MX2018012818A - Presentacion de proteina de membrana integral en viriones envueltos extracelulares de poxvirus. - Google Patents

Presentacion de proteina de membrana integral en viriones envueltos extracelulares de poxvirus.

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Publication number
MX2018012818A
MX2018012818A MX2018012818A MX2018012818A MX2018012818A MX 2018012818 A MX2018012818 A MX 2018012818A MX 2018012818 A MX2018012818 A MX 2018012818A MX 2018012818 A MX2018012818 A MX 2018012818A MX 2018012818 A MX2018012818 A MX 2018012818A
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MX
Mexico
Prior art keywords
integral membrane
membrane protein
protein display
enveloped virions
extracellular enveloped
Prior art date
Application number
MX2018012818A
Other languages
English (en)
Inventor
S Smith Ernest
Paris Mark
G M Scrivens Maria
A Kirk Renee
A Cornelison Angelica
Original Assignee
Vaccinex Inc
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Publication date
Application filed by Vaccinex Inc filed Critical Vaccinex Inc
Publication of MX2018012818A publication Critical patent/MX2018012818A/es

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Abstract

Esta descripción proporciona composiciones y métodos para expresar y presentar proteínas de membrana integrales (IMPs) aisladas o fragmentos de las mismas en una conformación nativa para usarse en el cribado, selección, e identificación de anticuerpos o moléculas tipo anticuerpo que se unen a un IMP objetivo de interés.
MX2018012818A 2016-04-22 2017-04-21 Presentacion de proteina de membrana integral en viriones envueltos extracelulares de poxvirus. MX2018012818A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662326501P 2016-04-22 2016-04-22
PCT/US2017/028787 WO2017184951A1 (en) 2016-04-22 2017-04-21 Integral membrane protein display on poxvirus extracellular enveloped virions

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MX2018012818A true MX2018012818A (es) 2019-07-04

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MX2018012818A MX2018012818A (es) 2016-04-22 2017-04-21 Presentacion de proteina de membrana integral en viriones envueltos extracelulares de poxvirus.
MX2021013783A MX2021013783A (es) 2016-04-22 2018-10-19 Presentacion de proteina de membrana integral en viriones envueltos extracelulares de poxvirus.

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Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG175417A1 (en) 2009-05-08 2011-12-29 Vaccinex Inc Anti-cd100 antibodies and methods for using the same
JP6395606B2 (ja) 2011-10-11 2018-09-26 バクシネックス インコーポレーティッド 血液脳関門透過性の調節のためのセマフォリン−4d結合分子の使用
US9708601B2 (en) 2012-04-26 2017-07-18 Vaccinex, Inc. Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus
DK3013350T3 (da) 2013-06-25 2020-04-14 Vaccinex Inc Anvendelse af semaphorin-4D-hæmmende molekyler i kombination med en immunmodulerende terapi for at hæmme tumorvækst og metastaser
NZ630892A (en) 2013-10-21 2016-03-31 Vaccinex Inc Use of semaphorin-4d binding molecules for treating neurodegenerative disorders
MX2019001453A (es) 2016-08-02 2019-06-20 Vaccinex Inc Metodos mejorados para producir genotecas de polinucleotidos en virus vacuna/ celulas eucariotas.
CN109706177A (zh) * 2019-01-24 2019-05-03 浙江省医学科学院 一种重组痘苗病毒表面展示系统载体质粒及应用
WO2021066612A2 (ko) * 2019-10-02 2021-04-08 주식회사 바이오녹스 종양 표적화 단백질 또는 이의 단편 및 그것에 결합하는 항체 및 이의 용도
KR20230008794A (ko) 2020-05-06 2023-01-16 백시넥스 인코포레이티드 폭스바이러스 세포외 피막형 비리온 상에서의 내재막 단백질 디스플레이
KR20230037560A (ko) * 2020-07-14 2023-03-16 에프. 호프만-라 로슈 아게 고정 용량 조합에 대한 분석
KR102419397B1 (ko) * 2021-04-02 2022-07-14 주식회사 바이오녹스 항암바이러스 유래 단백질을 표적으로 하는 키메라 항원 수용체, 이를 발현하는 면역세포 및 이들의 용도
US20240093177A1 (en) 2022-06-10 2024-03-21 Vaccinex, Inc. Methods to select antibodies specific to complex membrane antigens

