PT1384710E - Síntese de compostos heterocíclicos contendo anéis com cinco ou seis membros - Google Patents

Síntese de compostos heterocíclicos contendo anéis com cinco ou seis membros Download PDF

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Publication number
PT1384710E
PT1384710E PT03010988T PT03010988T PT1384710E PT 1384710 E PT1384710 E PT 1384710E PT 03010988 T PT03010988 T PT 03010988T PT 03010988 T PT03010988 T PT 03010988T PT 1384710 E PT1384710 E PT 1384710E
Authority
PT
Portugal
Prior art keywords
nitrogen
halo
carbon
och2
excess
Prior art date
Application number
PT03010988T
Other languages
English (en)
Portuguese (pt)
Inventor
Andrew V Schally
Nagy Attila
Zhi Cai Ren
Original Assignee
Univ Tulane
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24247176&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT1384710(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Tulane filed Critical Univ Tulane
Publication of PT1384710E publication Critical patent/PT1384710E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PT03010988T 1995-11-27 1996-11-14 Síntese de compostos heterocíclicos contendo anéis com cinco ou seis membros PT1384710E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/562,652 US5843903A (en) 1995-11-27 1995-11-27 Targeted cytotoxic anthracycline analogs

Publications (1)

Publication Number Publication Date
PT1384710E true PT1384710E (pt) 2008-10-08

Family

ID=24247176

Family Applications (2)

Application Number Title Priority Date Filing Date
PT03010988T PT1384710E (pt) 1995-11-27 1996-11-14 Síntese de compostos heterocíclicos contendo anéis com cinco ou seis membros
PT96938216T PT863917E (pt) 1995-11-27 1996-11-14 Analogos de antraciclina citotoxicos direccionados

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT96938216T PT863917E (pt) 1995-11-27 1996-11-14 Analogos de antraciclina citotoxicos direccionados

Country Status (27)

Country Link
US (2) US5843903A (enExample)
EP (2) EP1384710B1 (enExample)
JP (2) JP3987575B2 (enExample)
KR (2) KR100467899B1 (enExample)
CN (2) CN1137136C (enExample)
AT (2) ATE401305T1 (enExample)
AU (1) AU709539B2 (enExample)
BR (1) BR9611647B1 (enExample)
CA (2) CA2238574C (enExample)
CZ (1) CZ297297B6 (enExample)
DE (2) DE69637604D1 (enExample)
DK (2) DK1384710T3 (enExample)
EA (1) EA001372B1 (enExample)
ES (2) ES2310222T3 (enExample)
HK (1) HK1052920B (enExample)
HU (1) HU229870B1 (enExample)
IL (3) IL119691A (enExample)
IS (2) IS2178B (enExample)
MX (1) MX9804119A (enExample)
NO (2) NO324035B1 (enExample)
NZ (1) NZ322054A (enExample)
PL (3) PL191781B1 (enExample)
PT (2) PT1384710E (enExample)
SK (2) SK284672B6 (enExample)
UA (1) UA67722C2 (enExample)
WO (1) WO1997019954A1 (enExample)
ZA (1) ZA969709B (enExample)

