MX2021013783A - Presentacion de proteina de membrana integral en viriones envueltos extracelulares de poxvirus. - Google Patents
Presentacion de proteina de membrana integral en viriones envueltos extracelulares de poxvirus.Info
- Publication number
- MX2021013783A MX2021013783A MX2021013783A MX2021013783A MX2021013783A MX 2021013783 A MX2021013783 A MX 2021013783A MX 2021013783 A MX2021013783 A MX 2021013783A MX 2021013783 A MX2021013783 A MX 2021013783A MX 2021013783 A MX2021013783 A MX 2021013783A
- Authority
- MX
- Mexico
- Prior art keywords
- integral membrane
- membrane protein
- protein display
- enveloped virions
- extracellular enveloped
- Prior art date
Links
- 102000018697 Membrane Proteins Human genes 0.000 title abstract 3
- 108010052285 Membrane Proteins Proteins 0.000 title abstract 3
- 210000002845 virion Anatomy 0.000 title 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12N15/86—Viral vectors
- C12N15/863—Poxviral vectors, e.g. entomopoxvirus
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- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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Abstract
Esta descripción proporciona composiciones y métodos para expresar y presentar proteínas de membrana integrales (IMPs) aisladas o fragmentos de las mismas en una conformación nativa para usarse en el cribado, selección, e identificación de anticuerpos o moléculas tipo anticuerpo que se unen a un IMP objetivo de interés.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US201662326501P | 2016-04-22 | 2016-04-22 |
Publications (1)
Publication Number | Publication Date |
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MX2021013783A true MX2021013783A (es) | 2021-12-10 |
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ID=60116403
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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MX2018012818A MX2018012818A (es) | 2016-04-22 | 2017-04-21 | Presentacion de proteina de membrana integral en viriones envueltos extracelulares de poxvirus. |
MX2021013783A MX2021013783A (es) | 2016-04-22 | 2018-10-19 | Presentacion de proteina de membrana integral en viriones envueltos extracelulares de poxvirus. |
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Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT2427212T (pt) | 2009-05-08 | 2017-11-20 | Vaccinex Inc | Anticorpos anti-cd100 e métodos para utilização dos mesmos |
KR101999872B1 (ko) | 2011-10-11 | 2019-07-12 | 백시넥스 인코포레이티드 | 혈뇌 장벽 투과성의 조정에 있어서의 세마포린-4d 결합 분자의 용도 |
US9708601B2 (en) | 2012-04-26 | 2017-07-18 | Vaccinex, Inc. | Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus |
EA036591B1 (ru) | 2013-06-25 | 2020-11-26 | Вэксинекс, Инк. | Способ ингибирования, замедления или уменьшения роста раковой опухоли у субъекта |
NZ630892A (en) | 2013-10-21 | 2016-03-31 | Vaccinex Inc | Use of semaphorin-4d binding molecules for treating neurodegenerative disorders |
JP7128177B2 (ja) | 2016-08-02 | 2022-08-30 | バクシネックス インコーポレーティッド | ワクシニアウイルス/真核細胞においてポリヌクレオチドライブラリを生成するための改善された方法 |
CN109706177A (zh) * | 2019-01-24 | 2019-05-03 | 浙江省医学科学院 | 一种重组痘苗病毒表面展示系统载体质粒及应用 |
CA3156346A1 (en) * | 2019-10-02 | 2021-04-08 | Bionoxx Inc. | PROTEIN TARGETING A TUMOR OR ASSOCIATED FRAGMENT, ANTIBODY BINDING THEREOF AND USE THEREOF |
WO2021226169A1 (en) * | 2020-05-06 | 2021-11-11 | Vaccinex, Inc. | Integral membrane protein display on poxvirus extracellular enveloped virions |
MX2023000622A (es) * | 2020-07-14 | 2023-02-22 | Genentech Inc | Ensayos para combinaciones de dosis fija. |
