DK200101219A - Fremgangsmåde til fremstilling af citalopram - Google Patents

Fremgangsmåde til fremstilling af citalopram Download PDF

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Publication number
DK200101219A
DK200101219A DK200101219A DKPA200101219A DK200101219A DK 200101219 A DK200101219 A DK 200101219A DK 200101219 A DK200101219 A DK 200101219A DK PA200101219 A DKPA200101219 A DK PA200101219A DK 200101219 A DK200101219 A DK 200101219A
Authority
DK
Denmark
Prior art keywords
alkyl
formula
compound
aryl
alkylamino
Prior art date
Application number
DK200101219A
Other languages
Danish (da)
English (en)
Inventor
Petersen Hans
Ahmadian Haleh
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Priority to DK200101219A priority Critical patent/DK200101219A/da
Publication of DK200101219A publication Critical patent/DK200101219A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
DK200101219A 2000-08-18 2001-08-14 Fremgangsmåde til fremstilling af citalopram DK200101219A (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK200101219A DK200101219A (da) 2000-08-18 2001-08-14 Fremgangsmåde til fremstilling af citalopram

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200001231 2000-08-18
DK200101219A DK200101219A (da) 2000-08-18 2001-08-14 Fremgangsmåde til fremstilling af citalopram

Publications (1)

Publication Number Publication Date
DK200101219A true DK200101219A (da) 2002-02-19

Family

ID=8159660

Family Applications (4)

Application Number Title Priority Date Filing Date
DK01957785T DK1309581T3 (da) 2000-08-18 2001-08-14 Fremgangsmåde til fremstilling af citalopram
DK01957786T DK1309582T3 (da) 2000-08-18 2001-08-14 Fremgangsmåde til fremstilling af citalopram
DK200101219A DK200101219A (da) 2000-08-18 2001-08-14 Fremgangsmåde til fremstilling af citalopram
DK200101216A DK200101216A (da) 2000-08-18 2001-08-14 Fremgangsmåde til fremstilling af citalopram

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK01957785T DK1309581T3 (da) 2000-08-18 2001-08-14 Fremgangsmåde til fremstilling af citalopram
DK01957786T DK1309582T3 (da) 2000-08-18 2001-08-14 Fremgangsmåde til fremstilling af citalopram

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK200101216A DK200101216A (da) 2000-08-18 2001-08-14 Fremgangsmåde til fremstilling af citalopram

Country Status (41)

