DK2207529T3 - Lægemiddelkerner til langvarig frigivelse af terapeutiske midler - Google Patents
Lægemiddelkerner til langvarig frigivelse af terapeutiske midler Download PDFInfo
- Publication number
- DK2207529T3 DK2207529T3 DK08830451T DK08830451T DK2207529T3 DK 2207529 T3 DK2207529 T3 DK 2207529T3 DK 08830451 T DK08830451 T DK 08830451T DK 08830451 T DK08830451 T DK 08830451T DK 2207529 T3 DK2207529 T3 DK 2207529T3
- Authority
- DK
- Denmark
- Prior art keywords
- drug
- core
- therapeutic agent
- drug core
- agent
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- A61K9/2036—Silicones; Polysiloxanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0069—Three-dimensional shapes cylindrical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00772—Apparatus for restoration of tear ducts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
- A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Surgery (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Medicinal Preparation (AREA)
Claims (18)
- so1. Lægemiddelindsats, der er tilpasset til placering i et tårekanalsimplantat, hvilket tårekanalsimplantat er tilpasset til indsætning via et tårepunkt i øjet for at befinde sig i øjets canaliculus, hvilken indsats omfatter en lægemiddelkeme og et hylsterlegeme, der delvist dækker lægemiddelkemen, hvilken lægemiddelkeme omfatter et terapeutisk middel og en matrix, hvilket terapeutisk middel er udvalgt fra gruppen bestående af bimatoprost, latanoprost og travoprost, hvilken matrix omfatter en siliconepolymer, hvilket hylsterlegeme er placeret over en del af lægemiddelkemen for at hæmme frigivelse af midlet fra delen og for således at definere mindst én eksponeret overflade af lægemiddelkemen, der er tilpasset til at frigive midlet til øjet eller det omgivende væv eller begge efter kontakt med tårevæske, når implantatet er indsat i en patient, og hvor en mængde af det terapeutiske middel i en makroskopisk volumetrisk del af lægemiddelkemen maksimalt varierer med 30 % fra en mængde af det terapeutiske middel i en hvilken som helst anden tilsvarende makroskopisk volumetrisk del af lægemiddelkemen.
- 2. Lægemiddelindsats ifølge krav 1, hvor: a) det terapeutiske middel ensartet og homogent dispergeres gennem matrixen; eller b) det terapeutiske middel mindst delvist danner faste eller flydende inklusioner inde i matrixen.
- 3. Lægemiddelindsats ifølge krav 1 eller 2, hvor mængden af det terapeutiske middel i den makroskopiske vo lumetriske del af lægemiddelkemen maksimalt varierer med 10 % fra mængden af det terapeutiske middel i en hvilken som helst anden tilsvarende makroskopisk volumetrisk del af lægemiddelkemen.
- 4. Flerhed af lægemiddelindsatseme ifølge et hvilket som helst af kravene 1 -3, hvor hver af flerheden af indsatserne omfatter en koncentration af midlet, der maksimalt varierer med 30 % fra koncentrationer af midlerne i andre indsatser af flerheden.
- 5. Flerhed af lægemiddelindsatser ifølge krav 4, hvor koncentrationen af midlet maksimalt varierer med 10 % derimellem.
- 6. Lægemiddelindsats ifølge et hvilket som helst af kravene 1-5, hvor lægemiddelkemen omfatter 0,1 vægt-% til 50 vægt-% af midlet.
- 7. Lægemiddelindsats ifølge et hvilket som helst af kravene 1-6, hvor hylsterlegemet omfatter en polymer, der omfatter mindst ét af polyimid, PMMA eller PET, hvor polymeren er ekstruderet eller støbt; eller et metal indeholdende rustfrit stål eller titan.
- 8. Lægemiddelindsats ifølge et hvilket som helst af kravene 1 -7, hvor lægemiddelindsatsen omfatter et materiale til ændring af frigivelseshastigheden omfattende et inert fyldstof, et salt, et overfladeaktivt middel, et dispergeringsmiddel, en anden polymer, en oligomer eller en kombination deraf.
- 9. Lægemiddelindsats ifølge et hvilket som helst af kravene 1-8, hvor lægemiddelkemen i alt væsentligt er cylindrisk i form, har en akse, hvor den eksponerede overflade af lægemiddelkemen placeres på en ende af den cylindriske form, og en overflade af lægemiddelkemen, der er dækket af hylsterlegemet, udgør en rest af overfladen af den cylindriske form.
- 10. Lægemiddelindsats ifølge et hvilket som helst af kravene 1-9, hvor midlet er opløst i matrixen i lægemiddelkemen.
- 11. Lægemiddelindsats ifølge et hvilket som helst af kravene 1-10, hvor midlet er latanoprost.
- 12. Lægemiddelindsats ifølge et hvilket som helst af kravene 1-10, hvor midlet er bimatoprost.
- 13. Lægemiddelindsats ifølge et hvilket som helst af kravene 1-12, hvor kernen omfatter to eller flere terapeutiske midler.
- 14. Lægemiddelindsats ifølge krav 13, hvor lægemiddelindsatsen omfatter to lægemiddelkemer, der er placeret i hylsterlegemet, hvor en første lægemiddelkeme omfatter et første middel og en første matrix, og en anden lægemiddelkeme omfatter et andet middel og en anden matrix, hvor det første middel og det andet middel er forskellige, og hvor den første matrix og den anden matrix enten er ens eller adskiller sig fra hinanden; hvor implantatet omfatter en åbning, der er tilpasset til at modtage den første og den anden kerne, der er placeret i hylsterlegemet, hvilke lægemiddelkemer er tilpasset til at blive placeret i hylsteret i åbningen af implantatet.
- 15. Lægemiddelindsats ifølge krav 14 hvor det første terapeutiske middel har en ffigørelsesprofil, hvor det første middel frigives ved terapeutiske niveauer over et første tidsrum og det andet terapeutiske middel har en anden frigørelsesprofil, hvor det andet middel frigøres ved terapeutiske niveauer over det andet tidsrum.
- 16. Fremgangsmåde til fremstilling af en lægemiddelindsats, der er tilpasset til anbringelse i et tårekanalsimplantat ifølge et hvilket som helst af kravene 1 til 15, hvilken fremgangsmåde omfatter injektion ind i hylsterlegemet, ved en temperatur på mindre end 25 °C, af en blanding omfattende en matrixprækursor og det terapeutiske middel, således at hylsterlegemet i alt væsentligt fyldes dermed; derefter hærdning af blandingen i hylsterlegemet for i hylsterlegemet at danne lægemiddelkemen.
