DK1803417T3 - Törre hæmostatiske sammensætninger og fremgangsmåder til fremstilling deraf - Google Patents

Törre hæmostatiske sammensætninger og fremgangsmåder til fremstilling deraf

Info

Publication number
DK1803417T3
DK1803417T3 DK07005206T DK07005206T DK1803417T3 DK 1803417 T3 DK1803417 T3 DK 1803417T3 DK 07005206 T DK07005206 T DK 07005206T DK 07005206 T DK07005206 T DK 07005206T DK 1803417 T3 DK1803417 T3 DK 1803417T3
Authority
DK
Denmark
Prior art keywords
cross
linked gelatin
processes
preparation
powder
Prior art date
Application number
DK07005206T
Other languages
Danish (da)
English (en)
Inventor
Edward A Osawa
Zhen Qian
Cary J Reich
Original Assignee
Baxter Int
Baxter Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int, Baxter Healthcare Sa filed Critical Baxter Int
Application granted granted Critical
Publication of DK1803417T3 publication Critical patent/DK1803417T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0031—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/104—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Materials Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK07005206T 2001-07-17 2002-06-21 Törre hæmostatiske sammensætninger og fremgangsmåder til fremstilling deraf DK1803417T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/908,464 US7435425B2 (en) 2001-07-17 2001-07-17 Dry hemostatic compositions and methods for their preparation
PCT/US2002/020022 WO2003007845A1 (en) 2001-07-17 2002-06-21 Dry hemostatic compositions and methods for their preparation

Publications (1)

Publication Number Publication Date
DK1803417T3 true DK1803417T3 (da) 2009-03-16

Family

ID=25425842

Family Applications (2)

Application Number Title Priority Date Filing Date
DK07005206T DK1803417T3 (da) 2001-07-17 2002-06-21 Törre hæmostatiske sammensætninger og fremgangsmåder til fremstilling deraf
DK02744588T DK1414370T3 (da) 2001-07-17 2002-06-21 Törre hæmostatiske sammensætninger og fremgangsmåder til deres fremstilling

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK02744588T DK1414370T3 (da) 2001-07-17 2002-06-21 Törre hæmostatiske sammensætninger og fremgangsmåder til deres fremstilling

Country Status (16)