KR102419397B1 (ko) * | 2021-04-02 | 2022-07-14 | 주식회사 바이오녹스 | 항암바이러스 유래 단백질을 표적으로 하는 키메라 항원 수용체, 이를 발현하는 면역세포 및 이들의 용도 |
WO2023240292A1 (en) | 2022-06-10 | 2023-12-14 | Vaccinex, Inc. | Methods to select antibodies specific to complex membrane antigens |
Family Cites Families (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US5892019A (en) | 1987-07-15 | 1999-04-06 | The United States Of America, As Represented By The Department Of Health And Human Services | Production of a single-gene-encoded immunoglobulin |
US6218525B1 (en) | 1988-02-25 | 2001-04-17 | The General Hospital Corporation | Nucleic acid encoding CD28 |
US6576754B2 (en) | 1995-11-09 | 2003-06-10 | Dana-Farber Cancer Institute | CD100 antigen and uses therefor |
EP0897980A3 (en) * | 1997-08-20 | 2002-04-17 | Smithkline Beecham Corporation | CXCR4B: A human splice variant of CXCR4 chemokine receptor |
WO2000028016A1 (en) | 1998-11-10 | 2000-05-18 | University Of Rochester | T cells specific for target antigens and methods and vaccines based thereon |
US7198920B1 (en) | 1999-01-29 | 2007-04-03 | Corika Corporation | HER-2/neu fusion proteins |
AU6267000A (en) | 1999-06-30 | 2001-01-22 | Evotec Oai Ag | Virus like particles, their preparation and their use preferably in pharmaceutical screening and functional genomics |
US20040014033A1 (en) * | 1999-06-30 | 2004-01-22 | Evotec Biosystems Ag, A Corporation Of Germany | Virus like particles, their preparation and their use preferably in pharmaceutical screening and functional genomics |
EP1340088B1 (en) | 2000-11-17 | 2007-01-17 | University Of Rochester | In vitro methods of producing and identifying immunoglobulin molecules in eukaryotic cells |
US7645456B2 (en) * | 2001-04-23 | 2010-01-12 | Sanofi Pasteur Biologics Co. | Vaccinia virus strains |
US20030044409A1 (en) | 2001-05-01 | 2003-03-06 | Carson Dennis A. | Immunologic compositions and methods for studying and treating cancers expressing frizzled antigens |
US7244592B2 (en) * | 2002-03-07 | 2007-07-17 | Dyax Corp. | Ligand screening and discovery |
US20040014034A1 (en) | 2002-06-06 | 2004-01-22 | Evans David H | Method of producing a recombinant virus |
US20060003316A1 (en) | 2002-07-15 | 2006-01-05 | John Simard | Immunogenic compositions derived from poxviruses and methods of using same |
US9809654B2 (en) | 2002-09-27 | 2017-11-07 | Vaccinex, Inc. | Targeted CD1d molecules |
US20060263774A1 (en) | 2002-11-01 | 2006-11-23 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
EP1442749A1 (en) | 2003-01-31 | 2004-08-04 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of anti-CD100 antibodies for the treatment and the diagnosis of inflammatory disorder affecting the central nervous system |
NZ547591A (en) | 2003-12-04 | 2009-11-27 | Vaccinex Inc | Methods of killing tumor cells by targeting internal antigens exposed on apoptotic tumor cells |
JP5226311B2 (ja) | 2004-08-27 | 2013-07-03 | アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ | 免疫及び自己免疫の調節因子としてのセラミド誘導体 |
US8022043B2 (en) | 2004-08-27 | 2011-09-20 | Albert Einstein College Of Medicine Of Yeshiva University | Ceramide derivatives as modulators of immunity and autoimmunity |
CN101128586A (zh) * | 2004-12-22 | 2008-02-20 | 健泰科生物技术公司 | 制备可溶性多跨膜蛋白的方法 |
US9382327B2 (en) | 2006-10-10 | 2016-07-05 | Vaccinex, Inc. | Anti-CD20 antibodies and methods of use |
DE602008004296D1 (de) | 2007-02-14 | 2011-02-17 | Vaccinex Inc | Humanisierte anti-cd100-antikörper |