- 17. Terapeutisk middel, hvilket terapeutisk middel er udvalgt fra gruppen bestående af bimatoprost, latanoprost, og travoprost, til anvendelse ved behandling af en lidelse hos en patient, hvilket terapeutisk middel er omfattet af lægemiddelindsatsen ifølge et hvilket som helst af kravene 1-15, hvor det terapeutiske middel er tilpasset til at behandle lidelsen, hvor lidelsen omfatter glaukom, og hvor implantatet skal indsættes i patienten, i eller i umiddelbar nærhed af ét af patientens øjne, således at det terapeutiske middel frigøres i kropsvæv eller -fluid. ao
- 18. Anvendelse af en lægemiddelindsats ifølge et hvilket som helst af kravene 1-15 i fremstillingen af et implantat til tårekanalen, hvilket implantat er tilpasset til behandling af en lidelse hos en patient, der har behov derfor.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97082007P | 2007-09-07 | 2007-09-07 | |
US97069907P | 2007-09-07 | 2007-09-07 | |
US97070907P | 2007-09-07 | 2007-09-07 | |
US4931708P | 2008-04-30 | 2008-04-30 | |
PCT/US2008/010487 WO2009035562A2 (en) | 2007-09-07 | 2008-09-05 | Drug cores for sustained release of therapeutic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2207529T3 true DK2207529T3 (da) | 2015-03-09 |
Family
ID=39874137
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK08830451T DK2207529T3 (da) | 2007-09-07 | 2008-09-05 | Lægemiddelkerner til langvarig frigivelse af terapeutiske midler |
DK12192860.0T DK2614844T3 (da) | 2007-09-07 | 2008-09-05 | Fremgangsmåde til fremstilling af lægemiddelindlæg til langvarig frigivelse af terapeutiske midler |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK12192860.0T DK2614844T3 (da) | 2007-09-07 | 2008-09-05 | Fremgangsmåde til fremstilling af lægemiddelindlæg til langvarig frigivelse af terapeutiske midler |
Country Status (19)
Country | Link |
---|---|
US (5) | US20090104243A1 (da) |
EP (2) | EP2614844B1 (da) |
JP (5) | JP5555162B2 (da) |
KR (3) | KR101996336B1 (da) |
CN (2) | CN101984745B (da) |
AU (1) | AU2008300013A1 (da) |
BR (1) | BRPI0817075A2 (da) |
CA (1) | CA2698573C (da) |
DK (2) | DK2207529T3 (da) |
ES (2) | ES2538838T3 (da) |
HK (2) | HK1155104A1 (da) |
IL (2) | IL253005A0 (da) |
MX (1) | MX2010002616A (da) |
NZ (2) | NZ583678A (da) |
RU (1) | RU2478366C2 (da) |
SG (1) | SG184738A1 (da) |
TW (1) | TWI543776B (da) |
WO (1) | WO2009035562A2 (da) |
ZA (1) | ZA201001586B (da) |
Families Citing this family (133)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
US7291125B2 (en) | 2003-11-14 | 2007-11-06 | Transcend Medical, Inc. | Ocular pressure regulation |
US20050232972A1 (en) | 2004-04-15 | 2005-10-20 | Steven Odrich | Drug delivery via punctal plug |
US7922702B2 (en) * | 2004-07-02 | 2011-04-12 | Qlt Inc. | Treatment medium delivery device and methods for delivery of such treatment mediums to the eye using such a delivery device |
MX2007013633A (es) | 2005-05-04 | 2008-03-13 | Etech Ag | Elemento de union rigido, de contraccion lenta, para medicina y otros usos. |
US8795711B2 (en) | 2006-03-31 | 2014-08-05 | Mati Therapeutics Inc. | Drug delivery methods, structures, and compositions for nasolacrimal system |
CA2667890C (en) * | 2006-10-31 | 2015-01-27 | Surmodics Pharmaceuticals, Inc. | Spheronized polymer particles |
DK2207529T3 (da) | 2007-09-07 | 2015-03-09 | Mati Therapeutics Inc | Lægemiddelkerner til langvarig frigivelse af terapeutiske midler |
EP2205193A2 (en) | 2007-09-07 | 2010-07-14 | QLT Plug Delivery, Inc. | Lacrimal implant detection |
KR20100050566A (ko) * | 2007-09-07 | 2010-05-13 | 큐엘티 플러그 딜리버리, 인코포레이티드 | 눈물 임플랜트 및 이에 관련된 방법 |
TW200930343A (en) | 2007-09-21 | 2009-07-16 | Organon Nv | Drug delivery system |
CN104825270B (zh) * | 2008-02-18 | 2017-10-24 | 马缇医疗股份有限公司 | 泪管植入物及相关方法 |
CN104623741A (zh) | 2008-04-30 | 2015-05-20 | 马缇医疗股份有限公司 | 复合泪管植入物及相关方法 |
JP2011520805A (ja) * | 2008-05-09 | 2011-07-21 | キューエルティー プラグ デリバリー,インク. | 緑内障および高眼圧症治療のための活性剤の持続送達 |
CN102119075A (zh) | 2008-05-30 | 2011-07-06 | Qlt栓塞输送公司 | 表面处理的可植入制品和相关方法 |
DE102008002396A1 (de) * | 2008-06-12 | 2009-12-17 | Biotronik Vi Patent Ag | Implantierbares Wirkstoffreservoir und Vorrichtung mit einem implantierbaren Wirkstoffreservoir |
GB2460915B (en) | 2008-06-16 | 2011-05-25 | Biovascular Inc | Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor |
TW201012469A (en) * | 2008-06-24 | 2010-04-01 | Qlt Plug Delivery Inc | Combination treatment of glaucoma |
EP2328527A1 (en) * | 2008-07-08 | 2011-06-08 | QLT Plug Delivery, Inc. | Lacrimal implant body including comforting agent |
WO2010071844A1 (en) * | 2008-12-19 | 2010-06-24 | Qlt Plug Delivery, Inc | Substance delivering punctum implants and methods |
WO2010083129A2 (en) * | 2009-01-13 | 2010-07-22 | The Regents Of The University Of California | Implantable delivery vehicle for ocular delivery of muscarinic antagonists |
JP5885244B2 (ja) * | 2009-01-23 | 2016-03-15 | マティ セラピューティクス,インク. | 1つまたは複数の薬剤の徐放性送達 |
EP3735947B1 (en) | 2009-01-28 | 2022-05-04 | Alcon Inc. | Ocular implant delivery system |
US8623395B2 (en) | 2010-01-29 | 2014-01-07 | Forsight Vision4, Inc. | Implantable therapeutic device |
EP2391419B1 (en) | 2009-01-29 | 2019-06-12 | ForSight Vision4, Inc. | Posterior segment drug delivery |
MX2011008875A (es) * | 2009-02-23 | 2011-09-26 | Quadra Logic Tech Inc | Implantes lagrimales y metodos relacionados. |
US9421127B2 (en) | 2009-03-31 | 2016-08-23 | Johnson & Johnson Vision Care, Inc. | Punctal plugs |
TWI495459B (zh) * | 2009-03-31 | 2015-08-11 | Johnson & Johnson Vision Care | 淚管塞(二) |
WO2010135369A1 (en) * | 2009-05-18 | 2010-11-25 | Dose Medical Corporation | Drug eluting ocular implant |
US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
CN102596097B (zh) | 2009-06-03 | 2015-05-20 | 弗赛特实验室有限责任公司 | 一种眼插入件 |
US8808257B2 (en) | 2009-08-31 | 2014-08-19 | Johnson & Johnson Vision Care, Inc. | Methods and apparatus for pulsatile release of medicaments from a punctal plug |
CA2781629A1 (en) | 2009-11-27 | 2011-06-03 | Sascha K. Zarins | Lacrimal implants including split and insertable drug core |
JP2013515735A (ja) * | 2009-12-23 | 2013-05-09 | アリメラ・サイエンシーズ,インコーポレーテッド | 眼内でのコルチコステロイド使用に伴う眼圧の発生を減少させる方法 |