Country Link
US (4) US7435425B2 (de)
EP (2) EP1414370B1 (de)
JP (1) JP4316374B2 (de)
KR (1) KR100904582B1 (de)
CN (2) CN101284146B (de)
AT (2) ATE358455T1 (de)
AU (1) AU2002345846B2 (de)
BR (1) BRPI0211258B8 (de)
CA (1) CA2453592C (de)
DE (2) DE60219319T2 (de)
DK (2) DK1803417T3 (de)
ES (2) ES2317600T3 (de)
HK (2) HK1060277A1 (de)
MX (1) MXPA04000514A (de)
PT (2) PT1414370E (de)
WO (1) WO2003007845A1 (de)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6066325A (en) * 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US7435425B2 (en) * 2001-07-17 2008-10-14 Baxter International, Inc. Dry hemostatic compositions and methods for their preparation
US8303981B2 (en) 1996-08-27 2012-11-06 Baxter International Inc. Fragmented polymeric compositions and methods for their use
US7871637B2 (en) 1996-08-27 2011-01-18 Baxter International Inc. Dry hemostatic compositions and methods for their preparation
US8603511B2 (en) 1996-08-27 2013-12-10 Baxter International, Inc. Fragmented polymeric compositions and methods for their use
US7923431B2 (en) * 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
US7955288B2 (en) 2002-12-11 2011-06-07 Ferrosan Medical Devices A/S Gelatine-based materials as swabs
US8834864B2 (en) 2003-06-05 2014-09-16 Baxter International Inc. Methods for repairing and regenerating human dura mater
US8440225B2 (en) * 2003-08-07 2013-05-14 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
US7927626B2 (en) * 2003-08-07 2011-04-19 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
US20060019868A1 (en) * 2004-01-30 2006-01-26 Pendharkar Sanyog M Hemostatic compositions and devices
US7109163B2 (en) * 2004-01-30 2006-09-19 Ethicon, Inc. Hemostatic compositions and devices
CA2554994C (en) * 2004-01-30 2015-05-19 Ferrosan A/S Haemostatic sprays and compositions
US8119160B2 (en) * 2004-06-29 2012-02-21 Ethicon, Inc. Hemostatic compositions and devices
CN101001649B (zh) 2004-07-09 2011-08-31 弗罗桑医疗设备公司 包括透明质酸的止血组合物及其制备方法
FR2881651A1 (fr) * 2005-02-09 2006-08-11 Urodelia Sa Nouveau produit pharmaceutique et procede de fabrication de ce produit pharmaceutique
CA2616865C (en) * 2005-07-28 2014-07-08 Carnegie Mellon University Biocompatible polymers and methods of use
ES2362897T3 (es) * 2005-12-16 2011-07-14 Oxthera, Inc. Composiciones y métodos para reducción del oxalato.
EP2021045B1 (de) 2006-05-31 2016-03-16 Baxter International Inc. Kollagen für Einsatz in der Prävention von peridural Bildung Fibrose nach Wirbelsäulenchirurgie
TWI436793B (zh) 2006-08-02 2014-05-11 Baxter Int 快速作用之乾密封膠及其使用和製造方法
KR101428122B1 (ko) 2006-12-15 2014-08-07 라이프본드 엘티디. 젤라틴-트랜스글루타미나아제 지혈 드레싱 및 실란트
US8133484B2 (en) 2006-12-15 2012-03-13 Lifebond Ltd Hemostatic materials and dressing
US20100143447A1 (en) * 2006-12-19 2010-06-10 Ferrosan A/S Wound or tissue dressing comprising lactic acid bacteria
DE102007038125A1 (de) 2007-08-03 2009-02-05 Aesculap Ag Kombination zum Verkleben von biologischen Geweben
AU2008317874B2 (en) 2007-10-30 2013-12-19 Baxter Healthcare S.A. Use of a regenerative biofunctional collagen biomatrix for treating visceral or parietal defects
US20090130756A1 (en) * 2007-11-20 2009-05-21 Pioneer Surgical Orthobiologics,Inc. Cryopreservation of cells using cross-linked bioactive hydrogel matrix particles
CN102014973A (zh) 2008-02-29 2011-04-13 弗罗桑医疗设备公司 用于促进止血和/或伤口愈合的装置
US9629798B2 (en) 2008-04-03 2017-04-25 Mallinckrodt Pharma Ip Trading D.A.C. Hemostatic microspheres
CN102124058B (zh) 2008-06-18 2014-05-28 生命连结有限公司 改进的交联组合物
US8110208B1 (en) 2009-03-30 2012-02-07 Biolife, L.L.C. Hemostatic compositions for arresting blood flow from an open wound or surgical site
US9039783B2 (en) 2009-05-18 2015-05-26 Baxter International, Inc. Method for the improvement of mesh implant biocompatibility
KR101699992B1 (ko) 2009-06-16 2017-01-26 백스터 인터내셔널 인코포레이티드 지혈용 스펀지
US20110081398A1 (en) * 2009-10-01 2011-04-07 Tyco Healthcare Group Lp Multi-mechanism surgical compositions
US20110081701A1 (en) * 2009-10-02 2011-04-07 Timothy Sargeant Surgical compositions
US8968785B2 (en) * 2009-10-02 2015-03-03 Covidien Lp Surgical compositions
CA2784432C (en) 2009-12-16 2019-01-15 Baxter Healthcare S.A. Hemostatic sponge
CA2782863A1 (en) 2009-12-22 2011-06-30 Lifebond Ltd Modification of enzymatic crosslinkers for controlling properties of crosslinked matrices
