MX2019001453A - Metodos mejorados para producir genotecas de polinucleotidos en virus vacuna/ celulas eucariotas. - Google Patents
Metodos mejorados para producir genotecas de polinucleotidos en virus vacuna/ celulas eucariotas.Info
- Publication number
- MX2019001453A MX2019001453A MX2019001453A MX2019001453A MX2019001453A MX 2019001453 A MX2019001453 A MX 2019001453A MX 2019001453 A MX2019001453 A MX 2019001453A MX 2019001453 A MX2019001453 A MX 2019001453A MX 2019001453 A MX2019001453 A MX 2019001453A
- Authority
- MX
- Mexico
- Prior art keywords
- vaccinia virus
- eukaryotic cells
- improved methods
- polynucleotide libraries
- interest
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 102000040430 polynucleotide Human genes 0.000 title abstract 3
- 108091033319 polynucleotide Proteins 0.000 title abstract 3
- 239000002157 polynucleotide Substances 0.000 title abstract 3
- 241000700618 Vaccinia virus Species 0.000 title abstract 2
- 210000003527 eukaryotic cell Anatomy 0.000 title 1
- 238000010276 construction Methods 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 abstract 1
- 229960001225 rifampicin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1082—Preparation or screening gene libraries by chromosomal integration of polynucleotide sequences, HR-, site-specific-recombination, transposons, viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Computational Biology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Esta descripción proporciona un método mejorado para construir una genoteca de polinucleotidos de interés en un poxvirus, por ejemplo, un sistema del vector del virus vacuna, en donde los polinucleotidos de interés codifican los polipéptidos de interés; el método comprende construir la genoteca en presencia de un inhibidor del ensamble de poxvirus, por ejemplo, rifampicina, que permite la construcción de las genotecas con complejidad y diversidad mas elevadas que los métodos anteriores.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662370009P | 2016-08-02 | 2016-08-02 | |
| PCT/US2017/044688 WO2018026715A1 (en) | 2016-08-02 | 2017-07-31 | Improved methods for producing polynucleotide libraries in vaccinia virus/eukaryotic cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019001453A true MX2019001453A (es) | 2019-06-20 |
Family
ID=61073907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019001453A MX2019001453A (es) | 2016-08-02 | 2017-07-31 | Metodos mejorados para producir genotecas de polinucleotidos en virus vacuna/ celulas eucariotas. |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20190169606A1 (es) |
| EP (1) | EP3494131A4 (es) |
| JP (2) | JP7128177B2 (es) |
| KR (1) | KR102449406B1 (es) |
| CN (1) | CN109563143A (es) |
| AU (1) | AU2017306062B2 (es) |
| BR (1) | BR112019001944A2 (es) |
| CA (1) | CA3032512A1 (es) |
| IL (1) | IL264343B2 (es) |
| MX (1) | MX2019001453A (es) |
| RU (1) | RU2747557C2 (es) |
| SG (1) | SG11201900595YA (es) |
| WO (1) | WO2018026715A1 (es) |
| ZA (1) | ZA201901286B (es) |
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| SG11201401458UA (en) | 2011-10-11 | 2014-07-30 | Vaccinex Inc | Use of semaphorin-4d binding molecules for modulation of blood brain barrier permeability |
| US9708601B2 (en) | 2012-04-26 | 2017-07-18 | Vaccinex, Inc. | Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus |
| CA2916245C (en) | 2013-06-25 | 2023-01-24 | Vaccinex, Inc. | Use of semaphorin-4d inhibitory molecules in combination with an immune modulating therapy to inhibit tumor growth and metastases |
| NZ630892A (en) | 2013-10-21 | 2016-03-31 | Vaccinex Inc | Use of semaphorin-4d binding molecules for treating neurodegenerative disorders |
| MX2018012818A (es) | 2016-04-22 | 2019-07-04 | Vaccinex Inc | Presentacion de proteina de membrana integral en viriones envueltos extracelulares de poxvirus. |
| IL264343B2 (en) * | 2016-08-02 | 2024-05-01 | Vaccinex Inc | Improved methods for generating polynucleotide libraries in cowpox/eukaryotic cells |
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-
2017
- 2017-07-31 IL IL264343A patent/IL264343B2/en unknown
- 2017-07-31 US US16/320,950 patent/US20190169606A1/en not_active Abandoned
- 2017-07-31 EP EP17837472.4A patent/EP3494131A4/en active Pending
- 2017-07-31 KR KR1020197005952A patent/KR102449406B1/ko active IP Right Grant
- 2017-07-31 WO PCT/US2017/044688 patent/WO2018026715A1/en unknown
- 2017-07-31 SG SG11201900595YA patent/SG11201900595YA/en unknown
- 2017-07-31 JP JP2019505498A patent/JP7128177B2/ja active Active
- 2017-07-31 AU AU2017306062A patent/AU2017306062B2/en active Active
- 2017-07-31 CN CN201780047905.6A patent/CN109563143A/zh active Pending
- 2017-07-31 CA CA3032512A patent/CA3032512A1/en active Pending
- 2017-07-31 MX MX2019001453A patent/MX2019001453A/es unknown
- 2017-07-31 RU RU2019105695A patent/RU2747557C2/ru active
- 2017-07-31 BR BR112019001944-8A patent/BR112019001944A2/pt unknown
-
2019
- 2019-02-28 ZA ZA2019/01286A patent/ZA201901286B/en unknown
- 2019-04-15 US US16/384,078 patent/US10640765B2/en active Active
-
2020
- 2020-04-28 US US16/860,217 patent/US20200299683A1/en not_active Abandoned
-
2022
- 2022-04-19 JP JP2022068581A patent/JP2022109946A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| RU2747557C2 (ru) | 2021-05-06 |
| AU2017306062B2 (en) | 2021-12-09 |
| SG11201900595YA (en) | 2019-02-27 |
| RU2019105695A3 (es) | 2020-11-02 |
| IL264343A (en) | 2019-02-28 |
| BR112019001944A2 (pt) | 2019-05-07 |
| US20190169606A1 (en) | 2019-06-06 |
| JP7128177B2 (ja) | 2022-08-30 |
| KR102449406B1 (ko) | 2022-09-29 |
| EP3494131A4 (en) | 2020-04-15 |
| CN109563143A (zh) | 2019-04-02 |
| KR20190034304A (ko) | 2019-04-01 |
| RU2019105695A (ru) | 2020-09-07 |
| US10640765B2 (en) | 2020-05-05 |
| WO2018026715A1 (en) | 2018-02-08 |
| US20200299683A1 (en) | 2020-09-24 |
| ZA201901286B (en) | 2023-05-31 |
| EP3494131A1 (en) | 2019-06-12 |
| IL264343B2 (en) | 2024-05-01 |
| JP2019524126A (ja) | 2019-09-05 |
| IL264343B1 (en) | 2024-01-01 |
| JP2022109946A (ja) | 2022-07-28 |
| AU2017306062A1 (en) | 2019-02-07 |
| US20190241889A1 (en) | 2019-08-08 |
| CA3032512A1 (en) | 2018-02-08 |
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