EA001372B1 - Направленные цитотоксические аналоги антрациклина, композиция и способ лечения рака у млекопитающего - Google Patents

Направленные цитотоксические аналоги антрациклина, композиция и способ лечения рака у млекопитающего Download PDF

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Publication number
EA001372B1
EA001372B1 EA199800492A EA199800492A EA001372B1 EA 001372 B1 EA001372 B1 EA 001372B1 EA 199800492 A EA199800492 A EA 199800492A EA 199800492 A EA199800492 A EA 199800492A EA 001372 B1 EA001372 B1 EA 001372B1
Authority
EA
Eurasian Patent Office
Prior art keywords
compound according
tgr
compound
doxorubicin
nmol
Prior art date
Application number
EA199800492A
Other languages
English (en)
Russian (ru)
Other versions
EA199800492A1 (ru
Inventor
Рен-Жи Кэй
Эттила Э. Нэги
Эндрю В. Шелли
Original Assignee
Аста Медика Акциенгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24247176&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA001372(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Аста Медика Акциенгезельшафт filed Critical Аста Медика Акциенгезельшафт
Publication of EA199800492A1 publication Critical patent/EA199800492A1/ru
Publication of EA001372B1 publication Critical patent/EA001372B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EA199800492A 1995-11-27 1996-11-14 Направленные цитотоксические аналоги антрациклина, композиция и способ лечения рака у млекопитающего EA001372B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/562,652 US5843903A (en) 1995-11-27 1995-11-27 Targeted cytotoxic anthracycline analogs
PCT/EP1996/005029 WO1997019954A1 (en) 1995-11-27 1996-11-14 Targeted cytotoxic anthracycline analogs

Publications (2)

Publication Number Publication Date
EA199800492A1 EA199800492A1 (ru) 1998-12-24
EA001372B1 true EA001372B1 (ru) 2001-02-26

Family

ID=24247176

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800492A EA001372B1 (ru) 1995-11-27 1996-11-14 Направленные цитотоксические аналоги антрациклина, композиция и способ лечения рака у млекопитающего

Country Status (27)

Country Link
US (2) US5843903A (enExample)
EP (2) EP1384710B1 (enExample)
JP (2) JP3987575B2 (enExample)
KR (2) KR100467899B1 (enExample)
CN (2) CN1137136C (enExample)
AT (2) ATE401305T1 (enExample)
AU (1) AU709539B2 (enExample)
BR (1) BR9611647B1 (enExample)
CA (2) CA2471775C (enExample)
CZ (1) CZ297297B6 (enExample)
DE (2) DE69637604D1 (enExample)
DK (2) DK1384710T3 (enExample)
EA (1) EA001372B1 (enExample)
ES (2) ES2205067T3 (enExample)
HK (1) HK1052920B (enExample)
HU (1) HU229870B1 (enExample)
IL (3) IL119691A (enExample)
IS (2) IS2178B (enExample)
MX (1) MX9804119A (enExample)
NO (2) NO324035B1 (enExample)
NZ (1) NZ322054A (enExample)
PL (3) PL188786B1 (enExample)
PT (2) PT1384710E (enExample)
SK (2) SK284672B6 (enExample)
UA (1) UA67722C2 (enExample)
WO (1) WO1997019954A1 (enExample)
ZA (1) ZA969709B (enExample)