SA111320355B1 (ar) 2010-04-07 2015-01-08 Baxter Heathcare S A إسفنجة لايقاف النزف
GB201008404D0 (en) * 2010-05-20 2010-07-07 Fujifilm Mfg Europe Bv Hemostatic compositions
MX345479B (es) * 2010-06-01 2017-02-01 Baxter Int Inc * Proceso para elaborar composiciones hemostaticas secas y estables.
WO2011151384A1 (en) 2010-06-01 2011-12-08 Baxter International Inc. Process for making dry and stable hemostatic compositions
ES2682302T3 (es) 2010-06-01 2018-09-19 Baxter International Inc Proceso para la producción de composiciones hemostáticas secas y estables
EP2600910B1 (de) 2010-08-05 2016-01-20 Lifebond Ltd Wundverbände mit einer trockenzusammung und haftstoffe
WO2012138453A1 (en) 2011-04-03 2012-10-11 The General Hospital Corporation Efficient protein expression in vivo using modified rna (mod-rna)
US9149511B2 (en) * 2011-06-30 2015-10-06 Ethicon, Inc. Procoagulant peptides and their derivatives and uses therefor
AU2012318258B2 (en) * 2011-10-11 2015-07-09 Baxter Healthcare S.A. Hemostatic compositions
KR102102002B1 (ko) 2011-10-11 2020-04-20 백스터 인터내셔널 인코포레이티드 지혈 조성물
WO2013053749A2 (en) 2011-10-11 2013-04-18 Baxter International Inc. Hemostatic compositions
EP4137166A1 (de) 2011-10-11 2023-02-22 Baxter International Inc Hämostatische zusammensetzungen
SG11201401878SA (en) * 2011-10-27 2014-09-26 Baxter Int Hemostatic compositions
WO2013060769A2 (en) 2011-10-27 2013-05-02 Baxter International Inc. Hemostatic compositions
WO2013096650A2 (en) 2011-12-23 2013-06-27 Pioneer Surgical Technology Continuous matrix with osteoconductive particles dispersed therein, method of forming thereof, and method of regenerating bone therewith
CA2865349C (en) 2012-03-06 2021-07-06 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
RU2636240C2 (ru) 2012-06-12 2017-11-21 Ферросан Медикал Дивайсиз А/С Сухая гемостатическая композиция
AU2014283170B2 (en) 2013-06-21 2017-11-02 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
RU2678592C1 (ru) 2013-12-11 2019-01-30 Ферросан Медикал Дивайсиз А/С Сухая композиция, содержащая компонент, улучшающий экструзию
US10814032B2 (en) 2014-08-08 2020-10-27 The Brigham And Women's Hospital, Inc. Elastic biopolymer and use as a tissue adhesive
WO2016058612A1 (en) 2014-10-13 2016-04-21 Ferrosan Medical Devices A/S Dry composition for use in haemostasis and wound healing
AU2015371184B2 (en) 2014-12-24 2020-06-25 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
EP3270985B1 (de) 2015-03-19 2021-02-24 The Brigham and Women's Hospital, Inc. Polypeptidzusammensetzungen und verfahren zur verwendung davon
EP3316930B1 (de) 2015-07-03 2019-07-31 Ferrosan Medical Devices A/S Spritze zum mischen zweier komponenten und zum aufrechterhalten eines vakuums im lagerzustand
EP3943127A1 (de) 2015-09-01 2022-01-26 Baxter International Inc Hämostatisches material
AU2017217454B2 (en) 2016-02-08 2021-05-27 Massachusetts Eye And Ear Infirmary Bioadhesive for corneal repair
CN105879109A (zh) * 2016-03-31 2016-08-24 武汉华同信生物科技有限公司 一种医用胶粘剂及其制备方法
KR20180027126A (ko) * 2016-09-06 2018-03-14 (주)한국비엠아이 가교화 히알루론산 유도체 매트릭스가 포함된 지혈 조성물
US11679177B2 (en) 2017-08-08 2023-06-20 Baxter International Inc. Polymeric compositions, delivery devices, and methods
ES2902773T3 (es) 2017-11-03 2022-03-29 Baxter Int Composiciones poliméricas, dispositivos de administración y métodos
CN111867641A (zh) * 2017-11-28 2020-10-30 巴克斯特国际公司 治疗伤口的吸收剂
KR20200105680A (ko) 2017-12-29 2020-09-08 백스터 인터내셔널 인코포레이티드 분무-건조된 트롬빈, 및 분무-건조된 트롬빈의 사용 및 제조 방법
BR112020021998A2 (pt) 2018-05-09 2021-01-26 Ferrosan Medical Devices A/S métodos para preparar uma composição hemostática e para reconstituir uma composição de trombina seca, composição hemostática, e, estojo.
US11998654B2 (en) 2018-07-12 2024-06-04 Bard Shannon Limited Securing implants and medical devices
WO2020051133A1 (en) 2018-09-04 2020-03-12 Massachusetts Eye And Ear Infirmary Light activated adhesive scaffold
CA3146680A1 (en) 2019-07-12 2021-01-21 Gatt Technologies B.V. Haemostatic powder
JPWO2021261080A1 (de) * 2020-06-26 2021-12-30
CN116744983A (zh) 2021-01-08 2023-09-12 西拉格国际有限公司 生物可吸收性密封粉末
CN113144277B (zh) * 2021-04-13 2022-06-14 武汉理工大学 一种可注射流体明胶及其制备方法和应用
CN113209357B (zh) * 2021-05-14 2023-02-17 南方科技大学 复合止血粉
JP2024534444A (ja) * 2021-09-16 2024-09-20 エシコン・インコーポレイテッド 組織経路封止用組成物のためのキット
CN117298327B (zh) * 2023-11-15 2024-10-01 北京帝康医药投资管理有限公司 一种止血微球颗粒及其制备方法和应用

