceuticals, Inc. | Chromenone analogs as sirtuin modulators |
| CA2779303A1 (en) | 2009-10-29 | 2011-05-19 | Sirtris Pharmaceuticals, Inc. | Bicyclic pyridines and analogs as sirtuin modulators |
| EP2827869A4 (en) | 2012-03-23 | 2015-09-23 | Dennis Brown | COMPOSITIONS AND METHODS FOR IMPROVING THE THERAPEUTIC BENEFIT OF INDIRUBIN AND ANALOGUE THEREOF, WITH MEISOINDIGO |
| AU2013259624B2 (en) | 2012-05-08 | 2017-10-19 | Lycera Corporation | Tetrahydro[1,8]naphthyridine sulfonamide and related compounds for use as agonists of RORy and the treatment of disease |
| US9657033B2 (en) | 2012-05-08 | 2017-05-23 | Lycera Corporation | Tetrahydronaphthyridine and related bicyclic compounds for inhibition of RORγ activity and the treatment of disease |
| JP2015525223A (ja) | 2012-06-14 | 2015-09-03 | ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ | 動物有害生物を駆除するための置換３−ピリジルチアゾール化合物および誘導体を使用する有害生物防除方法 |
| WO2016081692A2 (en) * | 2014-11-19 | 2016-05-26 | Glaxosmithkline Llc | Substituted bridged urea analogs as sirtuin modulators |
| RU2015153061A (ru) | 2013-05-13 | 2017-06-15 | ГЛЭКСОСМИТКЛАЙН ЭлЭлСи | Замещенные связанные мостиковой связью мочевинные аналоги в качестве модуляторов сиртуина |
| US10172915B2 (en) | 2013-10-20 | 2019-01-08 | Duke University | Methods and compositions for activation of sirtuins with Annexin A1 peptides |
| US9663502B2 (en) | 2013-12-20 | 2017-05-30 | Lycera Corporation | 2-Acylamidomethyl and sulfonylamidomethyl benzoxazine carbamates for inhibition of RORgamma activity and the treatment of disease |
| US9809561B2 (en) | 2013-12-20 | 2017-11-07 | Merck Sharp & Dohme Corp. | Tetrahydronaphthyridine, benzoxazine, aza-benzoxazine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease |
| WO2015095792A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Carbamate benzoxaxine propionic acids and acid derivatives for modulation of rorgamma activity and the treatment of disease |
| CA2939305A1 (en) | 2014-02-27 | 2015-09-03 | Lycera Corporation | Adoptive cellular therapy using an agonist of retinoic acid receptor-related orphan receptor gamma & related therapeutic methods |
| JP6728061B2 (ja) | 2014-05-05 | 2020-07-22 | リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ | ＲＯＲγアゴニストとして用いるテトラヒドロキノリンスルホンアミド及び関連化合物ならびに疾患の治療 |
| WO2015171558A2 (en) | 2014-05-05 | 2015-11-12 | Lycera Corporation | BENZENESULFONAMIDO AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORγ AND THE TREATEMENT OF DISEASE |
| US10316054B2 (en) | 2014-06-02 | 2019-06-11 | Glaxosmithkline Intellectual Property (No. 2) Limited | Preparation and use of crystalline beta-D-nicotinamide riboside |
| JP6559713B2 (ja) | 2014-06-06 | 2019-08-14 | グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ | ニコチンアミドリボシド類似体ならびにその医薬組成物および使用 |
| WO2016130818A1 (en) | 2015-02-11 | 2016-08-18 | Merck Sharp & Dohme Corp. | SUBSTITUTED PYRAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF |
| JP2018515491A (ja) | 2015-05-05 | 2018-06-14 | リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ | ＲＯＲγの作動薬及び疾患の療法として使用するジヒドロ−２Ｈ−ベンゾ［ｂ］［１，４］オキサジンスルホンアミド及び関連化合物 |
| WO2016201225A1 (en) | 2015-06-11 | 2016-12-15 | Lycera Corporation | Aryl dihydro-2h-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of rory and the treatment of disease |
| US9782859B2 (en) * | 2015-07-16 | 2017-10-10 | Siemens Energy, Inc. | Slag free flux for additive manufacturing |
| US10344000B2 (en) | 2015-10-27 | 2019-07-09 | Merck Sharp & Dohme Corp. | Substituted bicyclic pyrazole compounds as RORgammaT inhibitors and uses thereof |