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5892019A (en) 1987-07-15 1999-04-06 The United States Of America, As Represented By The Department Of Health And Human Services Production of a single-gene-encoded immunoglobulin
US6218525B1 (en) * 1988-02-25 2001-04-17 The General Hospital Corporation Nucleic acid encoding CD28
US6576754B2 (en) 1995-11-09 2003-06-10 Dana-Farber Cancer Institute CD100 antigen and uses therefor
EP0897980A3 (en) * 1997-08-20 2002-04-17 Smithkline Beecham Corporation CXCR4B: A human splice variant of CXCR4 chemokine receptor
WO2000028016A1 (en) 1998-11-10 2000-05-18 University Of Rochester T cells specific for target antigens and methods and vaccines based thereon
US7198920B1 (en) * 1999-01-29 2007-04-03 Corika Corporation HER-2/neu fusion proteins
US20040014033A1 (en) * 1999-06-30 2004-01-22 Evotec Biosystems Ag, A Corporation Of Germany Virus like particles, their preparation and their use preferably in pharmaceutical screening and functional genomics
JP2003504014A (ja) * 1999-06-30 2003-02-04 エボテック オーアーイー アクチェンゲゼルシャフト ウイルス状粒子、それらの調製及び好ましくは薬学的スクリーニング及び機能的ゲノムにおけるそれらの使用
AU2001297872B2 (en) 2000-11-17 2006-11-09 University Of Rochester In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells
US7645456B2 (en) * 2001-04-23 2010-01-12 Sanofi Pasteur Biologics Co. Vaccinia virus strains
US20030044409A1 (en) * 2001-05-01 2003-03-06 Carson Dennis A. Immunologic compositions and methods for studying and treating cancers expressing frizzled antigens
US7244592B2 (en) * 2002-03-07 2007-07-17 Dyax Corp. Ligand screening and discovery
US20040014034A1 (en) * 2002-06-06 2004-01-22 Evans David H Method of producing a recombinant virus
US20060003316A1 (en) * 2002-07-15 2006-01-05 John Simard Immunogenic compositions derived from poxviruses and methods of using same
US9809654B2 (en) 2002-09-27 2017-11-07 Vaccinex, Inc. Targeted CD1d molecules
WO2004041170A2 (en) 2002-11-01 2004-05-21 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
EP1442749A1 (en) 2003-01-31 2004-08-04 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of anti-CD100 antibodies for the treatment and the diagnosis of inflammatory disorder affecting the central nervous system
JP5042631B2 (ja) 2003-12-04 2012-10-03 バクシネックス インコーポレーティッド アポトーシス腫瘍細胞上に露出した細胞内抗原をターゲッティングすることによって腫瘍細胞を死滅させる方法
US8022043B2 (en) 2004-08-27 2011-09-20 Albert Einstein College Of Medicine Of Yeshiva University Ceramide derivatives as modulators of immunity and autoimmunity
JP5226311B2 (ja) 2004-08-27 2013-07-03 アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ 免疫及び自己免疫の調節因子としてのセラミド誘導体
EP1833970A2 (en) * 2004-12-22 2007-09-19 Genentech, Inc. Methods for producing soluble multi-membrane-spanning proteins
US9382327B2 (en) 2006-10-10 2016-07-05 Vaccinex, Inc. Anti-CD20 antibodies and methods of use
US7919594B2 (en) 2007-02-14 2011-04-05 Vaccinex, Inc. Human anti-CD100 antibodies
JP5357782B2 (ja) 2007-02-21 2013-12-04 バクシネックス インコーポレーティッド 抗原負荷CD1d分子によるNKT細胞活性の調節
US8309088B2 (en) 2007-08-10 2012-11-13 Regeneron Pharmaceuticals, Inc. Method of treating osteoarthritis with an antibody to NGF