Country Link
US (2) US6426422B1 (sr)
EP (2) EP1309581B1 (sr)
JP (2) JP2004506730A (sr)
KR (2) KR100887206B1 (sr)
CN (3) CN1239490C (sr)
AR (3) AR029598A1 (sr)
AT (4) ATE281448T1 (sr)
AU (6) AU7960901A (sr)
BE (2) BE1013443A6 (sr)
BG (2) BG65964B1 (sr)
CA (2) CA2354877C (sr)
CH (2) CH691969A5 (sr)
CL (2) CL2008002412A1 (sr)
CZ (2) CZ294746B6 (sr)
DE (4) DE60106933T2 (sr)
DK (4) DK1309581T3 (sr)
EA (2) EA005811B1 (sr)
ES (4) ES2228920T3 (sr)
FI (2) FI20011622A (sr)
FR (2) FR2813077B1 (sr)
GB (2) GB2362647B (sr)
GR (1) GR1004074B (sr)
HK (3) HK1044538B (sr)
HR (2) HRP20030064A2 (sr)
HU (2) HUP0103291A3 (sr)
IE (2) IES20010760A2 (sr)
IL (2) IL144817A0 (sr)
IS (2) IS2120B (sr)
ME (2) MEP2308A (sr)
MX (2) MXPA03001329A (sr)
NL (2) NL1018776C1 (sr)
NO (2) NO326570B1 (sr)
NZ (2) NZ523853A (sr)
PL (2) PL359969A1 (sr)
PT (2) PT1309582E (sr)
RS (2) RS50258B (sr)
SI (2) SI1309582T1 (sr)
SK (2) SK287236B6 (sr)
UA (2) UA72340C2 (sr)
WO (2) WO2002016342A1 (sr)
ZA (1) ZA200106683B (sr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
PL198024B1 (pl) * 1999-04-14 2008-05-30 Lundbeck & Co As H Sposób wytwarzania citalopramu, związki pośrednie i ich zastosowanie do wytwarzania citalopramu
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ATE355268T1 (de) 1999-10-25 2006-03-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
SI1246812T1 (en) 1999-12-28 2004-08-31 H. Lundbeck A/S Method for the preparation of citalopram
WO2001049672A1 (en) 1999-12-30 2001-07-12 H. Lundbeck A/S Method for the preparation of citalopram
CZ20022601A3 (cs) * 2000-01-14 2002-10-16 H. Lundbeck A/S Způsob výroby 5-kyanoftalidu
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
EA200200968A1 (ru) * 2000-03-13 2003-02-27 Х.Лундбекк А/С Поэтапное алкилирование 5-замещенных 1-(4-фторфенил)-1,3-дигидроизобензофуранов
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
EP1265883A1 (en) * 2000-03-13 2002-12-18 H. Lundbeck A/S Method for the preparation of citalopram
PT1265882E (pt) 2000-03-14 2004-06-30 Lundbeck & Co As H Metodo para preparacao de citalopram; composto e citalopram
CN1418206A (zh) * 2000-03-16 2003-05-14 H·隆德贝克有限公司 5－氰基－1－(4－氟苯基)－1,3－二氢异苯并呋喃的制备方法
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
CA2354877C (en) 2000-08-18 2006-05-02 H. Lundbeck A/S Method for the preparation of citalopram
IL147226A (en) 2000-12-22 2006-04-10 Lundbeck & Co As H Process for the preparation of pure cithalopram
AU2003222435A1 (en) * 2002-01-07 2003-07-24 Sun Pharmaceutical Industries Limited Process for the preparation of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
TWI306846B (en) * 2002-08-12 2009-03-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
AU2003223105A1 (en) * 2003-03-24 2004-10-18 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
US9339500B2 (en) * 2008-03-04 2016-05-17 Intra-Cellular Therapies, Inc. Methods of treating vasomotor symptoms
US20100087664A1 (en) * 2008-10-07 2010-04-08 Ravindra Vedantham Preparation of citalopram and salts thereof
JP6222973B2 (ja) * 2013-04-19 2017-11-01 日本テルペン化学株式会社 ジベンジルトリチオカーボネート誘導体
CN103936702A (zh) * 2014-05-07 2014-07-23 成都诺维尔生物医药有限公司 艾司西酞普兰杂质j的合成方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143703A (sr) 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
DE3926765A1 (de) 1989-08-12 1991-02-14 Hoechst Ag Verfahren zur verminderung von primaerem und sekundaerem amin in einem tertiaeren amin
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DK213290D0 (da) 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
ZA9711376B (en) 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
EP1015416B1 (en) 1997-07-08 2001-09-19 H. Lundbeck A/S Method for the preparation of citalopram
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
CZ292911B6 (cs) 1997-11-11 2004-01-14 H. Lundbeck A/S Způsob výroby citalopramu
EA002977B1 (ru) 1998-10-20 2002-12-26 Х.Лундбекк А/С Способ получения циталопрама
WO2000039112A1 (en) 1998-12-23 2000-07-06 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
PL198024B1 (pl) 1999-04-14 2008-05-30 Lundbeck & Co As H Sposób wytwarzania citalopramu, związki pośrednie i ich zastosowanie do wytwarzania citalopramu
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
WO2000012044A2 (en) 1999-10-25 2000-03-09 H. Lundbeck A/S Method for the preparation of citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
FR2805812A1 (fr) 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) * 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
CA2354877C (en) 2000-08-18 2006-05-02 H. Lundbeck A/S Method for the preparation of citalopram
IL147226A (en) 2000-12-22 2006-04-10 Lundbeck & Co As H Process for the preparation of pure cithalopram
ATE222899T1 (de) 2000-12-28 2002-09-15 Lundbeck & Co As H Verfahren zur herstellung von reinem citalopram