Family Cites Families (138)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2507244A (en) 1947-04-14 1950-05-09 Upjohn Co Surgical gelatin dusting powder and process for preparing same
CH264752A (de) 1947-06-03 1949-10-31 Hoffmann La Roche Verfahren zur Herstellung von Trägern für Arzneimittel.
US3089315A (en) 1961-09-25 1963-05-14 Gen Electric Convertible self-contained cooling unit for air conditioning
SE420565B (sv) 1974-06-06 1981-10-19 Pharmacia Ab Hjelpmedel for intravaskuler administraring for anvendning i samband med intravaskuler administrering av en losning eller en suspension av ett diagnostiseringsmedel
US4013078A (en) * 1974-11-25 1977-03-22 Feild James Rodney Intervertebral protector means
US4006220A (en) 1975-06-04 1977-02-01 Gottlieb Sheldon K Compositions and methods useful for repairing depressed cutaneous scars
US4164559A (en) * 1977-09-21 1979-08-14 Cornell Research Foundation, Inc. Collagen drug delivery device
DE2843963A1 (de) * 1978-10-09 1980-04-24 Merck Patent Gmbh Im koerper resorbierbare geformte masse auf basis von kollagen und ihre verwendung in der medizin
US4265233A (en) * 1978-04-12 1981-05-05 Unitika Ltd. Material for wound healing
US4179400A (en) 1978-05-09 1979-12-18 W. R. Grace & Co. Process for preparing catalytic solutions of sulfonium salts
AT359652B (de) 1979-02-15 1980-11-25 Immuno Ag Verfahren zur herstellung eines gewebekleb- stoffes
AT359653B (de) * 1979-02-15 1980-11-25 Immuno Ag Verfahren zur herstellung eines gewebekleb- stoffes
DE3036033A1 (de) 1980-09-24 1982-05-06 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Wundbehandlungsmittel in pulverform und verfahren zu seiner herstellung
US4300494A (en) 1979-09-26 1981-11-17 Shell Oil Company Thermal insulated intake ports
US4292972A (en) 1980-07-09 1981-10-06 E. R. Squibb & Sons, Inc. Lyophilized hydrocolloio foam
US4443332A (en) * 1980-07-14 1984-04-17 Oros Company Cross flow solid-to-solid heat transfer apparatus
DE3105624A1 (de) * 1981-02-16 1982-09-02 Hormon-Chemie München GmbH, 8000 München Material zum abdichten und heilen von wunden
US4424208A (en) * 1982-01-11 1984-01-03 Collagen Corporation Collagen implant material and method for augmenting soft tissue
DE3360633D1 (en) * 1982-02-12 1985-10-03 Unitika Ltd Anti-cancer device
US4482386A (en) 1982-03-26 1984-11-13 Warner-Lambert Company Method of conditioning a water swellable hydrocolloid
US4543332A (en) 1982-03-29 1985-09-24 Miles Laboratories, Inc. Method for the preparation of spherical microorganism cell aggregates
US4540410A (en) 1982-11-16 1985-09-10 Serono Pharmaceutical Partners Lyophilized compositions, preparation and use thereof
EP0132983B2 (de) 1983-07-14 1991-06-12 Hitachi Chemical Co., Ltd. Herstellung von kugelförmigen Gelatinegelen und ihre Verwendung
JPS60100516A (ja) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
US4515637A (en) * 1983-11-16 1985-05-07 Seton Company Collagen-thrombin compositions
AT389815B (de) * 1984-03-09 1990-02-12 Immuno Ag Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern in blutprodukten
US4600574A (en) * 1984-03-21 1986-07-15 Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte Method of producing a tissue adhesive
US4837285A (en) * 1984-03-27 1989-06-06 Medimatrix Collagen matrix beads for soft tissue repair
JPS6144825A (ja) * 1984-08-09 1986-03-04 Unitika Ltd 止血剤
GB8422950D0 (en) * 1984-09-11 1984-10-17 Warne K J Hydrogel
JPS61122222A (ja) * 1984-11-19 1986-06-10 Koken:Kk コラ−ゲン又はゼラチンとプロタミンとよりなる止血剤
US5178883A (en) * 1984-11-29 1993-01-12 Regents Of The University Of Minnesota Method for promoting hair growth
US5165938A (en) 1984-11-29 1992-11-24 Regents Of The University Of Minnesota Wound healing agents derived from platelets
US4600533A (en) 1984-12-24 1986-07-15 Collagen Corporation Collagen membranes for medical use
US5007916A (en) * 1985-08-22 1991-04-16 Johnson & Johnson Medical, Inc. Method and material for prevention of surgical adhesions
IE59361B1 (en) * 1986-01-24 1994-02-09 Akzo Nv Pharmaceutical preparation for obtaining a highly viscous hydrogel or suspension