JP5723531B2 (ja) * | 2010-01-20 | 2015-05-27 | Dsファーマアニマルヘルス株式会社 | チューブ内に保持された凍結乾燥製剤 |
US10453157B2 (en) | 2010-01-22 | 2019-10-22 | Deka Products Limited Partnership | System, method, and apparatus for electronic patient care |
US11244745B2 (en) | 2010-01-22 | 2022-02-08 | Deka Products Limited Partnership | Computer-implemented method, system, and apparatus for electronic patient care |
US9259352B2 (en) | 2010-03-29 | 2016-02-16 | Johnson & Johnson Vision Care, Inc. | Punctal plugs |
US9259351B2 (en) | 2010-03-29 | 2016-02-16 | Johnson & Johnson Vision Care, Inc. | Punctal plugs |
JP2013523821A (ja) * | 2010-04-06 | 2013-06-17 | アラーガン、インコーポレイテッド | 前房内薬剤送達のための徐放性リザーバーインプラント |
US11033624B2 (en) | 2010-06-02 | 2021-06-15 | Novaflux Inc. | Medical item for prevention and treatment of ear infection |
US20110301555A1 (en) * | 2010-06-03 | 2011-12-08 | Gonzalez-Zugasti Javier P | Porous matrix drug core for lacrimal insert device |
WO2012012162A2 (en) * | 2010-06-30 | 2012-01-26 | Surmodics Pharmaceuticals, Inc. | Core-sheath implant device having an inner core lobe |
WO2012003210A1 (en) * | 2010-06-30 | 2012-01-05 | Surmodics Pharmaceuticals, Inc. | Implant processing methods for thermally labile and other bioactive agents and implants prepared from same |
PT2600812T (pt) | 2010-08-05 | 2021-11-09 | Forsight Vision4 Inc | Aparelho para tratar um olho |
JP6111194B2 (ja) * | 2010-08-05 | 2017-04-05 | フォーサイト・ビジョン フォー・インコーポレーテッド | 組み合わせ薬物送達方法および装置 |
AU2011285545B2 (en) | 2010-08-05 | 2014-03-13 | Forsight Vision4, Inc. | Injector apparatus and method for drug delivery |
US8591484B2 (en) | 2010-09-15 | 2013-11-26 | AlphaMed, Inc. | Lacrimal punctum measurement and occlusion |
US9022967B2 (en) | 2010-10-08 | 2015-05-05 | Sinopsys Surgical, Inc. | Implant device, tool, and methods relating to treatment of paranasal sinuses |
EP2640360A2 (en) | 2010-11-19 | 2013-09-25 | Forsight Vision4, Inc. | Therapeutic agent formulations for implanted devices |
US20120157938A1 (en) * | 2010-12-16 | 2012-06-21 | Tokarski Jason M | Punctal plug with drug core retention features |
US20120276186A1 (en) | 2011-04-29 | 2012-11-01 | Ghebremeskel Alazar N | Sustained release latanoprost implant |
US20120312840A1 (en) * | 2011-05-13 | 2012-12-13 | Ayako Hasegawa | Container closure system with integral antimicrobial additives |
US10245178B1 (en) | 2011-06-07 | 2019-04-02 | Glaukos Corporation | Anterior chamber drug-eluting ocular implant |
EP4249059A3 (en) | 2011-06-28 | 2023-11-29 | ForSight Vision4, Inc. | An apparatus for collecting a sample of fluid from a reservoir chamber of a therapeutic device for the eye |
WO2013011511A1 (en) * | 2011-07-18 | 2013-01-24 | Mor Research Applications Ltd. | A device for adjusting the intraocular pressure |
EP2739252A4 (en) | 2011-08-05 | 2015-08-12 | Forsight Vision4 Inc | SMALL MOLECULE ADMINISTRATION USING AN IMPLANTABLE THERAPEUTIC DEVICE |
CN103889401B (zh) | 2011-08-29 | 2017-10-13 | Qlt公司 | 持续释放递送活性剂以治疗青光眼和高眼压 |
US9974685B2 (en) | 2011-08-29 | 2018-05-22 | Mati Therapeutics | Drug delivery system and methods of treating open angle glaucoma and ocular hypertension |
CN103917202B (zh) | 2011-09-14 | 2016-06-29 | 弗赛特影像5股份有限公司 | 眼插入件装置和方法 |
HUE054578T2 (hu) | 2011-09-16 | 2021-09-28 | Forsight Vision4 Inc | Fluidumcserélõ berendezés |
US9107737B2 (en) * | 2011-11-21 | 2015-08-18 | Alan Schwartz | Goggles with facial conforming eyepieces |
US8765210B2 (en) | 2011-12-08 | 2014-07-01 | Aquesys, Inc. | Systems and methods for making gelatin shunts |
US9241829B2 (en) * | 2011-12-20 | 2016-01-26 | Abbott Medical Optics Inc. | Implantable intraocular drug delivery apparatus, system and method |
US10010448B2 (en) | 2012-02-03 | 2018-07-03 | Forsight Vision4, Inc. | Insertion and removal methods and apparatus for therapeutic devices |
TWI556785B (zh) * | 2012-03-01 | 2016-11-11 | 信迪思有限公司 | 具軟質芯材之手術用縫合線 |
US20130245759A1 (en) * | 2012-03-09 | 2013-09-19 | The Florida International University Board Of Trustees | Medical devices incorporating silicone nanoparticles, and uses thereof |
EP2836170B1 (en) | 2012-04-11 | 2018-02-14 | Sinopsys Surgical, Inc. | Implantation tools, tool assemblies and kits |
US10085633B2 (en) | 2012-04-19 | 2018-10-02 | Novartis Ag | Direct visualization system for glaucoma treatment |
US9241832B2 (en) | 2012-04-24 | 2016-01-26 | Transcend Medical, Inc. | Delivery system for ocular implant |
CN105473130A (zh) | 2012-05-03 | 2016-04-06 | 麦提疗法有限公司 | 治疗开角型青光眼和高眼压症的药物递送系统和方法 |
ES2633185T3 (es) | 2012-09-17 | 2017-09-19 | Novartis Ag | Dispositivos de implante ocular expansibles |
EP2911623B1 (en) | 2012-10-26 | 2019-08-14 | Forsight Vision5, Inc. | Ophthalmic system for sustained release of drug to eye |
WO2014113384A2 (en) | 2013-01-15 | 2014-07-24 | The Regents Of The University Of Colorado, A Body Corporate | Lacrimal system drug delivery device |
PT2903575T (pt) | 2013-01-25 | 2018-01-08 | Sinopsys Surgical Inc | Dispositivo e kit de implante para acesso ao seio paranasal |
US9125723B2 (en) | 2013-02-19 | 2015-09-08 | Aquesys, Inc. | Adjustable glaucoma implant |
US10159600B2 (en) | 2013-02-19 | 2018-12-25 | Aquesys, Inc. | Adjustable intraocular flow regulation |
WO2014152959A1 (en) | 2013-03-14 | 2014-09-25 | Forsight Vision4, Inc. | Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant |
WO2014160828A1 (en) * | 2013-03-27 | 2014-10-02 | Forsight Vision5, Inc. | Bimatoprost ocular silicone inserts and methods of use thereof |
EP2978393B1 (en) | 2013-03-28 | 2023-12-27 | ForSight Vision4, Inc. | Ophthalmic implant for delivering therapeutic substances |
KR20140144843A (ko) * | 2013-06-12 | 2014-12-22 | 주식회사 엘지화학 | 실링부가 경화성 물질로 절연되어 있는 파우치형 전지셀의 제조방법 |
CA2922095C (en) * | 2013-08-21 | 2021-12-28 | Senseonics, Incorporated | Drug elution for in vivo protection of bio-sensing analytes |
US9700459B2 (en) | 2013-10-16 | 2017-07-11 | Sinopsys Surgical, Inc. | Apparatuses, tools and kits relating to fluid manipulation treatments of paranasal sinuses |
BR122020011777B1 (pt) | 2013-11-14 | 2022-01-25 | AqueSys, Inc | Dispositivo de inserção para o tratamento de glaucoma |