US8637026B2 (en) 2007-12-26 2014-01-28 Vaccinex, Inc. Anti-C35 antibody combination therapies and methods
WO2010044919A2 (en) * 2008-05-28 2010-04-22 Vgx Pharmaceuticals, Inc. Smallpox dna vaccine and the antigens therein that elicit an immune response
WO2010081026A1 (en) 2009-01-08 2010-07-15 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Bacterial vaccines with cell wall-associated ceramide-like glycolipids and uses thereof
SG175417A1 (en) 2009-05-08 2011-12-29 Vaccinex Inc Anti-cd100 antibodies and methods for using the same
NZ604464A (en) 2010-06-14 2014-03-28 Vaccinex Inc Anti-vegf antibodies and uses thereof
WO2012006342A2 (en) 2010-07-07 2012-01-12 Albert Einstein College Of Medicine Of Yeshiva University Ceramide-like glycolipid-associated bacterial vaccines and uses thereof
WO2012031099A2 (en) 2010-09-02 2012-03-08 Vaccinex, Inc. Anti-cxcl13 antibodies and methods of using the same
ES2640567T3 (es) 2011-05-13 2017-11-03 National University Corporation Tokyo Medical And Dental University Promotor de la osteogénesis
JP6395606B2 (ja) 2011-10-11 2018-09-26 バクシネックス インコーポレーティッド 血液脳関門透過性の調節のためのセマフォリン−4d結合分子の使用
US8790652B2 (en) 2011-12-06 2014-07-29 Vaccinex, Inc. Use of the combination of semaphorin-4D inhibitory molecules and VEGF inhibitory molecules to inhibit angiogenesis
WO2013130959A1 (en) 2012-03-02 2013-09-06 Vaccinex, Inc. Methods for the treatment of b cell-mediated inflammatory diseases
US9090709B2 (en) 2012-03-28 2015-07-28 Vaccinex, Inc. Anti-SEMA4D antibodies and epitopes
US9708601B2 (en) * 2012-04-26 2017-07-18 Vaccinex, Inc. Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus
US10494440B2 (en) 2012-05-11 2019-12-03 Vaccinex, Inc. Use of semaphorin-4D binding molecules to promote neurogenesis following stroke
EP2951204B1 (en) 2013-01-31 2019-05-22 Vaccinex, Inc. Methods for increasing immunoglobulin a levels
US9371352B2 (en) 2013-02-08 2016-06-21 Vaccinex, Inc. Modified glycolipids and methods of making and using the same
DK3013350T3 (da) 2013-06-25 2020-04-14 Vaccinex Inc Anvendelse af semaphorin-4D-hæmmende molekyler i kombination med en immunmodulerende terapi for at hæmme tumorvækst og metastaser
NZ630881A (en) 2013-10-10 2016-03-31 Vaccinex Inc Use of semaphorin-4d binding molecules for treatment of atherosclerosis
NZ630892A (en) 2013-10-21 2016-03-31 Vaccinex Inc Use of semaphorin-4d binding molecules for treating neurodegenerative disorders
WO2015193143A1 (en) * 2014-06-18 2015-12-23 Morphosys Ag Fusion proteins and uses thereof
MX2019001453A (es) 2016-08-02 2019-06-20 Vaccinex Inc Metodos mejorados para producir genotecas de polinucleotidos en virus vacuna/ celulas eucariotas.
RU2766341C2 (ru) 2017-02-22 2022-03-15 Вакцинекс, Инк. Раннее обнаружение активации глиальных клеток при нейродегенеративных или нейровоспалительных заболеваниях
MX2019011130A (es) 2017-03-20 2019-11-05 Vaccinex Inc Tratamiento del cancer con un anticuerpo semaforina-4d en combinacion con un agente de modulacion epigenetica.
JP7246320B2 (ja) 2017-05-05 2023-03-27 バクシネックス インコーポレーティッド ヒト抗セマフォリン4d抗体

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