IL78826A (en) * 1986-05-19 1991-05-12 Yissum Res Dev Co Precursor composition for the preparation of a biodegradable implant for the sustained release of an active material and such implants prepared therefrom
US5300494A (en) * 1986-06-06 1994-04-05 Union Carbide Chemicals & Plastics Technology Corporation Delivery systems for quaternary and related compounds
US4946870A (en) * 1986-06-06 1990-08-07 Union Carbide Chemicals And Plastics Company Inc. Delivery systems for pharmaceutical or therapeutic actives
US4832686A (en) * 1986-06-24 1989-05-23 Anderson Mark E Method for administering interleukin-2
US4803075A (en) * 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability
US4885161A (en) 1987-03-11 1989-12-05 Medi-Tech International Corporation Wound dressings in gelled paste form
CA1305069C (en) 1987-03-11 1992-07-14 John Cornell Wound dressings in sheet or gelled paste form
US5080893A (en) * 1988-05-31 1992-01-14 University Of Florida Method for preventing surgical adhesions using a dilute solution of polymer
US5017229A (en) * 1990-06-25 1991-05-21 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
US5350573A (en) * 1988-05-31 1994-09-27 University Of Florida Research Foundation, Inc. Method and composition for preventing surgical adhesions
US5140016A (en) * 1988-05-31 1992-08-18 University Of Florida Method and composition for preventing surgical adhesions using a dilute solution of polymer
US5447966A (en) * 1988-07-19 1995-09-05 United States Surgical Corporation Treating bioabsorbable surgical articles by coating with glycerine, polalkyleneoxide block copolymer and gelatin
US5041292A (en) * 1988-08-31 1991-08-20 Theratech, Inc. Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents
US4925677A (en) * 1988-08-31 1990-05-15 Theratech, Inc. Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents
US5135751A (en) * 1988-11-16 1992-08-04 Mediventures Incorporated Composition for reducing postsurgical adhesions
US5126141A (en) * 1988-11-16 1992-06-30 Mediventures Incorporated Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers and ionic polysaccharides
US5614587A (en) * 1988-11-21 1997-03-25 Collagen Corporation Collagen-based bioadhesive compositions
US5510418A (en) * 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US5162430A (en) * 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US4891359A (en) * 1988-12-08 1990-01-02 Johnson & Johnson Patient Care, Inc. Hemostatic collagen paste composition
DE3903672C1 (de) * 1989-02-08 1990-02-01 Lohmann Gmbh & Co Kg
DE69004098T2 (de) 1989-08-10 1994-08-04 Gore & Ass Medizinisches spendesystem für gewebeklebstoffkomponenten.
US5196185A (en) 1989-09-11 1993-03-23 Micro-Collagen Pharmaceutics, Ltd. Collagen-based wound dressing and method for applying same
US5061274A (en) 1989-12-04 1991-10-29 Kensey Nash Corporation Plug device for sealing openings and method of use
US5219328A (en) * 1990-01-03 1993-06-15 Cryolife, Inc. Fibrin sealant delivery method
US5134229A (en) * 1990-01-12 1992-07-28 Johnson & Johnson Medical, Inc. Process for preparing a neutralized oxidized cellulose product and its method of use
JPH0813750B2 (ja) * 1990-03-01 1996-02-14 持田製薬株式会社 経口用トロンビン製剤
US5306501A (en) * 1990-05-01 1994-04-26 Mediventures, Inc. Drug delivery by injection with thermoreversible gels containing polyoxyalkylene copolymers
US5595735A (en) * 1990-05-23 1997-01-21 Johnson & Johnson Medical, Inc. Hemostatic thrombin paste composition
US5292362A (en) * 1990-07-27 1994-03-08 The Trustees Of Columbia University In The City Of New York Tissue bonding and sealing composition and method of using the same
US5209776A (en) * 1990-07-27 1993-05-11 The Trustees Of Columbia University In The City Of New York Tissue bonding and sealing composition and method of using the same
US5192300A (en) * 1990-10-01 1993-03-09 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5108421A (en) * 1990-10-01 1992-04-28 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
ZA918168B (en) * 1990-10-16 1993-04-14 Takeda Chemical Industries Ltd Prolonged release preparation and polymers thereof.
US5129882A (en) * 1990-12-27 1992-07-14 Novoste Corporation Wound clotting device and method of using same