US10596103B2 (en) | 2013-12-11 | 2020-03-24 | Merek Sharp & Dohme B.V. | Drug delivery system for delivery of anti-virals |
US10413504B2 (en) | 2013-12-11 | 2019-09-17 | Merck Sharp & Dohme Corp. | Intravaginal ring drug delivery system |
WO2015168642A1 (en) * | 2014-05-02 | 2015-11-05 | Labib Mohamed E | Drug-releasing device usable in mucosal body cavities |
JP6655610B2 (ja) | 2014-05-29 | 2020-02-26 | グローコス コーポレーション | 制御された薬物送達機能を備えるインプラント及びそれを使用する方法 |
WO2016011191A1 (en) | 2014-07-15 | 2016-01-21 | Forsight Vision4, Inc. | Ocular implant delivery device and method |
EP3179968B1 (en) | 2014-07-24 | 2019-09-11 | Sinopsys Surgical, Inc. | Paranasal sinus access implant devices and related products and methods |
EP3177289A4 (en) | 2014-08-08 | 2018-03-21 | Forsight Vision4, Inc. | Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof |
ES2756301T3 (es) * | 2014-08-19 | 2020-04-27 | Univ California | Implantes de administración localizada de fármacos y métodos de uso de los mismos |
US10507101B2 (en) | 2014-10-13 | 2019-12-17 | W. L. Gore & Associates, Inc. | Valved conduit |
SG11201703726XA (en) | 2014-11-10 | 2017-06-29 | Forsight Vision4 Inc | Expandable drug delivery devices and method of use |
EP3223793B1 (en) * | 2014-11-25 | 2023-06-28 | Eximore Ltd. | Compositions and methods for delivering a bio-active agent or bio-active agents |
KR101717585B1 (ko) | 2014-12-31 | 2017-03-20 | 중앙대학교 산학협력단 | 약물 방출 조절이 가능한 스캐폴드 |
US20160296532A1 (en) | 2015-04-13 | 2016-10-13 | Forsight Vision5, Inc. | Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent |
WO2017007819A1 (en) * | 2015-07-06 | 2017-01-12 | The Regents Of The University Of Colorado, A Body Corporate | Lacrimal drainage system diagnostic implant |
WO2017040855A1 (en) * | 2015-09-02 | 2017-03-09 | Dose Medical Corporation | Drug delivery implants as intraocular drug depots and methods of using same |
US11925578B2 (en) | 2015-09-02 | 2024-03-12 | Glaukos Corporation | Drug delivery implants with bi-directional delivery capacity |
US11564833B2 (en) * | 2015-09-25 | 2023-01-31 | Glaukos Corporation | Punctal implants with controlled drug delivery features and methods of using same |
CN108430405B (zh) | 2015-11-20 | 2021-04-13 | 弗赛特影像4股份有限公司 | 用于缓释药物递送装置的多孔结构 |
US11857461B2 (en) * | 2015-11-23 | 2024-01-02 | The Regents Of The University Of Colorado, A Body Corporate | Lacrimal system for drug delivery |
WO2017151480A1 (en) * | 2016-03-01 | 2017-09-08 | Bruder Healthcare Company, Llc | Therapeutic eye mask system |
US11998480B2 (en) * | 2016-03-01 | 2024-06-04 | The Hilsinger Company Parent, Llc | Self-heating compress for moist heat delivery |
US20190216639A1 (en) * | 2016-03-01 | 2019-07-18 | Bruder Healthcare Company, Llc | Therapeutic eye compress system |
US12011388B2 (en) * | 2016-03-01 | 2024-06-18 | The Hilsinger Company Parent, Llc | Therapeutic thermal compress with phase-change material |
WO2017176886A1 (en) | 2016-04-05 | 2017-10-12 | Forsight Vision4, Inc. | Implantable ocular drug delivery devices |
US11318043B2 (en) | 2016-04-20 | 2022-05-03 | Dose Medical Corporation | Bioresorbable ocular drug delivery device |
WO2017201255A1 (en) | 2016-05-20 | 2017-11-23 | The Regents Of The University Of Colorado, A Body Corporate | Lacrimal drug delivery device |
USD871598S1 (en) | 2016-11-30 | 2019-12-31 | Bruder Healthcare Company, Llc | Therapeutic eye mask |
USD844795S1 (en) | 2016-11-30 | 2019-04-02 | Bruder Healthcare Company, Llc | Therapeutic eye mask |
CN108339147B (zh) * | 2017-01-24 | 2021-05-07 | 沈阳何氏眼产业集团有限公司 | 玻璃体或视网膜手术切口用粘合剂及粘合系统 |
US11523940B2 (en) | 2017-03-17 | 2022-12-13 | W. L. Gore & Associates, Inc. | Delivery aids for glaucoma shunts |
US20190053886A1 (en) * | 2017-08-15 | 2019-02-21 | Covidien Lp | Methods and tools for treating diseased tissue |
CN111356422B (zh) | 2017-09-20 | 2022-08-09 | 西诺普西斯外科股份有限公司 | 鼻旁窦流体进入植入工具、组件、套件及方法 |
WO2019103906A1 (en) | 2017-11-21 | 2019-05-31 | Forsight Vision4, Inc. | Fluid exchange apparatus for expandable port delivery system and methods of use |
CA3095460A1 (en) * | 2018-03-29 | 2019-10-03 | Mati Therapeutics, Inc. | Ophthalmic drug sustained release formulation and uses for dry eye syndrome treatment |
WO2019226516A1 (en) | 2018-05-24 | 2019-11-28 | Celanese EVA Performance Polymers Corporation | Implantable device for sustained release of a macromolecular drug compound |
CN111989068A (zh) | 2018-05-24 | 2020-11-24 | 塞拉尼斯伊娃高性能聚合物公司 | 用于持续释放大分子药物化合物的可植入器件 |
EP3810082A1 (en) * | 2018-06-19 | 2021-04-28 | Cella Therapeutics, LLC | Sustained-release drug delivery systems comprising an intraocular pressure lowering agent, a cnp compound, an npr-b compound, a tie-2 agonist, or neurotrophic agent for use for treating glaucoma or ocular hypertension |
MX2020014160A (es) * | 2018-06-25 | 2021-03-09 | Titan Pharmaceuticals Inc | Implantes para liberacion de sustancias farmaceuticas lipofilicas o anfifilicas. |
US20210268001A1 (en) * | 2018-09-05 | 2021-09-02 | Edson DOS SANTOS-NETO | USE OF MIOTIC CHOLINERGIC SUBSTANCES AND F2a PROSTAGLANDIN ANALOGUES FOR PREVENTION AND TREATMENT OF MYOPIA |
WO2020064556A1 (en) * | 2018-09-27 | 2020-04-02 | Novaliq Gmbh | Topical sunscreen formulation |
US11678983B2 (en) | 2018-12-12 | 2023-06-20 | W. L. Gore & Associates, Inc. | Implantable component with socket |
IT201900003597A1 (it) * | 2019-03-12 | 2020-09-12 | Milano Politecnico | Dispositivo per il rilascio controllato |
US11207267B2 (en) | 2019-10-02 | 2021-12-28 | Segal Innovations LLC | Bio-adhesive dissolving compounds and device |
JP6925464B1 (ja) * | 2020-02-21 | 2021-08-25 | 巨晰光纖股▲ふん▼有限公司 | 生体活性ガラス薬物キャリア機能付き分流器 |
US11173291B2 (en) | 2020-03-20 | 2021-11-16 | The Regents Of The University Of California | Implantable drug delivery devices for localized drug delivery |
US11344526B2 (en) | 2020-03-20 | 2022-05-31 | The Regents Of The University Of California | Implantable drug delivery devices for localized drug delivery |
US11338119B2 (en) | 2020-03-20 | 2022-05-24 | The Regents Of The University Of California | Implantable drug delivery devices for localized drug delivery |
