HUP0303025A2 - Eljárás ariletanoldiaminok előállítására - Google Patents
Eljárás ariletanoldiaminok előállításáraInfo
- Publication number
- HUP0303025A2 HUP0303025A2 HU0303025A HUP0303025A HUP0303025A2 HU P0303025 A2 HUP0303025 A2 HU P0303025A2 HU 0303025 A HU0303025 A HU 0303025A HU P0303025 A HUP0303025 A HU P0303025A HU P0303025 A2 HUP0303025 A2 HU P0303025A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- alkyl
- atom
- trifluoromethyl
- alkoxy
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- -1 nitro- Chemical class 0.000 abstract 8
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 229910052799 carbon Inorganic materials 0.000 abstract 5
- 125000005843 halogen group Chemical group 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 239000000556 agonist Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- HRDXJKGNWSUIBT-UHFFFAOYSA-N methoxybenzene Chemical group [CH2]OC1=CC=CC=C1 HRDXJKGNWSUIBT-UHFFFAOYSA-N 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/26—Radicals substituted by carbon atoms having three bonds to hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Glass Compositions (AREA)
- Valve Device For Special Equipments (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cephalosporin Compounds (AREA)
Abstract
A találmány tárgya eljárás (IA) általános képletűariletanoldiaminszármazékok és gyógyászatilag elfogadható sóikelőállítására, ahol R1 jelentése aril-, fenoximetil- vagy 5- vagy 6-tagú heteroaromás csoport, amelyek mindegyike adott esetben azalábbiak közül választott egy vagy több szubsztituensselhelyettesített: halogénatom, 1-6 szénatomos alkoxi-, 1-6 szénatomosalkil-, nitro-, ciano-, trifluormetil- , -NR8R9- és -NHSO2R8 csoport;R2 jelentése hidrogénatom vagy 1-6 szénatomos alkilcsoport, R3 jelentése hidrogénatom vagy 1-6 szénatomos alkilcsoport, X1 ésX2 jelentése egymástól függetlenül (a) hidrogénatom, (b) 1-6szénatomos alkil-CO- vagy (c) adott esetben halogénatommal vagy 1-6szénatomos alkilcsoporttal helyettesített aril-CO-csoport, azzal amegkötéssel, hogy ha az egyik jelentése (b) vagy (c), akkor a másikhidrogénatom (a); R4 jelentése (a) az alábbiak közül választott egyvagy több szubsztituenssel helyettesített fenilcsoport: 1-6 szénatomosalkilcsoport, halogénatom, trifluormetil-, 1-6 szénatomos alkoxi-, -CO2H és -CO2R8; vagy (b), fenoximetil- vagy adott esetben az alábbiakközül választott egy vagy több szubsztituenssel helyettesített 5- vagy6-tagú heteroaromás csoport: 1-6 szénatomos alkilcsoport, halogénatom,trifluormetil-, 1-6 szénatomos alkoxi-, -CO2H, -CO2R8, CN, NO2,hidroximetilcsoport és -CONHR8; vagy (c) (W) általános képletűcsoport, ahol A jelentése arilcsoport vagy 5- vagy 6-tagú heteroaromáscsoport, R5 jelentése ciano-, tetrazol-5-il-, -CO2H vagy -CO2R8csoport; R6 és R7 jelentése egymástól függetlenül hidrogénatom, 1-6szénatomos alkil-, -CO2H, -CO2R8, ciano-, tetrazol-5-il-csoport,halogénatom, trifluormetil- vagy 1-6 szénatomos alkoxicsoport, vagy haR6 és R7 szomszédos szénatomokhoz kapcsolódik, akkor R6 és R7 azokkala szénatomokkal együtt, amelyekhez kapcsolódnak, 5- vagy 6-tagú adottesetben egy vagy két nitrogénatomot, oxigénatomot vagy kénatomottartalmazó kondenzált gyűrűt képez; valamennyi R12 jelentése egymástólfüggetlenül 1-6 szénatomos alkilcsoport, halogénatom, trifluormetil-vagy 1-6 szénatomos alkoxicsoport, és n értéke 0 és 4 közötti egészszám; és R8 és R9 jelentése egymástól függetlenül 1-6 szénatomosalkilcsoport. A találmány szerinti vegyületek az atípusos béta-adrenoreceptor agonistái, így többek között magas vércukorszintkezelésében alkalmazhatók. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0102407.4A GB0102407D0 (en) | 2001-01-31 | 2001-01-31 | Process |