Also Published As

Publication number Publication date
SK287236B6 (sk) 2010-04-07
PT1309582E (pt) 2005-03-31
EP1309581A1 (en) 2003-05-14
US6509483B2 (en) 2003-01-21
FR2813078A1 (fr) 2002-02-22
HK1047086A1 (en) 2003-02-07
PL359825A1 (en) 2004-09-06
NO20013943D0 (no) 2001-08-14
WO2002016342A1 (en) 2002-02-28
FR2813078B1 (fr) 2004-04-02
AT5026U1 (de) 2002-02-25
UA72340C2 (uk) 2005-02-15
DE60106933T2 (de) 2005-12-01
CA2354877A1 (en) 2002-02-18
GB2362647B (en) 2002-09-18
CL2008002412A1 (es) 2009-01-02
AU2001100278B4 (en) 2001-11-29
US20020025982A1 (en) 2002-02-28
US20020026062A1 (en) 2002-02-28
IS2120B (is) 2006-06-15
CN1515564A (zh) 2004-07-28
AU2001100271A4 (en) 2001-09-13
SK287008B6 (sk) 2009-09-07
HRP20030065A2 (en) 2005-02-28
ATE281448T1 (de) 2004-11-15
MXPA03001329A (es) 2003-06-06
EP1309581B1 (en) 2004-11-03
JP2004506730A (ja) 2004-03-04
DE10140029A1 (de) 2002-05-02
CN1339435A (zh) 2002-03-13
CL2008002673A1 (es) 2009-01-02
EP1309582A1 (en) 2003-05-14
MEP2308A (xx) 2010-02-10
ES2170734A1 (es) 2002-08-01
FI20011622A (fi) 2002-02-19
UA71676C2 (en) 2004-12-15
CA2354877C (en) 2006-05-02
IL144816A (en) 2005-09-25
SK3222003A3 (en) 2003-08-05
AU7960901A (en) 2002-03-04
HK1047086B (zh) 2005-04-22
ATE281447T1 (de) 2004-11-15
CZ20012959A3 (cs) 2002-04-17
CN1239490C (zh) 2006-02-01
HUP0103295A3 (en) 2005-01-28
HK1044538A1 (en) 2002-10-25
AU2001279608B2 (en) 2006-10-05
BG65964B1 (bg) 2010-07-30
FI20011622A0 (fi) 2001-08-09
GR20010100398A (el) 2002-05-24
GR1004074B (el) 2002-11-26
WO2002016341A1 (en) 2002-02-28
CN1339436A (zh) 2002-03-13
BE1013443A6 (fr) 2002-01-15
NZ523877A (en) 2004-08-27
CZ295863B6 (cs) 2005-11-16
EA200300279A1 (ru) 2003-08-28
EP1309582B1 (en) 2004-11-03
SI1309582T1 (en) 2005-06-30
US6426422B1 (en) 2002-07-30
AU2001100271B4 (en) 2001-11-29
HRP20030064A2 (en) 2005-02-28
HK1044538B (zh) 2006-07-07
NO20013942D0 (no) 2001-08-14
JP2004506729A (ja) 2004-03-04
HU0103291D0 (en) 2001-10-28
FR2813077A1 (fr) 2002-02-22
BG65965B1 (bg) 2010-07-30
BG107583A (bg) 2004-01-30
YU11503A (sh) 2006-05-25
SI1309581T1 (en) 2005-04-30
MXPA03000913A (es) 2003-06-24
AR066694A2 (es) 2009-09-09
AU2001100278A4 (en) 2001-09-13
EA005946B1 (ru) 2005-08-25
PL359969A1 (en) 2004-09-06
NL1018775C1 (nl) 2001-10-24
ES2228920T3 (es) 2005-04-16
DK200101216A (da) 2002-02-19
GB2365865B (en) 2002-07-17
HUP0103295A2 (hu) 2002-05-29
CA2354880C (en) 2003-06-03
DK1309581T3 (da) 2005-03-14
NZ523853A (en) 2004-07-30
GB0119733D0 (en) 2001-10-03
CH691968A5 (de) 2001-12-14
IL144816A0 (en) 2002-06-30
ZA200106683B (en) 2002-08-05
KR100887206B1 (ko) 2009-03-06
AR029597A1 (es) 2003-07-10
ES2170735A1 (es) 2002-08-01
DK1309582T3 (da) 2005-03-14
HUP0103291A2 (hu) 2002-05-29
EA005811B1 (ru) 2005-06-30
IS2121B (is) 2006-06-15
RS50287B (sr) 2009-09-08
YU6903A (sh) 2006-05-25
IS6047A (is) 2001-10-20
GB2362647A (en) 2001-11-28
FR2813077B1 (fr) 2004-08-20
DE10140028A1 (de) 2002-04-18
IS6048A (is) 2001-10-19
AR029598A1 (es) 2003-07-10
KR100887207B1 (ko) 2009-03-06
DE60106933D1 (de) 2004-12-09
ES2170734B2 (es) 2003-09-16
HK1068069A1 (en) 2005-04-22
CZ294746B6 (cs) 2005-03-16
NO20013943L (no) 2002-02-19
IES20010760A2 (en) 2002-02-20
PT1309581E (pt) 2005-03-31
MEP2208A (xx) 2010-02-10
EA200300277A1 (ru) 2003-08-28
NO20013942L (no) 2002-02-19
KR20030022378A (ko) 2003-03-15
IES20010761A2 (en) 2002-02-20
NO326570B1 (no) 2009-01-12
CH691969A5 (de) 2001-12-14
CZ20012958A3 (cs) 2002-04-17
CN1159307C (zh) 2004-07-28
GB0119734D0 (en) 2001-10-03
BE1013444A6 (fr) 2002-01-15
DE60106932T2 (de) 2005-11-03
GB2365865A (en) 2002-02-27
NO326772B1 (no) 2009-02-16
ES2170735B2 (es) 2003-09-16
FI20011621A0 (fi) 2001-08-09
IL144817A0 (en) 2002-06-30
CA2354880A1 (en) 2002-01-22
SK3202003A3 (en) 2003-08-05
RS50258B (sr) 2009-07-15
BG107584A (bg) 2004-01-30
KR20030022385A (ko) 2003-03-15
CN1222517C (zh) 2005-10-12
HUP0103291A3 (en) 2003-02-28
ES2230347T3 (es) 2005-05-01
NL1018776C1 (nl) 2001-10-24
FI20011621A (fi) 2002-02-19
AU2001279609B2 (en) 2007-09-06
AU7960801A (en) 2002-03-04
DE60106932D1 (de) 2004-12-09
AT4946U1 (de) 2002-01-25

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