WO2021222117A1 (en) * | 2020-04-27 | 2021-11-04 | Ocular Therapeutix, Inc. | Methods of treating allergic conjunctivitis |
CN112618791A (zh) * | 2020-12-25 | 2021-04-09 | 福建医科大学附属协和医院 | 聚醚醚酮三维多孔化并修饰聚多巴胺/庆大霉素用于植入物抗菌、抗炎及促进骨整合 |
Family Cites Families (173)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3865108A (en) * | 1971-05-17 | 1975-02-11 | Ortho Pharma Corp | Expandable drug delivery device |
US3828777A (en) * | 1971-11-08 | 1974-08-13 | Alza Corp | Microporous ocular device |
US3949750A (en) * | 1974-10-07 | 1976-04-13 | Freeman Jerre M | Punctum plug and method for treating keratoconjunctivitis sicca (dry eye) and other ophthalmic aliments using same |
US4014335A (en) * | 1975-04-21 | 1977-03-29 | Alza Corporation | Ocular drug delivery device |
US4205128A (en) * | 1976-03-31 | 1980-05-27 | Denki Kagaku Kogyo Kabushiki Kaisha | Process for producing immobilized enzyme compositions |
US4281654A (en) * | 1980-04-07 | 1981-08-04 | Alza Corporation | Drug delivery system for controlled ocular therapy |
US4322323A (en) * | 1980-12-01 | 1982-03-30 | Alza Corporation | Erodible device comprising surfactant for modifying the rate of erosion of the device |
US5053030A (en) | 1984-11-07 | 1991-10-01 | Herrick Robert S | Intracanalicular implant for horizontal canalicular blockade treatment of the eye |
US4660546A (en) * | 1984-11-07 | 1987-04-28 | Robert S. Herrick | Method for treating for deficiency of tears |
US5049142A (en) * | 1984-11-07 | 1991-09-17 | Herrick Robert S | Intracanalicular implant for horizontal canalicular blockade treatment of the eye |
US5229128A (en) * | 1986-06-11 | 1993-07-20 | Haddad Heskel M | Drug delivery ophthalmic insert and method of preparing same |
ATE71293T1 (de) * | 1986-09-18 | 1992-01-15 | London Pharmacy Innovation | Arzneiformulierung. |
US5322691A (en) * | 1986-10-02 | 1994-06-21 | Sohrab Darougar | Ocular insert with anchoring protrusions |
US4983390A (en) * | 1987-04-01 | 1991-01-08 | Lee County Mosquito Control District | Terrestrial delivery compositions and methods for controlling insect and habitat-associated pest populations in terrestrial environments |
FR2618329B1 (fr) * | 1987-07-22 | 1997-03-28 | Dow Corning Sa | Procede de fabrication d'un anneau capable d'assurer la liberation d'un agent therapeutique, et anneau fabrique par ce procede |
US4886488A (en) | 1987-08-06 | 1989-12-12 | White Thomas C | Glaucoma drainage the lacrimal system and method |
US4915684A (en) * | 1988-06-21 | 1990-04-10 | Mackeen Donald L | Method and apparatus for modulating the flow of lacrimal fluid through a punctum and associated canaliculus |
US5133159A (en) * | 1989-01-13 | 1992-07-28 | Nestle S.A. | Method for polishing silicone products |
US4959048A (en) * | 1989-01-17 | 1990-09-25 | Helix Medical, Inc. | Lacrimal duct occluder |
US5098443A (en) * | 1989-03-23 | 1992-03-24 | University Of Miami | Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents |
US5128058A (en) * | 1989-05-31 | 1992-07-07 | Hoya Corporation | Contact lens cleaner containing a microcapsular polishing agent |
IE910450A1 (en) | 1990-02-15 | 1991-08-28 | Bausch & Lomb | Soft contact lens processing aid |
US5171270A (en) | 1990-03-29 | 1992-12-15 | Herrick Robert S | Canalicular implant having a collapsible flared section and method |
US5163959A (en) | 1990-03-29 | 1992-11-17 | Herrick Robert S | Method for treating an eye with a canalicular implant having a collapsible flared section |
US5041081A (en) * | 1990-05-18 | 1991-08-20 | Odrich Ronald B | Ocular implant for controlling glaucoma |
US5116371A (en) * | 1990-07-06 | 1992-05-26 | Christensen James M | Prosthesis with improved biocompatibility |
US5378475A (en) * | 1991-02-21 | 1995-01-03 | University Of Kentucky Research Foundation | Sustained release drug delivery devices |
US5283063A (en) * | 1992-01-31 | 1994-02-01 | Eagle Vision | Punctum plug method and apparatus |
US5334137A (en) * | 1992-02-21 | 1994-08-02 | Eagle Vision, Inc. | Lacrimal fluid control device |
ES2150427T3 (es) | 1992-06-02 | 2000-12-01 | Bard Inc C R | Procedimiento y dispositivo de implante para el suministro de farmacos a largo plazo. |
US5469867A (en) | 1992-09-02 | 1995-11-28 | Landec Corporation | Cast-in place thermoplastic channel occluder |
US5318513A (en) * | 1992-09-24 | 1994-06-07 | Leib Martin L | Canalicular balloon fixation stent |
US5707643A (en) * | 1993-02-26 | 1998-01-13 | Santen Pharmaceutical Co., Ltd. | Biodegradable scleral plug |
JP3000187B2 (ja) * | 1993-02-26 | 2000-01-17 | 参天製薬株式会社 | 生体分解性強膜プラグ |
US5417651A (en) * | 1993-07-01 | 1995-05-23 | Guena; Nicolas | Punctum plug and monocanalicular probe for lacrimal pathology |
US5770589A (en) * | 1993-07-27 | 1998-06-23 | The University Of Sydney | Treatment of macular degeneration |
US5423777A (en) * | 1993-10-27 | 1995-06-13 | Tajiri; Akira | Punctum plug |
US5417744A (en) * | 1993-12-29 | 1995-05-23 | Ameron, Inc. | Optically clear hydrophobic coating composition |
US5426166A (en) * | 1994-01-26 | 1995-06-20 | Caschem, Inc. | Urethane adhesive compositions |
US5466233A (en) | 1994-04-25 | 1995-11-14 | Escalon Ophthalmics, Inc. | Tack for intraocular drug delivery and method for inserting and removing same |
JP3486758B2 (ja) | 1994-06-24 | 2004-01-13 | 株式会社高研 | 注入可能な涙小管閉鎖剤 |
US5605696A (en) * | 1995-03-30 | 1997-02-25 | Advanced Cardiovascular Systems, Inc. | Drug loaded polymeric material and method of manufacture |
EP0830111B1 (en) * | 1995-06-07 | 2003-05-21 | Keravision, Inc. | Radial intrastromal corneal insert |
US6149684A (en) | 1995-06-07 | 2000-11-21 | Herrick; Robert S. | Punctum plug having a thin elongated lip and a distal starting tip and method of using |
US5723005A (en) * | 1995-06-07 | 1998-03-03 | Herrick Family Limited Partnership | Punctum plug having a collapsible flared section and method |
US5766243A (en) * | 1995-08-21 | 1998-06-16 | Oasis Medical, Inc. | Abrasive polished canalicular implant |
US5773019A (en) * | 1995-09-27 | 1998-06-30 | The University Of Kentucky Research Foundation | Implantable controlled release device to deliver drugs directly to an internal portion of the body |