JP5357782B2 (ja) | 2007-02-21 | 2013-12-04 | バクシネックス インコーポレーティッド | 抗原負荷CD1d分子によるNKT細胞活性の調節 |
US8309088B2 (en) | 2007-08-10 | 2012-11-13 | Regeneron Pharmaceuticals, Inc. | Method of treating osteoarthritis with an antibody to NGF |
EP2237792B1 (en) | 2007-12-26 | 2017-05-24 | Vaccinex, Inc. | Anti-c35 antibody combination therapies and methods |
WO2010044919A2 (en) * | 2008-05-28 | 2010-04-22 | Vgx Pharmaceuticals, Inc. | Smallpox dna vaccine and the antigens therein that elicit an immune response |
JP2012514476A (ja) | 2009-01-08 | 2012-06-28 | アルバート アインシュタイン カレッジ オブ メディシン オブ イェシバ ユニバーシティ,ア ディビジョン オブ イェシバ ユニバーシティ | 細胞壁結合セラミド様糖脂質による細菌ワクチンおよびその使用 |
PT2427212T (pt) | 2009-05-08 | 2017-11-20 | Vaccinex Inc | Anticorpos anti-cd100 e métodos para utilização dos mesmos |
EP2579895A4 (en) | 2010-06-14 | 2013-12-18 | Vaccinex Inc | ANTI-VEGF ANTIBODIES AND USES THEREOF |
US20130164325A1 (en) | 2010-07-07 | 2013-06-27 | Albert Einstein College Of Medicine Of Yeshiva University | Ceramide-like glycolipid-associated bacterial vaccines and uses thereof |
BR112013005145B1 (pt) | 2010-09-02 | 2022-02-15 | Vaccinex, Inc | Anticorpo isolado ou seu fragmento de ligação ao antígeno que se liga especificamente ao cxcl13, composição e uso de uma composição |
US9447191B2 (en) | 2011-05-13 | 2016-09-20 | National University Corporation Tokyo Medical And Dental University | Osteogenesis promoter |
KR101999872B1 (ko) | 2011-10-11 | 2019-07-12 | 백시넥스 인코포레이티드 | 혈뇌 장벽 투과성의 조정에 있어서의 세마포린-4d 결합 분자의 용도 |
US8790652B2 (en) | 2011-12-06 | 2014-07-29 | Vaccinex, Inc. | Use of the combination of semaphorin-4D inhibitory molecules and VEGF inhibitory molecules to inhibit angiogenesis |
CA2865928C (en) | 2012-03-02 | 2021-02-16 | Vaccinex, Inc. | Cxcl13 antagonist for the treatment of sjogren's syndrome |
US9090709B2 (en) | 2012-03-28 | 2015-07-28 | Vaccinex, Inc. | Anti-SEMA4D antibodies and epitopes |
US9708601B2 (en) * | 2012-04-26 | 2017-07-18 | Vaccinex, Inc. | Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus |
US10494440B2 (en) | 2012-05-11 | 2019-12-03 | Vaccinex, Inc. | Use of semaphorin-4D binding molecules to promote neurogenesis following stroke |
WO2014121053A1 (en) | 2013-01-31 | 2014-08-07 | Vaccinex, Inc. | Methods for increasing immunoglobulin a levels |
US9371352B2 (en) | 2013-02-08 | 2016-06-21 | Vaccinex, Inc. | Modified glycolipids and methods of making and using the same |
EA036591B1 (ru) | 2013-06-25 | 2020-11-26 | Вэксинекс, Инк. | Способ ингибирования, замедления или уменьшения роста раковой опухоли у субъекта |
NZ630881A (en) | 2013-10-10 | 2016-03-31 | Vaccinex Inc | Use of semaphorin-4d binding molecules for treatment of atherosclerosis |
NZ630892A (en) | 2013-10-21 | 2016-03-31 | Vaccinex Inc | Use of semaphorin-4d binding molecules for treating neurodegenerative disorders |
DK3158058T3 (da) * | 2014-06-18 | 2019-07-01 | Morphosys Ag | Fusionsproteiner og bruger deraf |
JP7128177B2 (ja) | 2016-08-02 | 2022-08-30 | バクシネックス インコーポレーティッド | ワクシニアウイルス/真核細胞においてポリヌクレオチドライブラリを生成するための改善された方法 |
SG11201906670PA (en) | 2017-02-22 | 2019-08-27 | Vaccinex Inc | Early detection of glial cell activation in neurodegenerative or neuroinflammatory diseases |
MX2019011130A (es) | 2017-03-20 | 2019-11-05 | Vaccinex Inc | Tratamiento del cancer con un anticuerpo semaforina-4d en combinacion con un agente de modulacion epigenetica. |
MX2019013110A (es) | 2017-05-05 | 2019-12-16 | Vaccinex Inc | Anticuerpo anti-semaforina 4d humano. |
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