US5690675A (en) 1991-02-13 1997-11-25 Fusion Medical Technologies, Inc. Methods for sealing of staples and other fasteners in tissue
WO1992022304A1 (en) * 1991-06-14 1992-12-23 Amgen Inc. Collagen film drug delivery for proteins
AT398079B (de) * 1991-11-04 1994-09-26 Immuno Ag Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung
US5204382A (en) * 1992-02-28 1993-04-20 Collagen Corporation Injectable ceramic compositions and methods for their preparation and use
EP1120439B1 (de) 1992-02-28 2004-06-16 Cohesion Technologies, Inc. Injektierbare, keramische Verbindungen sowie Verfahren zu deren Herstellung und Anwendung
ATE193037T1 (de) * 1992-02-28 2000-06-15 Collagen Corp Hochkonzentrierte homogenisierte kollagenzusammensetzungen
US5384333A (en) * 1992-03-17 1995-01-24 University Of Miami Biodegradable injectable drug delivery polymer
EP0637226A4 (de) * 1992-04-23 1995-06-14 Scimed Life Systems Inc Vorrichtung und verfahren zum verschliessen von vaskularen punktionen.
IL105529A0 (en) * 1992-05-01 1993-08-18 Amgen Inc Collagen-containing sponges as drug delivery for proteins
WO1993024476A1 (en) * 1992-06-04 1993-12-09 Clover Consolidated, Limited Water-soluble polymeric carriers for drug delivery
US5385606A (en) * 1992-07-06 1995-01-31 Kowanko; Nicholas Adhesive composition and method
US5413571A (en) * 1992-07-16 1995-05-09 Sherwood Medical Company Device for sealing hemostatic incisions
US5428022A (en) * 1992-07-29 1995-06-27 Collagen Corporation Composition of low type III content human placental collagen
US5514379A (en) * 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
DE4227681C2 (de) 1992-08-21 1995-05-18 Becker & Co Naturinwerk Wundabdeckungsmaterial auf der Basis von Kollagenfasern und Verfahren zu seiner Herstellung
EP0668747B1 (de) * 1992-11-12 2001-10-10 ALLEYNE, Neville Einrichtung zum schutz des herzens
US5667839A (en) * 1993-01-28 1997-09-16 Collagen Corporation Human recombinant collagen in the milk of transgenic animals
EP0702959B1 (de) 1993-05-31 2001-08-08 Kaken Pharmaceutical Co., Ltd. Eine gelpräparation aus vernetzter gelatine, die einen basischen wachstumsfaktor für fibroblasten enthält
FR2715309B1 (fr) * 1994-01-24 1996-08-02 Imedex Composition adhésive, à usage chirurgical, à base de collagène modifié par coupure oxydative et non réticulé.
US5674275A (en) 1994-04-06 1997-10-07 Graphic Controls Corporation Polyacrylate and polymethacrylate ester based hydrogel adhesives
US5531759A (en) * 1994-04-29 1996-07-02 Kensey Nash Corporation System for closing a percutaneous puncture formed by a trocar to prevent tissue at the puncture from herniating
DE69530553T2 (de) * 1994-05-13 2004-03-25 KURARAY CO., LTD, Kurashiki Medizinisches polymergel
GB9415739D0 (en) 1994-07-30 1994-09-21 Scimat Ltd Gel wound dressing
US5516532A (en) * 1994-08-05 1996-05-14 Children's Medical Center Corporation Injectable non-immunogenic cartilage and bone preparation
US5931165A (en) * 1994-09-06 1999-08-03 Fusion Medical Technologies, Inc. Films having improved characteristics and methods for their preparation and use
US20030039695A1 (en) 2001-08-10 2003-02-27 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Collagen carrier of therapeutic genetic material, and method
US5698213A (en) 1995-03-06 1997-12-16 Ethicon, Inc. Hydrogels of absorbable polyoxaesters
US5580923A (en) 1995-03-14 1996-12-03 Collagen Corporation Anti-adhesion films and compositions for medical use
US6129761A (en) 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
US5874500A (en) * 1995-12-18 1999-02-23 Cohesion Technologies, Inc. Crosslinked polymer compositions and methods for their use
US6458889B1 (en) 1995-12-18 2002-10-01 Cohesion Technologies, Inc. Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
US5752974A (en) * 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
US5748318A (en) * 1996-01-23 1998-05-05 Brown University Research Foundation Optical stress generator and detector
RU2193897C2 (ru) 1996-04-04 2002-12-10 Бакстер Акциенгезельшафт Гемостатическая губка, основанная на коллагене, способ ее получения, повязка для ран, включающая такую губку, и набор для приготовления повязки для ран