US5741292A (en) * | 1995-10-26 | 1998-04-21 | Eagle Vision | Punctum dilating and plug inserting instrument with push-button plug release |
US5824073A (en) | 1996-03-18 | 1998-10-20 | Peyman; Gholam A. | Macular indentor for use in the treatment of subretinal neovascular membranes |
US5993407A (en) | 1996-10-25 | 1999-11-30 | Moazed; Kambiz Thomas | Transnasal lacrimal insert |
ES2175485T3 (es) * | 1996-11-01 | 2002-11-16 | Alcon Lab Inc | Metodo criogenico de pulir para articulos acrilicos blandos. |
WO1998033461A1 (fr) * | 1997-02-04 | 1998-08-06 | Alain Fouere | Tampon meatique vissable pour canal lacrymal |
US6041785A (en) * | 1997-03-27 | 2000-03-28 | Eaglevision, Inc. | Punctum plug |
US6027470A (en) * | 1998-06-10 | 2000-02-22 | Eagle Vision, Inc. | Punctum plug and method for inserting the same into the punctual opening |
US6082362A (en) * | 1997-03-27 | 2000-07-04 | Eagle Vision, Inc. | Punctum plug |
US6016806A (en) * | 1997-03-27 | 2000-01-25 | Eaglevision, Inc | Punctum plug |
US5961370A (en) | 1997-05-08 | 1999-10-05 | Chiron Vision Corporation | Intraocular lens tumbling process using coated beads |
MY125870A (en) * | 1997-07-25 | 2006-08-30 | Alza Corp | Osmotic delivery system flow modulator apparatus and method |
JPH1147183A (ja) * | 1997-08-05 | 1999-02-23 | Kaneka Medics:Kk | 涙点プラグ装置 |
US6306426B1 (en) * | 1997-08-11 | 2001-10-23 | Allergan Sales, Inc. | Implant device with a retinoid for improved biocompatibility |
US5830171A (en) | 1997-08-12 | 1998-11-03 | Odyssey Medical, Inc. | Punctal occluder |
US6060439A (en) | 1997-09-29 | 2000-05-09 | Kyzen Corporation | Cleaning compositions and methods for cleaning resin and polymeric materials used in manufacture |
US6335335B2 (en) | 1997-11-05 | 2002-01-01 | Senju Pharmaceutical Co., Ltd. | Prolonged-action eye drop |
US6203513B1 (en) * | 1997-11-20 | 2001-03-20 | Optonol Ltd. | Flow regulating implant, method of manufacture, and delivery device |
US6290684B1 (en) * | 1998-03-02 | 2001-09-18 | Herrick Family Limited Partnership | Punctum plug having a collapsible expanded section and distal tip extending substantially perpendicular thereto and method of inserting same |
US6196993B1 (en) * | 1998-04-20 | 2001-03-06 | Eyelab Group, Llc | Ophthalmic insert and method for sustained release of medication to the eye |
US6306114B1 (en) | 1998-06-16 | 2001-10-23 | Eagle Vision, Inc. | Valved canalicular plug for lacrimal duct occlusion |
US6117441A (en) * | 1998-07-02 | 2000-09-12 | The Population Council, Inc. | Silicone core long term androgen delivery implant |
JP2000070296A (ja) * | 1998-08-27 | 2000-03-07 | M L C:Kk | 涙道内挿管器具 |
US6095901A (en) * | 1998-12-09 | 2000-08-01 | Alcon Laboratories, Inc. | Polishing method for soft acrylic articles |
US20040121014A1 (en) * | 1999-03-22 | 2004-06-24 | Control Delivery Systems, Inc. | Method for treating and/or preventing retinal diseases with sustained release corticosteroids |
US6234175B1 (en) * | 1999-03-23 | 2001-05-22 | Medennium, Inc. | Smart ocular plug design and method of insertion for punctal and intracanalicular implants |
US6383192B1 (en) * | 1999-04-28 | 2002-05-07 | Mlc Limited Company | Apparatus for intubation of lacrimal duct |
US6428502B1 (en) * | 1999-06-25 | 2002-08-06 | Alcon Manufacturing, Ltd. | Punctal cannula |
US6706275B1 (en) * | 1999-09-08 | 2004-03-16 | Matthew W. Camp | Scleral plug system |
US6331313B1 (en) | 1999-10-22 | 2001-12-18 | Oculex Pharmaceticals, Inc. | Controlled-release biocompatible ocular drug delivery implant devices and methods |
US6264971B1 (en) * | 1999-11-04 | 2001-07-24 | Btg International Limited | Ocular insert |
US6706034B1 (en) | 1999-12-30 | 2004-03-16 | Advanced Cardiovascular Systems, Inc. | Process for agent retention in biological tissues |
AU2626601A (en) * | 2000-01-03 | 2001-07-16 | Johns Hopkins University, The | Device and method for manual retinal vein catheterization |
US20050119737A1 (en) * | 2000-01-12 | 2005-06-02 | Bene Eric A. | Ocular implant and methods for making and using same |
US20030096831A1 (en) | 2000-01-18 | 2003-05-22 | Stone Richard A. | Ocular growth and nicotinic antagonists |
US6344047B1 (en) * | 2000-02-02 | 2002-02-05 | Eagle Vision | Instrument for inserting a punctum plug and method for manufacturing the instrument |
US7708711B2 (en) * | 2000-04-14 | 2010-05-04 | Glaukos Corporation | Ocular implant with therapeutic agents and methods thereof |
US7867186B2 (en) * | 2002-04-08 | 2011-01-11 | Glaukos Corporation | Devices and methods for treatment of ocular disorders |
US6638239B1 (en) * | 2000-04-14 | 2003-10-28 | Glaukos Corporation | Apparatus and method for treating glaucoma |
US6375972B1 (en) * | 2000-04-26 | 2002-04-23 | Control Delivery Systems, Inc. | Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof |
US20040208910A1 (en) | 2000-04-26 | 2004-10-21 | Control Delivery Systems, Inc. | Sustained release device and method for ocular delivery of adrenergic agents |
US20040175410A1 (en) * | 2000-04-26 | 2004-09-09 | Control Delivery Systems, Inc. | Sustained release device and method for ocular delivery of carbonic anhydrase inhibitors |
US6371122B1 (en) * | 2000-06-20 | 2002-04-16 | Robert M. Mandelkorn | Gauge/dilator apparatus |
US6629533B1 (en) | 2000-06-30 | 2003-10-07 | Eagle Vision, Inc. | Punctum plug with at least one anchoring arm |
US6534693B2 (en) * | 2000-11-06 | 2003-03-18 | Afmedica, Inc. | Surgically implanted devices having reduced scar tissue formation |
EP1345588A2 (en) * | 2000-12-29 | 2003-09-24 | Bausch & Lomb Incorporated | Sustained release drug delivery devices |
WO2002053129A1 (en) | 2001-01-03 | 2002-07-11 | Bausch & Lomb Incorporated | Sustained release drug delivery devices with prefabricated permeable plugs |
US6991808B2 (en) * | 2001-01-26 | 2006-01-31 | Bausch & Lomb Inc. | Process for the production of sustained release drug delivery devices |
WO2002072105A2 (en) | 2001-02-21 | 2002-09-19 | Alcon, Inc. | Improved prostanoid therapies for the treatment of glaucoma |
US6713081B2 (en) * | 2001-03-15 | 2004-03-30 | The United States Of America As Represented By The Department Of Health And Human Services | Ocular therapeutic agent delivery devices and methods for making and using such devices |
