DK2566517T3 - Antistoffer, der binder csf1r - Google Patents
Antistoffer, der binder csf1r Download PDFInfo
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- DK2566517T3 DK2566517T3 DK11778283.9T DK11778283T DK2566517T3 DK 2566517 T3 DK2566517 T3 DK 2566517T3 DK 11778283 T DK11778283 T DK 11778283T DK 2566517 T3 DK2566517 T3 DK 2566517T3
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- antibody
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- heavy chain
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- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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Claims (21)
1. Isoleret antistof omfattende en tung kæde og en let kæde, hvor antistoffet omfatter: (i) en tung kæde omfattende en tungkæde-(HC-) CDR1 med sekvensen med SEQ ID NO: 15, en HC-CDR2 med sekvensen med SEQ ID NO: 16 og en HC-CDR3 med sekvensen med SEQ ID NO: 17 og (ii) en let kæde omfattende en letkæde-(LC-) CDR1 med sekvensen med SEQ ID NO: 18, en LC-CDR2 med sekvensen med SEQ ID NO: 19 og en LC-CDR3 med sekvensen med SEQ ID NO: 20; hvor antistoffet binder human CSF1R, blokerer bindingen af CSF1 og IL34 til CSF1 R'en og inhiberer CSF1 - og IL34-induceret CSF1 R-phosphorylering.
2. Antistof ifølge krav 1, hvor antistoffet omfatter: (a) en tung kæde omfattende en sekvens med SEQ ID NO: 39 og en let kæde omfattende en sekvens med SEQ ID NO: 46; (b) en tung kæde omfattende en sekvens med SEQ ID NO: 9 og en let kæde omfattende en sekvens med SEQ ID NO: 10; (c) en tung kæde omfattende en sekvens med SEQ ID NO: 40 og en let kæde omfattende en sekvens med SEQ ID NO: 46; (d) en tung kæde omfattende en sekvens med SEQ ID NO: 41 og en let kæde omfattende en sekvens med SEQ ID NO: 46; (e) en tung kæde omfattende en sekvens med SEQ ID NO: 39 og en let kæde omfattende en sekvens med SEQ ID NO: 47; (f) en tung kæde omfattende en sekvens med SEQ ID NO: 40 og en let kæde omfattende en sekvens med SEQ ID NO: 47; eller (g) en tung kæde omfattende en sekvens med SEQ ID NO: 41 og en let kæde omfattende en sekvens med SEQ ID NO: 47.
3. Antistof ifølge krav 2, hvor antistoffet omfatter: (a) en tung kæde omfattende en sekvens med SEQ ID NO: 53 og en let kæde omfattende en sekvens med SEQ ID NO: 60; eller (b) en tung kæde omfattende en sekvens med SEQ ID NO: 53 og en let kæde omfattende en sekvens med SEQ ID NO: 61.
4. Antistof ifølge krav 2, hvor antistoffet omfatter: (a) en tung kæde bestående af sekvensen med SEQ ID NO: 53 og en let kæde bestående af sekvensen med SEQ ID NO: 60; eller (b) en tung kæde bestående af sekvensen med SEQ ID NO: 53 og en let kæde bestående af sekvensen med SEQ ID NO: 61.
5. Antistof ifølge krav 2, hvor antistoffet omfatter en tung kæde omfattende en sekvens med SEQ ID NO: 39 og en let kæde omfattende en sekvens med SEQ ID NO: 46.
6. Antistof ifølge krav 2, hvor antistoffet omfatter en tung kæde omfattende en sekvens med SEQ ID NO: 53 og en let kæde omfattende en sekvens med SEQ ID NO: 60.
7. Antistof ifølge krav 2, hvor antistoffet omfatter en tung kæde bestående af sekvensen med SEQ ID NO: 53 og en let kæde bestående af sekvensen med SEQ ID NO: 60.
8. Antistof ifølge et hvilket som helst af de foregående krav, hvor antistoffet er et kimært antistof eller et humaniseret antistof.
9. Antistof ifølge krav 1,2, 5, eller 8, hvor antistoffet er udvalgt blandt et Fab, et Fv, et scFv, et Fab' og et (Fab')2.
10. Antistof ifølge et hvilket som helst af kravene 1 til 8, hvor antistoffet er udvalgt blandt et IgA, et IgG og et IgD.
11. Antistof ifølge et hvilket som helst af kravene 1 til 8, hvor antistoffet er et lgG1-, lgG2- eller lgG4-antistof.
12. Antistof ifølge krav 11, hvor antistoffet er et IgG 1-antistof.
13. Antistof ifølge krav 11, hvor antistoffet er et lgG4-antistof omfattende en S241 P-mutation.
14. Farmaceutisk sammensætning omfattende et antistof ifølge et hvilket som helst af de foregående krav.
15. Sammensætning omfattende en første nukleinsyre og en anden nukleinsyre, hvor den første nukleinsyre omfatter en første polynukleotidsekvens, og den anden nukleinsyre omfatter en anden polynukleotidsekvens, hvor den første polynukleotidsekvens og den anden polynukleotidsekvens koder for henholdsvis en tung kæde og en let kæde af et antistof ifølge et hvilket som helst af kravene 1 til 13.
16. Isoleret nukleinsyre omfattende en første polynukleotidsekvens og en anden polynukleotidsekvens, hvor den første polynukleotidsekvens og den anden polynukleotidsekvens koder for henholdsvis en tung kæde og en let kæde af et antistof ifølge et hvilket som helst af kravenel til 13.
17. Værtscelle omfattende sammensætningen ifølge krav 15 eller den isolerede nukleinsyre ifølge krav 16.
18. Værtscelle ifølge krav 17, hvor cellen er en eukaryotisk værtscelle eller en pattedy rsvæ rtscel I e.
19. Antistof ifølge et hvilket som helst af kravene 1 til 13 til anvendelse i en fremgangsmåde til behandling af cancer, autoimmune sygdomme, inflammatoriske tilstande eller osteolytisk knogletab.
20. Antistof til anvendelse i en fremgangsmåde til behandling af autoimmune sygdomme ifølge krav 19, hvor den autoimmune sygdom er udvalgt blandt multipel sklerose og reumatoid artritis, og hvor det osteolytiske knogletab er udvalgt blandt osteoporose, metastase-induceret osteolytisk knogletab og reumatoid artritis-induceret knogletab.
21. Antistof til anvendelse i en fremgangsmåde til behandling af cancer ifølge krav 19, hvor canceren er udvalgt blandt brystcancer, prostatacancer, endo-metriecancer, blærecancer, nyrecancer, øsofaguscancer, pladecellekarcinom, uvealt melanom, follikulært lymfom, renalcellecarcinom, cervicixcancer, ova riecancer, lungecancer, kolorektal cancer, hjernecancer, pancreascancer, hoved- og halscancer, levercancer, leukæmi, lymfom, Hodgkins sygdom, myelo-matose, melanom, astrocytom, mavecancer og lungeadenokarcinom.
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