US5902832A (en) * 1996-08-20 1999-05-11 Menlo Care, Inc. Method of synthesizing swollen hydrogel for sphincter augmentation
US7320962B2 (en) * 1996-08-27 2008-01-22 Baxter International Inc. Hemoactive compositions and methods for their manufacture and use
US6706690B2 (en) * 1999-06-10 2004-03-16 Baxter Healthcare Corporation Hemoactive compositions and methods for their manufacture and use
US6063061A (en) * 1996-08-27 2000-05-16 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US7435425B2 (en) * 2001-07-17 2008-10-14 Baxter International, Inc. Dry hemostatic compositions and methods for their preparation
US6066325A (en) 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US7871637B2 (en) * 1996-08-27 2011-01-18 Baxter International Inc. Dry hemostatic compositions and methods for their preparation
CN1157355A (zh) * 1996-10-21 1997-08-20 山西省化学纤维研究所 止血纤维组成及其气体牵伸法纺丝工艺
PT986408E (pt) * 1997-06-03 2005-09-30 Innogenetics Nv Novos medicamentos baseados em polimeros compostos por gelatina modificada com metacrilamida
US5908054A (en) 1997-06-16 1999-06-01 Fusion Medical Technologies, Inc. Fluid dispersion and delivery assembly and method
EP1017415B1 (de) 1997-09-16 2005-10-19 Integra Lifesciences Corporation Zusammensetzung zur förderung des wachstums von duralem oder meningealem gewebe enthaltend kollagen
US5997895A (en) 1997-09-16 1999-12-07 Integra Lifesciences Corporation Dural/meningeal repair product using collagen matrix
US6179872B1 (en) * 1998-03-17 2001-01-30 Tissue Engineering Biopolymer matt for use in tissue repair and reconstruction
US6227394B1 (en) * 1998-06-09 2001-05-08 Asahi Glass Company Ltd. Glass bulb for a cathode ray tube and a method for producing a cathode ray tube
US6110484A (en) * 1998-11-24 2000-08-29 Cohesion Technologies, Inc. Collagen-polymer matrices with differential biodegradability
US6328229B1 (en) 1998-12-18 2001-12-11 Cohesion Technologies, Inc. Low volume mixing spray head for mixing and dispensing of two reactive fluid components
US6312725B1 (en) 1999-04-16 2001-11-06 Cohesion Technologies, Inc. Rapid gelling biocompatible polymer composition
US6221109B1 (en) 1999-09-15 2001-04-24 Ed. Geistlich Söhne AG fur Chemische Industrie Method of protecting spinal area
US6312474B1 (en) 1999-09-15 2001-11-06 Bio-Vascular, Inc. Resorbable implant materials
CN1114728C (zh) * 2000-04-21 2003-07-16 中国石油化工集团公司 止血纤维及其制造方法
EP1320390A2 (de) 2000-09-18 2003-06-25 Organogenesis Inc. Bioartifizielle flache schichtförmige prothesen und ihre verwendung
AR032517A1 (es) 2001-01-25 2003-11-12 Nycomed Pharma As Un metodo para preparar una esponja de colageno, un dispositivo para extraer una parte de una espuma de colageno, y una esponja de colageno alargada
ATE315413T1 (de) 2003-06-05 2006-02-15 Baxter Int Zubereitungen zur wiederherstellung und regeneration humaner dura mater
US8834864B2 (en) * 2003-06-05 2014-09-16 Baxter International Inc. Methods for repairing and regenerating human dura mater
EP1682196A2 (de) * 2003-11-10 2006-07-26 Angiotech International Ag Medizinische implantate und anti-narben-mittel
US20080091277A1 (en) * 2004-08-13 2008-04-17 Kai Deusch Surgical prosthesis having biodegradable and nonbiodegradable regions
WO2006118460A1 (en) 2005-05-04 2006-11-09 Suprapolix B.V. Hydrogen bonded hydrogels
WO2007001926A2 (en) 2005-06-24 2007-01-04 Hyperbranch Medical Technology, Inc. Low-swelling hydrogel sealants for wound repair
EP2021045B1 (de) * 2006-05-31 2016-03-16 Baxter International Inc. Kollagen für Einsatz in der Prävention von peridural Bildung Fibrose nach Wirbelsäulenchirurgie
TWI436793B (zh) 2006-08-02 2014-05-11 Baxter Int 快速作用之乾密封膠及其使用和製造方法
AU2008317874B2 (en) * 2007-10-30 2013-12-19 Baxter Healthcare S.A. Use of a regenerative biofunctional collagen biomatrix for treating visceral or parietal defects
US9039783B2 (en) 2009-05-18 2015-05-26 Baxter International, Inc. Method for the improvement of mesh implant biocompatibility
KR101699992B1 (ko) 2009-06-16 2017-01-26 백스터 인터내셔널 인코포레이티드 지혈용 스펀지