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US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6528481B1 (en) 1999-02-16 2003-03-04 The Burnam Institute NG2/HM proteoglycan-binding peptides that home to angiogenic vasculature and related methods
US6380161B1 (en) 1999-06-21 2002-04-30 Inkine Pharmaceutical Company, Inc. Compositions for treating chemotherapy-resistant tumor cells and targeted chemotherapy compositions
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EP1452543A3 (en) * 2000-04-26 2005-08-03 BioSynthema, Inc RGD (ARG-GLY-ASP) coupled to (neuro)peptides
US7420030B2 (en) 2000-09-08 2008-09-02 The Board Of Regents Of The University Of Texas System Aminopeptidase A (APA) targeting peptides for the treatment of cancer
US20040170955A1 (en) 2000-09-08 2004-09-02 Wadih Arap Human and mouse targeting peptides identified by phage display
US7452964B2 (en) 2001-09-07 2008-11-18 Board Of Regents, The University Of Texas System Compositions and methods of use of targeting peptides against placenta and adipose tissues
KR100420007B1 (ko) * 2001-04-25 2004-03-02 노영쇠 안트라사이클린 유도체 및 이를 포함하는 항암제
IL160993A0 (en) * 2001-09-21 2004-08-31 Univ Tulane Diagnostic or therapeutic somatostatin or bombesin analog conjugates and uses thereof
EP1531846A4 (en) * 2002-02-27 2006-04-19 Us Gov Health & Human Serv Conjugates of ligand, linker and cytotoxic agent and related compositions and methods of use
WO2003074551A2 (en) 2002-03-01 2003-09-12 The Administrators Of The Tulane Educational Fund Conjugates of therapeutic or cytotoxic agents and biologically active peptides
US7544767B2 (en) 2002-04-05 2009-06-09 Burnham Institute For Medical Research HMGN2 peptides and related molecules that selectively home to tumor blood vessels and tumor cells
JP5000848B2 (ja) * 2002-05-21 2012-08-15 第一三共株式会社 グレリン含有医薬組成物
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US20040202666A1 (en) * 2003-01-24 2004-10-14 Immunomedics, Inc. Anti-cancer anthracycline drug-antibody conjugates
US20050043215A1 (en) 2003-02-19 2005-02-24 Tamara Minko Complex drug delivery composition and method for treating cancer
AU2007221964B2 (en) * 2003-04-22 2008-12-11 Ipsen Pharma S.A.S. Peptide vectors
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US7097993B2 (en) 2003-06-25 2006-08-29 Wisconsin Alumni Research Foundation Method for identifying an agent that modulates type 1 phosphatidylinositol phosphate kinase isoform β661 activity
US20080132458A1 (en) * 2004-03-10 2008-06-05 Threshold Pharmaceuticals, Inc. Hypoxia-Activated Anti-Cancer Agents
US20070060534A1 (en) * 2005-06-30 2007-03-15 Threshold Pharmaceuticals, Inc. Anthracycline analogs
JP5340155B2 (ja) * 2006-09-06 2013-11-13 エテルナ ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング 細胞結合分子を有するジソラゾールのコンジュゲート及びそれらの誘導体、新規ジソラゾール誘導体、それらの製法ならびに使用
EP1900742A1 (en) 2006-09-07 2008-03-19 AEterna Zentaris GmbH Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof
WO2008100591A2 (en) * 2007-02-14 2008-08-21 The General Hospital Corporation Modulation of nitric oxide signaling to normalize tumor vasculature
RU2377247C2 (ru) * 2007-12-27 2009-12-27 Федеральное государственное образовательное учреждение высшего профессионального образования Санкт-Петербургский государственный университет Молекулярный конъюгат на основе синтетических аналогов люлиберина и его применение в качестве средства доставки днк в клетки гормон-чувствительных опухолей (варианты)
WO2009099741A1 (en) * 2008-02-01 2009-08-13 Genentech, Inc. Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods
ES2655243T3 (es) * 2008-04-11 2018-02-19 Tianjin Hemay Oncology Pharmaceutical Co., Ltd Derivados antibióticos de antraciclina con alta actividad, métodos de preparación y usos de los mismos
AU2009235897B2 (en) * 2008-04-11 2012-04-12 Tianjin Hemay Oncology Pharmaceutical Co., Ltd Anthracycline antibiotic derivatives with high activity, preparation methods and uses thereof
MX2011000509A (es) 2008-07-15 2011-04-05 Genentech Inc Conjugados derivados de antraciclina, proceso para su preparacion y su uso como compuestos antitumorales.
CA2752608A1 (en) 2009-02-20 2010-08-26 Ipsen Pharma S.A.S. Cytotoxic conjugates having neuropeptide y receptor binding compound
CN102050856B (zh) * 2009-11-03 2014-04-30 天津和美生物技术有限公司 具有高活性的表阿霉素的衍生物及其制备和应用
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CN105198966B (zh) * 2014-06-26 2019-06-21 中国人民解放军军事医学科学院毒物药物研究所 GnRH类似物-细胞毒分子缀合物、其制备方法及用途
KR102062025B1 (ko) * 2014-06-30 2020-01-03 타베다 세라퓨틱스, 인코포레이티드 표적화된 콘주게이트 및 입자 및 그것의 제형
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Also Published As