US6981958B1 (en) | 2001-05-02 | 2006-01-03 | Glaukos Corporation | Implant with pressure sensor for glaucoma treatment |
US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
WO2002080811A2 (en) | 2001-04-07 | 2002-10-17 | Glaukos Corporation | Glaucoma stent and methods thereof for glaucoma treatment |
US6605108B2 (en) | 2001-04-13 | 2003-08-12 | Eagle Vision, Inc. | Monocanalicular stent |
US6982090B2 (en) * | 2001-05-10 | 2006-01-03 | Gillespie Donald E | More easily visualized punctum plug configurations |
WO2002096418A1 (en) | 2001-05-25 | 2002-12-05 | Valley Forge Pharmaceuticals | Pirenzepine ophthalmic gel |
US7404825B2 (en) * | 2001-06-11 | 2008-07-29 | Herrick Ii Robert S | Implant capable of forming a differential image in an eye |
US20050129732A1 (en) * | 2001-07-13 | 2005-06-16 | Flow Focusing, Inc. | Biodegradable, antibiotic, controlled release tape |
FR2829019B3 (fr) | 2001-08-31 | 2003-10-31 | Alain Fouere | Bouchons lacrymaux et methodes de mise en place de ces dispositifs |
CA2452194A1 (en) * | 2001-09-11 | 2003-03-20 | Smart Drug Systems Inc | Sustained release pharmaceutical compositions comprising a silicone support material |
AU2002365403B2 (en) * | 2001-11-21 | 2009-07-09 | Iscience Interventional Corporation | Ophthalmic microsurgical system |
US6729939B2 (en) * | 2001-12-17 | 2004-05-04 | Bausch & Lomb Incorporated | Polishing method for intraocular lens |
US7204995B2 (en) * | 2002-01-31 | 2007-04-17 | El-Sherif Dalia M | Treatment and control of dry eye by use of biodegradable polymer capsules |
US9301875B2 (en) | 2002-04-08 | 2016-04-05 | Glaukos Corporation | Ocular disorder treatment implants with multiple opening |
US20040147870A1 (en) * | 2002-04-08 | 2004-07-29 | Burns Thomas W. | Glaucoma treatment kit |
US8871241B2 (en) * | 2002-05-07 | 2014-10-28 | Psivida Us, Inc. | Injectable sustained release delivery devices |
US6866563B2 (en) * | 2002-06-27 | 2005-03-15 | Bausch & Lomb Incorporated | Apparatus and method for target polishing intraocular lenses |
FR2841770B1 (fr) * | 2002-07-05 | 2004-10-01 | Ioltechnologie Production | Clou meatique d'obturation d'un meat lacrymal |
JP4463681B2 (ja) * | 2002-07-15 | 2010-05-19 | アルコン,インコーポレイテッド | 眼内使用のための非ポリマー親油性薬学的インプラント組成物 |
FR2844182B1 (fr) | 2002-09-11 | 2004-12-03 | Humanoptics Ag | Bouchon d'obturation d'un canalicule lacrymal |
US7169163B2 (en) * | 2002-09-30 | 2007-01-30 | Bruce Becker | Transnasal method and catheter for lacrimal system |
AU2003297511B2 (en) * | 2002-12-20 | 2010-01-21 | Chakshu Research, Inc. | Ophthalmic formulation for the prevention and treatment of ocular conditions |
US20040137059A1 (en) * | 2003-01-09 | 2004-07-15 | Thierry Nivaggioli | Biodegradable ocular implant |
AR043356A1 (es) * | 2003-01-24 | 2005-07-27 | Control Delivery Sys Inc | Dispositvo de liberacion sostenida para la administracion ocular de inhibidores de la anhidrasa carbonica y uso de inhibidores de la anhidrasa carbonica para su preparacion |
ES2332720T3 (es) | 2003-01-24 | 2010-02-11 | Psivida Us Inc. | Dispositivo y procedimiento de liberacion sostenida para la administracion ocular de agentes adrenergicos. |
WO2004075781A2 (en) | 2003-02-26 | 2004-09-10 | Medivas, Llc | Bioactive stents and methods for use thereof |
US6699282B1 (en) | 2003-03-06 | 2004-03-02 | Gelsus Research And Consulting, Inc. | Method and apparatus for delivery of medication |
US20050283109A1 (en) | 2003-03-07 | 2005-12-22 | Peyman Gholam A | Method and apparatus for lacrimal canal obstruction |
EP1633320A2 (en) * | 2003-05-02 | 2006-03-15 | SurModics, Inc. | Implantable controlled release bioactive agent delivery device |
US7204253B2 (en) | 2003-05-22 | 2007-04-17 | Clarity Corporation | Punctum plug |
US7017580B2 (en) | 2003-05-22 | 2006-03-28 | Clarity Corporation | Punctum plug system including a punctum plug and passive insertion tool therefor |
US20040236343A1 (en) | 2003-05-23 | 2004-11-25 | Taylor Jon B. | Insertion tool for ocular implant and method for using same |
JP4104137B2 (ja) * | 2003-05-30 | 2008-06-18 | 有限会社エム・エル・シー | 涙点プラグ |
US7662864B2 (en) * | 2003-06-04 | 2010-02-16 | Rutgers, The State University Of New Jersey | Solution polymerization processes to prepare a polymer that degrades to release a physiologically active agent |
JP4339635B2 (ja) | 2003-06-12 | 2009-10-07 | 有限会社エム・エル・シー | 涙点プラグ |
US6994684B2 (en) * | 2003-06-16 | 2006-02-07 | Alphamed Inc. | Punctum plugs having fluid collecting recesses and methods of punctal occlusion |
US20040265356A1 (en) | 2003-06-30 | 2004-12-30 | Bausch & Lomb Incorporated | Drug delivery device |
WO2005004837A1 (en) * | 2003-07-10 | 2005-01-20 | Galen (Chemicals) Limited | Intravaginal drug delivery devices |
US7198205B1 (en) * | 2003-07-24 | 2007-04-03 | Anderson & Associates, Llc | Silicone protective coating |
JP4280128B2 (ja) | 2003-08-19 | 2009-06-17 | 有限会社エム・エル・シー | 涙点プラグ |
JP2005110765A (ja) | 2003-10-03 | 2005-04-28 | M L C:Kk | 涙点プラグセット |
JP2005110930A (ja) | 2003-10-07 | 2005-04-28 | M L C:Kk | 涙点プラグセット |
US20050129731A1 (en) | 2003-11-03 | 2005-06-16 | Roland Horres | Biocompatible, biostable coating of medical surfaces |
US20050095269A1 (en) * | 2003-11-04 | 2005-05-05 | Ainpour Parviz R. | Gel plug for blockage of the canaliculus |
US20050197614A1 (en) | 2004-03-04 | 2005-09-08 | Wilson Pritchard | Occlusive biomedical devices, punctum plugs, and methods of use thereof |
US20050220882A1 (en) | 2004-03-04 | 2005-10-06 | Wilson Pritchard | Materials for medical implants and occlusive devices |
US20050232972A1 (en) | 2004-04-15 | 2005-10-20 | Steven Odrich | Drug delivery via punctal plug |
JP2004202276A (ja) | 2004-04-16 | 2004-07-22 | M L C:Kk | 涙道再建用挿管器具 |
US20050244469A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Extended therapeutic effect ocular implant treatments |
JP2005312835A (ja) | 2004-04-30 | 2005-11-10 | M L C:Kk | 糸で補強した涙道ステント |
US7589057B2 (en) * | 2004-04-30 | 2009-09-15 | Allergan, Inc. | Oil-in-water method for making alpha-2 agonist polymeric drug delivery systems |