Also Published As

Publication number Publication date
US8092820B2 (en) 2012-01-10
EP1803417B1 (de) 2008-11-26
US8383141B2 (en) 2013-02-26
DE60219319D1 (de) 2007-05-16
CA2453592A1 (en) 2003-01-30
CN101284146A (zh) 2008-10-15
WO2003007845A1 (en) 2003-01-30
PT1803417E (pt) 2008-12-31
KR20040025698A (ko) 2004-03-24
DK1414370T3 (da) 2007-04-30
ES2317600T3 (es) 2009-04-16
BRPI0211258B1 (pt) 2015-06-02
PT1414370E (pt) 2007-05-31
ATE358455T1 (de) 2007-04-15
WO2003007845A9 (en) 2004-04-01
US20070248685A1 (en) 2007-10-25
CN100402096C (zh) 2008-07-16
HK1060277A1 (en) 2004-08-06
HK1103342A1 (en) 2007-12-21
AU2002345846B2 (en) 2007-08-23
BR0211258A (pt) 2004-07-27
EP1414370B1 (de) 2007-04-04
BRPI0211258B8 (pt) 2021-07-27
CA2453592C (en) 2009-10-06
ES2284883T3 (es) 2007-11-16
CN101284146B (zh) 2013-05-08
EP1803417A1 (de) 2007-07-04
JP2005500102A (ja) 2005-01-06
US7547446B2 (en) 2009-06-16
CN1555249A (zh) 2004-12-15
KR100904582B1 (ko) 2009-06-25
DE60230079D1 (de) 2009-01-08
JP4316374B2 (ja) 2009-08-19
DE60219319T2 (de) 2008-01-03
US20090227779A1 (en) 2009-09-10
MXPA04000514A (es) 2005-03-07
US7435425B2 (en) 2008-10-14
EP1414370A4 (de) 2005-11-09
US20030064109A1 (en) 2003-04-03
ATE415136T1 (de) 2008-12-15
US20080286376A1 (en) 2008-11-20
EP1414370A1 (de) 2004-05-06

Similar Documents

Publication Publication Date Title
DK1803417T3 (da) Törre hæmostatiske sammensætninger og fremgangsmåder til fremstilling deraf
DE60138362D1 (de) Bioadhäsive zusammensetzung
WO2003020117A3 (en) Tissue repair compositions and methods for their manufacture and use
ES2062041T3 (es) Composicion hemostatica de pasta de colageno.
NO180363C (no) Beskyttelsesmiddelblandinger for stabilisering av liposomer under törking
HUP9902165A2 (hu) Nagy fajlagos felületű D-mannit, eljárás előállítására, valamint ilyen mannitot tartalmazó szilárd kompozíciók
DK1402222T3 (da) Fremgangsmåde til tørring af klæbrige materialer
IS5646A (is) Aðferð til að breyta prótínbyggingu fóðurtaflna, fóðurkúlna eða annarra fóðurköggla sem fengið hafalokalögun til að ná fram stöðugleika í lögun, og fóðurmassa í samræmi við það sem aðferðin segir til um
DK0426831T3 (da) Fremgangsmåde til fremstilling af en stabiliseret aspartambestanddel med hurtig frigivelse til tyggegummi
SE7910628L (sv) Forfarande for hojning pa mekanisk veg av trehalten i treflis
DK0948318T3 (da) Granulater omfattende en vandoplöselig forbindelse og cellulose
DK1135239T3 (da) Formuleringer til trækonservering
ATE248214T1 (de) Verfahren zur herstellung von cogranulaten, hieraus erhaltene cogranulate und verwendung als komponente in waschmittelzusammensetzungen
WO2002016338A8 (fr) Aminoalkenylbenzoyl-benzofuranes ou benzothiophenes, leur procede de preparation et les compositions les contenant
MD1186G2 (ro) Procedeu de uscare a prunelor
UA7484C2 (uk) Спосіб одержання сухого концентрату топінамбуру
JPS5234456A (en) Contious drying method of band shape veneer
JPS51111745A (en) Dry dehumidifier
JPS56151471A (en) Preparation of instant dried rice
WO2003082534A3 (en) Method for the treatment of wood, wood powder and such, equipment for the treatment of wood and products made from the modified wood and wood powder
RU96101724A (ru) Абразивный материал для отделочной обработки
JPS56118485A (en) Preparation of soil conditioner
JPS52131253A (en) Control method of dryer
SE9002749L (sv) Foerfarande foer att behandla trae
RU96119888A (ru) Вяжущее