Publication number Publication date
CZ135798A3 (cs) 1998-10-14
IS2634B (is) 2010-06-15
IL134685A0 (en) 2001-04-30
JP2000502055A (ja) 2000-02-22
KR20040037176A (ko) 2004-05-04
NO20051111L (no) 2005-03-01
BR9611647B1 (pt) 2010-03-09
CA2471775A1 (en) 1997-06-05
CZ297297B6 (cs) 2006-11-15
ES2205067T3 (es) 2004-05-01
SK284392B6 (sk) 2005-03-04
CN1137136C (zh) 2004-02-04
ATE401305T1 (de) 2008-08-15
HUP9903771A2 (hu) 2000-02-28
HU229870B1 (en) 2014-10-28
IS8567A (is) 2006-11-09
SK62898A3 (en) 1999-06-11
PL326865A1 (en) 1998-10-26
US5843903A (en) 1998-12-01
PL187230B1 (pl) 2004-06-30
CN1166597C (zh) 2004-09-15
IL134685A (en) 2002-12-01
EA001372B1 (ru) 2001-02-26
IS2178B (is) 2006-12-15
AU709539B2 (en) 1999-09-02
DK0863917T3 (da) 2004-01-19
BR9611647A (pt) 1999-02-23
JP4778405B2 (ja) 2011-09-21
JP2007045845A (ja) 2007-02-22
KR100445754B1 (ko) 2004-12-08
CA2238574A1 (en) 1997-06-05
PT863917E (pt) 2004-02-27
DK1384710T3 (da) 2008-11-17
EP1384710A1 (en) 2004-01-28
HK1052920B (zh) 2005-03-04
HK1052920A1 (en) 2003-10-03
HUP9903771A3 (en) 2000-07-28
NO982252L (no) 1998-05-15
CN1202903A (zh) 1998-12-23
DE69637604D1 (de) 2008-08-28
ZA969709B (en) 1997-08-25
CA2238574C (en) 2004-10-19
DE69630233T2 (de) 2004-08-05
ATE251179T1 (de) 2003-10-15
KR100467899B1 (ko) 2005-01-24
MX9804119A (es) 1998-09-30
NO982252D0 (no) 1998-05-15
CN1405127A (zh) 2003-03-26
EA199800492A1 (ru) 1998-12-24
JP3987575B2 (ja) 2007-10-10
IS4734A (is) 1998-05-05
KR19990071672A (ko) 1999-09-27
UA67722C2 (en) 2004-07-15
HK1017363A1 (en) 1999-11-19
US6184374B1 (en) 2001-02-06
EP0863917B1 (en) 2003-10-01
NZ322054A (en) 1999-04-29
IL119691A0 (en) 1997-02-18
PL191781B1 (pl) 2006-07-31
ES2310222T3 (es) 2009-01-01
AU7572296A (en) 1997-06-19
IL119691A (en) 2002-02-10
NO324035B1 (no) 2007-07-30
WO1997019954A1 (en) 1997-06-05
PL188786B1 (pl) 2005-04-29
CA2471775C (en) 2008-01-29
EP0863917A1 (en) 1998-09-16
DE69630233D1 (de) 2003-11-06
SK284672B6 (sk) 2005-08-04
EP1384710B1 (en) 2008-07-16

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