JP4644438B2 (ja) | 2004-05-11 | 2011-03-02 | 有限会社エム・エル・シー | ツバつき涙道ステント |
JP4510511B2 (ja) | 2004-05-18 | 2010-07-28 | 有限会社エム・エル・シー | ツバを円盤で補強した涙道ステント及び涙道プラグ |
US7922702B2 (en) * | 2004-07-02 | 2011-04-12 | Qlt Inc. | Treatment medium delivery device and methods for delivery of such treatment mediums to the eye using such a delivery device |
EP1778198A1 (en) | 2004-07-26 | 2007-05-02 | Clarity Corporation | Implantable device having reservoir with controlled release of medication and method of manufacturing the same |
US20060020253A1 (en) | 2004-07-26 | 2006-01-26 | Prescott Anthony D | Implantable device having reservoir with controlled release of medication and method of manufacturing the same |
US7117870B2 (en) * | 2004-07-26 | 2006-10-10 | Clarity Corporation | Lacrimal insert having reservoir with controlled release of medication and method of manufacturing the same |
US20080038317A1 (en) * | 2004-09-10 | 2008-02-14 | Chin-Ming Chang | Therapeutic Lacrimal Canalicular Inserts And Related Methods |
US20060074370A1 (en) * | 2004-09-24 | 2006-04-06 | Medennium, Inc. | Ocular occluder and method of insertion |
CN101132800A (zh) * | 2004-11-24 | 2008-02-27 | 席拉坎有限责任公司 | 一种用于眼内药物释出的植入体 |
US20060233858A1 (en) | 2005-03-08 | 2006-10-19 | Allergan, Inc. | Systems and methods providing targeted intraocular drug delivery |
US7862532B2 (en) * | 2005-10-07 | 2011-01-04 | Delta Life Sciences, Inc. | Punctum plugs having insertion guides and strengthening beams |
US20070132125A1 (en) * | 2005-12-08 | 2007-06-14 | Bausch & Lomb Incorporated | Use of a super-cooled fluid in lens processing |
JP4078371B2 (ja) | 2006-01-27 | 2008-04-23 | 章弘 小栗 | 涙点プラグ |
US8795711B2 (en) * | 2006-03-31 | 2014-08-05 | Mati Therapeutics Inc. | Drug delivery methods, structures, and compositions for nasolacrimal system |
US9474645B2 (en) | 2006-06-21 | 2016-10-25 | Johnson & Johnson Vision Care, Inc. | Punctal plugs for the delivery of active agents |
US20080045911A1 (en) * | 2006-06-21 | 2008-02-21 | Borgia Maureen J | Punctal plugs for the delivery of active agents |
US9173773B2 (en) | 2006-06-21 | 2015-11-03 | Johnson & Johnson Vision Care, Inc. | Punctal plugs for the delivery of active agents |
CN101505696B (zh) * | 2006-06-21 | 2012-11-14 | 庄臣及庄臣视力保护公司 | 用于递送活性试剂的泪点塞 |
FR2908042B1 (fr) | 2006-11-08 | 2009-06-05 | Bruno Fayet | Ensemble d'intubation monocanaliculonasal et/ou monocanaliculaire,notamment pour l'imperforation lacrymonasale. |
UY30883A1 (es) * | 2007-01-31 | 2008-05-31 | Alcon Res | Tapones punctales y metodos de liberacion de agentes terapeuticos |
EP2173289A4 (en) | 2007-07-17 | 2010-11-24 | Transcend Medical Inc | EYE IMPLANT WITH HYDROGEL EXPANSION CAPABILITIES |
WO2009035567A2 (en) * | 2007-09-07 | 2009-03-19 | Qlt Plug Delivery, Inc | Insertion and extraction tools for lacrimal implants |
KR20100050566A (ko) * | 2007-09-07 | 2010-05-13 | 큐엘티 플러그 딜리버리, 인코포레이티드 | 눈물 임플랜트 및 이에 관련된 방법 |
DK2207529T3 (da) | 2007-09-07 | 2015-03-09 | Mati Therapeutics Inc | Lægemiddelkerner til langvarig frigivelse af terapeutiske midler |
CN104623741A (zh) | 2008-04-30 | 2015-05-20 | 马缇医疗股份有限公司 | 复合泪管植入物及相关方法 |
JP2011520805A (ja) | 2008-05-09 | 2011-07-21 | キューエルティー プラグ デリバリー,インク. | 緑内障および高眼圧症治療のための活性剤の持続送達 |
-
2008
- 2008-09-05 DK DK08830451T patent/DK2207529T3/da active
- 2008-09-05 EP EP12192860.0A patent/EP2614844B1/en active Active
- 2008-09-05 US US12/231,986 patent/US20090104243A1/en not_active Abandoned
- 2008-09-05 CN CN2008801149482A patent/CN101984745B/zh active Active
- 2008-09-05 KR KR1020177000553A patent/KR101996336B1/ko active IP Right Grant
- 2008-09-05 RU RU2010113387/15A patent/RU2478366C2/ru active
- 2008-09-05 EP EP08830451.4A patent/EP2207529B1/en active Active
- 2008-09-05 ES ES12192860.0T patent/ES2538838T3/es active Active
- 2008-09-05 CA CA2698573A patent/CA2698573C/en active Active
- 2008-09-05 CN CN201310300219.9A patent/CN103349799B/zh active Active
- 2008-09-05 DK DK12192860.0T patent/DK2614844T3/da active
- 2008-09-05 NZ NZ583678A patent/NZ583678A/en unknown
- 2008-09-05 ES ES08830451.4T patent/ES2533359T3/es active Active
- 2008-09-05 WO PCT/US2008/010487 patent/WO2009035562A2/en active Application Filing
- 2008-09-05 SG SG2012067161A patent/SG184738A1/en unknown
- 2008-09-05 KR KR1020157032899A patent/KR101696301B1/ko active IP Right Grant
- 2008-09-05 JP JP2010524050A patent/JP5555162B2/ja active Active
- 2008-09-05 NZ NZ598483A patent/NZ598483A/xx not_active IP Right Cessation
- 2008-09-05 BR BRPI0817075A patent/BRPI0817075A2/pt not_active IP Right Cessation
- 2008-09-05 KR KR1020107007527A patent/KR101571434B1/ko active IP Right Grant
- 2008-09-05 AU AU2008300013A patent/AU2008300013A1/en not_active Abandoned
- 2008-09-05 MX MX2010002616A patent/MX2010002616A/es unknown
- 2008-09-08 TW TW097134438A patent/TWI543776B/zh active
-
2010
- 2010-03-04 ZA ZA2010/01586A patent/ZA201001586B/en unknown
-
2011
- 2011-09-09 HK HK11109558.2A patent/HK1155104A1/xx unknown
-
2012
- 2012-02-07 US US13/367,823 patent/US8628792B2/en active Active
-
2013
- 2013-12-05 US US14/098,317 patent/US20140186420A1/en not_active Abandoned
-
2014
- 2014-03-18 HK HK14102722.5A patent/HK1189521A1/zh unknown
- 2014-05-30 JP JP2014111843A patent/JP5933630B2/ja active Active
-
2016
- 2016-05-02 JP JP2016092471A patent/JP2016165503A/ja active Pending
-
2017
- 2017-05-17 US US15/598,035 patent/US20170304194A1/en not_active Abandoned
- 2017-06-19 IL IL253005A patent/IL253005A0/en unknown
- 2017-07-07 JP JP2017133916A patent/JP2017205545A/ja active Pending
-
2018
- 2018-10-11 US US16/157,712 patent/US20190105265A1/en not_active Abandoned
-
2019
- 2019-09-05 JP JP2019161681A patent/JP2020062381A/ja active Pending
-
2020
- 2020-03-29 IL IL273683A patent/IL273683A/en unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK2207529T3 (da) | Lægemiddelkerner til langvarig frigivelse af terapeutiske midler | |
KR101270113B1 (ko) | 비루관계에 대한 약물 전달 방법, 구조, 및 조성물 | |
JP2016127945A (ja) | 1つまたは複数の薬剤の徐放性送達 | |
TW200946093A (en) | Lacrimal implants and related methods | |
AU2011235979A1 (en) | Drug delivery methods, structures, and compositions for nasolacrimal system |