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FR2786397B1 (fr) * 1998-11-30 2003-01-10 Synt Em Vecteurs peptidiques de substances a travers la barriere hematoencephalique pour etre utilises dans le diagnostic ou la therapie d'une affection du snc
FR2786398B1 (fr) * 1998-11-30 2002-12-27 Synt Em Composition pharmaceutique anti-cancereuse et anti-chimioresistance comprenant un agent anticancereux et au moins un peptide
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
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US6528481B1 (en) 1999-02-16 2003-03-04 The Burnam Institute NG2/HM proteoglycan-binding peptides that home to angiogenic vasculature and related methods
US6380161B1 (en) 1999-06-21 2002-04-30 Inkine Pharmaceutical Company, Inc. Compositions for treating chemotherapy-resistant tumor cells and targeted chemotherapy compositions
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US7420030B2 (en) 2000-09-08 2008-09-02 The Board Of Regents Of The University Of Texas System Aminopeptidase A (APA) targeting peptides for the treatment of cancer
US20040170955A1 (en) 2000-09-08 2004-09-02 Wadih Arap Human and mouse targeting peptides identified by phage display
US7452964B2 (en) 2001-09-07 2008-11-18 Board Of Regents, The University Of Texas System Compositions and methods of use of targeting peptides against placenta and adipose tissues
KR100420007B1 (ko) * 2001-04-25 2004-03-02 노영쇠 안트라사이클린 유도체 및 이를 포함하는 항암제
BR0212897A (pt) * 2001-09-21 2004-08-24 Univ Tulane Conjugados de análogos de somatostatina ou bombesina diagnóstica ou terapêutica e usos dos mesmos
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US7771727B2 (en) 2002-03-01 2010-08-10 The Administrators Of The Tulane Educational Fund Conjugates of therapeutic or cytotoxic agents and biologically active peptides
US7544767B2 (en) 2002-04-05 2009-06-09 Burnham Institute For Medical Research HMGN2 peptides and related molecules that selectively home to tumor blood vessels and tumor cells
JP5000848B2 (ja) * 2002-05-21 2012-08-15 第一三共株式会社 グレリン含有医薬組成物
CN101134119A (zh) 2002-05-24 2008-03-05 血管技术国际股份公司 用于涂覆医用植入物的组合物和方法
US8313760B2 (en) 2002-05-24 2012-11-20 Angiotech International Ag Compositions and methods for coating medical implants
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US20040202666A1 (en) * 2003-01-24 2004-10-14 Immunomedics, Inc. Anti-cancer anthracycline drug-antibody conjugates
US20050043215A1 (en) 2003-02-19 2005-02-24 Tamara Minko Complex drug delivery composition and method for treating cancer
AU2007221964B2 (en) * 2003-04-22 2008-12-11 Ipsen Pharma S.A.S. Peptide vectors
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US7097993B2 (en) 2003-06-25 2006-08-29 Wisconsin Alumni Research Foundation Method for identifying an agent that modulates type 1 phosphatidylinositol phosphate kinase isoform β661 activity
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US20070060534A1 (en) * 2005-06-30 2007-03-15 Threshold Pharmaceuticals, Inc. Anthracycline analogs
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HRP20160631T1 (hr) * 2006-09-06 2016-07-15 Æterna Zentaris Gmbh Konjugati disorazola i njihovi derivati sa staničnovezajućim molekulama, novi derivati disorazola, postupci njihove pripreme i njihove uporabe
WO2008100591A2 (en) * 2007-02-14 2008-08-21 The General Hospital Corporation Modulation of nitric oxide signaling to normalize tumor vasculature
RU2377247C2 (ru) * 2007-12-27 2009-12-27 Федеральное государственное образовательное учреждение высшего профессионального образования Санкт-Петербургский государственный университет Молекулярный конъюгат на основе синтетических аналогов люлиберина и его применение в качестве средства доставки днк в клетки гормон-чувствительных опухолей (варианты)
EP2240495B1 (en) * 2008-02-01 2015-07-15 Genentech, Inc. Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods
EP2277884B1 (en) * 2008-04-11 2017-08-23 Tianjin Hemay Oncology Pharmaceutical Co., Ltd Anthracycline antibiotic derivatives with high activity, preparation methods and uses thereof
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Also Published As

Publication number Publication date
EP0863917B1 (en) 2003-10-01
SK284672B6 (sk) 2005-08-04
PL326865A1 (en) 1998-10-26
KR20040037176A (ko) 2004-05-04
PT1384710E (pt) 2008-10-08
CA2471775A1 (en) 1997-06-05
AU7572296A (en) 1997-06-19
EA199800492A1 (ru) 1998-12-24
CA2238574A1 (en) 1997-06-05
ES2205067T3 (es) 2004-05-01
IL119691A (en) 2002-02-10
ES2310222T3 (es) 2009-01-01
CN1405127A (zh) 2003-03-26
NO982252L (no) 1998-05-15
KR19990071672A (ko) 1999-09-27
JP2000502055A (ja) 2000-02-22
CA2471775C (en) 2008-01-29
HUP9903771A2 (hu) 2000-02-28
SK62898A3 (en) 1999-06-11
EP1384710B1 (en) 2008-07-16
EP0863917A1 (en) 1998-09-16
JP3987575B2 (ja) 2007-10-10
DE69630233T2 (de) 2004-08-05
KR100467899B1 (ko) 2005-01-24
MX9804119A (es) 1998-09-30
CN1202903A (zh) 1998-12-23
IS4734A (is) 1998-05-05
PL188786B1 (pl) 2005-04-29
CA2238574C (en) 2004-10-19
BR9611647A (pt) 1999-02-23
CN1137136C (zh) 2004-02-04
NO324035B1 (no) 2007-07-30
UA67722C2 (en) 2004-07-15
HK1052920A1 (en) 2003-10-03
NO20051111L (no) 2005-03-01
HUP9903771A3 (en) 2000-07-28
IL119691A0 (en) 1997-02-18
NZ322054A (en) 1999-04-29
CN1166597C (zh) 2004-09-15
ATE401305T1 (de) 2008-08-15
BR9611647B1 (pt) 2010-03-09
EP1384710A1 (en) 2004-01-28
IL134685A0 (en) 2001-04-30
HK1052920B (zh) 2005-03-04
JP4778405B2 (ja) 2011-09-21
IL134685A (en) 2002-12-01
ZA969709B (en) 1997-08-25
PT863917E (pt) 2004-02-27
DK0863917T3 (da) 2004-01-19
KR100445754B1 (ko) 2004-12-08
WO1997019954A1 (en) 1997-06-05
CZ135798A3 (cs) 1998-10-14
ATE251179T1 (de) 2003-10-15
IS2178B (is) 2006-12-15
NO982252D0 (no) 1998-05-15
IS8567A (is) 2006-11-09
JP2007045845A (ja) 2007-02-22
DK1384710T3 (da) 2008-11-17
DE69637604D1 (de) 2008-08-28
PL191781B1 (pl) 2006-07-31
US6184374B1 (en) 2001-02-06
CZ297297B6 (cs) 2006-11-15
DE69630233D1 (de) 2003-11-06
PL187230B1 (pl) 2004-06-30
HU229870B1 (en) 2014-10-28
HK1017363A1 (en) 1999-11-19
SK284392B6 (sk) 2005-03-04
AU709539B2 (en) 1999-09-02
US5843903A (en) 1998-12-01
IS2634B (is) 2010-06-15

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