| PCT/US2001/049355 WO2002066418A2 (en) | 2001-01-31 | 2001-12-17 | Process for the preparation of arylethanoldiamines useful as agonists of the beta-3-adrenoceptor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0303025A2 true HUP0303025A2 (hu) | 2003-12-29 |
| HUP0303025A3 HUP0303025A3 (en) | 2012-01-30 |
Family
ID=9907833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0303025A HUP0303025A3 (en) | 2001-01-31 | 2001-12-17 | Process for the preparation of arylethanoldiamines |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7425639B2 (hu) |
| EP (1) | EP1366016B1 (hu) |
| JP (2) | JP4421818B2 (hu) |
| KR (1) | KR100895159B1 (hu) |
| CN (3) | CN100390160C (hu) |
| AT (1) | ATE478838T1 (hu) |
| AU (1) | AU2002253815B2 (hu) |
| BR (1) | BR0116853B1 (hu) |
| CA (1) | CA2435126C (hu) |
| CZ (1) | CZ304887B6 (hu) |
| DE (1) | DE60142931D1 (hu) |
| ES (1) | ES2349455T3 (hu) |
| GB (1) | GB0102407D0 (hu) |
| HK (1) | HK1060873A1 (hu) |
| HU (1) | HUP0303025A3 (hu) |
| IL (4) | IL156640A0 (hu) |
| MX (1) | MXPA03006845A (hu) |
| NO (1) | NO20033400L (hu) |
| NZ (1) | NZ526845A (hu) |
| PL (1) | PL209540B1 (hu) |
| WO (1) | WO2002066418A2 (hu) |
| ZA (1) | ZA200305039B (hu) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010118291A2 (en) | 2009-04-10 | 2010-10-14 | Auspex Pharmaceuticals, Inc. | Biphenyl-3-carboxylic acid modulators of beta-3-adrenoreceptor |
| US9522129B2 (en) | 2010-08-03 | 2016-12-20 | Velicept Therapeutics, Inc. | Pharmaceutical Combination |
| US9907767B2 (en) | 2010-08-03 | 2018-03-06 | Velicept Therapeutics, Inc. | Pharmaceutical compositions and the treatment of overactive bladder |
| KR20150020160A (ko) | 2012-02-09 | 2015-02-25 | 앨씨알엑스, 인크. | 과민성 방광의 치료를 위한 무스카린 수용체 길항제 및 베타―3 아드레날린 수용체 작용제의 조합물 |
| KR20170086659A (ko) | 2014-12-03 | 2017-07-26 | 벨리셉트 테라퓨틱스, 인크. | 하부 요로 증상을 위한 변형 방출형 솔라베그론을 이용한 조성물 및 방법 |
| CN114230477A (zh) * | 2015-10-23 | 2022-03-25 | B3Ar治疗股份有限公司 | 索拉贝隆两性离子及其应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE200619C (hu) | ||||
| DE2965655D1 (en) | 1978-06-28 | 1983-07-21 | Beecham Group Plc | Secondary amines, their preparation, pharmaceutical compositions containing them and their use |
| DD200619A1 (de) * | 1981-08-21 | 1983-05-25 | Heinz Paul | Verfahren zur herstellung von 1,2-disubstituierten deltaquadrat-imidazolinen und deren salzen |
| EP0103830A3 (de) | 1982-09-22 | 1985-07-31 | Bayer Ag | Wachstumsfördernde Phenylethylamin-Derivate |
| GB8519154D0 (en) | 1985-07-30 | 1985-09-04 | Ici Plc | Aromatic ethers |
| DE3718638A1 (de) | 1987-06-04 | 1988-12-22 | Thomae Gmbh Dr K | Neue phenylethanolamine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| DE3934436A1 (de) | 1989-06-01 | 1991-04-18 | Thomae Gmbh Dr K | 2-hydroxy-n-propylamine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| US5061727A (en) | 1990-05-04 | 1991-10-29 | American Cyanamid Company | Substituted 5-(2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles |
| GB9111426D0 (en) | 1991-05-28 | 1991-07-17 | Ici Plc | Chemical compounds |
| GB9111425D0 (en) | 1991-05-28 | 1991-07-17 | Ici Plc | Chemical compounds |
| NO179246C (no) | 1991-11-20 | 1996-09-04 | Sankyo Co | Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav |
| GB9207964D0 (en) | 1992-04-10 | 1992-05-27 | Ici Plc | Chemical compounds |
| GB9313574D0 (en) | 1993-07-01 | 1993-08-18 | Glaxo Group Ltd | Medicaments |
| AU2737295A (en) | 1994-06-09 | 1996-01-04 | Glaxo Group Limited | Phenethanolamine derivatives and their use as atypical beta-adrenoceptor agonists |
| GB9525177D0 (en) * | 1995-12-08 | 1996-02-07 | Glaxo Group Ltd | Chemical compounds |
| GB9525121D0 (en) * | 1995-12-08 | 1996-02-07 | Glaxo Group Ltd | Chemical compounds |
| FR2751646B1 (fr) | 1996-07-23 | 1999-01-22 | Sanofi Sa | Phenoxypropanolamine a action antagoniste beta3-adrenergique |
| GB9812709D0 (en) * | 1998-06-13 | 1998-08-12 | Glaxo Group Ltd | Chemical compounds |
| GB0102408D0 (en) * | 2001-01-31 | 2001-03-14 | Glaxo Group Ltd | Chemical compounds |
-
2001
- 2001-01-31 GB GBGB0102407.4A patent/GB0102407D0/en not_active Ceased
- 2001-12-17 CN CNB2005101039974A patent/CN100390160C/zh not_active Expired - Fee Related
- 2001-12-17 BR BRPI0116853-3A patent/BR0116853B1/pt not_active IP Right Cessation
- 2001-12-17 CA CA2435126A patent/CA2435126C/en not_active Expired - Fee Related
- 2001-12-17 US US10/470,907 patent/US7425639B2/en not_active Expired - Lifetime
- 2001-12-17 CN CNA018224393A patent/CN1487916A/zh active Pending
- 2001-12-17 WO PCT/US2001/049355 patent/WO2002066418A2/en active IP Right Grant
- 2001-12-17 CZ CZ2003-2086A patent/CZ304887B6/cs not_active IP Right Cessation
- 2001-12-17 DE DE60142931T patent/DE60142931D1/de not_active Expired - Lifetime
- 2001-12-17 IL IL15664001A patent/IL156640A0/xx unknown
- 2001-12-17 EP EP01270138A patent/EP1366016B1/en not_active Expired - Lifetime
- 2001-12-17 JP JP2002565936A patent/JP4421818B2/ja not_active Expired - Fee Related
- 2001-12-17 AT AT01270138T patent/ATE478838T1/de not_active IP Right Cessation
- 2001-12-17 KR KR1020037010058A patent/KR100895159B1/ko not_active IP Right Cessation
- 2001-12-17 CN CNA2005101039989A patent/CN1765886A/zh active Pending
- 2001-12-17 NZ NZ526845A patent/NZ526845A/en unknown
- 2001-12-17 AU AU2002253815A patent/AU2002253815B2/en not_active Ceased
- 2001-12-17 MX MXPA03006845A patent/MXPA03006845A/es active IP Right Grant
- 2001-12-17 PL PL363360A patent/PL209540B1/pl unknown
- 2001-12-17 HU HU0303025A patent/HUP0303025A3/hu unknown
- 2001-12-17 ES ES01270138T patent/ES2349455T3/es not_active Expired - Lifetime
-
2003
- 2003-06-25 IL IL156640A patent/IL156640A/en not_active IP Right Cessation
- 2003-06-27 ZA ZA200305039A patent/ZA200305039B/en unknown
- 2003-07-30 NO NO20033400A patent/NO20033400L/no unknown
-
2004
- 2004-05-28 HK HK04103859.0A patent/HK1060873A1/xx not_active IP Right Cessation
-
2008
- 2008-11-11 JP JP2008288698A patent/JP5049946B2/ja not_active Expired - Fee Related
- 2008-11-19 IL IL195384A patent/IL195384A0/en unknown
- 2008-11-19 IL IL195385A patent/IL195385A0/en unknown
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