| AU2016344118A1 (en) | 2015-10-27 | 2018-05-10 | Merck Sharp & Dohme Corp. | Heteroaryl substituted benzoic acids as rorgammat inhibitors and uses thereof |
| JP2018535958A (ja) | 2015-10-27 | 2018-12-06 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | ＲＯＲγＴ阻害薬としての置換インダゾール化合物及びその使用 |
| EP3419981A4 (en) | 2016-02-23 | 2019-09-18 | Indiana University Research & Technology Corporation | COMBINATION THERAPIES FOR THE TREATMENT OF SPINAL MUSCLE ATROPHY |
| WO2020247608A1 (en) * | 2019-06-04 | 2020-12-10 | The Regents Of The University Of California | Small molecule inhibitors of a protein complex |
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-
2009
- 2009-12-18 KR KR1020117016678A patent/KR20110110194A/ko not_active Abandoned
- 2009-12-18 EP EP09833859.3A patent/EP2376502B1/en active Active
- 2009-12-18 MY MYPI2011002853A patent/MY160006A/en unknown
- 2009-12-18 US US13/139,796 patent/US8343997B2/en not_active Expired - Fee Related
- 2009-12-18 EA EA201170847A patent/EA021424B1/ru not_active IP Right Cessation
- 2009-12-18 PE PE2011001241A patent/PE20120057A1/es not_active Application Discontinuation
- 2009-12-18 MX MX2011006555A patent/MX2011006555A/es active IP Right Grant
- 2009-12-18 NZ NZ594122A patent/NZ594122A/xx not_active IP Right Cessation
- 2009-12-18 JP JP2011542514A patent/JP5628828B2/ja not_active Expired - Fee Related
- 2009-12-18 BR BRPI0922435A patent/BRPI0922435A2/pt not_active Application Discontinuation
- 2009-12-18 ES ES09833859.3T patent/ES2544258T3/es active Active
- 2009-12-18 CN CN200980157247.1A patent/CN102388054B/zh not_active Expired - Fee Related
- 2009-12-18 CA CA2747715A patent/CA2747715A1/en not_active Abandoned
- 2009-12-18 UA UAA201109066A patent/UA104447C2/uk unknown
- 2009-12-18 SG SG2011038486A patent/SG171835A1/en unknown
- 2009-12-18 WO PCT/US2009/068865 patent/WO2010071853A1/en not_active Ceased
-
2011
- 2011-05-30 IL IL213217A patent/IL213217A0/en unknown
- 2011-06-01 ZA ZA2011/04060A patent/ZA201104060B/en unknown
- 2011-06-15 DO DO2011000188A patent/DOP2011000188A/es unknown
- 2011-06-17 MA MA33955A patent/MA32909B1/fr unknown
- 2011-06-22 CR CR20110353A patent/CR20110353A/es unknown
- 2011-06-23 CO CO11079280A patent/CO6400181A2/es active IP Right Grant
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2012
- 2012-11-15 US US13/678,292 patent/US8492401B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20130085155A1 (en) | 2013-04-04 |
| KR20110110194A (ko) | 2011-10-06 |
| UA104447C2 (uk) | 2014-02-10 |
| EA201170847A1 (ru) | 2011-12-30 |
| JP2012512907A (ja) | 2012-06-07 |
| ZA201104060B (en) | 2012-02-29 |
| MA32909B1 (fr) | 2011-12-01 |
| US8343997B2 (en) | 2013-01-01 |
| EP2376502B1 (en) | 2015-06-17 |
| WO2010071853A1 (en) | 2010-06-24 |
| MY160006A (en) | 2017-02-15 |
| SG171835A1 (en) | 2011-07-28 |
| EP2376502A4 (en) | 2012-07-18 |
| MX2011006555A (es) | 2011-08-03 |
| US20110306609A1 (en) | 2011-12-15 |
| CN102388054A (zh) | 2012-03-21 |
| EA021424B1 (ru) | 2015-06-30 |
| JP5628828B2 (ja) | 2014-11-19 |
| PE20120057A1 (es) | 2012-02-24 |
| US8492401B2 (en) | 2013-07-23 |
| CR20110353A (es) | 2011-10-27 |
| IL213217A0 (en) | 2011-07-31 |
| AU2009327373A1 (en) | 2011-06-30 |
| ES2544258T3 (es) | 2015-08-28 |
| NZ594122A (en) | 2013-03-28 |
| BRPI0922435A2 (pt) | 2018-09-11 |
| DOP2011000188A (es) | 2011-07-31 |
| EP2376502A1 (en) | 2011-10-19 |
| CO6400181A2 (es) | 2012-03-15 |
| CN102388054B (zh) | 2015-03-04 |
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